Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0528 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | Spleenocytes | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0528 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | Spleenocytes | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0529 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | Spleenocytes | Leucine-rich Repeat (LRR) Domain | P58682.fasta | P58682 | 1032 | It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0529 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice (Murine) | Spleenocytes | Leucine-rich Repeat (LRR) Domain | P58682.fasta | P58682 | 1032 | It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0530 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | HEK293 | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | It has the role in the inflammation. | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0530 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | HEK293 | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | It has the role in the inflammation. | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0531 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | HEK293 | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It has the role in the inflammation. | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0531 | Gardiquimod Click for more detail | imidazoquinoline (others) | CCNCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | HEK293 | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It has the role in the inflammation. | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0532 | gB/gH Click for more detail | Human cytomegalovirus (virus) | NA | NA | Glycoprotein | Natural | Activate NF-κB | Toll-like receptor 2/1 (TLR2/1) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Produce proinflammatory cytokines | NA | 20672047 | 2010 | NA |
| PRRID_0532 | gB/gH Click for more detail | Human cytomegalovirus (virus) | NA | NA | Glycoprotein | Natural | Activate NF-κB | Toll-like receptor 2/1 (TLR2/1) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Produce proinflammatory cytokines | NA | 20672047 | 2010 | NA |
| PRRID_0533 | genomic DNA Click for more detail | HSV-1 and HSV-2 (virus) | NA | NA | Nucleic Acid | Natural | It mediates tumor necrosis factor alpha and CCL5 production in murine macrophages | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice (Murine) | plasmacytoid dendritic cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It has the role in the inflammation. | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0533 | genomic DNA Click for more detail | HSV-1 and HSV-2 (virus) | NA | NA | Nucleic Acid | Natural | It mediates tumor necrosis factor alpha and CCL5 production in murine macrophages | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice (Murine) | plasmacytoid dendritic cells | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It has the role in the inflammation. | NA | 20739519 | 2010 | Pubchem Assay |
| PRRID_0534 | genomic DNA Click for more detail | Salmonella enterica (Bacteria) | NA | NA | Nucleic Acid | Natural | The binding leads to the activation of the NF- | chToll-like receptor 21 (TLR21) | Toll-like receptor (TLR) | Chicken | HD11 macrophage | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leads to the inflammatory response from the immune system leads to the clearance of pathogens | Luciferase assay | 20498358 | 2010 | NA |
| PRRID_0534 | genomic DNA Click for more detail | Salmonella enterica (Bacteria) | NA | NA | Nucleic Acid | Natural | The binding leads to the activation of the NF- | chToll-like receptor 21 (TLR21) | Toll-like receptor (TLR) | Chicken | HD11 macrophage | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leads to the inflammatory response from the immune system leads to the clearance of pathogens | Luciferase assay | 20498358 | 2010 | NA |
| PRRID_0535 | Glycoinositol phospholipids Click for more detail | Trypanosoma (others) | C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O | NA | Lipid | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0535 | Glycoinositol phospholipids Click for more detail | Trypanosoma (others) | C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O | NA | Lipid | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0536 | Glycoinositol phospholipids Click for more detail | Trypanosoma (others) | C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O | NA | Lipid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0536 | Glycoinositol phospholipids Click for more detail | Trypanosoma (others) | C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O | NA | Lipid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0537 | Glycolipids Click for more detail | Treponema maltophilum (others) | NA | NA | Glycolipid | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0537 | Glycolipids Click for more detail | Treponema maltophilum (others) | NA | NA | Glycolipid | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0538 | Glycolipids Click for more detail | spirochetes (Bacteria) | NA | NA | Glycolipid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | NA | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NA | NA | 20679445 | 2010 | NA |
| PRRID_0538 | Glycolipids Click for more detail | spirochetes (Bacteria) | NA | NA | Glycolipid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | NA | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NA | NA | 20679445 | 2010 | NA |
| PRRID_0539 | Glycosylphosphatidyl inositol anchor Click for more detail | Protozoa (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0539 | Glycosylphosphatidyl inositol anchor Click for more detail | Protozoa (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0540 | Glycosylphosphatidyl inositol anchor Click for more detail | Trypanosoma Cruzi (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0540 | Glycosylphosphatidyl inositol anchor Click for more detail | Trypanosoma Cruzi (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0541 | Glycosylphosphophatidyl inositol mucin Click for more detail | Trypanosoma (others) | NA | NA | Glycoprotein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0541 | Glycosylphosphophatidyl inositol mucin Click for more detail | Trypanosoma (others) | NA | NA | Glycoprotein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0542 | gp350/gp220 Click for more detail | Epstein-Barr virus (virus) | MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTADVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGELALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYIKWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEISQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLGNNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPWDNGTESKAPDMTSSTSPVTTPTPNATSPTPAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATGPTVGETSPQANATNHTLGGTSPTPVVTSQPKNATSAVTTGQHNITSSSTSSMSLRPSSNPETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPQNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTSQPRFSNLSMLVLQWASLAVLTLLLLLVMADCAFRRNLSTSHTYTTPPYDDAETYV | 907 | Glycoprotein | Natural | Activate NF-κB | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Induce MCP-1 production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0542 | gp350/gp220 Click for more detail | Epstein-Barr virus (virus) | MEAALLVCQYTIQSLIHLTGEDPGFFNVEIPEFPFYPTCNVCTADVNVTINFDVGGKKHQLDLDFGQLTPHTKAVYQPRGAFGGSENATNLFLLELLGAGELALTMRSKKLPINVTTGEEQQVSLESVDVYFQDVFGTMWCHHAEMQNPVYLIPETVPYIKWDNCNSTNITAVVRAQGLDVTLPLSLPTSAQDSNFSVKTEMLGNEIDIECIMEDGEISQVLPGDNKFNITCSGYESHVPSGGILTSTSPVATPIPGTGYAYSLRLTPRPVSRFLGNNSILYVFYSGNGPKASGGDYCIQSNIVFSDEIPASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTETDFKCKWTLTSGTPSGCENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFADPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPWDNGTESKAPDMTSSTSPVTTPTPNATSPTPAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTLGKTSPTSAVTTPTPNATGPTVGETSPQANATNHTLGGTSPTPVVTSQPKNATSAVTTGQHNITSSSTSSMSLRPSSNPETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASISTHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPQNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRPRYNATTYLPPSTSSKLRPRWTFTSPPVTTAQATVPVPPTSQPRFSNLSMLVLQWASLAVLTLLLLLVMADCAFRRNLSTSHTYTTPPYDDAETYV | 907 | Glycoprotein | Natural | Activate NF-κB | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Induce MCP-1 production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0543 | GPI anchor Click for more detail | T. gondii (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | GPIs binds to the TLR2 and activaes the downstream processes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Recognition and phagocytosis | NA | 20729207 | 2010 | Pubchem Assay |
| PRRID_0543 | GPI anchor Click for more detail | T. gondii (others) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | GPIs binds to the TLR2 and activaes the downstream processes | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Recognition and phagocytosis | NA | 20729207 | 2010 | Pubchem Assay |
| PRRID_0544 | HA Click for more detail | Measles virus (virus) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Protein | Natural | Activate NF-κB | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Induce cytokine production such as such as IL-1α, IL-1β, IL-6, IL-8 and IL-12 | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0544 | HA Click for more detail | Measles virus (virus) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Protein | Natural | Activate NF-κB | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Induce cytokine production such as such as IL-1α, IL-1β, IL-6, IL-8 and IL-12 | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0545 | Heat shock protein Click for more detail | Endogenous (others) | NA | NA | Protein | Natural | activation of NF-κB and the synthesis of proinflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Endogenous | NA | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to the inflammation of the cell | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0545 | Heat shock protein Click for more detail | Endogenous (others) | NA | NA | Protein | Natural | activation of NF-κB and the synthesis of proinflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Endogenous | NA | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to the inflammation of the cell | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0547 | Heat shock protein Click for more detail | Endogenous (others) | NA | NA | Protein | Natural | activation of NF-κB and the synthesis of proinflammatory cytokines | MD2 Complex | Toll-like receptor (TLR) | Endogenous | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leads to the inflammation of the cell | NA | 20740341 | 2010 | NA |
| PRRID_0547 | Heat shock protein Click for more detail | Endogenous (others) | NA | NA | Protein | Natural | activation of NF-κB and the synthesis of proinflammatory cytokines | MD2 Complex | Toll-like receptor (TLR) | Endogenous | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leads to the inflammation of the cell | NA | 20740341 | 2010 | NA |
| PRRID_0548 | Heat-killed MTB Click for more detail | Mycobacterium tuberculosis (Bacteria) | NA | NA | Whole organism | Natural | It induces the production of IL-17A | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | PBMCs | LRR | O00206.fasta | O00206 | 839 | The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis | Cytokines assay | 20299682 | 2010 | Pubchem Assay |
| PRRID_0548 | Heat-killed MTB Click for more detail | Mycobacterium tuberculosis (Bacteria) | NA | NA | Whole organism | Natural | It induces the production of IL-17A | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | PBMCs | LRR | O00206.fasta | O00206 | 839 | The immunoprophylactic role played by Ara-LAM in conferring protection against visceral leishmaniasis | Cytokines assay | 20299682 | 2010 | Pubchem Assay |
| PRRID_0550 | Heat-shock protein 70 Click for more detail | Host (Endogenous) (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Protein | Natural | Induced NF-κB activation as well as the expression of TNF-α, IL1β and IL-6 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leads to the depression of myocardial contractility | NA | 20689929 | 2010 | NA |
| PRRID_0550 | Heat-shock protein 70 Click for more detail | Host (Endogenous) (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Protein | Natural | Induced NF-κB activation as well as the expression of TNF-α, IL1β and IL-6 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leads to the depression of myocardial contractility | NA | 20689929 | 2010 | NA |
| PRRID_0551 | Heat-shock proteins 60 Click for more detail | Host (Endogenous) (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Protein | Natural | Induces the expression of TNF-‚ç∫ | Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NA | NA | 20689929 | 2010 | NA |
| PRRID_0551 | Heat-shock proteins 60 Click for more detail | Host (Endogenous) (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Protein | Natural | Induces the expression of TNF-‚ç∫ | Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NA | NA | 20689929 | 2010 | NA |
| PRRID_0552 | Hemagglutinin Click for more detail | Measles virus (virus) | MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR | 617 | Glycoprotein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0552 | Hemagglutinin Click for more detail | Measles virus (virus) | MSPQRDRINAFYKDNPHPKGSRIVINREHLMIDRPYVLLAVLFVMFLSLIGLLAIAGIRLHRAAIYTAEIHKSLSTNLDVTNSIEHQVKDVLTPLFKIIGDEVGLRTPQRFTDLVKFISDKIKFLNPDREYDFRDLTWCINPPERIKLDYDQYCADVAAEELMNALVNSTLLETRTTNQFLAVSKGNCSGPTTIRGQFSNMSLSLLDLYLGRGYNVSSIVTMTSQGMYGGTYLVEKPNLSSKRSELSQLSMYRVFEVGVIRNPGLGAPVFHMTNYLEQPVSNDLSNCMVALGELKLAALCHGEDSITIPYQGSGKGVSFQLVKLGVWKSPTDMQSWVPLSTDDPVIDRLYLSSHRGVIADNQAKWAVPTTRTDDKLRMETCFQQACKGKIQALCENPEWAPLKDNRIPSYGVLSVDLSLTVELKIKIASGFGPLITHGSGMDLYKSNHNNVYWLTIPPMKNLALGVINTLEWIPRFKVSPYLFNVPIKEAGEDCHAPTYLPAEVDGDVKLSSNLVILPGQDLQYVLATYDTSRVEHAVVYYVYSPSRSFSYFYPFRLPIKGVPIELQVECFTWDQKLWCRHFCVLADSESGGHITHSGMEGMGVSCTVTREDGTNRR | 617 | Glycoprotein | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0553 | Heme Click for more detail | Host (Endogenous) (others) | CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C)CCC(=O)O)CCC(=O)O | NA | Endogenous | Natural | Binding of Heme to TLR4 leads to increased production of the proinflammatory cytokine, tumor necrosis factor-alpha | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | Macropahges | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NA | NA | 20689929 | 2010 | NA |
| PRRID_0553 | Heme Click for more detail | Host (Endogenous) (others) | CC1=C(C2=CC3=C(C(=C([N-]3)C=C4C(=C(C(=N4)C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C)CCC(=O)O)CCC(=O)O | NA | Endogenous | Natural | Binding of Heme to TLR4 leads to increased production of the proinflammatory cytokine, tumor necrosis factor-alpha | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | NA | Macropahges | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | NA | NA | 20689929 | 2010 | NA |
| PRRID_0556 | Hemozoin Click for more detail | Plasmodium (others) | CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5] | NA | NA | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD93 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0556 | Hemozoin Click for more detail | Plasmodium (others) | CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5] | NA | NA | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD93 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫ | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0559 | HMGB1 Click for more detail | Mouse model of endotoxemia | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | Acts as a mediator of inflammation and organ damage | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | Acts as a mediator of inflammation and organ damage | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0559 | HMGB1 Click for more detail | Mouse model of endotoxemia | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | Acts as a mediator of inflammation and organ damage | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | Acts as a mediator of inflammation and organ damage | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0560 | HMGB1 Click for more detail | Mouse model of endotoxemia | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | Acts as a mediator of inflammation and organ damage | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Acts as a mediator of inflammation and organ damage | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0560 | HMGB1 Click for more detail | Mouse model of endotoxemia | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | Acts as a mediator of inflammation and organ damage | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Acts as a mediator of inflammation and organ damage | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0562 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | It interacts with the TLR4 and elicit immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Rat | Endothelial cells | Leucine-rich Repeat (LRR) Domain | Q9QX05.fasta | Q9QX05 | 835 | It induced vascular endothelial activation | EMSA | 20714791 | 2010 | Pubchem Assay |
| PRRID_0562 | HMGB1 Click for more detail | Human (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | It interacts with the TLR4 and elicit immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Rat | Endothelial cells | Leucine-rich Repeat (LRR) Domain | Q9QX05.fasta | Q9QX05 | 835 | It induced vascular endothelial activation | EMSA | 20714791 | 2010 | Pubchem Assay |
| PRRID_0563 | HMGB1 Click for more detail | Host (Endogenous) (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | Epinephrine directly acts through Mφ β- adrenergic receptor to stimulate HMGB1 secretion from the Mφ in an autocrine manner | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | lung | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0563 | HMGB1 Click for more detail | Host (Endogenous) (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE | 215 | Protein | Natural | Epinephrine directly acts through Mφ β- adrenergic receptor to stimulate HMGB1 secretion from the Mφ in an autocrine manner | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | lung | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0564 | HMGB1 Click for more detail | Host (Endogenous) (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | induced cellular activation and NF-κB-dependent transcription | Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | HEK293 | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It generate the inflammatory response similar to intiated by LPS | NA | 20689929 | 2010 | NA |
| PRRID_0564 | HMGB1 Click for more detail | Host (Endogenous) (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | induced cellular activation and NF-κB-dependent transcription | Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | HEK293 | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It generate the inflammatory response similar to intiated by LPS | NA | 20689929 | 2010 | NA |
| PRRID_0565 | HpaA Click for more detail | H. pylori (Bacteria) | NA | NA | Lipoprotein | Natural | It activates the TLR2, which leads to the secretion of IL-12 and IFN- | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Natural Killer cells | LRR | O60603.fasta | O60603 | 784 | It has a immunostimulatory role | ELISA | 20130107 | 2010 | Pubchem Assay |
| PRRID_0565 | HpaA Click for more detail | H. pylori (Bacteria) | NA | NA | Lipoprotein | Natural | It activates the TLR2, which leads to the secretion of IL-12 and IFN- | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Natural Killer cells | LRR | O60603.fasta | O60603 | 784 | It has a immunostimulatory role | ELISA | 20130107 | 2010 | Pubchem Assay |
| PRRID_0567 | HSP72 Click for more detail | Host (Endogenous) (others) | NA | NA | Protein | Natural | increases in MIP-2 release | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | hepatocytes | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20689929 | 2010 | Pubchem Assay |
| PRRID_0567 | HSP72 Click for more detail | Host (Endogenous) (others) | NA | NA | Protein | Natural | increases in MIP-2 release | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | hepatocytes | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | NA | NA | 20689929 | 2010 | Pubchem Assay |
| PRRID_0569 | Hyaluronan Click for more detail | Prepared by HCL degradation (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Carbohydrate | Synthetic | Its binding leads to the production of interleukin-10, and down-regulated chemokine production. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | MRL-lpr/lpr Mice | Large intestinal epithelial cells | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It modulates Th-1-type autoimmune disease and inflammation by up-regulating SOCS3 expression and down-regulating pleiotrophin expression via TLR-4 in intestinal epithelial cells and hence promotes the survival. | Array Analysis | 20504769 | 2010 | Pubchem Assay |
| PRRID_0569 | Hyaluronan Click for more detail | Prepared by HCL degradation (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Carbohydrate | Synthetic | Its binding leads to the production of interleukin-10, and down-regulated chemokine production. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | MRL-lpr/lpr Mice | Large intestinal epithelial cells | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It modulates Th-1-type autoimmune disease and inflammation by up-regulating SOCS3 expression and down-regulating pleiotrophin expression via TLR-4 in intestinal epithelial cells and hence promotes the survival. | Array Analysis | 20504769 | 2010 | Pubchem Assay |
| PRRID_0570 | Hyaluronic acid Click for more detail | Host (Endogenous) (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Glycosaminoglycan | Natural | Interaction between lower molecular weight HA and TLR leads to decrease in CD44-dependent clearance of HA leads to enhanced lung inflammation and injury | Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macropahges | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leads to the production of inflammatory chemokines and cytokines | NA | 20689929 | 2010 | NA |
| PRRID_0570 | Hyaluronic acid Click for more detail | Host (Endogenous) (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Glycosaminoglycan | Natural | Interaction between lower molecular weight HA and TLR leads to decrease in CD44-dependent clearance of HA leads to enhanced lung inflammation and injury | Toll-like receptor 2 (TLR2)/Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macropahges | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leads to the production of inflammatory chemokines and cytokines | NA | 20689929 | 2010 | NA |
| PRRID_0571 | hypomethylated DNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | release of proinflammatory cytokines and Pathgen Clearance | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It has the role in the inflammation. | NA | 20739362 | 2010 | Pubchem Assay |
| PRRID_0571 | hypomethylated DNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | release of proinflammatory cytokines and Pathgen Clearance | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It has the role in the inflammation. | NA | 20739362 | 2010 | Pubchem Assay |
| PRRID_0574 | Imiquimod Click for more detail | imidazoquinoline (others) | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It induces inflammatory responses when applied to the skin | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It leads to the inflammation of the cell | NA | 20739947 | 2010 | Pubchem Assay |
| PRRID_0574 | Imiquimod Click for more detail | imidazoquinoline (others) | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It induces inflammatory responses when applied to the skin | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | NA | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It leads to the inflammation of the cell | NA | 20739947 | 2010 | Pubchem Assay |
| PRRID_0575 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It induces translocation of NF-kB and production of IFN-α, TNF-α, IL-6, and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Cyprinus carpio L | head kidney | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It has the role in the inflammation. | NA | 20709611 | 2010 | NA |
| PRRID_0575 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It induces translocation of NF-kB and production of IFN-α, TNF-α, IL-6, and IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Cyprinus carpio L | head kidney | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It has the role in the inflammation. | NA | 20709611 | 2010 | NA |
| PRRID_0576 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Their binding leads to the enhanced production of type I IFNs, TNF-‚ç∫, IL-12 and driving a Th1 reponse pTTERN | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | NA | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppresses angiogenesis and presents proapoptotic activity | NA | 20636030 | 2010 | NA |
| PRRID_0576 | Imiquimod Click for more detail | NA | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | Their binding leads to the enhanced production of type I IFNs, TNF-‚ç∫, IL-12 and driving a Th1 reponse pTTERN | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | NA | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppresses angiogenesis and presents proapoptotic activity | NA | 20636030 | 2010 | NA |
| PRRID_0577 | Imiquimod Click for more detail | imidazoquinoline (others) | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | imidazoquinolines | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | Spleenocytes | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0577 | Imiquimod Click for more detail | imidazoquinoline (others) | CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N | NA | imidazoquinolines | Synthetic | It activates the NF- | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | Spleenocytes | Leucine-rich Repeat (LRR) Domain | P58681.fasta | P58681 | 1050 | It leads to the activation of splenocytes and the inhibition of murine B16 melanoma growth and metastasis | NA | 20543857 | 2010 | Pubchem Assay |
| PRRID_0578 | imiquimod (R-837) and resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0578 | imiquimod (R-837) and resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0579 | imiquimod (R-837) and resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NR97.fasta | Q9NR97 | 1041 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0579 | imiquimod (R-837) and resiquimod (R-848) Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2N | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NR97.fasta | Q9NR97 | 1041 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0580 | IMO-1 Click for more detail | NA | 5'-TCTGToCG2TTGT-X-TGTTG2CoTGTCT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-1 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0580 | IMO-1 Click for more detail | NA | 5'-TCTGToCG2TTGT-X-TGTTG2CoTGTCT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-1 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0581 | IMO-10 Click for more detail | NA | 5'-TCG2TCG2TTdUY-M-YdUTTG2CTG2CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-10 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0581 | IMO-10 Click for more detail | NA | 5'-TCG2TCG2TTdUY-M-YdUTTG2CTG2CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-10 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0582 | IMO-11 Click for more detail | NA | 5'-TCG1TACG1TACG1-X-G1CATG1CATG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-11 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0582 | IMO-11 Click for more detail | NA | 5'-TCG1TACG1TACG1-X-G1CATG1CATG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-11 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0583 | IMO-12 Click for more detail | NA | 5'-TCG1AACG1TTCoG-Z-GoCTTG1CAAG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-12 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0583 | IMO-12 Click for more detail | NA | 5'-TCG1AACG1TTCoG-Z-GoCTTG1CAAG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-12 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0584 | IMO-13 Click for more detail | NA | 5'-TCG1AACG1TTCG1-L-G1CTTG1CAAG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-13 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0584 | IMO-13 Click for more detail | NA | 5'-TCG1AACG1TTCG1-L-G1CTTG1CAAG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-13 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0585 | IMO-14 Click for more detail | NA | 5'-TCG1AACG1ToTCoG-m-GoCToTG1CAAG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-14 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0585 | IMO-14 Click for more detail | NA | 5'-TCG1AACG1ToTCoG-m-GoCToTG1CAAG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-14 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0586 | IMO-15 Click for more detail | NA | 5'-TCG1AACG1dUdUCoG-M-GoCdUdUG1CAAG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-15 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0586 | IMO-15 Click for more detail | NA | 5'-TCG1AACG1dUdUCoG-M-GoCdUdUG1CAAG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-15 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0587 | IMO-16 Click for more detail | NA | 5'-ACACACCAACT-X-TCAACCACACA-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-16 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0587 | IMO-16 Click for more detail | NA | 5'-ACACACCAACT-X-TCAACCACACA-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-16 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0588 | IMO-2 Click for more detail | NA | 5'-TCTGTCG2TTCU-X-UCTTG2CTGTCT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-2 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0588 | IMO-2 Click for more detail | NA | 5'-TCTGTCG2TTCU-X-UCTTG2CTGTCT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-2 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |