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Details of TopicalPdb ID 1097

PRIMARY INFORMATION
ID1097
PMID22009459
Year2012
SequenceACSSSPSKHCG
NameTD-1
Length11
N-Terminal ModificationFITC linked through aminocaproic (Acp) spacer
C-Terminal ModificationFree
Linear/ CyclicCyclic (C2-C10)
ChiralityL
Chemical ModificationNone
Origin of PeptideSynthetic
Nature of Peptide/CargoTransdermal Delivery enhancer
MechanismCell junction structures were disrupted in the footpad skin
Cargo Sequence/StructureUUCUCCGAACGUGUCACGUTT
Name of cargo
FAM-labeled siRNA
AssayFluorescence microscopy, Transmission electron microscopy
EnhancerHair shaved skin of back
Properties of enhancerNot applicable
Concentration1000 µg/ml
Incubation time30 minutes
Tissue permeability (value with units)Co-administered FAM-labeled siRNA gathered in the hair follicle 30 min after application
Tissue SampleBack skin of rats
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](C)C(=O)N[C@H]1CSSC[C@H]
(NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC
(=O)[C@H]2N(C(=O)[C@@H](NC(=O)[C@@H](NC
(=O)[C@@H](NC1=O)CO)CO)CO)CCC2)CO)
CCCC[NH3])Cc1nc[nH]c1)C(=O)NCC=O