| ID | 1084 | |
| PMID | 22306174 | |
| Year | 2012 | |
| Sequence | RQIKIWFQNRRMKWKK | |
| Name | Penetratin (PEN) | |
| Length | 16 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Linear | |
| Chirality | L | |
| Chemical Modification | None | |
| Origin of Peptide | Third helix of the Antennapedia homeodomain | |
| Nature of Peptide/Cargo | Penetrate through cell and nucleus membranes | |
| Mechanism | Membrane electroporation | |
| Cargo Sequence/Structure | NSAID | |
| Name of cargo | Diclofenac | |
| Assay | Franz diffusion cell system, HPLC with photodiode array detector | |
| Enhancer | HII mesophase | |
| Properties of enhancer | Excellent matrix for drug solubilization | |
| Concentration | 200mg containing 1 wt% of Na-DFC-PEN | |
| Incubation time | 25 hours | |
| Tissue permeability (value with units) | 2.8 wt% of the initial amount | |
| Tissue Sample | Porcine ear skin | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
| |
| SMILES | N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H] (CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H] (CCCC[NH3])C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H] (Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O) N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC (=O)N)C(=O)N[C@@H](CCCNC(=[NH2])N)C(=O)N[C@@H] (CCCNC(=[NH2])N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H] (CCCC[NH3])C(=O)N[C@@H](Cc1c[nH]c2ccccc12) C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H](CCCC[NH3])C=O | |