| Primary information |
|---|
| PRRID | PRRID_0569 |
| Ligand Name | Hyaluronan |
| Source | Prepared by HCL degradation (others) |
| Sequence of ligand | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O |
| Length | NA |
| Type | Carbohydrate |
| Occurence | Synthetic |
| Role of Ligand | Its binding leads to the production of interleukin-10, and down-regulated chemokine production. |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | MRL-lpr/lpr Mice |
| Localization | Large intestinal epithelial cells |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | Q9QUK6.fasta |
| Swiss prot ID | Q9QUK6 |
| Length Of Receptor | 835 |
| Function | It modulates Th-1-type autoimmune disease and inflammation by up-regulating SOCS3 expression and down-regulating pleiotrophin expression via TLR-4 in intestinal epithelial cells and hence promotes the survival. |
| Assay used | Array Analysis |
| PMID | 20504769 |
| Year of Publication | 2010 |
| Pubchem assay | Pubchem Assay |
| Primary information |
|---|
| PRRID | PRRID_0569 |
| Ligand Name | Hyaluronan |
| Source | Prepared by HCL degradation (others) |
| Sequence of ligand | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O |
| Length | NA |
| Type | Carbohydrate |
| Occurence | Synthetic |
| Role of Ligand | Its binding leads to the production of interleukin-10, and down-regulated chemokine production. |
| Name of receptor | Toll-like receptor 4 (TLR4) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | MRL-lpr/lpr Mice |
| Localization | Large intestinal epithelial cells |
| Domain | Leucine-rich Repeat (LRR) Domain |
| Sequence of Receptor | Q9QUK6.fasta |
| Swiss prot ID | Q9QUK6 |
| Length Of Receptor | 835 |
| Function | It modulates Th-1-type autoimmune disease and inflammation by up-regulating SOCS3 expression and down-regulating pleiotrophin expression via TLR-4 in intestinal epithelial cells and hence promotes the survival. |
| Assay used | Array Analysis |
| PMID | 20504769 |
| Year of Publication | 2010 |
| Pubchem assay | Pubchem Assay |