| PRIMARY INFORMATION |
|---|
| ID | 1018 |
| PMID | 24134794 |
| Year | 2014 |
| Sequence | GKKKKKKKRRRRRRRR |
| Name | R16 (arginine-terminated peptide dendrimers) |
| Length | 16 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Free |
| Linear/ Cyclic | Linear (Branched) |
| Chirality | L |
| Chemical Modification | None |
| Origin of Peptide | Arginine-terminated peptide dendrimers of varying positive charge |
| Nature of Peptide/Cargo | Peptide dendrimers are wedge-like molecules comprising an amino acid branching core that is most typically decorated with various basic amino acids (e.g. Lys, His, Arg) on their head groups |
| Mechanism | Increased transepidermal water loss and decreased skin resistance due to the interaction of dendrimers with skin lipids |
| Cargo Sequence/Structure | Not mentioned |
Name of cargo
| 5-fluorouracil |
| Assay | Franz diffusion cell |
| Enhancer | None |
| Properties of enhancer | Not applicable |
| Concentration | 0.5 mL of 20 mg/mL dendrimer in HEPES solution (pH 7.4) for a predetermined time (2 h) after hydration.A minute quantity of 5-FU was added to make it as a suspension to maintain high thermodynamic activity |
| Incubation time | 48 hours |
| Tissue permeability (value with units) | Flux (mg/cm2/h) 27.16 ± 2.65, Q48 (mg) 1256.61 ± 55.70, Drug content in skin (mg/cm2) 156 ± 6.26 |
| Tissue Sample | Human epidermal skin |
| Ex vivo/In vivo/In vitro | in vitro |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
