Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1512NACHT

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BacteriaNANAProteinNaturalNAAAMPNOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1512NACHT

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BacteriaNANAProteinNaturalNAAAMPNOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1535Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPGN is known to be a potent activator of NF-κB and TNF-α through TLR2Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)Humanlymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epitheliumIntracellular receptorsQ9Y239.fastaQ9Y239953play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.NA248291462014Pubchem_assay
PRRID_1535Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPGN is known to be a potent activator of NF-κB and TNF-α through TLR2Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)Humanlymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epitheliumIntracellular receptorsQ9Y239.fastaQ9Y239953play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.NA248291462014Pubchem_assay
PRRID_1536Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPGN is known to be a potent activator of NF-κB and TNF-α through TLR2Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)Micelymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epitheliumIntracellular receptorsQ8BHB0.fastaQ8BHB0953play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.NA248291462014Pubchem_assay
PRRID_1536Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPGN is known to be a potent activator of NF-κB and TNF-α through TLR2Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)Micelymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epitheliumIntracellular receptorsQ8BHB0.fastaQ8BHB0953play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.NA248291462014Pubchem_assay
PRRID_1537Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPGN is known to be a potent activator of NF-κB and TNF-α through TLR2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)Humanlymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epitheliumIntracellular receptorsQ9HC29.fastaQ9HC291040play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.NA248291462014Pubchem_assay
PRRID_1537Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPGN is known to be a potent activator of NF-κB and TNF-α through TLR2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)Humanlymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epitheliumIntracellular receptorsQ9HC29.fastaQ9HC291040play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.NA248291462014Pubchem_assay
PRRID_1538Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPGN is known to be a potent activator of NF-κB and TNF-α through TLR2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)Micelymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epitheliumIntracellular receptorsQ8K3Z0.fastaQ8K3Z01020play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.NA248291462014Pubchem_assay
PRRID_1538Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPGN is known to be a potent activator of NF-κB and TNF-α through TLR2Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)Micelymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epitheliumIntracellular receptorsQ8K3Z0.fastaQ8K3Z01020play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.NA248291462014Pubchem_assay
PRRID_1547Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)Humanperipheral blood mononuclear cells such as macrophages, granulocytes, dendritic cells, and along the intestinal epithelial cellsintracellular receptorsQ9HC29.fastaQ9HC291040recognizes fragments of the bacterial cell wall.Luciferase assay247900892014Pubchem_assay
PRRID_1547Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)Humanperipheral blood mononuclear cells such as macrophages, granulocytes, dendritic cells, and along the intestinal epithelial cellsintracellular receptorsQ9HC29.fastaQ9HC291040recognizes fragments of the bacterial cell wall.Luciferase assay247900892014Pubchem_assay
PRRID_1548Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturaltriggers immune responsesNod-like receptor 1 (NLR1)NOD-like receptor (NLR)Micelymphocytes, macrophages, dendritic cellsintracellular receptorsNANANAtriggering of these receptors induces activation of the NF-κB pathway and consequently, an immune responseNA247793902014NA
PRRID_1548Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturaltriggers immune responsesNod-like receptor 1 (NLR1)NOD-like receptor (NLR)Micelymphocytes, macrophages, dendritic cellsintracellular receptorsNANANAtriggering of these receptors induces activation of the NF-κB pathway and consequently, an immune responseNA247793902014NA
PRRID_1550Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturaltriggers immune responsesNod-like receptor 1 (NLR1)NOD-like receptor (NLR)Humanlymphocytes, macrophages, dendritic cellsintracellular receptorsNANANAtriggering of these receptors induces activation of the NF-κB pathway and consequently, an immune responseNA247793902014NA
PRRID_1550Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturaltriggers immune responsesNod-like receptor 1 (NLR1)NOD-like receptor (NLR)Humanlymphocytes, macrophages, dendritic cellsintracellular receptorsNANANAtriggering of these receptors induces activation of the NF-κB pathway and consequently, an immune responseNA247793902014NA
PRRID_1554Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalNANucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1554Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalNANucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1560Peptidoglycan (PGN)

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Gram negative Bacteria (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseNucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)European and African Childrenmost adult tissuessignals via a caspase- activated recruitment domain (CARD)Q9Y239.fastaQ9Y239953induce autophagy and inflammatory responses in host cells.ELISA247465522014Pubchem_assay
PRRID_1560Peptidoglycan (PGN)

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Gram negative Bacteria (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseNucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)European and African Childrenmost adult tissuessignals via a caspase- activated recruitment domain (CARD)Q9Y239.fastaQ9Y239953induce autophagy and inflammatory responses in host cells.ELISA247465522014Pubchem_assay
PRRID_1563CARDs

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BacteriaNANAProteinNaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1563CARDs

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BacteriaNANAProteinNaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)NANANANANANANANA255201852014NA
PRRID_1650Tri-DAP

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Gram-positive and negative bacteriaCC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)NNAPeptideNaturalactivate NF-κBNucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)Micemacrophages and mesothelial cellsserine/threonine RIP2 (RICK, CARDIAK) kinaseQ8BHB0.fastaQ8BHB0953interacts with IKK to trigger the activation of NF-kB and the production of inflammatory cytokines, such as TNF-a and IL-6ELISA247665502014Pubchem_assay
PRRID_1650Tri-DAP

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Gram-positive and negative bacteriaCC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)NNAPeptideNaturalactivate NF-κBNucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)Micemacrophages and mesothelial cellsserine/threonine RIP2 (RICK, CARDIAK) kinaseQ8BHB0.fastaQ8BHB0953interacts with IKK to trigger the activation of NF-kB and the production of inflammatory cytokines, such as TNF-a and IL-6ELISA247665502014Pubchem_assay
PRRID_1651Tri-DAP

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Gram-positive and negative bacteriaCC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)NNAPeptideNaturalactivate NF-κBNucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)Humanmacrophages and mesothelial cellsserine/threonine RIP2 (RICK, CARDIAK) kinaseQ8BHB0.fastaQ8BHB0953interacts with IKK to trigger the activation of NF-kB and the production of inflammatory cytokines, such as TNF-a and IL-6ELISA247665502014Pubchem_assay
PRRID_1651Tri-DAP

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Gram-positive and negative bacteriaCC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)NNAPeptideNaturalactivate NF-κBNucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)Humanmacrophages and mesothelial cellsserine/threonine RIP2 (RICK, CARDIAK) kinaseQ8BHB0.fastaQ8BHB0953interacts with IKK to trigger the activation of NF-kB and the production of inflammatory cytokines, such as TNF-a and IL-6ELISA247665502014Pubchem_assay
PRRID_18956-O-stearoyl-MDP (L18- MDP)

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NACCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideSyntheticAgonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokinesNod-like receptor C2 (NLRC2)NOD-like receptor (NLR)HumanIntracellularC-terminal leucine-rich regions and NOD domainsNANANAtriggering production of β-defensins via an NF-κB signaling pathwayNA287764162017NA
PRRID_18956-O-stearoyl-MDP (L18- MDP)

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NACCCCCCCCCCCCCCCCCC(=O)NCCCCC(C(=O)O)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideSyntheticAgonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokinesNod-like receptor C2 (NLRC2)NOD-like receptor (NLR)HumanIntracellularC-terminal leucine-rich regions and NOD domainsNANANAtriggering production of β-defensins via an NF-κB signaling pathwayNA287764162017NA
PRRID_1899Ab

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)NaturalCellular injury and necrosisNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanNANAQ96P20.fastaQ96P201036Activate NF-KBNA280491422017Pubchem_assay
PRRID_1899Ab

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)NaturalCellular injury and necrosisNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanNANAQ96P20.fastaQ96P201036Activate NF-KBNA280491422017Pubchem_assay
PRRID_1900Ab

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)NaturalCellular injury and necrosis Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)HumanNANAQ9C000.fastaQ9C0001473Activate NF-KBNA280491422017Pubchem_assay
PRRID_1900Ab

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)NaturalCellular injury and necrosis Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)HumanNANAQ9C000.fastaQ9C0001473Activate NF-KBNA280491422017Pubchem_assay
PRRID_1911Amyloid-β fibrils

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NAMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN770Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288051212017Pubchem_assay
PRRID_1911Amyloid-β fibrils

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NAMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN770Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288051212017Pubchem_assay
PRRID_1912Amyloid-β fibrils

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NAMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN770Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1912Amyloid-β fibrils

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NAMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN770Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1913Amyloid-β fibrils

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NAMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN770Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanBrainNAQ96P20.fastaQ96P201036protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1913Amyloid-β fibrils

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NAMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN770Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanBrainNAQ96P20.fastaQ96P201036protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1914Amyloid-β fibrils

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NAMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN770Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Ratprimary astrocytesNAD4A523.fastaD4A5231035protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_1914Amyloid-β fibrils

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NAMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN770Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Ratprimary astrocytesNAD4A523.fastaD4A5231035protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_1915Amyloid-β fibrils

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NAMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN770Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_1915Amyloid-β fibrils

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NAMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN770Damage-associated molecular patterns (DAMPs)NaturalImmunostimulantNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_1917Anthrax lethal toxin

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NANANAProteinNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)RatHippocampusNAD9I2G4 .fastaD9I2G41218NLRP1 inflammasome activation in agingNA288015212017Pubchem_assay
PRRID_1917Anthrax lethal toxin

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NANANAProteinNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)RatHippocampusNAD9I2G4 .fastaD9I2G41218NLRP1 inflammasome activation in agingNA288015212017Pubchem_assay
PRRID_1918Anthrax lethal toxin

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NANANAProteinNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)Humanhippocampus (neurons)NAQ9C000.fastaQ9C0001473protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairmentNA288015212017Pubchem_assay
PRRID_1918Anthrax lethal toxin

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NANANAProteinNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)Humanhippocampus (neurons)NAQ9C000.fastaQ9C0001473protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairmentNA288015212017Pubchem_assay
PRRID_1919Anthrax lethal toxin

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NANANAProteinNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)Micemodels of ADNAQ2LKU9.fastaQ2LKU91182protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairmentNA288015212017Pubchem_assay
PRRID_1919Anthrax lethal toxin

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NANANAProteinNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)Micemodels of ADNAQ2LKU9.fastaQ2LKU91182protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairmentNA288015212017Pubchem_assay
PRRID_1920Anthrax lethal toxin

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NANANAProteinNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ2LKU9.fastaQ2LKU91182protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1920Anthrax lethal toxin

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NANANAProteinNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ2LKU9.fastaQ2LKU91182protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1921Anthrax lethal toxin

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NANANAProteinNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)HumanBrainNAQ9C000.fastaQ9C0001473protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1921Anthrax lethal toxin

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NANANAProteinNaturalNA Nod-like receptor protein 1 (NLRP1)NOD-like receptor (NLR)HumanBrainNAQ9C000.fastaQ9C0001473protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1922Anthrax lethal toxin

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BacteriaNANAProteinNaturalNANALP3/ cryopyrinNOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_1922Anthrax lethal toxin

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BacteriaNANAProteinNaturalNANALP3/ cryopyrinNOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_1926ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288051212017Pubchem_assay
PRRID_1926ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMicrogliaNAQ8R4B8.fastaQ8R4B81033NLRP3 inflammasome activation in AD modelsNA288051212017Pubchem_assay
PRRID_1927ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1927ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micecortical neurons (cell culture, stroke model)NAQ8R4B8.fastaQ8R4B81033protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1928ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanBrainNAQ96P20.fastaQ96P201036protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1928ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanBrainNAQ96P20.fastaQ96P201036protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficitsNA288015212017Pubchem_assay
PRRID_1929ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Ratprimary astrocytesNAD4A523.fastaD4A5231035protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_1929ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Ratprimary astrocytesNAD4A523.fastaD4A5231035protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_1930ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_1930ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Micesubstantia nigraNAQ8R4B8.fastaQ8R4B81033protein ‚Üë, activation of NLRP3 inflammasome in PD modelsNA288015212017Pubchem_assay
PRRID_1931ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalActivate human dendritic cellsP2X7RNOD-like receptor (NLR)HumanDendritic cellsNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1931ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalActivate human dendritic cellsP2X7RNOD-like receptor (NLR)HumanDendritic cellsNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1932ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalActivate human dendritic cellsNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanDendritic cellsNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1932ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalActivate human dendritic cellsNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanDendritic cellsNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1933ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the secretion of IL-1β and IL-18 by human monocytesP2X7RNOD-like receptor (NLR)HumanMonocyteNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1933ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the secretion of IL-1β and IL-18 by human monocytesP2X7RNOD-like receptor (NLR)HumanMonocyteNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1934ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the secretion of IL-1β and IL-18 by human monocytesNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanMonocyteNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1934ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the secretion of IL-1β and IL-18 by human monocytesNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanMonocyteNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1935ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the secretion of IL-1β by murine and human neutrophilsP2X7RNOD-like receptor (NLR)HumanNeutrophilsNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1935ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the secretion of IL-1β by murine and human neutrophilsP2X7RNOD-like receptor (NLR)HumanNeutrophilsNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1936ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the secretion of IL-1β by murine and human neutrophilsNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanNeutrophilsNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1936ATP

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NAC1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)ONADamage-associated molecular patterns (DAMPs)NaturalInduce the secretion of IL-1β by murine and human neutrophilsNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanNeutrophilsNAQ96P20.fastaQ96P201036NANA289610192017Pubchem_assay
PRRID_1952Bacterial MDP

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RSV, IAV, and HCMV (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalLikely tetramerization into washer- locker structureNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)HumanCytoplasm. Macrophages, monocytes, Paneth cells, DCsNAQ9HC29.fastaQ9HC291040RIP2-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1952Bacterial MDP

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RSV, IAV, and HCMV (virus)NANAPattern-associated molecular patterns (PAMPs)NaturalLikely tetramerization into washer- locker structureNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)HumanCytoplasm. Macrophages, monocytes, Paneth cells, DCsNAQ9HC29.fastaQ9HC291040RIP2-IKKs-NF-jBNA283749032017Pubchem_assay
PRRID_1959Biglycan

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Proteoglycan (others)MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1959Biglycan

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Proteoglycan (others)MWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalinvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunityNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)NANALeucine-rich Repeat (LRR) DomainNANANANANA292901392017NA
PRRID_1962Biglycan

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NAMWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalInduce the secretion of TNF-α, MIP-2 and IL-1β by murine macrophagesNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMacrophagesNAQ8R4B8.fastaQ8R4B81033NANA289610192017Pubchem_assay
PRRID_1962Biglycan

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NAMWPLWRLVSLLALSQALPFEQRGFWDFTLDDGPFMMNDEEASGADTSGVLDPDSVTPTYSAMCPFGCHCHLRVVQCSDLGLKSVPKEISPDTTLLDLQNNDISELRKDDFKGLQHLYVRSWEEPAGLQQRAGVRALVLVNNKISKIHEKAFSPLRKLQKLYISKNHLVEIPPNLPSSLVELRIHDNRIRKVPKGVFSGLRNMNCIEMGGNPLENSGFEPGAFDGLKLNYLRISEAKLT238CarbohydrateNaturalInduce the secretion of TNF-α, MIP-2 and IL-1β by murine macrophagesNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)MiceMacrophagesNAQ8R4B8.fastaQ8R4B81033NANA289610192017Pubchem_assay
PRRID_1981Chromogranin A

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)Naturalactivate microglial cellsNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanNANAQ96P20.fastaQ96P201036Activate NF-KBNA280491422017Pubchem_assay
PRRID_1981Chromogranin A

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All vertebrates(others)NANADamage-associated molecular patterns (DAMPs)Naturalactivate microglial cellsNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanNANAQ96P20.fastaQ96P201036Activate NF-KBNA280491422017Pubchem_assay
PRRID_1987CpG motif

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NANANAProteinNaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Humanhuman peripheral B­lymphocytesNAQ96P20.fastaQ96P201036NANA291706652017Pubchem_assay
PRRID_1987CpG motif

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NANANAProteinNaturalNANod-like receptor P3 (NLRP3)NOD-like receptor (NLR)Humanhuman peripheral B­lymphocytesNAQ96P20.fastaQ96P201036NANA291706652017Pubchem_assay
PRRID_1993d-lactoyl-l-Ala-d-Glu-meso-DAP-l-Gly

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NANANAAgonistSyntheticAgonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokinesNod-like receptor C1 (NLRC1)NOD-like receptor (NLR)HumanIntracellularC-terminal leucine-rich regions and NOD domainsNANANAtriggering production of β-defensins via an NF-κB signaling pathwayNA287764162017NA
PRRID_1993d-lactoyl-l-Ala-d-Glu-meso-DAP-l-Gly

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NANANAAgonistSyntheticAgonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokinesNod-like receptor C1 (NLRC1)NOD-like receptor (NLR)HumanIntracellularC-terminal leucine-rich regions and NOD domainsNANANAtriggering production of β-defensins via an NF-κB signaling pathwayNA287764162017NA
PRRID_2000diaminopimelic acid (DAP)

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Gram-negative and Gram-positive bacteriaC(CC(C(=O)O)N)CC(C(=O)O)NNAAgonistSyntheticAgonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokinesNod-like receptor C1 (NLRC1)NOD-like receptor (NLR)HumanIntracellularC-terminal leucine-rich regions and NOD domainsNANANAtriggering production of β-defensins via an NF-κB signaling pathwayNA287764162017NA
PRRID_2000diaminopimelic acid (DAP)

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Gram-negative and Gram-positive bacteriaC(CC(C(=O)O)N)CC(C(=O)O)NNAAgonistSyntheticAgonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokinesNod-like receptor C1 (NLRC1)NOD-like receptor (NLR)HumanIntracellularC-terminal leucine-rich regions and NOD domainsNANANAtriggering production of β-defensins via an NF-κB signaling pathwayNA287764162017NA
PRRID_2009dsRNA

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Hepatitis C Virus (virus)NANANucleic AcidNaturalActivation of NOD1Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953Independent of MAVS; likely dsRNA produced by NS5B polymeraseNA288235102017Pubchem_assay
PRRID_2009dsRNA

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Hepatitis C Virus (virus)NANANucleic AcidNaturalActivation of NOD1Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)MiceMacrophagesnucleotide-binding oligomerization domainQ8BHB0.fastaQ8BHB0953Independent of MAVS; likely dsRNA produced by NS5B polymeraseNA288235102017Pubchem_assay
PRRID_2012dsRNA

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flu virus, SeV and bacteriaNANANucleic AcidNaturalpotassium efflux-NEK7 involved NLRP3 inflammasome complexNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanCytoplasm. Ubiquitously expressedNAQ96P20.fastaQ96P201036ASC-inflammasome- caspase-1-IL-1/IL-18NA283749032017Pubchem_assay
PRRID_2012dsRNA

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flu virus, SeV and bacteriaNANANucleic AcidNaturalpotassium efflux-NEK7 involved NLRP3 inflammasome complexNod-like receptor P3 (NLRP3)NOD-like receptor (NLR)HumanCytoplasm. Ubiquitously expressedNAQ96P20.fastaQ96P201036ASC-inflammasome- caspase-1-IL-1/IL-18NA283749032017Pubchem_assay
PRRID_2040Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInnate immunity elicitorNAIP5/NLRC4 inflammasome receptorNOD-like receptor (NLR)HumanintracellularNANANANARecognizes flagellin and bind it.Co-immunoprecipitataion Binding assay288278252017NA
PRRID_2040Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalInnate immunity elicitorNAIP5/NLRC4 inflammasome receptorNOD-like receptor (NLR)HumanintracellularNANANANARecognizes flagellin and bind it.Co-immunoprecipitataion Binding assay288278252017NA
PRRID_2042Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNANod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANANANA288015212017NA
PRRID_2042Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNANod-like receptor C4 (NLRC4)NOD-like receptor (NLR)NANANANANANANANA288015212017NA
PRRID_2047Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAIPAFNOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_2047Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalNAIPAFNOD-like receptor (NLR)NANANANANANANANA280630152017NA