Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1081

PRIMARY INFORMATION
ID1081
PMID22564052
Year2013
SequenceCSNLSTCVLGKLSQELH
KLQTYPRTNTGSGTP
NamesCT
Length32
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSalmon calcitonin
Nature of Peptide/CargoCell penetrating peptide
MechanismInhibits bone resorption by inhibiting the activity of osteoclasts
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayVertical Franz diffusion cell, HPLC
EnhancerNone
Properties of enhancerNot applicable
Concentration1ml
Incubation time3 hours
Tissue permeability (value with units)Cumulative amounts 0.33 ± 0.09 mg/cm2 and fluxes 0.11 ± 0.03 mg/cm2·h
Tissue SampleViable epidermis and dermis (VED) abdominal skin of Sprague Dawley (SD) rats
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C
(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H]
(C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N
[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC
(=O)N[C@H](C(=O)N[C@H](C=O)CCC)[C@H](O)C)
CO)[C@H](O)C)CC(=O)N)[C@H](O)C)CCC
NC(=N)N)CCC)Cc1ccc(cc1)O)[C@H]
(O)C)CCC(=O)N)CC(C)C)CCCCN)Cc1[nH]cnc1)CC
(C)C)CCC(=O)O)CCC(=O)N)CO)CC(C)C)CCCCN)
CC(C)C)C(C)C)CS)[C@H](O)C)CO)CC(C)
C)CC(=O)N)CO)CS