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Details of TopicalPdb ID 1013

PRIMARY INFORMATION
ID1013
PMID24134794
Year2014
SequenceGKKKRRRR
NameR8 (arginine-terminated peptide dendrimers)
Length8
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear (Branched)
ChiralityL
Chemical ModificationNone
Origin of PeptideArginine-terminated peptide dendrimers of varying positive charge
Nature of Peptide/CargoPeptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups
MechanismIncreased transepidermal water loss and decreased skin resistance due to the interaction of dendrimers with skin lipids
Cargo Sequence/StructureNot mentioned
Name of cargo
5-fluorouracil
AssayFranz diffusion cell
EnhancerNone
Properties of enhancerNot applicable
Concentration0.5 mL of 20 mg/mL dendrimer in HEPES solution (pH 7.4) for a predetermined time (2 h) after hydration.A minute quantity of 5-FU was added to make it as a suspension to maintain high thermodynamic activity
Incubation time48 hours
Tissue permeability (value with units)Flux (mg/cm2/h) ± 4.83 , Q48(mg) 2706.53 ± 123.60, Drug content in skin (mg/cm2) 204 ± 8.41
Tissue SampleHuman epidermal skin
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.