Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0528	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	Spleenocytes	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis	NA	20543857	2010	Pubchem Assay
PRRID_0528	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	Spleenocytes	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis	NA	20543857	2010	Pubchem Assay
PRRID_0529	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice (Murine)	Spleenocytes	Leucine-rich Repeat (LRR) Domain	P58682.fasta	P58682	1032	It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis	NA	20543857	2010	Pubchem Assay
PRRID_0529	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Mice (Murine)	Spleenocytes	Leucine-rich Repeat (LRR) Domain	P58682.fasta	P58682	1032	It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis	NA	20543857	2010	Pubchem Assay
PRRID_0530	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	HEK293	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	It has the role in the inflammation.	NA	20543857	2010	Pubchem Assay
PRRID_0530	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	HEK293	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	It has the role in the inflammation.	NA	20543857	2010	Pubchem Assay
PRRID_0531	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	HEK293	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It has the role in the inflammation.	NA	20543857	2010	Pubchem Assay
PRRID_0531	Gardiquimod Click for more detail	imidazoquinoline (others)	CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	HEK293	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It has the role in the inflammation.	NA	20543857	2010	Pubchem Assay
PRRID_0532	gB/gH Click for more detail	Human cytomegalovirus (virus)	NA	NA	Glycoprotein	Natural	Activate NF-Œ∫B	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Produce proinflammatory cytokines	NA	20672047	2010	NA
PRRID_0532	gB/gH Click for more detail	Human cytomegalovirus (virus)	NA	NA	Glycoprotein	Natural	Activate NF-Œ∫B	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Produce proinflammatory cytokines	NA	20672047	2010	NA
PRRID_0533	genomic DNA Click for more detail	HSV-1 and HSV-2 (virus)	NA	NA	Nucleic Acid	Natural	It mediates tumor necrosis factor alpha and CCL5 production in murine macrophages	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid dendritic cells	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It has the role in the inflammation.	NA	20739519	2010	Pubchem Assay
PRRID_0533	genomic DNA Click for more detail	HSV-1 and HSV-2 (virus)	NA	NA	Nucleic Acid	Natural	It mediates tumor necrosis factor alpha and CCL5 production in murine macrophages	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice (Murine)	plasmacytoid dendritic cells	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It has the role in the inflammation.	NA	20739519	2010	Pubchem Assay
PRRID_0534	genomic DNA Click for more detail	Salmonella enterica (Bacteria)	NA	NA	Nucleic Acid	Natural	The binding leads to the activation of the NF-	chToll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	HD11 macrophage	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leads to the inflammatory response from the immune system leads to the clearance of pathogens	Luciferase assay	20498358	2010	NA
PRRID_0534	genomic DNA Click for more detail	Salmonella enterica (Bacteria)	NA	NA	Nucleic Acid	Natural	The binding leads to the activation of the NF-	chToll-like receptor 21 (TLR21)	Toll-like receptor (TLR)	Chicken	HD11 macrophage	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leads to the inflammatory response from the immune system leads to the clearance of pathogens	Luciferase assay	20498358	2010	NA
PRRID_0535	Glycoinositol phospholipids Click for more detail	Trypanosoma (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	20713100	2010	Pubchem Assay
PRRID_0535	Glycoinositol phospholipids Click for more detail	Trypanosoma (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	20713100	2010	Pubchem Assay
PRRID_0536	Glycoinositol phospholipids Click for more detail	Trypanosoma (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	It leadsto the secretion of the proinfalmmatory cytokines and IFN-Œ≤	NA	20620129	2010	Pubchem Assay
PRRID_0536	Glycoinositol phospholipids Click for more detail	Trypanosoma (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	It leadsto the secretion of the proinfalmmatory cytokines and IFN-Œ≤	NA	20620129	2010	Pubchem Assay
PRRID_0537	Glycolipids Click for more detail	Treponema maltophilum (others)	NA	NA	Glycolipid	Natural	Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-Œ± and induces augment PMN migration.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung's endothelial cell	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20706658	2010	Pubchem Assay
PRRID_0537	Glycolipids Click for more detail	Treponema maltophilum (others)	NA	NA	Glycolipid	Natural	Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-Œ± and induces augment PMN migration.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung's endothelial cell	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20706658	2010	Pubchem Assay
PRRID_0538	Glycolipids Click for more detail	spirochetes (Bacteria)	NA	NA	Glycolipid	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	20679445	2010	NA
PRRID_0538	Glycolipids Click for more detail	spirochetes (Bacteria)	NA	NA	Glycolipid	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	20679445	2010	NA
PRRID_0539	Glycosylphosphatidyl inositol anchor Click for more detail	Protozoa (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0539	Glycosylphosphatidyl inositol anchor Click for more detail	Protozoa (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0540	Glycosylphosphatidyl inositol anchor Click for more detail	Trypanosoma Cruzi (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-Œ± and induces augment PMN migration.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung's endothelial cell	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20706658	2010	Pubchem Assay
PRRID_0540	Glycosylphosphatidyl inositol anchor Click for more detail	Trypanosoma Cruzi (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-Œ± and induces augment PMN migration.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung's endothelial cell	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20706658	2010	Pubchem Assay
PRRID_0541	Glycosylphosphophatidyl inositol mucin Click for more detail	Trypanosoma (others)	NA	NA	Glycoprotein	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	Pubchem Assay
PRRID_0541	Glycosylphosphophatidyl inositol mucin Click for more detail	Trypanosoma (others)	NA	NA	Glycoprotein	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	Pubchem Assay
PRRID_0542	gp350/gp220 Click for more detail	Epstein-Barr virus (virus)	MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTADVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGELALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYIKWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEISQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLGNNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPWDNGTESKAPDMTSSTSPVTTPTPNATSPTPAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATGPTVGETSPQANATNHTLGGTSPTPVVTSQPKNATSAVTTGQHNITSSSTSSMSLRPSSNPETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPQNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTSQPRFSNLSMLVLQWASLAVLTLLLLLVMADCAFRRNLSTSHTYTTPPYDDAETYV	907	Glycoprotein	Natural	Activate NF-Œ∫B	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Induce MCP-1 production	NA	20672047	2010	Pubchem Assay
PRRID_0542	gp350/gp220 Click for more detail	Epstein-Barr virus (virus)	MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTADVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGELALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYIKWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEISQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLGNNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPWDNGTESKAPDMTSSTSPVTTPTPNATSPTPAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATGPTVGETSPQANATNHTLGGTSPTPVVTSQPKNATSAVTTGQHNITSSSTSSMSLRPSSNPETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPQNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTSQPRFSNLSMLVLQWASLAVLTLLLLLVMADCAFRRNLSTSHTYTTPPYDDAETYV	907	Glycoprotein	Natural	Activate NF-Œ∫B	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Induce MCP-1 production	NA	20672047	2010	Pubchem Assay
PRRID_0543	GPI anchor Click for more detail	T. gondii (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	GPIs binds to the TLR2 and activaes the downstream processes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Recognition and phagocytosis	NA	20729207	2010	Pubchem Assay
PRRID_0543	GPI anchor Click for more detail	T. gondii (others)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	GPIs binds to the TLR2 and activaes the downstream processes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Recognition and phagocytosis	NA	20729207	2010	Pubchem Assay
PRRID_0544	HA Click for more detail	Measles virus (virus)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Protein	Natural	Activate NF-Œ∫B	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Induce cytokine production such as such as IL-1Œ±, IL-1Œ≤, IL-6, IL-8 and IL-12	NA	20672047	2010	Pubchem Assay
PRRID_0544	HA Click for more detail	Measles virus (virus)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Protein	Natural	Activate NF-Œ∫B	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Induce cytokine production such as such as IL-1Œ±, IL-1Œ≤, IL-6, IL-8 and IL-12	NA	20672047	2010	Pubchem Assay
PRRID_0545	Heat shock protein Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	activation of NF-Œ∫B and the synthesis of proinflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endogenous	NA	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It leads to the inflammation of the cell	NA	20740341	2010	Pubchem Assay
PRRID_0545	Heat shock protein Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	activation of NF-Œ∫B and the synthesis of proinflammatory cytokines	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Endogenous	NA	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It leads to the inflammation of the cell	NA	20740341	2010	Pubchem Assay
PRRID_0547	Heat shock protein Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	activation of NF-Œ∫B and the synthesis of proinflammatory cytokines	MD2 Complex	Toll-like receptor (TLR)	Endogenous	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leads to the inflammation of the cell	NA	20740341	2010	NA
PRRID_0547	Heat shock protein Click for more detail	Endogenous (others)	NA	NA	Protein	Natural	activation of NF-Œ∫B and the synthesis of proinflammatory cytokines	MD2 Complex	Toll-like receptor (TLR)	Endogenous	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leads to the inflammation of the cell	NA	20740341	2010	NA
PRRID_0548	Heat-killed MTB Click for more detail	Mycobacterium tuberculosis (Bacteria)	NA	NA	Whole organism	Natural	It induces the production of IL-17A	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	PBMCs	LRR	O00206.fasta	O00206	839	The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis	Cytokines assay	20299682	2010	Pubchem Assay
PRRID_0548	Heat-killed MTB Click for more detail	Mycobacterium tuberculosis (Bacteria)	NA	NA	Whole organism	Natural	It induces the production of IL-17A	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	PBMCs	LRR	O00206.fasta	O00206	839	The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis	Cytokines assay	20299682	2010	Pubchem Assay
PRRID_0550	Heat-shock protein 70 Click for more detail	Host (Endogenous) (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Protein	Natural	Induced NF-Œ∫B activation as well as the expression of TNF-Œ±, IL1Œ≤ and IL-6	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leads to the depression of myocardial contractility	NA	20689929	2010	NA
PRRID_0550	Heat-shock protein 70 Click for more detail	Host (Endogenous) (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Protein	Natural	Induced NF-Œ∫B activation as well as the expression of TNF-Œ±, IL1Œ≤ and IL-6	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leads to the depression of myocardial contractility	NA	20689929	2010	NA
PRRID_0551	Heat-shock proteins 60 Click for more detail	Host (Endogenous) (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Protein	Natural	Induces the expression of TNF-‚ç∫	Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	20689929	2010	NA
PRRID_0551	Heat-shock proteins 60 Click for more detail	Host (Endogenous) (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Protein	Natural	Induces the expression of TNF-‚ç∫	Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	20689929	2010	NA
PRRID_0552	Hemagglutinin Click for more detail	Measles virus (virus)	MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR	617	Glycoprotein	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	Pubchem Assay
PRRID_0552	Hemagglutinin Click for more detail	Measles virus (virus)	MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR	617	Glycoprotein	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	Pubchem Assay
PRRID_0553	Heme Click for more detail	Host (Endogenous) (others)	CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C)CCC(=O)O)CCC(=O)O	NA	Endogenous	Natural	Binding of Heme to TLR4 leads to increased production of the proinflammatory cytokine, tumor necrosis factor-alpha	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	Macropahges	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	20689929	2010	NA
PRRID_0553	Heme Click for more detail	Host (Endogenous) (others)	CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C)CCC(=O)O)CCC(=O)O	NA	Endogenous	Natural	Binding of Heme to TLR4 leads to increased production of the proinflammatory cytokine, tumor necrosis factor-alpha	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	Macropahges	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	20689929	2010	NA
PRRID_0556	Hemozoin Click for more detail	Plasmodium (others)	CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]	NA	NA	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD93	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Endosomes	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫	NA	20620129	2010	Pubchem Assay
PRRID_0556	Hemozoin Click for more detail	Plasmodium (others)	CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5]	NA	NA	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD93	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Endosomes	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫	NA	20620129	2010	Pubchem Assay
PRRID_0559	HMGB1 Click for more detail	Mouse model of endotoxemia	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Acts as a mediator of inflammation and organ damage	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	Acts as a mediator of inflammation and organ damage	NA	20740341	2010	Pubchem Assay
PRRID_0559	HMGB1 Click for more detail	Mouse model of endotoxemia	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Acts as a mediator of inflammation and organ damage	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	Acts as a mediator of inflammation and organ damage	NA	20740341	2010	Pubchem Assay
PRRID_0560	HMGB1 Click for more detail	Mouse model of endotoxemia	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Acts as a mediator of inflammation and organ damage	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	Acts as a mediator of inflammation and organ damage	NA	20740341	2010	Pubchem Assay
PRRID_0560	HMGB1 Click for more detail	Mouse model of endotoxemia	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Acts as a mediator of inflammation and organ damage	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	Acts as a mediator of inflammation and organ damage	NA	20740341	2010	Pubchem Assay
PRRID_0562	HMGB1 Click for more detail	Human (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	It interacts with the TLR4 and elicit immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Rat	Endothelial cells	Leucine-rich Repeat (LRR) Domain	Q9QX05.fasta	Q9QX05	835	It induced vascular endothelial activation	EMSA	20714791	2010	Pubchem Assay
PRRID_0562	HMGB1 Click for more detail	Human (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	It interacts with the TLR4 and elicit immune response	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Rat	Endothelial cells	Leucine-rich Repeat (LRR) Domain	Q9QX05.fasta	Q9QX05	835	It induced vascular endothelial activation	EMSA	20714791	2010	Pubchem Assay
PRRID_0563	HMGB1 Click for more detail	Host (Endogenous) (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Epinephrine directly acts through MœÜ Œ≤- adrenergic receptor to stimulate HMGB1 secretion from the MœÜ in an autocrine manner	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	lung	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	20706658	2010	Pubchem Assay
PRRID_0563	HMGB1 Click for more detail	Host (Endogenous) (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	Epinephrine directly acts through MœÜ Œ≤- adrenergic receptor to stimulate HMGB1 secretion from the MœÜ in an autocrine manner	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	lung	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	20706658	2010	Pubchem Assay
PRRID_0564	HMGB1 Click for more detail	Host (Endogenous) (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	induced cellular activation and NF-Œ∫B-dependent transcription	Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	HEK293	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It generate the inflammatory response similar to intiated by LPS	NA	20689929	2010	NA
PRRID_0564	HMGB1 Click for more detail	Host (Endogenous) (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	induced cellular activation and NF-Œ∫B-dependent transcription	Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	HEK293	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It generate the inflammatory response similar to intiated by LPS	NA	20689929	2010	NA
PRRID_0565	HpaA Click for more detail	H. pylori (Bacteria)	NA	NA	Lipoprotein	Natural	It activates the TLR2, which leads to the secretion of IL-12 and IFN-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Natural Killer cells	LRR	O60603.fasta	O60603	784	It has a immunostimulatory role	ELISA	20130107	2010	Pubchem Assay
PRRID_0565	HpaA Click for more detail	H. pylori (Bacteria)	NA	NA	Lipoprotein	Natural	It activates the TLR2, which leads to the secretion of IL-12 and IFN-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Natural Killer cells	LRR	O60603.fasta	O60603	784	It has a immunostimulatory role	ELISA	20130107	2010	Pubchem Assay
PRRID_0567	HSP72 Click for more detail	Host (Endogenous) (others)	NA	NA	Protein	Natural	increases in MIP-2 release	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	hepatocytes	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	20689929	2010	Pubchem Assay
PRRID_0567	HSP72 Click for more detail	Host (Endogenous) (others)	NA	NA	Protein	Natural	increases in MIP-2 release	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	hepatocytes	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	NA	NA	20689929	2010	Pubchem Assay
PRRID_0569	Hyaluronan Click for more detail	Prepared by HCL degradation (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Carbohydrate	Synthetic	Its binding leads to the production of interleukin-10, and down-regulated chemokine production.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	MRL-lpr/lpr Mice	Large intestinal epithelial cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It modulates Th-1-type autoimmune disease and inflammation by up-regulating SOCS3 expression and down-regulating pleiotrophin expression via TLR-4 in intestinal epithelial cells and hence promotes the survival.	Array Analysis	20504769	2010	Pubchem Assay
PRRID_0569	Hyaluronan Click for more detail	Prepared by HCL degradation (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Carbohydrate	Synthetic	Its binding leads to the production of interleukin-10, and down-regulated chemokine production.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	MRL-lpr/lpr Mice	Large intestinal epithelial cells	Leucine-rich Repeat (LRR) Domain	Q9QUK6.fasta	Q9QUK6	835	It modulates Th-1-type autoimmune disease and inflammation by up-regulating SOCS3 expression and down-regulating pleiotrophin expression via TLR-4 in intestinal epithelial cells and hence promotes the survival.	Array Analysis	20504769	2010	Pubchem Assay
PRRID_0570	Hyaluronic acid Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	Interaction between lower molecular weight HA and TLR leads to decrease in CD44-dependent clearance of HA leads to enhanced lung inflammation and injury	Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macropahges	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leads to the production of inflammatory chemokines and cytokines	NA	20689929	2010	NA
PRRID_0570	Hyaluronic acid Click for more detail	Host (Endogenous) (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Glycosaminoglycan	Natural	Interaction between lower molecular weight HA and TLR leads to decrease in CD44-dependent clearance of HA leads to enhanced lung inflammation and injury	Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	Macropahges	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leads to the production of inflammatory chemokines and cytokines	NA	20689929	2010	NA
PRRID_0571	hypomethylated DNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	release of proinflammatory cytokines and Pathgen Clearance	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It has the role in the inflammation.	NA	20739362	2010	Pubchem Assay
PRRID_0571	hypomethylated DNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	release of proinflammatory cytokines and Pathgen Clearance	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It has the role in the inflammation.	NA	20739362	2010	Pubchem Assay
PRRID_0574	Imiquimod Click for more detail	imidazoquinoline (others)	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces inflammatory responses when applied to the skin	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It leads to the inflammation of the cell	NA	20739947	2010	Pubchem Assay
PRRID_0574	Imiquimod Click for more detail	imidazoquinoline (others)	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces inflammatory responses when applied to the skin	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It leads to the inflammation of the cell	NA	20739947	2010	Pubchem Assay
PRRID_0575	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces translocation of NF-kB and production of IFN-Œ±, TNF-Œ±, IL-6, and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Cyprinus carpio L	head kidney	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It has the role in the inflammation.	NA	20709611	2010	NA
PRRID_0575	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It induces translocation of NF-kB and production of IFN-Œ±, TNF-Œ±, IL-6, and IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Cyprinus carpio L	head kidney	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It has the role in the inflammation.	NA	20709611	2010	NA
PRRID_0576	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of type I IFNs, TNF-‚ç∫, IL-12 and driving a Th1 reponse pTTERN	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Suppresses angiogenesis and presents proapoptotic activity	NA	20636030	2010	NA
PRRID_0576	Imiquimod Click for more detail	NA	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of type I IFNs, TNF-‚ç∫, IL-12 and driving a Th1 reponse pTTERN	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Suppresses angiogenesis and presents proapoptotic activity	NA	20636030	2010	NA
PRRID_0577	Imiquimod Click for more detail	imidazoquinoline (others)	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	Spleenocytes	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis	NA	20543857	2010	Pubchem Assay
PRRID_0577	Imiquimod Click for more detail	imidazoquinoline (others)	CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N	NA	imidazoquinolines	Synthetic	It activates the NF-	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Mice (Murine)	Spleenocytes	Leucine-rich Repeat (LRR) Domain	P58681.fasta	P58681	1050	It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis	NA	20543857	2010	Pubchem Assay
PRRID_0578	imiquimod (R-837) and resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It produce pro-inflammatory cytokines including IFNŒ±, TNFŒ± and/or IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	Itresults into the inflammatory response	NA	20713100	2010	Pubchem Assay
PRRID_0578	imiquimod (R-837) and resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It produce pro-inflammatory cytokines including IFNŒ±, TNFŒ± and/or IL-12	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	Itresults into the inflammatory response	NA	20713100	2010	Pubchem Assay
PRRID_0579	imiquimod (R-837) and resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It produce pro-inflammatory cytokines including IFNŒ±, TNFŒ± and/or IL-12	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	Itresults into the inflammatory response	NA	20713100	2010	Pubchem Assay
PRRID_0579	imiquimod (R-837) and resiquimod (R-848) Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N	NA	Nucleic Acid	Synthetic	It produce pro-inflammatory cytokines including IFNŒ±, TNFŒ± and/or IL-12	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells	Leucine-rich Repeat (LRR) Domain	Q9NR97.fasta	Q9NR97	1041	Itresults into the inflammatory response	NA	20713100	2010	Pubchem Assay
PRRID_0580	IMO-1 Click for more detail	NA	5'-TCTGToCG2TTGT-X-TGTTG2CoTGTCT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-1	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0580	IMO-1 Click for more detail	NA	5'-TCTGToCG2TTGT-X-TGTTG2CoTGTCT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-1	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0581	IMO-10 Click for more detail	NA	5'-TCG2TCG2TTdUY-M-YdUTTG2CTG2CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-10	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0581	IMO-10 Click for more detail	NA	5'-TCG2TCG2TTdUY-M-YdUTTG2CTG2CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-10	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0582	IMO-11 Click for more detail	NA	5'-TCG1TACG1TACG1-X-G1CATG1CATG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-11	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0582	IMO-11 Click for more detail	NA	5'-TCG1TACG1TACG1-X-G1CATG1CATG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-11	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0583	IMO-12 Click for more detail	NA	5'-TCG1AACG1TTCoG-Z-GoCTTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-12	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0583	IMO-12 Click for more detail	NA	5'-TCG1AACG1TTCoG-Z-GoCTTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-12	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0584	IMO-13 Click for more detail	NA	5'-TCG1AACG1TTCG1-L-G1CTTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-13	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0584	IMO-13 Click for more detail	NA	5'-TCG1AACG1TTCG1-L-G1CTTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-13	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0585	IMO-14 Click for more detail	NA	5'-TCG1AACG1ToTCoG-m-GoCToTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-14	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0585	IMO-14 Click for more detail	NA	5'-TCG1AACG1ToTCoG-m-GoCToTG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-14	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0586	IMO-15 Click for more detail	NA	5'-TCG1AACG1dUdUCoG-M-GoCdUdUG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-15	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0586	IMO-15 Click for more detail	NA	5'-TCG1AACG1dUdUCoG-M-GoCdUdUG1CAAG1CT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-15	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0587	IMO-16 Click for more detail	NA	5'-ACACACCAACT-X-TCAACCACACA-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-16	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0587	IMO-16 Click for more detail	NA	5'-ACACACCAACT-X-TCAACCACACA-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-16	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0588	IMO-2 Click for more detail	NA	5'-TCTGTCG2TTCU-X-UCTTG2CTGTCT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-2	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay
PRRID_0588	IMO-2 Click for more detail	NA	5'-TCTGTCG2TTCU-X-UCTTG2CTGTCT-5'	NA	Nucleic Acid	Synthetic	Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-2	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Mice	HEK293 cells, Bcells, PDCs, mDCs, PBMC	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	This has immunostimulatory effect	Cytokines assay	20381019	2010	Pubchem Assay

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