Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RID_0001 | 6-O-stearoyl-MDP (L18- MDP) Click for more detail | MDP (others) | CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Synthetic | It leads to the induction of interferon in the lung. | Nod-like receptor 2 (NOD2) | NOD-like receptor (NLR) | Lungs | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It augments host-resistance to viral infection. | Interferon assay | 2417426 | 1985 | Pubchem Assay | |
| RID_0001 | 6-O-stearoyl-MDP (L18- MDP) Click for more detail | MDP (others) | CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Synthetic | It leads to the induction of interferon in the lung. | Nod-like receptor 2 (NOD2) | NOD-like receptor (NLR) | Lungs | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It augments host-resistance to viral infection. | Interferon assay | 2417426 | 1985 | Pubchem Assay | |
| PRRID_0002 | N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) Click for more detail | NA | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Synthetic | It leads to the induction of interferon in the lung. | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Sendai virus infected mice | Lungs | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It augments host-resistance to viral infection. | Interferon assay | 2417426 | 1985 | Pubchem Assay |
| PRRID_0002 | N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) Click for more detail | NA | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Synthetic | It leads to the induction of interferon in the lung. | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Sendai virus infected mice | Lungs | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It augments host-resistance to viral infection. | Interferon assay | 2417426 | 1985 | Pubchem Assay |
| PRRID_0003 | N(alpha)-acetylmuramyl-L-alanyl-D-isoglutaminyl-N(epsilon)-stearoyl'L'lysine (MDP-L ys-L18) Click for more detail | MDP (others) | CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Synthetic | It leads to the induction of interferon in the lung. | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Sendai virus infected mice | Lungs | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It augments host-resistance to viral infection. | Interferon assay | 2417426 | 1985 | Pubchem Assay |
| PRRID_0003 | N(alpha)-acetylmuramyl-L-alanyl-D-isoglutaminyl-N(epsilon)-stearoyl'L'lysine (MDP-L ys-L18) Click for more detail | MDP (others) | CCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Synthetic | It leads to the induction of interferon in the lung. | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Sendai virus infected mice | Lungs | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It augments host-resistance to viral infection. | Interferon assay | 2417426 | 1985 | Pubchem Assay |
| PRRID_0163 | C12-iE-DAP Click for more detail | Chemical derivative of iE-DAP(others) | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Peptide | Synthetic | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice (Murine) | Macrophages | NA | Q8BHB0.fasta | Q8BHB0 | 953 | mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan. | ELISA | 12796777 | 2003 | Pubchem Assay |
| PRRID_0163 | C12-iE-DAP Click for more detail | Chemical derivative of iE-DAP(others) | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Peptide | Synthetic | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice (Murine) | Macrophages | NA | Q8BHB0.fasta | Q8BHB0 | 953 | mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan. | ELISA | 12796777 | 2003 | Pubchem Assay |
| PRRID_0166 | GlcNAc-MurNAc dipeptide (GM-Di) Click for more detail | Gram-negative bacteria | NA | NA | Carbohydrate | Natural | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9HC29.fasta | Q9HC29 | 1040 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0166 | GlcNAc-MurNAc dipeptide (GM-Di) Click for more detail | Gram-negative bacteria | NA | NA | Carbohydrate | Natural | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9HC29.fasta | Q9HC29 | 1040 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0167 | GlcNAc-MurNAc tripeptide muropeptide (GM-TriDAP) Click for more detail | Gram-negative bacteria | NA | NA | Carbohydrate | Natural | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9Y239.fasta | Q9Y239 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0167 | GlcNAc-MurNAc tripeptide muropeptide (GM-TriDAP) Click for more detail | Gram-negative bacteria | NA | NA | Carbohydrate | Natural | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9Y239.fasta | Q9Y239 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0173 | iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail | Bacteria | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Peptide | Natural | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice (Murine) | Macrophages | NA | Q8BHB0.fasta | Q8BHB0 | 953 | mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan. | ELISA | 12796777 | 2003 | Pubchem Assay |
| PRRID_0173 | iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail | Bacteria | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Peptide | Natural | elicit innate immune response | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice (Murine) | Macrophages | NA | Q8BHB0.fasta | Q8BHB0 | 953 | mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan. | ELISA | 12796777 | 2003 | Pubchem Assay |
| PRRID_0178 | M-Tri-DAP (MurNAc-L-Ala-D-g-Glu-mDAP) Click for more detail | Gram-negative bacteria | NA | NA | Peptide | Natural | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | production of pro-inflammatory cytokines | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0178 | M-Tri-DAP (MurNAc-L-Ala-D-g-Glu-mDAP) Click for more detail | Gram-negative bacteria | NA | NA | Peptide | Natural | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | production of pro-inflammatory cytokines | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0180 | muramyl tripeptide Click for more detail | muramyl dipeptide derivative (others) | CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC | NA | Peptide | Synthetic | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | production of pro-inflammatory cytokines | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0180 | muramyl tripeptide Click for more detail | muramyl dipeptide derivative (others) | CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC | NA | Peptide | Synthetic | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | production of pro-inflammatory cytokines | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0181 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9Y239.fasta | Q9Y239 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0181 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | HEK293T (human embryonic kidney 293T cells) | NA | Q9Y239.fasta | Q9Y239 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 12871942 | 2003 | Pubchem Assay |
| PRRID_0188 | Tri-DAP (L-Ala-D-g-Glu-mDAP) Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N | NA | Peptide | Natural | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0188 | Tri-DAP (L-Ala-D-g-Glu-mDAP) Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N | NA | Peptide | Natural | activation of the NF-κB pro-inflammatory cascade | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Macrophages | NA | Q9Y239.fasta | Q9Y239 | 953 | Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation | NA | 12527755 | 2003 | Pubchem Assay |
| PRRID_0220 | FK156 Click for more detail | NA | CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)NCC(=O)O)C(=O)O)NC(=O)C(C)O | NA | Peptide | Synthetic | It induces the secretion of the IL-8 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Monocytes | NA | Q9Y239.fasta | Q9Y239 | 953 | It leads to the maturation and activation of the host cells. | ELISA | 15617523 | 2005 | Pubchem Assay |
| PRRID_0220 | FK156 Click for more detail | NA | CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)NCC(=O)O)C(=O)O)NC(=O)C(C)O | NA | Peptide | Synthetic | It induces the secretion of the IL-8 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Monocytes | NA | Q9Y239.fasta | Q9Y239 | 953 | It leads to the maturation and activation of the host cells. | ELISA | 15617523 | 2005 | Pubchem Assay |
| PRRID_0221 | FK565 Click for more detail | NA | CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OC(C)(C)C | NA | Peptide | Synthetic | It induces the secretion of the IL-8 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Monocytes | NA | Q9Y239.fasta | Q9Y239 | 953 | It leads to the maturation and activation of the host cells. | ELISA | 15617523 | 2005 | Pubchem Assay |
| PRRID_0221 | FK565 Click for more detail | NA | CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OC(C)(C)C | NA | Peptide | Synthetic | It induces the secretion of the IL-8 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Monocytes | NA | Q9Y239.fasta | Q9Y239 | 953 | It leads to the maturation and activation of the host cells. | ELISA | 15617523 | 2005 | Pubchem Assay |
| PRRID_0225 | muramyl tetrapeptide Click for more detail | muramyl dipeptide derivative (others) | NA | NA | Peptide | Synthetic | Immunostimulant | Nucleotide-binding oligomerization domain protein 1 | NOD-like receptor (NLR) | Mice (Murine) | NA | NA | Q8BHB0.fasta | Q8BHB0 | 953 | NA | ELISA | 16211083 | 2005 | Pubchem Assay |
| PRRID_0225 | muramyl tetrapeptide Click for more detail | muramyl dipeptide derivative (others) | NA | NA | Peptide | Synthetic | Immunostimulant | Nucleotide-binding oligomerization domain protein 1 | NOD-like receptor (NLR) | Mice (Murine) | NA | NA | Q8BHB0.fasta | Q8BHB0 | 953 | NA | ELISA | 16211083 | 2005 | Pubchem Assay |
| PRRID_0275 | Chlamydia trachomatis Click for more detail | Chlamydia trachomatis(Bacteria) | NA | NA | Whole organism | Natural | Chlamydia trachomatis infection leads to up-regulation of inflammatory IL-8. | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | HeLa 229 epithelial cells | LRR | Q9Y239.fasta | Q9Y239 | 953 | NOD1 and RIP2 activation is needed for the IL-8 response to C. trachomatis infection. | ELISA | 18426885 | 2008 | Pubchem Assay |
| PRRID_0275 | Chlamydia trachomatis Click for more detail | Chlamydia trachomatis(Bacteria) | NA | NA | Whole organism | Natural | Chlamydia trachomatis infection leads to up-regulation of inflammatory IL-8. | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | HeLa 229 epithelial cells | LRR | Q9Y239.fasta | Q9Y239 | 953 | NOD1 and RIP2 activation is needed for the IL-8 response to C. trachomatis infection. | ELISA | 18426885 | 2008 | Pubchem Assay |
| PRRID_0368 | Hyaluronan Click for more detail | Host (Endogenous) (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Glycosaminoglycan | Natural | Hyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation. | Nod-like receptor protein P3/Cryopyrin (NLRP3/Cryopyrin) | NOD-like receptor (NLR) | Mice | Macropahges | NA | Q8BHB0.fasta | Q8BHB0 | 953 | It participates in the inflammatory response to injury or the cytokine response to hyaluronan. | ELISA | 19258328 | 2009 | Pubchem Assay |
| PRRID_0368 | Hyaluronan Click for more detail | Host (Endogenous) (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Glycosaminoglycan | Natural | Hyaluronan works through IL-1beta and the cryopyrin system to signal sterile inflammation. | Nod-like receptor protein P3/Cryopyrin (NLRP3/Cryopyrin) | NOD-like receptor (NLR) | Mice | Macropahges | NA | Q8BHB0.fasta | Q8BHB0 | 953 | It participates in the inflammatory response to injury or the cytokine response to hyaluronan. | ELISA | 19258328 | 2009 | Pubchem Assay |
| PRRID_0410 | Alpha toxin Click for more detail | S. aureus (Bacteria) | SDYYPRNSVDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWK | 71 | toxin | Natural | It’s binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1β | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | it activates the inflammasome via NLRP3 | NA | 20303873 | 2010 | NA |
| PRRID_0410 | Alpha toxin Click for more detail | S. aureus (Bacteria) | SDYYPRNSVDTKEYMSTLTYGFNGNVTGDDTGKIGGLIGANVSIGHTLKYVQPDFKTILESPTDKKVGWK | 71 | toxin | Natural | It’s binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1β | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | it activates the inflammasome via NLRP3 | NA | 20303873 | 2010 | NA |
| PRRID_0425 | Bacterial Antigen Click for more detail | S. aureus (Bacteria) | NA | NA | Whole organism | Natural | It led to the activation of NF-κB and stimulate the production of cytokines IL-6 and TNF-⍺ | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | Primary microglia and astrocytes | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It has the immunostimulatory role. | ELISA | 20226841 | 2010 | Pubchem Assay |
| PRRID_0425 | Bacterial Antigen Click for more detail | S. aureus (Bacteria) | NA | NA | Whole organism | Natural | It led to the activation of NF-κB and stimulate the production of cytokines IL-6 and TNF-⍺ | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | Primary microglia and astrocytes | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It has the immunostimulatory role. | ELISA | 20226841 | 2010 | Pubchem Assay |
| PRRID_0428 | BsaK Click for more detail | Burkholderia pseudomallei(Bacteria) | MVRLPDRHRPRVRRRREGSEQAVAGRPGEPHEKPERSDRARQLSDDHVRIQPVPERAEQRGQIDEGHRFVDRLELPLTLSTAPGRRGASRAAPGRTIMNITNPHAVPALPSLSEIESPERPATLDAILKQTLADANEKSNAAKTSIESRLADPVDFAQSEKLIALQTELSDYSIYVSLASTLARKAVSAVETLVKAQ | 197 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0428 | BsaK Click for more detail | Burkholderia pseudomallei(Bacteria) | MVRLPDRHRPRVRRRREGSEQAVAGRPGEPHEKPERSDRARQLSDDHVRIQPVPERAEQRGQIDEGHRFVDRLELPLTLSTAPGRRGASRAAPGRTIMNITNPHAVPALPSLSEIESPERPATLDAILKQTLADANEKSNAAKTSIESRLADPVDFAQSEKLIALQTELSDYSIYVSLASTLARKAVSAVETLVKAQ | 197 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0459 | Derivatives of peptidoglycans Click for more detail | Legionella pneumophila (Bacteria) | NA | NA | Peptidoglycan | Natural | The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS) | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice (Murine) | Aveolar macrphages | NA | Q8BHB0.fasta | Q8BHB0 | 953 | It leads to the strong neutrophil infiltartion in the infected mice lungs | NA | 20685341 | 2010 | Pubchem Assay |
| PRRID_0459 | Derivatives of peptidoglycans Click for more detail | Legionella pneumophila (Bacteria) | NA | NA | Peptidoglycan | Natural | The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS) | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice (Murine) | Aveolar macrphages | NA | Q8BHB0.fasta | Q8BHB0 | 953 | It leads to the strong neutrophil infiltartion in the infected mice lungs | NA | 20685341 | 2010 | Pubchem Assay |
| PRRID_0460 | Derivatives of peptidoglycans Click for more detail | Legionella pneumophila (Bacteria) | NA | NA | Peptidoglycan | Natural | The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS) | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | Aveolar macrphages | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It leads to the strong neutrophil infiltartion in the infected mice lungs | NA | 20685341 | 2010 | Pubchem Assay |
| PRRID_0460 | Derivatives of peptidoglycans Click for more detail | Legionella pneumophila (Bacteria) | NA | NA | Peptidoglycan | Natural | The interaction leads to the secretion system that facilitates the delivery of bacterial proteins into the host cell cytoplasm(dot/Icm/TFSS) | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | Aveolar macrphages | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It leads to the strong neutrophil infiltartion in the infected mice lungs | NA | 20685341 | 2010 | Pubchem Assay |
| PRRID_0464 | diaminopimelic acid (C12-iEDAP) Click for more detail | Gram-negative and Gram-positive bacteria | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Muropeptide | Natural | It's binding to NOD1 induce NFκB activation, activation of MAP kinases and expression of chemokines CCL5 (RANTES) and CXCL1 (KC) and of nitric oxide | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | C57BL/6 Mice | liver and Hepatocytes | NA | Q8BHB0.fasta | Q8BHB0 | 953 | It helps in attracting leukocytes to the liver during infection and for hepatic NLRs to augment innate immune responses to pathogens. | Immunoblotting and EMSA | 20615568 | 2010 | Pubchem Assay |
| PRRID_0464 | diaminopimelic acid (C12-iEDAP) Click for more detail | Gram-negative and Gram-positive bacteria | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Muropeptide | Natural | It's binding to NOD1 induce NFκB activation, activation of MAP kinases and expression of chemokines CCL5 (RANTES) and CXCL1 (KC) and of nitric oxide | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | C57BL/6 Mice | liver and Hepatocytes | NA | Q8BHB0.fasta | Q8BHB0 | 953 | It helps in attracting leukocytes to the liver during infection and for hepatic NLRs to augment innate immune responses to pathogens. | Immunoblotting and EMSA | 20615568 | 2010 | Pubchem Assay |
| PRRID_0497 | EprJ and EscI Click for more detail | E. coli(Bacteria) | MSVSNMPPIDRAEQSTAHEIQQAKVIDLNDRVLNLDNPDDKMISAFANYAVQTENWQQNALQALRSDKEGLTPEKLLVLQDHVLNYNVEVSLVEH, MIYFLTDLIKFYCLMKLYEYKNIKIDLVLTEDIIPEDKLLEIIQSDDIVKLARKKTCEHLLRARRKSKKLKTESRKKIARKIMAMRERIRKNNKIKLEKEVNKSIKWVKDIQDIELVLMQDIMNKVHSSLTNALHSLDTSSRINWDDLLNEVVRETLSHNNIVGAIKITKNPDIKLDPGEANNIQLINDADAPLNKIIIENEYMRITLDPLEQINILLNSFKENYLSIIQE | 95,231 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0497 | EprJ and EscI Click for more detail | E. coli(Bacteria) | MSVSNMPPIDRAEQSTAHEIQQAKVIDLNDRVLNLDNPDDKMISAFANYAVQTENWQQNALQALRSDKEGLTPEKLLVLQDHVLNYNVEVSLVEH, MIYFLTDLIKFYCLMKLYEYKNIKIDLVLTEDIIPEDKLLEIIQSDDIVKLARKKTCEHLLRARRKSKKLKTESRKKIARKIMAMRERIRKNNKIKLEKEVNKSIKWVKDIQDIELVLMQDIMNKVHSSLTNALHSLDTSSRINWDDLLNEVVRETLSHNNIVGAIKITKNPDIKLDPGEANNIQLINDADAPLNKIIIENEYMRITLDPLEQINILLNSFKENYLSIIQE | 95,231 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0498 | extracellular ATP Click for more detail | Injured cell (others) | C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O | NA | Endogenous | Natural | It’s binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1β | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It activates the inflammasome via NLRP3 | NA | 20303873 | 2010 | NA |
| PRRID_0498 | extracellular ATP Click for more detail | Injured cell (others) | C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O | NA | Endogenous | Natural | It’s binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1β | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It activates the inflammasome via NLRP3 | NA | 20303873 | 2010 | NA |
| PRRID_0502 | Fibrillar amyloid-b peptide Click for more detail | Alzheimer’s disease brain plaques(others) | MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN | 770 | Endogenous | Natural | It’s binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1β | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It activates the inflammasome via NLRP3 | NA | 20303873 | 2010 | NA |
| PRRID_0502 | Fibrillar amyloid-b peptide Click for more detail | Alzheimer’s disease brain plaques(others) | MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN | 770 | Endogenous | Natural | It’s binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1β | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It activates the inflammasome via NLRP3 | NA | 20303873 | 2010 | NA |
| PRRID_0509 | Flagellin Click for more detail | Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1β and IL-18, leads to pathogen clearance and sepsis resistance. | IPAF | NOD-like receptor (NLR) | Human | NA | NA | Q15399.fasta | Q15399 | 786 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0509 | Flagellin Click for more detail | Salmonella typhimurium, Pseudomonas aeruginosa, Legionella pneumophila (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1β and IL-18, leads to pathogen clearance and sepsis resistance. | IPAF | NOD-like receptor (NLR) | Human | NA | NA | Q15399.fasta | Q15399 | 786 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0518 | Flagellin Click for more detail | Legionella pneumophila (Bacteria) | MIINHNLAAINSHRVLKFQNEEVSKNMEKLSSGMRINRAGDDASGLAVSEKMRTQVNGLRQAERNTEDGMSLIQTTEGFLQESNDIIQRIRTLAIQSSNGIYTDEDRQMIQVEVSQLIDEVDRIASQAEFNKMNLLQGDFARGSRATSMWFHLGPNMHQRERVFIATMTARALNLKGQSGDLLSLSTADKSNDAIGTLDAALTRISKQRANLGAYFNRLEHAAKGLMNAYENTQASESRIRDADMAEETVAFTKNQILVQSGTAMLAQANVRPQGVLSLLR | 281 | Protein | Natural | Their bining activate the caspase-1 platform | Naip5 | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | implicated in the restriction of Legionella growth in macrophages, | NA | 20605429 | 2010 | NA |
| PRRID_0518 | Flagellin Click for more detail | Legionella pneumophila (Bacteria) | MIINHNLAAINSHRVLKFQNEEVSKNMEKLSSGMRINRAGDDASGLAVSEKMRTQVNGLRQAERNTEDGMSLIQTTEGFLQESNDIIQRIRTLAIQSSNGIYTDEDRQMIQVEVSQLIDEVDRIASQAEFNKMNLLQGDFARGSRATSMWFHLGPNMHQRERVFIATMTARALNLKGQSGDLLSLSTADKSNDAIGTLDAALTRISKQRANLGAYFNRLEHAAKGLMNAYENTQASESRIRDADMAEETVAFTKNQILVQSGTAMLAQANVRPQGVLSLLR | 281 | Protein | Natural | Their bining activate the caspase-1 platform | Naip5 | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | implicated in the restriction of Legionella growth in macrophages, | NA | 20605429 | 2010 | NA |
| PRRID_0521 | flagellin and functional type III or Type IV secretion systems Click for more detail | Salmonella (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Their bining activate the caspase-1 platform | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It helps in restriction of salmonella growth in macrophages, | NA | 20605429 | 2010 | NA |
| PRRID_0521 | flagellin and functional type III or Type IV secretion systems Click for more detail | Salmonella (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Their bining activate the caspase-1 platform | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It helps in restriction of salmonella growth in macrophages, | NA | 20605429 | 2010 | NA |
| PRRID_0522 | flagellin and functional type III or Type IV secretion systems Click for more detail | Legionella pneumophila (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Their bining activate the caspase-1 platform | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | implicated in the restriction of Legionella growth in macrophages, | NA | 20605429 | 2010 | NA |
| PRRID_0522 | flagellin and functional type III or Type IV secretion systems Click for more detail | Legionella pneumophila (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | Their bining activate the caspase-1 platform | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | implicated in the restriction of Legionella growth in macrophages, | NA | 20605429 | 2010 | NA |
| PRRID_0554 | hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail | Vibrio vulnificus (Bacteria) | MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY | 4595 | Protein | Natural | It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion. | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Macropahes | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | It leads to the pathogen clearance | ELISA | 20348425 | 2010 | Pubchem Assay |
| PRRID_0554 | hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail | Vibrio vulnificus (Bacteria) | MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGAKVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVNYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQDSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDVTLQGAGASNRIERTRQAEDVYVQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSGSSFDAQGMEYAKAEEIVLTAAQMHGLSIDNGNKFHAVTAVKSEREPNTYLFAIADGTYTKINKVRLYNDPETGKLKYYSEAWFKRGNHLAELARSDVSSAGGFEVNPINGGYTLSNIAVEHQQSVTVHAVEKNLTEYEWVTYGNGTLIDAKDVALSEAKMGGYAISTDGTAVDVQAVKSNRKPNTYVYAKVLGPYTKIVVVELANDPKTGALKYQARSWYKEGNHTADLANEDISSANGYHSMGKGGYSLSDLHYSVNAVRSTSETVADIDEYTDQTLFKPATDSGESSGDVHFNGAGGGNVIKSNVTRGNVYFNGGGIANVILHSSQFGHTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSKQGKMDVYAGGAVNVLVRIGDGQYLAHLLAYGNISVHKGNGNSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGNVASVLAGGANVLTKVGDGDLTAGMLGGANVITHISGDNETSNTTAVALGGANILTKKGKGNALAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGIMLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNANIFTHVGSGSTFAAMIGQANIMTKVGDDLTAALMVGKANIY | 4595 | Protein | Natural | It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion. | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Macropahes | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | It leads to the pathogen clearance | ELISA | 20348425 | 2010 | Pubchem Assay |
| PRRID_0555 | hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail | Vibrio cholerae (Bacteria) | MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL | 4558 | Protein | Natural | It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion. | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Macrophages | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | It leads to the pathogen clearance | ELISA | 20348425 | 2010 | Pubchem Assay |
| PRRID_0555 | hemolysin and multifunctional repeat-in-toxin (MARTX) Click for more detail | Vibrio cholerae (Bacteria) | MVFYLIPKRRVWLMGKPFWRSVEYFFTGNYSADDGNNNIVAIGFGGQIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLKVEDSTGHLIVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNHGDVSYGGAAAYNGITRKGLSGNVTFAGAGGYNALWHETNQGNLSFTGAGAGNKLDRTWSNRYQGSHGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTHQAEDVYTQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTIIRKGSGNDFAKEGMTNAKADEIVLTKAVMSGSWIGQDHHVTAVKSASEPNTYLFAFADSTYTKINKVQLRNDPQTGELKYYSTAWYKEVNHLSNLANQDISDNGGFTAVNINGAYTLSDLKVEHQQSVTVHAVEKSLTEYEWVTYANGAVIDAKEVSLSDAKMGGHAIYADGTKVDVKAVKSNRQPNTYIYAKVLGPYTKIVVVELANDPETGALKYQARSWYKEGDHTANIANQDISSATGYNPMGKGGYSLSDLHYSVNAVRSTSETVADIEEYTDQTLFKPANDSGESSGDVRFNGAGGGNVIKSNVTRGNVHFNGGGIANVILHSSQFGNTEFNGGGAANVIVKSGEEGDLTFRGAGLANVLVHQSEQGKMDVYAGGAVNVLVRLGDGQYLAHLLAYGNISVQKGSGDSRVVMLGGYNTHTQIGSGNGLWLAAGGFNVMTQVGKGDVAAVLAGGANVLTKMGEGELTSGMLGGANVITHISNDDQLSNTTAVALGGANILTKKGKGNTLAVMGGGANVLTHVGDGTTTGVMVGGANILTKVGNGDTTGILLGVGNVLTHVGDGQTLGVMGAAGNIFTKVGDGTSIAVMIGAGNIFTHVGEGNAWALMGGLGNVFTKVGNGDALALMVAEANVFTHIGDGMSVALMLAKGNVATKVGNGTTLAAMVGNVNIFTHIGHGSTFAAMIGQANIMTKVGNDLTAAL | 4558 | Protein | Natural | It elicit caspase-1 activation via the NLRP3 inflammasome and subsequent IL-1b secretion. | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Macrophages | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | It leads to the pathogen clearance | ELISA | 20348425 | 2010 | Pubchem Assay |
| PRRID_0568 | Hyaluronan Click for more detail | Injured cell (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Endogenous | Natural | It’s binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1β | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It activates the inflammasome via NLRP3 | NA | 20303873 | 2010 | NA |
| PRRID_0568 | Hyaluronan Click for more detail | Injured cell (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Endogenous | Natural | It’s binding to the NLRP3 leads to the activation of caspase-1, which in result lead to the maturation of IL-1β | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It activates the inflammasome via NLRP3 | NA | 20303873 | 2010 | NA |
| PRRID_0598 | KF1B Click for more detail | NA | NA | NA | NA | Synthetic | induction of chemokines and other proinflammatory molecules | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | NA | epithial cells | NA | NA | NA | NA | NA | NA | 20685341 | 2010 | NA |
| PRRID_0598 | KF1B Click for more detail | NA | NA | NA | NA | Synthetic | induction of chemokines and other proinflammatory molecules | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | NA | epithial cells | NA | NA | NA | NA | NA | NA | 20685341 | 2010 | NA |
| PRRID_0603 | lethal toxin (LeTx) Click for more detail | Bacillus anthracis(Bacteria) | NA | NA | toxin | Natural | It’s binding to the IPAF leads to the activation of caspase-1 via ASC adaptor protein | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Mice | Macropahges | NA | Q2LKU9.fasta | Q2LKU9 | 1182 | It activates the inflammasome via NLRP1 | NA | 20303873 | 2010 | Pubchem Assay |
| PRRID_0603 | lethal toxin (LeTx) Click for more detail | Bacillus anthracis(Bacteria) | NA | NA | toxin | Natural | It’s binding to the IPAF leads to the activation of caspase-1 via ASC adaptor protein | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Mice | Macropahges | NA | Q2LKU9.fasta | Q2LKU9 | 1182 | It activates the inflammasome via NLRP1 | NA | 20303873 | 2010 | Pubchem Assay |
| PRRID_0677 | MAVS Click for more detail | NA | NA | NA | Protein | Natural | Their bining activate the caspase-1 platform | Nod-like receptor X1 (NLRX1) | NOD-like receptor (NLR) | NA | Mitochondria | NA | NA | NA | NA | It suppresses MAVS-dependent antiviral pathways or promoting the generation of reactive oxygen species (ROS) | NA | 20605429 | 2010 | NA |
| PRRID_0677 | MAVS Click for more detail | NA | NA | NA | Protein | Natural | Their bining activate the caspase-1 platform | Nod-like receptor X1 (NLRX1) | NOD-like receptor (NLR) | NA | Mitochondria | NA | NA | NA | NA | It suppresses MAVS-dependent antiviral pathways or promoting the generation of reactive oxygen species (ROS) | NA | 20605429 | 2010 | NA |
| PRRID_0679 | mesodiaminopimelic acid Click for more detail | Bacteria | C(CC(C(=O)O)N)CC(C(=O)O)N | NA | Peptide | Natural | upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation | NA | 20303873 | 2010 | NA |
| PRRID_0679 | mesodiaminopimelic acid Click for more detail | Bacteria | C(CC(C(=O)O)N)CC(C(=O)O)N | NA | Peptide | Natural | upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation | NA | 20303873 | 2010 | NA |
| PRRID_0693 | muramyl dipeptide (MDP) Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation | NA | 20303873 | 2010 | NA |
| PRRID_0693 | muramyl dipeptide (MDP) Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation | NA | 20303873 | 2010 | NA |
| PRRID_0694 | muramyl dipeptide (MDP) + LPS + Poly(I:C) Click for more detail | Bacteria | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Peptide | Natural | It help in NF | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | C57BL/6 Mice | liver and Hepatocytes | NA | Q3UP24.fasta | Q3UP24 | 1024 | It plays an important regulatory role in many inflammatory processes involving the liver. | Immunoblotting and EMSA | 20615568 | 2010 | Pubchem Assay |
| PRRID_0694 | muramyl dipeptide (MDP) + LPS + Poly(I:C) Click for more detail | Bacteria | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Peptide | Natural | It help in NF | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | C57BL/6 Mice | liver and Hepatocytes | NA | Q3UP24.fasta | Q3UP24 | 1024 | It plays an important regulatory role in many inflammatory processes involving the liver. | Immunoblotting and EMSA | 20615568 | 2010 | Pubchem Assay |
| PRRID_0697 | MxiI Click for more detail | Shigella flexneri (Bacteria) | MNYIYPVNQVDIIKASDFQSQEISSLEDVVSAKYSDIKMDTDIQVSQIMEMVSNPESLNPESLAKLQTTLSNYSIGVSLAGTLARKTVSAVETLLKS | 97 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0697 | MxiI Click for more detail | Shigella flexneri (Bacteria) | MNYIYPVNQVDIIKASDFQSQEISSLEDVVSAKYSDIKMDTDIQVSQIMEMVSNPESLNPESLAKLQTTLSNYSIGVSLAGTLARKTVSAVETLLKS | 97 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0699 | N1L Click for more detail | Vaccinia(virus) | MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK | 117 | Protein | Natural | Suppress IRF3 activation (Bind to TBK1) | The class II transactivator (CIITA) | NOD-like receptor (NLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | P33076.fasta | P33076 | 1130 | Suppress IFN production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0699 | N1L Click for more detail | Vaccinia(virus) | MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK | 117 | Protein | Natural | Suppress IRF3 activation (Bind to TBK1) | The class II transactivator (CIITA) | NOD-like receptor (NLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | P33076.fasta | P33076 | 1130 | Suppress IFN production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0703 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | The class II transactivator (CIITA) | NOD-like receptor (NLR) | Human | NA | NA | P33076.fasta | P33076 | 1130 | It is a key regulator of class II MHC genes, such as it exert transcriptional regulator activity or other nuclear functions. | NA | 20303873 | 2010 | Pubchem Assay |
| PRRID_0703 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | The class II transactivator (CIITA) | NOD-like receptor (NLR) | Human | NA | NA | P33076.fasta | P33076 | 1130 | It is a key regulator of class II MHC genes, such as it exert transcriptional regulator activity or other nuclear functions. | NA | 20303873 | 2010 | Pubchem Assay |
| PRRID_0729 | Peptidoglycan (PGN) Click for more detail | Escherichia coli, Chlamydia pneumoniae, Campylobacter jejuni, Salmonella typhimurium, Pseudomonas ae | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Activates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1β, which results into pathogen clearance and sepsis resistance | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | NA | NA | Q9Y239.fasta | Q9Y239 | 953 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0729 | Peptidoglycan (PGN) Click for more detail | Escherichia coli, Chlamydia pneumoniae, Campylobacter jejuni, Salmonella typhimurium, Pseudomonas ae | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Activates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1β, which results into pathogen clearance and sepsis resistance | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | NA | NA | Q9Y239.fasta | Q9Y239 | 953 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0733 | Peptidoglycan (PGN) Click for more detail | E. coli K12(Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | Macropahges | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | NA | NA | 20696824 | 2010 | Pubchem Assay |
| PRRID_0733 | Peptidoglycan (PGN) Click for more detail | E. coli K12(Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | Macropahges | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | NA | NA | 20696824 | 2010 | Pubchem Assay |
| PRRID_0738 | Peptidoglycan (PGN) Click for more detail | Borrelia burgdorferi(Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | PBMCs | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It aids in the induction of inflammtory reaction against Borrelia burgdorferi | ELISA | 20441518 | 2010 | Pubchem Assay |
| PRRID_0738 | Peptidoglycan (PGN) Click for more detail | Borrelia burgdorferi(Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | PBMCs | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It aids in the induction of inflammtory reaction against Borrelia burgdorferi | ELISA | 20441518 | 2010 | Pubchem Assay |
| PRRID_0739 | Peptidoglycan (PGN) Click for more detail | Borrelia burgdorferi(Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | PBMCs | NA | Q9HC29.fasta | Q9HC29 | 1040 | It aids in the induction of inflammtory reaction against Borrelia burgdorferi | ELISA | 20441518 | 2010 | Pubchem Assay |
| PRRID_0739 | Peptidoglycan (PGN) Click for more detail | Borrelia burgdorferi(Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | PBMCs | NA | Q9HC29.fasta | Q9HC29 | 1040 | It aids in the induction of inflammtory reaction against Borrelia burgdorferi | ELISA | 20441518 | 2010 | Pubchem Assay |
| PRRID_0746 | PGNmonomer Click for more detail | S. aureus (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | It initiates the activation of NF- | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | NA | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It act as potent costimulator of the innate immune system in the presence of TLR signals | Luciferase assay | 20522786 | 2010 | Pubchem Assay |
| PRRID_0746 | PGNmonomer Click for more detail | S. aureus (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | It initiates the activation of NF- | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice (Murine) | NA | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | It act as potent costimulator of the innate immune system in the presence of TLR signals | Luciferase assay | 20522786 | 2010 | Pubchem Assay |
| PRRID_0775 | Pore-forming toxins Click for more detail | Listeria monocytogenes, Staphylococcus aureus, Aeromonas hydrophila, microbial toxins (Bacteria) | NA | NA | Protein | Natural | Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1β and IL-18, leads to pathogen clearance and sepsis resistance. | Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containin (NALP) | NOD-like receptor (NLR) | NA | NA | Q9C000.fasta | Q9C000 | 1473 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay | |
| PRRID_0775 | Pore-forming toxins Click for more detail | Listeria monocytogenes, Staphylococcus aureus, Aeromonas hydrophila, microbial toxins (Bacteria) | NA | NA | Protein | Natural | Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1β and IL-18, leads to pathogen clearance and sepsis resistance. | Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containin (NALP) | NOD-like receptor (NLR) | NA | NA | Q9C000.fasta | Q9C000 | 1473 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay | |
| PRRID_0777 | PrgJ Click for more detail | S. typhimurium (Bacteria) | MSIATIVPENAVIGQAVNIRSMETDIVSLDDRLLQAFSGSAIATAVDKQTITNRIEDPNLVTDPKELAISQEMISDYNLYVSMVSTLTRKGVGAVETLLRS | 101 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0777 | PrgJ Click for more detail | S. typhimurium (Bacteria) | MSIATIVPENAVIGQAVNIRSMETDIVSLDDRLLQAFSGSAIATAVDKQTITNRIEDPNLVTDPKELAISQEMISDYNLYVSMVSTLTRKGVGAVETLLRS | 101 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0780 | PscI Click for more detail | Pseudomonas aeruginosa (Bacteria) | MDISRMGAQAQITSLEELSGGPAGAAHVAEFERAMGGAGSLGGDLLSELGQIRERFSQAKQELQMELSTPGDDPNSLMQMQWSLMRITMQEELIAKTVGRMSQNVETLMKTQ | 112 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0780 | PscI Click for more detail | Pseudomonas aeruginosa (Bacteria) | MDISRMGAQAQITSLEELSGGPAGAAHVAEFERAMGGAGSLGGDLLSELGQIRERFSQAKQELQMELSTPGDDPNSLMQMQWSLMRITMQEELIAKTVGRMSQNVETLMKTQ | 112 | Protein | Natural | It activates caspase-1 through NLRC4 and secrete IL-1β | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Mice | Bone marrow–derived macrophages | NA | Q3UP24.fasta | Q3UP24 | 1024 | It leads to the clearance of the pathogen from the system | ELISA | 20133635 | 2010 | Pubchem Assay |
| PRRID_0814 | T3SS Click for more detail | Gram-negative bacteria | MKIPSLQSNFNFSAPAGYSAPIAPNRAENAYADYVLDIGKRIPLSAADLSNVYESVIRAVHDSRSRLIDQHTVDMIGNTVLDALSRSQTFRDAVSYGIHNEKVHIGCIKYRNEYELNEESSVKIDDIQSLTCNELYEYDVGQEPIFPICEAGENDNEEPYVSFSVAPDTDSYEMPSWQEGLIHEIIHHVTGSSDPSGDSNIELGPTEILARRVAQELGWSVPDFKGYAEPEREAHLRLRNLNALRQAAMRHEENERAFFERLGTISDRYEASPDFTEYSAVSNIGYGFIQQHDFPGLAINDNLQDANQIQLYHGAPYIFTFGDVDKHNQR | 330 | Protein | Natural | It activates caspase 1 dependent IL-1β and IL-18 secretion in response. | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It act as VAMPs, which results into the clearance of the pathogen due to the activation of the immune systems | NA | 20349122 | 2010 | NA |
| PRRID_0814 | T3SS Click for more detail | Gram-negative bacteria | MKIPSLQSNFNFSAPAGYSAPIAPNRAENAYADYVLDIGKRIPLSAADLSNVYESVIRAVHDSRSRLIDQHTVDMIGNTVLDALSRSQTFRDAVSYGIHNEKVHIGCIKYRNEYELNEESSVKIDDIQSLTCNELYEYDVGQEPIFPICEAGENDNEEPYVSFSVAPDTDSYEMPSWQEGLIHEIIHHVTGSSDPSGDSNIELGPTEILARRVAQELGWSVPDFKGYAEPEREAHLRLRNLNALRQAAMRHEENERAFFERLGTISDRYEASPDFTEYSAVSNIGYGFIQQHDFPGLAINDNLQDANQIQLYHGAPYIFTFGDVDKHNQR | 330 | Protein | Natural | It activates caspase 1 dependent IL-1β and IL-18 secretion in response. | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | It act as VAMPs, which results into the clearance of the pathogen due to the activation of the immune systems | NA | 20349122 | 2010 | NA |