Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1019

PRIMARY INFORMATION
ID1019
PMID23601371
Year2013
SequenceKETWWETWWTEWSQP
KKKRKV
NamePep-1
Length21
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideDerived from the simian virus 40 large T antigen
Nature of Peptide/CargoCell penetrating peptide
MechanismThe formation of pores through the membrane might be involved in cellular penetration property of Pep-1
Cargo Sequence/StructureNot mentioned
Name of cargo
Elastin congo red
AssayIn vivo imaging
EnhancerNone
Properties of enhancerNot applicable
Concentration50 µl (500 µM concentration of cargo)
Incubation time3 hours
Tissue permeability (value with units)Significant permeability of the peptide can be seen in in vivo images
Tissue SampleMouse skin cells
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](CCCC[NH3])C(=O)N[C@@H](CCC(=O)O)
C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c
[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C
(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H]
(C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C
(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N
[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC
(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)
N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O)
N1CCC[C@H]1C(=O)N[C@@H](CCCC[NH3])C(=O)
N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC
[NH3])C(=O)N[C@@H](CCCNC(=[NH2])N)
C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](C(C)C)C=O