Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1084

PRIMARY INFORMATION
ID1084
PMID22306174
Year2012
SequenceRQIKIWFQNRRMKWKK
NamePenetratin (PEN)
Length16
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideThird helix of the Antennapedia homeodomain
Nature of Peptide/CargoPenetrate through cell and nucleus membranes
MechanismMembrane electroporation
Cargo Sequence/StructureNSAID
Name of cargo
Diclofenac
AssayFranz diffusion cell system, HPLC with photodiode array detector
EnhancerHII mesophase
Properties of enhancerExcellent matrix for drug solubilization
Concentration200mg containing 1 wt% of Na-DFC-PEN
Incubation time25 hours
Tissue permeability (value with units)2.8 wt% of the initial amount
Tissue SamplePorcine ear skin
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]
(CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]
(CCCC[NH3])C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]
(Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)
N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC
(=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H]
(CCCNC(=[NH2])N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]
(CCCC[NH3])C(=O)N[C@@H](Cc1c[nH]c2ccccc12)
C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C=O