Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0651 | lipo-arabinomannan Click for more detail | M. tuberculosis (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | lipoprotein and lipoarabinomannan are the poteny activators of the TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | DNA samples from peripheral blood of TB patients | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Immunostimulation and inflammation | NA | 20797905 | 2010 | Pubchem Assay |
| PRRID_0651 | lipo-arabinomannan Click for more detail | M. tuberculosis (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | lipoprotein and lipoarabinomannan are the poteny activators of the TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | DNA samples from peripheral blood of TB patients | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Immunostimulation and inflammation | NA | 20797905 | 2010 | Pubchem Assay |
| PRRID_0652 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Amphiphile | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It coauses the inflammation | NA | 20740341 | 2010 | NA |
| PRRID_0652 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Amphiphile | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It coauses the inflammation | NA | 20740341 | 2010 | NA |
| PRRID_0653 | Lipoteichoic Acid (LTA) Click for more detail | E. coli(Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | Peptidoglycan is the potent activator of the TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | C57BL/6 Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implants | NA | 20729214 | 2010 | Pubchem Assay |
| PRRID_0653 | Lipoteichoic Acid (LTA) Click for more detail | E. coli(Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | Peptidoglycan is the potent activator of the TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | C57BL/6 Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implants | NA | 20729214 | 2010 | Pubchem Assay |
| PRRID_0654 | Lipoteichoic Acid (LTA) Click for more detail | Lactobacillus acidophilus, Prevotella melaninogenica, P. bivia and Mycobacterium smegmatis (Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | Enhanced HIV-1 expression in macrophages | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leads to the clearance of the pathogen from the system | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0654 | Lipoteichoic Acid (LTA) Click for more detail | Lactobacillus acidophilus, Prevotella melaninogenica, P. bivia and Mycobacterium smegmatis (Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | Enhanced HIV-1 expression in macrophages | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leads to the clearance of the pathogen from the system | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0655 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | NA | Toll-like receptor 2 Arg753Gln (TLR-2 Arg753Gln) | Toll-like receptor (TLR) | FMF patients | monocytes and granulocytes | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Upregulate inflammation in FMF patients | NA | 20714796 | 2010 | NA |
| PRRID_0655 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | NA | Toll-like receptor 2 Arg753Gln (TLR-2 Arg753Gln) | Toll-like receptor (TLR) | FMF patients | monocytes and granulocytes | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Upregulate inflammation in FMF patients | NA | 20714796 | 2010 | NA |
| PRRID_0656 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0656 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0657 | Lipoteichoic Acid (LTA) Click for more detail | Streptococcus (Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | NA |
| PRRID_0657 | Lipoteichoic Acid (LTA) Click for more detail | Streptococcus (Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | NA |
| PRRID_0660 | Low Molecular Weight Hyaluronic Acid (LMW-HA) Click for more detail | human umbilical cord (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Endogenous | Synthetic | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | embryonic mouse telencephalon and NPC | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | its activation inhibits NPC proliferation and decreases cell proliferation. | NA | 20456021 | 2010 | Pubchem Assay |
| PRRID_0660 | Low Molecular Weight Hyaluronic Acid (LMW-HA) Click for more detail | human umbilical cord (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Endogenous | Synthetic | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | embryonic mouse telencephalon and NPC | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | its activation inhibits NPC proliferation and decreases cell proliferation. | NA | 20456021 | 2010 | Pubchem Assay |
| PRRID_0661 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0661 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0662 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NR97.fasta | Q9NR97 | 1041 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0662 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NR97.fasta | Q9NR97 | 1041 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0663 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | NA | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It led to the activation of NF-κB and upregulate the expression of the antiapoptotic protein Bcl-2. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Lung cancer cells | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy. | ELISA | 20237413 | 2010 | Pubchem Assay |
| PRRID_0663 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | NA | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It led to the activation of NF-κB and upregulate the expression of the antiapoptotic protein Bcl-2. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Lung cancer cells | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy. | ELISA | 20237413 | 2010 | Pubchem Assay |
| PRRID_0664 | LpqH Click for more detail | Mtb H37Ra (Bacteria) | MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS | 159 | Lipoprotein | Natural | It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Primary Monocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leads to the clearance of the pathogen via autophagy | NA | 20560977 | 2010 | Pubchem Assay |
| PRRID_0664 | LpqH Click for more detail | Mtb H37Ra (Bacteria) | MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS | 159 | Lipoprotein | Natural | It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Primary Monocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leads to the clearance of the pathogen via autophagy | NA | 20560977 | 2010 | Pubchem Assay |
| PRRID_0665 | LpqH Click for more detail | Mtb H37Ra (Bacteria) | MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS | 159 | Lipoprotein | Natural | It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Human | Primary Monocytes | Leucine-rich Repeat (LRR) Domain | Q15399.fasta | Q15399 | 786 | It leads to the clearance of the pathogen via autophagy | NA | 20560977 | 2010 | Pubchem Assay |
| PRRID_0665 | LpqH Click for more detail | Mtb H37Ra (Bacteria) | MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS | 159 | Lipoprotein | Natural | It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Human | Primary Monocytes | Leucine-rich Repeat (LRR) Domain | Q15399.fasta | Q15399 | 786 | It leads to the clearance of the pathogen via autophagy | NA | 20560977 | 2010 | Pubchem Assay |
| PRRID_0667 | LprG (Rv1411c) Click for more detail | Mtb H37Rv (Bacteria) | MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLVEEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADFVVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQNTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLSKWGEKVQVTKPPVS | 236 | Lipoprotein | Natural | Delivery of glycolipds to TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | C57BL/6 Mouse pulmonary aerosol Infection models | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Reduces virulence of Mtb | ELISA | 20694006 | 2010 | Pubchem Assay |
| PRRID_0667 | LprG (Rv1411c) Click for more detail | Mtb H37Rv (Bacteria) | MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLVEEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADFVVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQNTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLSKWGEKVQVTKPPVS | 236 | Lipoprotein | Natural | Delivery of glycolipds to TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | C57BL/6 Mouse pulmonary aerosol Infection models | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Reduces virulence of Mtb | ELISA | 20694006 | 2010 | Pubchem Assay |
| PRRID_0670 | macrophage-activating lipopeptide Click for more detail | Mycoplasma fermentans (Bacteria) | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N | NA | Lipopeptides | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0670 | macrophage-activating lipopeptide Click for more detail | Mycoplasma fermentans (Bacteria) | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N | NA | Lipopeptides | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0671 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0671 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0672 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0672 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0680 | Mitochondrial DNA Click for more detail | rhabdomyosarcoma cells (others) | NA | NA | Nucleic Acid | Natural | It activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinases | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Neutrophils | NA | Q9NR96.fasta | Q9NR96 | 1032 | It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli. | Chemotaxis assay | 20203610 | 2010 | Pubchem Assay |
| PRRID_0680 | Mitochondrial DNA Click for more detail | rhabdomyosarcoma cells (others) | NA | NA | Nucleic Acid | Natural | It activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinases | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Neutrophils | NA | Q9NR96.fasta | Q9NR96 | 1032 | It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli. | Chemotaxis assay | 20203610 | 2010 | Pubchem Assay |
| PRRID_0682 | mmLDL Click for more detail | Native Human LDL (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Synthetic | The binding of mmLDL, induces the production of TNF-and increasing the expression of TLR2 and TLR5 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Monocytes and Macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages. | ELISA | 20472010 | 2010 | Pubchem Assay |
| PRRID_0682 | mmLDL Click for more detail | Native Human LDL (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Synthetic | The binding of mmLDL, induces the production of TNF-and increasing the expression of TLR2 and TLR5 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Monocytes and Macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages. | ELISA | 20472010 | 2010 | Pubchem Assay |
| PRRID_0683 | mmLDL Click for more detail | Native Human LDL (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Synthetic | The binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR6 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes and Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages. | ELISA | 20472010 | 2010 | Pubchem Assay |
| PRRID_0683 | mmLDL Click for more detail | Native Human LDL (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Synthetic | The binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR6 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes and Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages. | ELISA | 20472010 | 2010 | Pubchem Assay |
| PRRID_0684 | MOMP Click for more detail | Shigella flexneri (Bacteria) | NA | NA | Protein | Natural | It stimulates macrophages, up regulates the surface expression of MHC-II and B7-1 and enhances the production of different cytokines (such as ILp70, TNF-⍺, Il-6) and chemokines (like MIP-1⍺, MIP-1β and RANTES) | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Macropahes | LRR | Q9QUN7.fasta | Q9QUN7 | 784 | It initiates event in the antibacterial host response. | ELISA | 20347487 | 2010 | Pubchem Assay |
| PRRID_0684 | MOMP Click for more detail | Shigella flexneri (Bacteria) | NA | NA | Protein | Natural | It stimulates macrophages, up regulates the surface expression of MHC-II and B7-1 and enhances the production of different cytokines (such as ILp70, TNF-⍺, Il-6) and chemokines (like MIP-1⍺, MIP-1β and RANTES) | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Macropahes | LRR | Q9QUN7.fasta | Q9QUN7 | 784 | It initiates event in the antibacterial host response. | ELISA | 20347487 | 2010 | Pubchem Assay |
| PRRID_0685 | MPLA Click for more detail | Salmonella minnesota R595 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Rabbit | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | G1SH24.fasta | G1SH24 | 839 | 1,000-fold less toxic than LPS and can be used as vaccines | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0685 | MPLA Click for more detail | Salmonella minnesota R595 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Rabbit | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | G1SH24.fasta | G1SH24 | 839 | 1,000-fold less toxic than LPS and can be used as vaccines | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0686 | MPLA Click for more detail | Salmonella minnesota R595 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Guinea Pig | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | H0VSQ0.fasta | H0VSQ0 | 837 | 1,000-fold less toxic than LPS and can be used as vaccines | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0686 | MPLA Click for more detail | Salmonella minnesota R595 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Guinea Pig | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | H0VSQ0.fasta | H0VSQ0 | 837 | 1,000-fold less toxic than LPS and can be used as vaccines | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0687 | MPLA Click for more detail | Salmonella minnesota R595 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Dogs | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | F1PDB9.fasta | F1PDB9 | 833 | 1,000-fold less toxic than LPS and can be used as vaccines | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0687 | MPLA Click for more detail | Salmonella minnesota R595 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Dogs | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | F1PDB9.fasta | F1PDB9 | 833 | 1,000-fold less toxic than LPS and can be used as vaccines | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0688 | MPLA Click for more detail | Salmonella minnesota R595 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Horse | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | F6RL35.fasta | F6RL35 | 843 | 1,000-fold less toxic than LPS and can be used as vaccines | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0688 | MPLA Click for more detail | Salmonella minnesota R595 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Horse | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | F6RL35.fasta | F6RL35 | 843 | 1,000-fold less toxic than LPS and can be used as vaccines | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0689 | Mrp14 Click for more detail | Mice (others) | MIENYWTSFCGNHHTSSNCTVRFLQICFGITLSFLTLCICLFHKEPPKRIHQFFCLRLVSALFNGIIGSLDLVLGIWVLRENHSKPLILWLVILIQGFTWLFINLIICVRGTRIRKSSLRLLSIFSFFYGLVSSCLSVNNAVFGDELAVRTILDVLLLPGSVLLLLSAYKGYRFDESGESSLYEPLNAGDSNGFSEKADFDNRVSQFAKAGLFSTLSFWWLNSLIKRGNVKDLEEDDIPELRKEERAETCYSLFEENLIEQKRRLGSSCQPSILKVTVLCVWRELLTSGFFAFMKIVAVSAGPLLLNAFILVAEGNASFRYEGLVLAVLLFFSKMIESLSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGSEIMNYATVDAYRIGEFPYWFHQLWTTSFQLLIALGILFHSVGVATFSALAVIILTVLCNAPIAKLQNKFQSELMTSQDERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQMRKAYNAVLFWSSPVFVSAATFATCYFLDIPLRASNVFTFVATLRLVQDPVRMIPDVIGVTIQAKVAFSRIATFLEAPELQGGERRRKQRSEGNQNAIIIKSASFSWEEKGSTKPNLRNVRLEVKFGEKVAVCGEVGSGKSTLLAAILGETPCVSGTIDFYGTIAYVSQTAWIQTGTIRDNILFGGVMDEHRYRETIQKSSLDKDLELLPDGDQTEIGERGVNLSGGQKQRIQLARALYQDADIYLLDDPFSAVDAHTASSLFQEYVMDALAGKAVLLVTHQVDFLPAFDSVLLMSDGEITEADTYQELLARSRDFQDLVNAHRETAGSERVVAVENPTKPVKEINRVISSQSKVLKPSRLIKQEEREKGDTGLRPYIQYMNQNKGYIFFFIASLAQVTFAVGQILQNSWMAANVDNPQVSTLKLILVYLLIGLCSVLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPMSFYDSTPLGRILSRVSSDLSIVDLDV | 1453 | Damage-associated molecular patterns (DAMPs) | Natural | Binding leads to the secretion of the IL-18 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Leukocytes and endothelial cells | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It promotes the inflammation and might be involved in the progression of inflammation during CD40L-induced autoimmunity. It is also crucial for the devlopment of CD8+ T cells | ELISA | 20473308 | 2010 | Pubchem Assay |
| PRRID_0689 | Mrp14 Click for more detail | Mice (others) | MIENYWTSFCGNHHTSSNCTVRFLQICFGITLSFLTLCICLFHKEPPKRIHQFFCLRLVSALFNGIIGSLDLVLGIWVLRENHSKPLILWLVILIQGFTWLFINLIICVRGTRIRKSSLRLLSIFSFFYGLVSSCLSVNNAVFGDELAVRTILDVLLLPGSVLLLLSAYKGYRFDESGESSLYEPLNAGDSNGFSEKADFDNRVSQFAKAGLFSTLSFWWLNSLIKRGNVKDLEEDDIPELRKEERAETCYSLFEENLIEQKRRLGSSCQPSILKVTVLCVWRELLTSGFFAFMKIVAVSAGPLLLNAFILVAEGNASFRYEGLVLAVLLFFSKMIESLSQRQWYFRCRIVGLRVRSLLTAAINKKQLRLNNSSRLIHSGSEIMNYATVDAYRIGEFPYWFHQLWTTSFQLLIALGILFHSVGVATFSALAVIILTVLCNAPIAKLQNKFQSELMTSQDERLKACNESLVNMKVLKLYAWESHFKKVIEKLRNIELKSLKAVQMRKAYNAVLFWSSPVFVSAATFATCYFLDIPLRASNVFTFVATLRLVQDPVRMIPDVIGVTIQAKVAFSRIATFLEAPELQGGERRRKQRSEGNQNAIIIKSASFSWEEKGSTKPNLRNVRLEVKFGEKVAVCGEVGSGKSTLLAAILGETPCVSGTIDFYGTIAYVSQTAWIQTGTIRDNILFGGVMDEHRYRETIQKSSLDKDLELLPDGDQTEIGERGVNLSGGQKQRIQLARALYQDADIYLLDDPFSAVDAHTASSLFQEYVMDALAGKAVLLVTHQVDFLPAFDSVLLMSDGEITEADTYQELLARSRDFQDLVNAHRETAGSERVVAVENPTKPVKEINRVISSQSKVLKPSRLIKQEEREKGDTGLRPYIQYMNQNKGYIFFFIASLAQVTFAVGQILQNSWMAANVDNPQVSTLKLILVYLLIGLCSVLCLMVRSVCVVIMCMKSSASLFSQLLNSLFRAPMSFYDSTPLGRILSRVSSDLSIVDLDV | 1453 | Damage-associated molecular patterns (DAMPs) | Natural | Binding leads to the secretion of the IL-18 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Leukocytes and endothelial cells | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It promotes the inflammation and might be involved in the progression of inflammation during CD40L-induced autoimmunity. It is also crucial for the devlopment of CD8+ T cells | ELISA | 20473308 | 2010 | Pubchem Assay |
| PRRID_0690 | Mrp8 Click for more detail | Mice (others) | MPSELEKALSNLIDVYHNYSNIQGNHHALYKNDFKKMVTTECPQFVQNINIENLFRELDINSDNAINFEEFLAMVIKVGVASHKDSHKE | 89 | Damage-associated molecular patterns (DAMPs) | Natural | Binding leads to the secretion of the IL-17 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Leukocytes and endothelial cells | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It promotes the inflammation and might be involved in the progression of inflammation during CD40L-induced autoimmunity. It is also crucial for the devlopment of CD8+ T cells | ELISA | 20473308 | 2010 | Pubchem Assay |
| PRRID_0690 | Mrp8 Click for more detail | Mice (others) | MPSELEKALSNLIDVYHNYSNIQGNHHALYKNDFKKMVTTECPQFVQNINIENLFRELDINSDNAINFEEFLAMVIKVGVASHKDSHKE | 89 | Damage-associated molecular patterns (DAMPs) | Natural | Binding leads to the secretion of the IL-17 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Leukocytes and endothelial cells | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It promotes the inflammation and might be involved in the progression of inflammation during CD40L-induced autoimmunity. It is also crucial for the devlopment of CD8+ T cells | ELISA | 20473308 | 2010 | Pubchem Assay |
| PRRID_0691 | MsST Click for more detail | Streptococcus thermophilus lacZ (Bacteria) | MNMTEKIQTYLNDPKIVSVNTVDAHSDHKYFESLEEFSEGEMKLRQSLNGKWKIHYAQNTNQVLKDFYKTEFDETDLNFINVPGHLELQGFGSPQYVNTQYPWDGKEFLRPPQVPQESNAVASYVKHFTLNDALKDKKVFISFQGVATSIFVWVNGNFVGYSEDSFTPSEFEISDYLVEGDNKLAVAVYRYSTASWLEDQDFWRLYGIFRDVYLYAIPKVHVQDLFVKGDYDYQTKAGQLDIDLKTVGDYEDKKIKYVLSDYEGIVTEGDASVNGDGELSVSLENLKIKPWSAESPKLYDLILHVLDDDQVVEVVPVKVGFRRFEIKDKLMLLNGKRIVFKGVNRHEFNARTGRCITEEDMLWDIKVMKQHNINAVRTSHYPNQTRWYELCDEYGLYVIDEANLETHGTWQKLGLCEPSWNIPASEPEWLPACLDRANNMFQRDKNHASVIIWSCGNESYAGKDIADMADYFRSVDNTRPVHYEGVAWCREFDYITDIESRMYAKPADIEEYLTTGKLVDLSSVSDKHFASGNLTNKPQKPYISCEYMHTMGNSGGGLQLYTDLEKYPEYQGGFIWDFIDQAIYKTLPNGSEFLSYGGDWHDRPSDYEFCGNGIVFADRTLTPKLQTVKHLYSNIKIAVDEKSVTIKNDNLFEDLSAYTFLARVYEDGRKVSESEYHFDVKPGEEATFPVNFVVEASNSEQIYEVACVLREATEWAPKGHEIVRGQYVVEKISTETPVKAPLNVVEGDFNIGIQGQNFSILLSRAQNTLVSAKYNGVEFIEKGPKLSFTRAYTDNDRGAGYPFEMAGWKVAGNYSKVTDTQIQIEDDSVKVTYVHELPGLSDVEVKVTYQVDYKGRIFVTANYDGKAGLPNFPEFGLEFAIGSQFTNLSYYGYGAEESYRDKLPGAYLGRYETSVEKTFAPYLMPQESGNHYGTREFTVSDDNHNGLKFTALNKAFEFSALRNSTEQIENARHQYELQESDATWIKVLAAQMGVGGDDTW | 1026 | Nucleic Acid | Natural | It increases the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells and also induces the production of IL-6. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | Q99MB1.fasta | Q99MB1 | 905 | It is a potent stimulators of innate immunity. | ELISA | 20163626 | 2010 | Pubchem Assay |
| PRRID_0691 | MsST Click for more detail | Streptococcus thermophilus lacZ (Bacteria) | MNMTEKIQTYLNDPKIVSVNTVDAHSDHKYFESLEEFSEGEMKLRQSLNGKWKIHYAQNTNQVLKDFYKTEFDETDLNFINVPGHLELQGFGSPQYVNTQYPWDGKEFLRPPQVPQESNAVASYVKHFTLNDALKDKKVFISFQGVATSIFVWVNGNFVGYSEDSFTPSEFEISDYLVEGDNKLAVAVYRYSTASWLEDQDFWRLYGIFRDVYLYAIPKVHVQDLFVKGDYDYQTKAGQLDIDLKTVGDYEDKKIKYVLSDYEGIVTEGDASVNGDGELSVSLENLKIKPWSAESPKLYDLILHVLDDDQVVEVVPVKVGFRRFEIKDKLMLLNGKRIVFKGVNRHEFNARTGRCITEEDMLWDIKVMKQHNINAVRTSHYPNQTRWYELCDEYGLYVIDEANLETHGTWQKLGLCEPSWNIPASEPEWLPACLDRANNMFQRDKNHASVIIWSCGNESYAGKDIADMADYFRSVDNTRPVHYEGVAWCREFDYITDIESRMYAKPADIEEYLTTGKLVDLSSVSDKHFASGNLTNKPQKPYISCEYMHTMGNSGGGLQLYTDLEKYPEYQGGFIWDFIDQAIYKTLPNGSEFLSYGGDWHDRPSDYEFCGNGIVFADRTLTPKLQTVKHLYSNIKIAVDEKSVTIKNDNLFEDLSAYTFLARVYEDGRKVSESEYHFDVKPGEEATFPVNFVVEASNSEQIYEVACVLREATEWAPKGHEIVRGQYVVEKISTETPVKAPLNVVEGDFNIGIQGQNFSILLSRAQNTLVSAKYNGVEFIEKGPKLSFTRAYTDNDRGAGYPFEMAGWKVAGNYSKVTDTQIQIEDDSVKVTYVHELPGLSDVEVKVTYQVDYKGRIFVTANYDGKAGLPNFPEFGLEFAIGSQFTNLSYYGYGAEESYRDKLPGAYLGRYETSVEKTFAPYLMPQESGNHYGTREFTVSDDNHNGLKFTALNKAFEFSALRNSTEQIENARHQYELQESDATWIKVLAAQMGVGGDDTW | 1026 | Nucleic Acid | Natural | It increases the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells and also induces the production of IL-6. | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Spleenocytes | LRR | Q99MB1.fasta | Q99MB1 | 905 | It is a potent stimulators of innate immunity. | ELISA | 20163626 | 2010 | Pubchem Assay |
| PRRID_0695 | murine cytomegalovirus Click for more detail | MCMV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIF | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | it lead to the secretion of IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0695 | murine cytomegalovirus Click for more detail | MCMV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIF | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | it lead to the secretion of IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0696 | mutated SOD1 Click for more detail | exogenous (others) | NA | NA | Protein | Synthetic | NA | Toll-like receptor 14 (TLR14) | Toll-like receptor (TLR) | Mice | microglia | NA | P10810.fasta | P10810 | 366 | activation and toxicity of microglia | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0696 | mutated SOD1 Click for more detail | exogenous (others) | NA | NA | Protein | Synthetic | NA | Toll-like receptor 14 (TLR14) | Toll-like receptor (TLR) | Mice | microglia | NA | P10810.fasta | P10810 | 366 | activation and toxicity of microglia | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0698 | N1L Click for more detail | Vaccinia(virus) | MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK | 117 | Protein | Natural | Suppress NF-κB activation (Bind to IKKγ) | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0698 | N1L Click for more detail | Vaccinia(virus) | MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK | 117 | Protein | Natural | Suppress NF-κB activation (Bind to IKKγ) | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0700 | NA Click for more detail | Edwardsiella tarda(Bacteria) | NA | NA | NA | Natural | It's binding leads to the release of the arra of cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Paralichthys olivaceus | Head Kidney | Leucine-rich Repeat (LRR) Domain | E9RGG6.fasta | E9RGG6 | 868 | It provides immune response against the E.tarda | NA | 20728538 | 2010 | Pubchem Assay |
| PRRID_0700 | NA Click for more detail | Edwardsiella tarda(Bacteria) | NA | NA | NA | Natural | It's binding leads to the release of the arra of cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Paralichthys olivaceus | Head Kidney | Leucine-rich Repeat (LRR) Domain | E9RGG6.fasta | E9RGG6 | 868 | It provides immune response against the E.tarda | NA | 20728538 | 2010 | Pubchem Assay |
| PRRID_0706 | naked dsRNS (poly(I:C)) Click for more detail | Bacteria | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | induced a reduction in maximal mitochondrial respiration | Toll-like receptor 3,7,9 (TLR3/7/9) | Toll-like receptor (TLR) | Human | Human hepatocytes (HepG2 cells) | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | This resultsinto mitochondrial dysfunction which is accompanied by caspase-8 | NA | 20691286 | 2010 | NA |
| PRRID_0706 | naked dsRNS (poly(I:C)) Click for more detail | Bacteria | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | induced a reduction in maximal mitochondrial respiration | Toll-like receptor 3,7,9 (TLR3/7/9) | Toll-like receptor (TLR) | Human | Human hepatocytes (HepG2 cells) | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | This resultsinto mitochondrial dysfunction which is accompanied by caspase-8 | NA | 20691286 | 2010 | NA |
| PRRID_0707 | Nef Click for more detail | HIV-1 (virus) | MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC | 206 | Protein | Natural | Inhibit ERK activation (Dephosphorylation of ERK by induced MKP-1) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress TNF-α production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0707 | Nef Click for more detail | HIV-1 (virus) | MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC | 206 | Protein | Natural | Inhibit ERK activation (Dephosphorylation of ERK by induced MKP-1) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress TNF-α production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0710 | NS1 Click for more detail | Influenza A (virus) | MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV | 206 | Protein | Natural | Suppress of IRF3/7 activation | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Inhibit IFN production in pDC | NA | 20672047 | 2010 | NA |
| PRRID_0710 | NS1 Click for more detail | Influenza A (virus) | MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV | 206 | Protein | Natural | Suppress of IRF3/7 activation | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Inhibit IFN production in pDC | NA | 20672047 | 2010 | NA |
| PRRID_0711 | NS1 Click for more detail | Influenza A (virus) | MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV | 206 | Protein | Natural | Suppress of NF-κB and AP-1 activation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress DC and T cell activation | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0711 | NS1 Click for more detail | Influenza A (virus) | MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV | 206 | Protein | Natural | Suppress of NF-κB and AP-1 activation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress DC and T cell activation | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0713 | NS1, NS2 Click for more detail | Human respiratory syncytial virus (RSV) | MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP | 139, 124 | Protein | Natural | Suppress IRF3 activation | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | Suppress IFN production in mDC | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0713 | NS1, NS2 Click for more detail | Human respiratory syncytial virus (RSV) | MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP | 139, 124 | Protein | Natural | Suppress IRF3 activation | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | Suppress IFN production in mDC | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0715 | NS3/4A Click for more detail | Hepatitis C Virus (virus) | APITAYAQQTRGLLGTIVTGLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPSGAKSLEPCACGSADLYLITRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGVDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEIPFYGKAIPIALLKGGRHLIFCHSKKKCEEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTGLTHIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDETWKCLVRLKPTLHGPTPLLYRLGPIQNETCLTHPVTKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGSVVIVGHIELGGKPALVPDREVLYQQYDEMEEC | 685 | Protein | Natural | Degrade TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress IFN-α/β production and Suppress CD4+ T cell activation by dysfunction of mDCs | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0715 | NS3/4A Click for more detail | Hepatitis C Virus (virus) | APITAYAQQTRGLLGTIVTGLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPSGAKSLEPCACGSADLYLITRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGVDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEIPFYGKAIPIALLKGGRHLIFCHSKKKCEEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTGLTHIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDETWKCLVRLKPTLHGPTPLLYRLGPIQNETCLTHPVTKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGSVVIVGHIELGGKPALVPDREVLYQQYDEMEEC | 685 | Protein | Natural | Degrade TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress IFN-α/β production and Suppress CD4+ T cell activation by dysfunction of mDCs | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0716 | NS5A Click for more detail | Hepatitis C Virus (virus) | MAGSWLRDVWDWICTVLSDFKTWLQSKLLPRLPGVPFLSCQRGYRGVWRGDGIMHTTCPCGAEITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNIKCPCQVPAPEFFTELDGVRLHRYAPACKPLLRDEVTFLVGLHQYPVGSQLPCEPEPNVTVLTSMLTDPSHITAETAKRRLARGSPPSMASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRKFPQAMPIWARPDYNPPLLESWKNPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSESSAVDSGTATAPPDQPSDDGGSGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSH | 452 | Protein | Natural | Inhibit NF-κB activation (Bind to MyD88) and Inhibit JNK activation (Bind to TRAF2) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress cytokine production and Suppress TNF pathway activation | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0716 | NS5A Click for more detail | Hepatitis C Virus (virus) | MAGSWLRDVWDWICTVLSDFKTWLQSKLLPRLPGVPFLSCQRGYRGVWRGDGIMHTTCPCGAEITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNIKCPCQVPAPEFFTELDGVRLHRYAPACKPLLRDEVTFLVGLHQYPVGSQLPCEPEPNVTVLTSMLTDPSHITAETAKRRLARGSPPSMASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRKFPQAMPIWARPDYNPPLLESWKNPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSESSAVDSGTATAPPDQPSDDGGSGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSH | 452 | Protein | Natural | Inhibit NF-κB activation (Bind to MyD88) and Inhibit JNK activation (Bind to TRAF2) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress cytokine production and Suppress TNF pathway activation | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0717 | ODN with CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | ODN and CpG motifs activates the TLR9, which results in the activation of the downstream signalling cascade. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Raw 264.7 macrophage cell line | Cells of the immune system and initially localized at ER | Leucine-rich Repeat (LRR) Domain | Q9EQU3.fasta | Q9EQU3 | 1032 | Pleiotropic immune responses and regulates apoptosis | NA | 20739833 | 2010 | Pubchem Assay |
| PRRID_0717 | ODN with CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | ODN and CpG motifs activates the TLR9, which results in the activation of the downstream signalling cascade. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Raw 264.7 macrophage cell line | Cells of the immune system and initially localized at ER | Leucine-rich Repeat (LRR) Domain | Q9EQU3.fasta | Q9EQU3 | 1032 | Pleiotropic immune responses and regulates apoptosis | NA | 20739833 | 2010 | Pubchem Assay |
| PRRID_0718 | OM-174 Click for more detail | E. coli(Bacteria) | CCCCCCCCCCC[C@@H](O)CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]2NC(=O)C[C@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O[C@@H]1OP(O)(O)=O | NA | Lipid | Natural | it induce the expression of iNOS, tumour suppressive proteins and cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Rat | Liver | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It results into inhibition of invasion and metastasis of HCC | NA | 20675699 | 2010 | NA |
| PRRID_0718 | OM-174 Click for more detail | E. coli(Bacteria) | CCCCCCCCCCC[C@@H](O)CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]2NC(=O)C[C@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O[C@@H]1OP(O)(O)=O | NA | Lipid | Natural | it induce the expression of iNOS, tumour suppressive proteins and cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Rat | Liver | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It results into inhibition of invasion and metastasis of HCC | NA | 20675699 | 2010 | NA |
| PRRID_0719 | p30 Click for more detail | Human T-lymphotropic leukemia virus 1 (virus) | MALCCFAFSAPCLHLRSRRSCSSCFLLATSAAFFSARLLRRAFSSSFLFKYSAICFSSSFSRSFFRFLFSSARRCRSRCVSPRGGAFSPGGPRRSRPRLSSSKDSKPSSTASSSSLSFNSSSKDNSPSTNSSTSRSSGHDTGKHRNSPADTKLTMLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL | 241 | Protein | Natural | Suppress TLR4 expression and Inhibit GSK3-β | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress cytokine production ad enhance IL-10 prduction | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0719 | p30 Click for more detail | Human T-lymphotropic leukemia virus 1 (virus) | MALCCFAFSAPCLHLRSRRSCSSCFLLATSAAFFSARLLRRAFSSSFLFKYSAICFSSSFSRSFFRFLFSSARRCRSRCVSPRGGAFSPGGPRRSRPRLSSSKDSKPSSTASSSSLSFNSSSKDNSPSTNSSTSRSSGHDTGKHRNSPADTKLTMLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL | 241 | Protein | Natural | Suppress TLR4 expression and Inhibit GSK3-β | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress cytokine production ad enhance IL-10 prduction | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0720 | Paclitaxel Click for more detail | NA | C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C | NA | Drug | Synthetic | It hasthe role in the activation of the adapter protein MyD88 was linked to reduction of apoptosis in cancer cells. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human(Ovarian Cancer Patient) | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NA | NA | 20728343 | 2010 | Pubchem Assay |
| PRRID_0720 | Paclitaxel Click for more detail | NA | C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C | NA | Drug | Synthetic | It hasthe role in the activation of the adapter protein MyD88 was linked to reduction of apoptosis in cancer cells. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human(Ovarian Cancer Patient) | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NA | NA | 20728343 | 2010 | Pubchem Assay |
| PRRID_0721 | Diacylated Lipopeptide Click for more detail | Bacteria | NA | NA | Lipopeptides | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0721 | Diacylated Lipopeptide Click for more detail | Bacteria | NA | NA | Lipopeptides | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0722 | Pam2Cys Click for more detail | B. burgdorferi(Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Peptidoglycan | Synthetic | Induction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0722 | Pam2Cys Click for more detail | B. burgdorferi(Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Peptidoglycan | Synthetic | Induction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0723 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipopeptides | Synthetic | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | embryonic mouse telencephalon and NPC | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | its activation inhibits NPC proliferation and decreases cell proliferation. | NA | 20456021 | 2010 | Pubchem Assay |
| PRRID_0723 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipopeptides | Synthetic | Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-κB which results in secretion of proinflammatory cytokines | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | embryonic mouse telencephalon and NPC | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | its activation inhibits NPC proliferation and decreases cell proliferation. | NA | 20456021 | 2010 | Pubchem Assay |
| PRRID_0724 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipopeptides | Synthetic | It mediates the effect through a TLR2/PI3K/Aktdependent mechanism. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Heart | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It induces induce cardioprotection against ischaemia/reperfusion injury | EMSA | 20421349 | 2010 | Pubchem Assay |
| PRRID_0724 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipopeptides | Synthetic | It mediates the effect through a TLR2/PI3K/Aktdependent mechanism. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Heart | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It induces induce cardioprotection against ischaemia/reperfusion injury | EMSA | 20421349 | 2010 | Pubchem Assay |
| PRRID_0725 | Pam3Cys Click for more detail | Plasmodium falciparum circumsporozoite protein (others) | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Peptidoglycan | Synthetic | Vaccine targeting malaria | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0725 | Pam3Cys Click for more detail | Plasmodium falciparum circumsporozoite protein (others) | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Peptidoglycan | Synthetic | Vaccine targeting malaria | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0726 | Pam3CysSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Peptidoglycan | Synthetic | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | CNS | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It causes neurodegeneration | NA | 20706642 | 2010 | NA |
| PRRID_0726 | Pam3CysSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Peptidoglycan | Synthetic | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | CNS | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It causes neurodegeneration | NA | 20706642 | 2010 | NA |
| PRRID_0727 | Pam3CysSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Peptidoglycan | Synthetic | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Helps in IgM production and clear pathogen from blood | NA | 20696824 | 2010 | Pubchem Assay |
| PRRID_0727 | Pam3CysSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Peptidoglycan | Synthetic | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice (Murine) | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Helps in IgM production and clear pathogen from blood | NA | 20696824 | 2010 | Pubchem Assay |