Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID1001 | SequenceACSSSPSKHCG | NameTD1 | Nature of peptide or cargoTD1 enhances the transdermal delivery of macromolecules | AssayFranz diffusion cells | Tissue permeabilitySignificant increase in permeability of the peptide can be seen by the addition of ATP.The amount of protein that permeated the skin was determined with ELISA | Tissue SampleMale SD rats skin cells | PUBMED ID25269793 |
| ID1002 | SequenceAAPV | NameAAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=0.46 μg/cm2/h, Permeability coefficient=1.50×10−4Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1003 | SequenceAAPV | NameC6(D)-Laa-AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=2.29 μg/cm2/h, Permeability coefficient=7.6×10−4 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1004 | SequenceAAPV | NameC6(L)-Laa- AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=0.50 μg/cm2/h, Permeability coefficient=1.6×10−4 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1005 | SequenceAAPV | NameC8(D,L)-Laa-AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=10.08 μg/cm2/h, Permeability coefficient= 3.3×10−3 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1006 | SequenceAAPV | NameC8(D)-Laa-AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=7.42 μg/cm2/h, Permeability coefficient=1.90×10−2 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1007 | SequenceAAPV | NameC8(L)-Laa-AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=1.37 μg/cm2/h, Permeability coefficient=4.50×10−4 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1008 | SequenceAAPV | NameC10(D,L)-Laa-AAPV | Nature of peptide or cargoIt fits the P-P1 subsites of elastase and inhibits HNE competitively | AssayFranz diffusion cell, HPLC | Tissue permeabilityEpidermal flux=8.92 μg/cm2/h, Permeability coefficient=2.9×10−3 Kp(cm/h) | Tissue SampleHuman epidermal membranes were obtained by heat separation of whole skin | PUBMED ID24842663 |
| ID1009 | SequenceRRRRRRRRRRRLILV LLAI | Name11R-No. 10 | Nature of peptide or cargoMelanogenesis inhibitory peptide | AssayConfocal microscope | Tissue permeabilityWhen TMR-11R was topically applied for 24 h, the signals were only observed on the surface of the skin. In contrast, 12 h later, strong signals were detected showing that TMR-11R had arrived at the skin basal layer. Moreover, 24 and 48 hours later, the signals had spread out more and were stronger in both epidermis and dermis | Tissue SampleSkin from the back of a brown guinea pig | PUBMED ID24602570 |
| ID1010 | SequenceGKRR | NameR4 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 25.16 ± 2.31 , Q48 (mg) 1167.05 ± 50.10 Drug content in skin (mg/cm2) 146 ± 6.44 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1011 | SequenceGKRR | NameR4 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 43.74 ± 4.15 , Q48(mg) 2064.72 ± 100.05 Drug content in skin (mg/cm2) 180 ± 8.23 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1012 | SequenceGKRR | NameR4 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1013 | SequenceGKKKRRRR | NameR8 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1014 | SequenceGKKKRRRR | NameR8 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 57.66 ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1015 | SequenceGKKKRRRR | NameR8 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 78.07 ± 7.52, Q48 (mg) 3666.44 ± 162.70 Drug content in skin (mg/cm2) 378± 15.11 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1016 | SequenceGKKKKKKKRRRRRRRR | NameR16 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 21.43 ± 1.32 , Q48 (mg) 856.29 ± 39.50 Drug content in skin (mg/cm2) 151 ± 4.64 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1017 | SequenceGKKKKKKKRRRRRRRR | NameR16 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 23.46 ± 2.04 , Q48 (mg) 1106.03 ± 53.80 Drug content in skin (mg/cm2) 155 ± 4.85 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1018 | SequenceGKKKKKKKRRRRRRRR | NameR16 (arginine-terminated peptide dendrimers) | Nature of peptide or cargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups | AssayFranz diffusion cell | Tissue permeabilityFlux (mg/cm2/h) 27.16 ± 2.65, Q48 (mg) 1256.61 ± 55.70, Drug content in skin (mg/cm2) 156 ± 6.26 | Tissue SampleHuman epidermal skin | PUBMED ID24134794 |
| ID1019 | SequenceKETWWETWWTEWSQP KKKRKV | NamePep-1 | Nature of peptide or cargoCell penetrating peptide | AssayIn vivo imaging | Tissue permeabilitySignificant permeability of the peptide can be seen in in vivo images | Tissue SampleMouse skin cells | PUBMED ID23601371 |
| ID1020 | SequenceACSSSPSKHCG | NameTDN | Nature of peptide or cargoTD-1 has been testified to enhanced insulin transdermal delivery through hair follicles | AssayConfocal Laser Scanning Microscopy | Tissue permeabilitySignificant permeability of the peptide can be seen in confocal images | Tissue SampleMale SD rats skin cells | PUBMED ID23391375 |
| ID1021 | SequenceACSSKKSKHCG | NameTD-34 | Nature of peptide or cargoTD-1 has been testified to enhanced insulin transdermal delivery through hair follicles | AssayConfocal Laser Scanning Microscopy | Tissue permeabilitySignificant permeability of the peptide can be seen in confocal images | Tissue SampleMale SD rats skin cells | PUBMED ID23391375 |
| ID1022 | SequenceACSSSPSKHCG | NameTD1 | Nature of peptide or cargoTD1 enhances the transdermal delivery of macromolecules | AssayFranz diffusion cells, immunity fluorescence techniques | Tissue permeabilitySignificant permeability of the peptide can be seen. The amount of protein that permeated the skin was determined with immunity fluorescence techniques | Tissue SampleMale SD rats skin cells | PUBMED ID23385091 |
| ID1023 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell | Tissue permeabilityTP could not pass through the skin due to the charge repulsion effect between the negative charge of the TP and the negative charge of the skin | Tissue SampleAbdominal skin of Sprague–Dawley rats | PUBMED ID23311648 |
| ID1024 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell | Tissue permeabilityCumulative amounts0.10± 0.01 µg/cm2 and fluxes 0.60 ± 0.06 µg/cm2·h | Tissue SampleAcceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats | PUBMED ID23311648 |
| ID1025 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell | Tissue permeabilityCumulative amounts 0.31 ± 0.04 µg/cm2 and fluxes 1.86 ± 0.24 µg/cm2·h | Tissue SampleAbdominal skin of Sprague–Dawley rats | PUBMED ID23311648 |
| ID1026 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell | Tissue permeabilityCumulative amounts 1.02 ± 0.05 µg/cm2 and fluxes 6.13± 0.28 µg/cm2·h | Tissue SampleAcceptor compartment of Franz diffusion cell/Abdominal skin of Sprague–Dawley rats | PUBMED ID23311648 |
| ID1027 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell | Tissue permeabilityCumulative amounts 4.29 ± 0.40 µg/cm2 and fluxes 25.73 ± 2.40 µg/cm2·h | Tissue SampleAbdominal skin of Sprague–Dawley rats | PUBMED ID23311648 |
| ID1076 | SequenceRRRRRRRR | NamePolyarginine | Nature of peptide or cargoCell penetrating peptide | AssayFranz cell system | Tissue permeabilityThe SC, epidermal and dermal retention of SP for SP-NLC-R11 was 10.92, 7.02 and 0.82 mg/g of skin, respectively and the SC, epidermal and dermal retention of KP for KP-NLC-R11 was 0.75, 0.44 and 0.17 mg/g of skin, respectively | Tissue SampleSkin from the dorsal surface of hairless rat | PUBMED ID22617521 |
| ID1077 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell, HPLC | Tissue permeabilityCumulative amounts 0.20 ± 0.05 mg/cm2 and fluxes 0.20 ± 0.05 mg/cm2·h | Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | PUBMED ID22564052 |
| ID1078 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell, HPLC | Tissue permeabilityCumulative amounts 0.43 ± 0.04 mg/cm2 and fluxes 0.14 ± 0.01 mg/cm2·h | Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | PUBMED ID22564052 |
| ID1079 | SequenceGRKKRRQRRRPPQRKC | NameTat | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell, HPLC | Tissue permeabilityCumulative amounts 0.59 ± 0.12 mg/cm2 and fluxes 0.10 ± 0.02 mg/cm2·h | Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | PUBMED ID22564052 |
| ID1080 | SequenceCSNLSTCVLGKLSQELH KLQTYPRTNTGSGTP | NamesCT | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell, HPLC | Tissue permeabilityCumulative amounts 0.67 ± 0.10 mg/cm2 and fluxes 0.67 ± 0.10 mg/cm2·h | Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | PUBMED ID22564052 |
| ID1081 | SequenceCSNLSTCVLGKLSQELH KLQTYPRTNTGSGTP | NamesCT | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell, HPLC | Tissue permeabilityCumulative amounts 0.33 ± 0.09 mg/cm2 and fluxes 0.11 ± 0.03 mg/cm2·h | Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | PUBMED ID22564052 |
| ID1082 | SequenceCSNLSTCVLGKLSQELH KLQTYPRTNTGSGTP | NamesCT | Nature of peptide or cargoCell penetrating peptide | AssayVertical Franz diffusion cell, HPLC | Tissue permeabilityCumulative amounts 0.26 ± 0.02 mg/cm2 and fluxes 0.04 ± 0.00 mg/cm2·h | Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats | PUBMED ID22564052 |
| ID1083 | SequenceRQIKIWFQNRRMKWKK | NamePenetratin (PEN) | Nature of peptide or cargoPenetrate through cell and nucleus membranes | AssayFranz diffusion cell system, HPLC with photodiode array detector | Tissue permeability2-fold higher | Tissue SamplePorcine ear skin | PUBMED ID22306174 |
| ID1084 | SequenceRQIKIWFQNRRMKWKK | NamePenetratin (PEN) | Nature of peptide or cargoPenetrate through cell and nucleus membranes | AssayFranz diffusion cell system, HPLC with photodiode array detector | Tissue permeability2.8 wt% of the initial amount | Tissue SamplePorcine ear skin | PUBMED ID22306174 |
| ID1085 | SequenceRQIKIWFQNRRMKWKK | NamePenetratin (PEN) | Nature of peptide or cargoPenetrate through cell and nucleus membranes | AssayThe scotch tape method | Tissue permeability0.35 wt% of Na-DFC | Tissue SampleSC skin | PUBMED ID22306174 |
| ID1086 | SequenceRQIKIWFQNRRMKWKK | NamePenetratin (PEN) | Nature of peptide or cargoPenetrate through cell and nucleus membranes | AssayThe scotch tape method | Tissue permeability0.72 wt% of Na-DFC | Tissue SampleSC skin | PUBMED ID22306174 |
| ID1087 | SequenceRQIKIWFQNRRMKWKK | NamePenetratin (PEN) | Nature of peptide or cargoPenetrate through cell and nucleus membranes | AssayThe scotch tape method | Tissue permeability0.3 wt% of Na-DFC | Tissue SampleE + D skin | PUBMED ID22306174 |
| ID1088 | SequenceRQIKIWFQNRRMKWKK | NamePenetratin (PEN) | Nature of peptide or cargoPenetrate through cell and nucleus membranes | AssayThe scotch tape method | Tissue permeability0.57 wt% of Na-DFC | Tissue SampleE + D skin | PUBMED ID22306174 |
| ID1089 | Sequence(GSGAGA)n | NameSilk fibroin peptide (3,000 Da) | Nature of peptide or cargoAnti-inflammatory | AssayHistochemical analysis | Tissue permeabilitySignificant permeability of the silk peptide can be seen in histochemical images | Tissue SampleEar of mice | PUBMED ID22189681 |
| ID1090 | Sequence(GSGAGA)n | NameSilk fibroin peptide (3,000 Da) | Nature of peptide or cargoAnti-inflammatory | AssayRT-PCR, Western blotting | Tissue permeabilitySignificant decrease in translation of COX-2, IL-6 and IL-1β in presence of silk peptide +Tat-SOD can be seen in western blot images | Tissue SampleHaCaT keratinocytes | PUBMED ID22189681 |
| ID1091 | SequenceRKKRRQRRR | NameTat | Nature of peptide or cargoTat-SOD is anti-inflammatory | AssayHistochemical analysis | Tissue permeabilitySignificant permeability of the Tat-SOD peptide can be seen in histochemical images | Tissue SampleEar of mice | PUBMED ID22189681 |
| ID1092 | SequenceRKKRRQRRR | NameTat | Nature of peptide or cargoFor promoting the skin penetration of molecules | AssayFranz diffusion cells, HPLC | Tissue permeabilityPermeation parameters observed were 15.74 ± 1.31% | Tissue SampleDorsal skin of mice | PUBMED ID22072881 |
| ID1093 | SequenceRKKRRQRRR | NameTat | Nature of peptide or cargoFor promoting the skin penetration of molecules | AssayFranz diffusion cells, HPLC | Tissue permeabilityPermeation parameters observed were5.74 ± 1.32% | Tissue SampleDorsal skin of mice | PUBMED ID22072881 |
| ID1094 | SequenceRKKRRQRRR | NameTat | Nature of peptide or cargoFor promoting the skin penetration of molecules | AssayIn vivo therapeutic efficacy assay | Tissue permeabilityShow significantly improvement in wound and dry skin | Tissue SamplePostaxial back skin of the mice | PUBMED ID22072881 |
| ID1095 | SequenceRKKRRQRRR | NameTat | Nature of peptide or cargoFor promoting the skin penetration of molecules | AssayIn vivo therapeutic efficacy assay | Tissue permeabilityShow significantly improvement in wound and dry skin but lesser than EL/T | Tissue SamplePostaxial back skin of the mice | PUBMED ID22072881 |
| ID1096 | SequenceACSSSPSKHCG | NameTD-1 | Nature of peptide or cargoTransdermal Delivery enhancer | AssayFluorescence microscopy, Transmission electron microscopy | Tissue permeabilityPenetrates to the stratum corneum of rat footpad 15 min after topical application. | Tissue SampleFootpad skin of rats | PUBMED ID22009459 |
| ID1097 | SequenceACSSSPSKHCG | NameTD-1 | Nature of peptide or cargoTransdermal Delivery enhancer | AssayFluorescence microscopy, Transmission electron microscopy | Tissue permeabilityCo-administered FAM-labeled siRNA gathered in the hair follicle 30 min after application | Tissue SampleBack skin of rats | PUBMED ID22009459 |
| ID1098 | SequenceACSSSPSKHCG | NameTD-1 | Nature of peptide or cargoTransdermal Delivery enhancer | AssayFluorescence microscopy, Transmission electron microscopy | Tissue permeabilityFAM-labeled siRNA and TD-1 topically co-administered penetrated from the stratum corneum to subcutaneous tissue 15 min after application | Tissue SampleFootpad skin of rats | PUBMED ID22009459 |