Primary information |
---|
PRRID | PRRID_1538 |
Ligand Name | Peptidoglycan (PGN) |
Source | Gram-positive bacteria |
Sequence of ligand | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N |
Length | NA |
Type | Peptidoglycan |
Occurence | Natural |
Role of Ligand | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 |
Name of receptor | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) |
Type of receptor | NOD-like receptor (NLR) |
Source | Mice |
Localization | lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium |
Domain | Intracellular receptors |
Sequence of Receptor | Q8K3Z0.fasta |
Swiss prot ID | Q8K3Z0 |
Length Of Receptor | 1020 |
Function | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. |
Assay used | NA |
PMID | 24829146 |
Year of Publication | 2014 |
Pubchem assay | Pubchem_assay |
Primary information |
---|
PRRID | PRRID_1538 |
Ligand Name | Peptidoglycan (PGN) |
Source | Gram-positive bacteria |
Sequence of ligand | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N |
Length | NA |
Type | Peptidoglycan |
Occurence | Natural |
Role of Ligand | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 |
Name of receptor | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) |
Type of receptor | NOD-like receptor (NLR) |
Source | Mice |
Localization | lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium |
Domain | Intracellular receptors |
Sequence of Receptor | Q8K3Z0.fasta |
Swiss prot ID | Q8K3Z0 |
Length Of Receptor | 1020 |
Function | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. |
Assay used | NA |
PMID | 24829146 |
Year of Publication | 2014 |
Pubchem assay | Pubchem_assay |