ID | 1019 | |
PMID | 23601371 | |
Year | 2013 | |
Sequence | KETWWETWWTEWSQP KKKRKV | |
Name | Pep-1 | |
Length | 21 | |
N-Terminal Modification | Free | |
C-Terminal Modification | Free | |
Linear/ Cyclic | Linear | |
Chirality | L | |
Chemical Modification | None | |
Origin of Peptide | Derived from the simian virus 40 large T antigen | |
Nature of Peptide/Cargo | Cell penetrating peptide | |
Mechanism | The formation of pores through the membrane might be involved in cellular penetration property of Pep-1 | |
Cargo Sequence/Structure | Not mentioned | |
Name of cargo | Elastin congo red | |
Assay | In vivo imaging | |
Enhancer | None | |
Properties of enhancer | Not applicable | |
Concentration | 50 µl (500 µM concentration of cargo) | |
Incubation time | 3 hours | |
Tissue permeability (value with units) | Significant permeability of the peptide can be seen in in vivo images | |
Tissue Sample | Mouse skin cells | |
Ex vivo/In vivo/In vitro | in vivo | |
STRUCTURE |
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SMILES | N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCC(=O)O) C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c [nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C (=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H] (C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C (=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N [C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC (=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O) N[C@@H](CO)C(=O)N[C@@H](CCC(=O)N)C(=O) N1CCC[C@H]1C(=O)N[C@@H](CCCC[NH3])C(=O) N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC [NH3])C(=O)N[C@@H](CCCNC(=[NH2])N) C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](C(C)C)C=O |