Detailed description page of PRRDB2.0

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PRRID_1912 details
Primary information
PRRIDPRRID_1912
Ligand NameAmyloid-β fibrils
SourceNA
Sequence of ligandMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Length770
TypeDamage-associated molecular patterns (DAMPs)
OccurenceNatural
Role of LigandImmunostimulant
Name of receptorNod-like receptor P3 (NLRP3)
Type of receptorNOD-like receptor (NLR)
Source Mice
Localizationcortical neurons (cell culture, stroke model)
DomainNA
Sequence of ReceptorQ8R4B8.fasta
Swiss prot IDQ8R4B8
Length Of Receptor1033
Functionprotein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits
Assay usedNA
PMID28801521
Year of Publication2017
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1912
Ligand NameAmyloid-β fibrils
SourceNA
Sequence of ligandMLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
Length770
TypeDamage-associated molecular patterns (DAMPs)
OccurenceNatural
Role of LigandImmunostimulant
Name of receptorNod-like receptor P3 (NLRP3)
Type of receptorNOD-like receptor (NLR)
Source Mice
Localizationcortical neurons (cell culture, stroke model)
DomainNA
Sequence of ReceptorQ8R4B8.fasta
Swiss prot IDQ8R4B8
Length Of Receptor1033
Functionprotein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits
Assay usedNA
PMID28801521
Year of Publication2017
Pubchem assayPubchem_assay