Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0631 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | ankyrin-repeats | Human | corneal and conjunctival epithelia | NA | NA | NA | NA | suppress the production of proinflammatory cytokines | NA | 20703156 | 2010 | NA | |
| PRRID_0631 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | ankyrin-repeats | Human | corneal and conjunctival epithelia | NA | NA | NA | NA | suppress the production of proinflammatory cytokines | NA | 20703156 | 2010 | NA | |
| PRRID_0636 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | The binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cord blood cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NA | NA | 20636030 | 2010 | Pubchem Assay |
| PRRID_0636 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | The binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cord blood cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NA | NA | 20636030 | 2010 | Pubchem Assay |
| PRRID_0637 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contraction | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Intestinal Fibroblasts | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury. | Luciferase assay | 20632282 | 2010 | Pubchem Assay |
| PRRID_0637 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contraction | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Intestinal Fibroblasts | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury. | Luciferase assay | 20632282 | 2010 | Pubchem Assay |
| PRRID_0638 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0638 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0641 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP2 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0641 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP2 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0645 | Lipopolysaccharide (LPS) Click for more detail | Aspergillus fumigatus(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4). | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Telomerase-Immortalized Human Stroma Fibroblasts (THSFs) | NA | O00206.fasta | O00206 | 839 | It has the immunostimulatory role. | ELISA | 20305039 | 2010 | Pubchem Assay |
| PRRID_0645 | Lipopolysaccharide (LPS) Click for more detail | Aspergillus fumigatus(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4). | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Telomerase-Immortalized Human Stroma Fibroblasts (THSFs) | NA | O00206.fasta | O00206 | 839 | It has the immunostimulatory role. | ELISA | 20305039 | 2010 | Pubchem Assay |
| PRRID_0647 | Lipoprotein Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | Lipoprotein binds to the TLR2 and activates the downstream cascades | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20729207 | 2010 | Pubchem Assay |
| PRRID_0647 | Lipoprotein Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | Lipoprotein binds to the TLR2 and activates the downstream cascades | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20729207 | 2010 | Pubchem Assay |
| PRRID_0648 | NS3 Click for more detail | Hepatitis C Virus (virus) | APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT | 631 | Protein | Natural | Activate MAP kinase pathway, NF-κB, and AP-1 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocytes and Kupffer cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Dysfunction of pDCs by enhanced production of IL-10 and TNF- α | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0648 | NS3 Click for more detail | Hepatitis C Virus (virus) | APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT | 631 | Protein | Natural | Activate MAP kinase pathway, NF-κB, and AP-1 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocytes and Kupffer cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Dysfunction of pDCs by enhanced production of IL-10 and TNF- α | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0652 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Amphiphile | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It coauses the inflammation | NA | 20740341 | 2010 | NA |
| PRRID_0652 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Amphiphile | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It coauses the inflammation | NA | 20740341 | 2010 | NA |
| PRRID_0654 | Lipoteichoic Acid (LTA) Click for more detail | Lactobacillus acidophilus, Prevotella melaninogenica, P. bivia and Mycobacterium smegmatis (Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | Enhanced HIV-1 expression in macrophages | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leads to the clearance of the pathogen from the system | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0654 | Lipoteichoic Acid (LTA) Click for more detail | Lactobacillus acidophilus, Prevotella melaninogenica, P. bivia and Mycobacterium smegmatis (Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | Enhanced HIV-1 expression in macrophages | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leads to the clearance of the pathogen from the system | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0656 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0656 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0657 | Lipoteichoic Acid (LTA) Click for more detail | Streptococcus (Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | NA |
| PRRID_0657 | Lipoteichoic Acid (LTA) Click for more detail | Streptococcus (Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | NA |
| PRRID_0661 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0661 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NYK1.fasta | Q9NYK1 | 1049 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0662 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NR97.fasta | Q9NR97 | 1041 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0662 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12 | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | DCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cells | Leucine-rich Repeat (LRR) Domain | Q9NR97.fasta | Q9NR97 | 1041 | Itresults into the inflammatory response | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0663 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | NA | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It led to the activation of NF-κB and upregulate the expression of the antiapoptotic protein Bcl-2. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Lung cancer cells | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy. | ELISA | 20237413 | 2010 | Pubchem Assay |
| PRRID_0663 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | NA | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | It led to the activation of NF-κB and upregulate the expression of the antiapoptotic protein Bcl-2. | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Lung cancer cells | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy. | ELISA | 20237413 | 2010 | Pubchem Assay |
| PRRID_0664 | LpqH Click for more detail | Mtb H37Ra (Bacteria) | MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS | 159 | Lipoprotein | Natural | It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Primary Monocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leads to the clearance of the pathogen via autophagy | NA | 20560977 | 2010 | Pubchem Assay |
| PRRID_0664 | LpqH Click for more detail | Mtb H37Ra (Bacteria) | MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS | 159 | Lipoprotein | Natural | It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Primary Monocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leads to the clearance of the pathogen via autophagy | NA | 20560977 | 2010 | Pubchem Assay |
| PRRID_0665 | LpqH Click for more detail | Mtb H37Ra (Bacteria) | MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS | 159 | Lipoprotein | Natural | It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Human | Primary Monocytes | Leucine-rich Repeat (LRR) Domain | Q15399.fasta | Q15399 | 786 | It leads to the clearance of the pathogen via autophagy | NA | 20560977 | 2010 | Pubchem Assay |
| PRRID_0665 | LpqH Click for more detail | Mtb H37Ra (Bacteria) | MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS | 159 | Lipoprotein | Natural | It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. | Toll-like receptor 1 (TLR1) | Toll-like receptor (TLR) | Human | Primary Monocytes | Leucine-rich Repeat (LRR) Domain | Q15399.fasta | Q15399 | 786 | It leads to the clearance of the pathogen via autophagy | NA | 20560977 | 2010 | Pubchem Assay |
| PRRID_0666 | LpqH Click for more detail | Mtb H37Ra (Bacteria) | MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS | 159 | Lipoprotein | Natural | It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. | cluster of differentiation 14 (CD14) | Pattern recognition receptor (PRR) | Human | Primary Monocytes | Leucine-rich Repeat (LRR) Domain | P08571.fasta | P08571 | 375 | It leads to the clearance of the pathogen via autophagy | NA | 20560977 | 2010 | Pubchem Assay |
| PRRID_0666 | LpqH Click for more detail | Mtb H37Ra (Bacteria) | MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS | 159 | Lipoprotein | Natural | It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction. | cluster of differentiation 14 (CD14) | Pattern recognition receptor (PRR) | Human | Primary Monocytes | Leucine-rich Repeat (LRR) Domain | P08571.fasta | P08571 | 375 | It leads to the clearance of the pathogen via autophagy | NA | 20560977 | 2010 | Pubchem Assay |
| PRRID_0670 | macrophage-activating lipopeptide Click for more detail | Mycoplasma fermentans (Bacteria) | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N | NA | Lipopeptides | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0670 | macrophage-activating lipopeptide Click for more detail | Mycoplasma fermentans (Bacteria) | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N | NA | Lipopeptides | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0672 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0672 | Mannan Click for more detail | Candida albicans(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Polysaccharides | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0680 | Mitochondrial DNA Click for more detail | rhabdomyosarcoma cells (others) | NA | NA | Nucleic Acid | Natural | It activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinases | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Neutrophils | NA | Q9NR96.fasta | Q9NR96 | 1032 | It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli. | Chemotaxis assay | 20203610 | 2010 | Pubchem Assay |
| PRRID_0680 | Mitochondrial DNA Click for more detail | rhabdomyosarcoma cells (others) | NA | NA | Nucleic Acid | Natural | It activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinases | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Neutrophils | NA | Q9NR96.fasta | Q9NR96 | 1032 | It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli. | Chemotaxis assay | 20203610 | 2010 | Pubchem Assay |
| PRRID_0681 | mmLDL Click for more detail | Native Human LDL (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Synthetic | The binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR4 | cluster of differentiation 14 (CD14) | Pattern recognition receptor (PRR) | Human | Monocytes and Macrophages | NA | P08571.fasta | P08571 | 375 | It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages. | ELISA | 20472010 | 2010 | Pubchem Assay |
| PRRID_0681 | mmLDL Click for more detail | Native Human LDL (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Synthetic | The binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR4 | cluster of differentiation 14 (CD14) | Pattern recognition receptor (PRR) | Human | Monocytes and Macrophages | NA | P08571.fasta | P08571 | 375 | It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages. | ELISA | 20472010 | 2010 | Pubchem Assay |
| PRRID_0682 | mmLDL Click for more detail | Native Human LDL (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Synthetic | The binding of mmLDL, induces the production of TNF-and increasing the expression of TLR2 and TLR5 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Monocytes and Macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages. | ELISA | 20472010 | 2010 | Pubchem Assay |
| PRRID_0682 | mmLDL Click for more detail | Native Human LDL (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Synthetic | The binding of mmLDL, induces the production of TNF-and increasing the expression of TLR2 and TLR5 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Monocytes and Macrophages | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages. | ELISA | 20472010 | 2010 | Pubchem Assay |
| PRRID_0683 | mmLDL Click for more detail | Native Human LDL (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Synthetic | The binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR6 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes and Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages. | ELISA | 20472010 | 2010 | Pubchem Assay |
| PRRID_0683 | mmLDL Click for more detail | Native Human LDL (others) | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1 | NA | Lipoprotein | Synthetic | The binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR6 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Monocytes and Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages. | ELISA | 20472010 | 2010 | Pubchem Assay |
| PRRID_0692 | muramyl dipeptide (MDP) Click for more detail | Streptococcus pneumoniae, Mycobacterium tuberculosis, and Listeria monocytogenes (Bacteria) | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | Activates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1β, which results into pathogen clearance and sepsis resistance | cluster of differentiation 14 (CD14) | Pattern recognition receptor (PRR) | Human | NA | NA | Q9HC29.fasta | Q9HC29 | 1040 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0692 | muramyl dipeptide (MDP) Click for more detail | Streptococcus pneumoniae, Mycobacterium tuberculosis, and Listeria monocytogenes (Bacteria) | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | Activates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1β, which results into pathogen clearance and sepsis resistance | cluster of differentiation 14 (CD14) | Pattern recognition receptor (PRR) | Human | NA | NA | Q9HC29.fasta | Q9HC29 | 1040 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0695 | murine cytomegalovirus Click for more detail | MCMV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIF | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | it lead to the secretion of IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0695 | murine cytomegalovirus Click for more detail | MCMV (virus) | NA | NA | Nucleic Acid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIF | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Endosomes | Leucine-rich Repeat (LRR) Domain | O15455.fasta | O15455 | 904 | it lead to the secretion of IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0698 | N1L Click for more detail | Vaccinia(virus) | MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK | 117 | Protein | Natural | Suppress NF-κB activation (Bind to IKKγ) | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0698 | N1L Click for more detail | Vaccinia(virus) | MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK | 117 | Protein | Natural | Suppress NF-κB activation (Bind to IKKγ) | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Suppress cytokine production | NA | 20672047 | 2010 | NA |
| PRRID_0699 | N1L Click for more detail | Vaccinia(virus) | MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK | 117 | Protein | Natural | Suppress IRF3 activation (Bind to TBK1) | The class II transactivator (CIITA) | NOD-like receptor (NLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | P33076.fasta | P33076 | 1130 | Suppress IFN production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0699 | N1L Click for more detail | Vaccinia(virus) | MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK | 117 | Protein | Natural | Suppress IRF3 activation (Bind to TBK1) | The class II transactivator (CIITA) | NOD-like receptor (NLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | P33076.fasta | P33076 | 1130 | Suppress IFN production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0703 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | The class II transactivator (CIITA) | NOD-like receptor (NLR) | Human | NA | NA | P33076.fasta | P33076 | 1130 | It is a key regulator of class II MHC genes, such as it exert transcriptional regulator activity or other nuclear functions. | NA | 20303873 | 2010 | Pubchem Assay |
| PRRID_0703 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | The class II transactivator (CIITA) | NOD-like receptor (NLR) | Human | NA | NA | P33076.fasta | P33076 | 1130 | It is a key regulator of class II MHC genes, such as it exert transcriptional regulator activity or other nuclear functions. | NA | 20303873 | 2010 | Pubchem Assay |
| PRRID_0706 | naked dsRNS (poly(I:C)) Click for more detail | Bacteria | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | induced a reduction in maximal mitochondrial respiration | Toll-like receptor 3,7,9 (TLR3/7/9) | Toll-like receptor (TLR) | Human | Human hepatocytes (HepG2 cells) | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | This resultsinto mitochondrial dysfunction which is accompanied by caspase-8 | NA | 20691286 | 2010 | NA |
| PRRID_0706 | naked dsRNS (poly(I:C)) Click for more detail | Bacteria | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | induced a reduction in maximal mitochondrial respiration | Toll-like receptor 3,7,9 (TLR3/7/9) | Toll-like receptor (TLR) | Human | Human hepatocytes (HepG2 cells) | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | This resultsinto mitochondrial dysfunction which is accompanied by caspase-8 | NA | 20691286 | 2010 | NA |
| PRRID_0707 | Nef Click for more detail | HIV-1 (virus) | MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC | 206 | Protein | Natural | Inhibit ERK activation (Dephosphorylation of ERK by induced MKP-1) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress TNF-α production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0707 | Nef Click for more detail | HIV-1 (virus) | MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC | 206 | Protein | Natural | Inhibit ERK activation (Dephosphorylation of ERK by induced MKP-1) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress TNF-α production | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0710 | NS1 Click for more detail | Influenza A (virus) | MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV | 206 | Protein | Natural | Suppress of IRF3/7 activation | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Inhibit IFN production in pDC | NA | 20672047 | 2010 | NA |
| PRRID_0710 | NS1 Click for more detail | Influenza A (virus) | MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV | 206 | Protein | Natural | Suppress of IRF3/7 activation | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Inhibit IFN production in pDC | NA | 20672047 | 2010 | NA |
| PRRID_0711 | NS1 Click for more detail | Influenza A (virus) | MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV | 206 | Protein | Natural | Suppress of NF-κB and AP-1 activation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress DC and T cell activation | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0711 | NS1 Click for more detail | Influenza A (virus) | MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV | 206 | Protein | Natural | Suppress of NF-κB and AP-1 activation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress DC and T cell activation | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0712 | NS1 Click for more detail | Influenza A (virus) | MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV | 206 | Protein | Natural | Suppress of IRF3/7 activation | RIG-1 | Rig-like receptor (RLR) | Human | NA | NA | O95786.fasta | O95786 | 925 | Inhibit IFN production in mDC | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0712 | NS1 Click for more detail | Influenza A (virus) | MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV | 206 | Protein | Natural | Suppress of IRF3/7 activation | RIG-1 | Rig-like receptor (RLR) | Human | NA | NA | O95786.fasta | O95786 | 925 | Inhibit IFN production in mDC | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0713 | NS1, NS2 Click for more detail | Human respiratory syncytial virus (RSV) | MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP | 139, 124 | Protein | Natural | Suppress IRF3 activation | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | Suppress IFN production in mDC | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0713 | NS1, NS2 Click for more detail | Human respiratory syncytial virus (RSV) | MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP | 139, 124 | Protein | Natural | Suppress IRF3 activation | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | Suppress IFN production in mDC | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0714 | NS1, NS2 Click for more detail | Human respiratory syncytial virus (RSV) | MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP | 139, 124 | Protein | Natural | Suppress IRF3 activation | RIG-1 | Rig-like receptor (RLR) | Human | NA | NA | O95786.fasta | O95786 | 925 | Suppress IFN production in mDC | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0714 | NS1, NS2 Click for more detail | Human respiratory syncytial virus (RSV) | MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP | 139, 124 | Protein | Natural | Suppress IRF3 activation | RIG-1 | Rig-like receptor (RLR) | Human | NA | NA | O95786.fasta | O95786 | 925 | Suppress IFN production in mDC | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0715 | NS3/4A Click for more detail | Hepatitis C Virus (virus) | APITAYAQQTRGLLGTIVTGLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPSGAKSLEPCACGSADLYLITRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGVDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEIPFYGKAIPIALLKGGRHLIFCHSKKKCEEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTGLTHIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDETWKCLVRLKPTLHGPTPLLYRLGPIQNETCLTHPVTKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGSVVIVGHIELGGKPALVPDREVLYQQYDEMEEC | 685 | Protein | Natural | Degrade TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress IFN-α/β production and Suppress CD4+ T cell activation by dysfunction of mDCs | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0715 | NS3/4A Click for more detail | Hepatitis C Virus (virus) | APITAYAQQTRGLLGTIVTGLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPSGAKSLEPCACGSADLYLITRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGVDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEIPFYGKAIPIALLKGGRHLIFCHSKKKCEEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTGLTHIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDETWKCLVRLKPTLHGPTPLLYRLGPIQNETCLTHPVTKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGSVVIVGHIELGGKPALVPDREVLYQQYDEMEEC | 685 | Protein | Natural | Degrade TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress IFN-α/β production and Suppress CD4+ T cell activation by dysfunction of mDCs | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0716 | NS5A Click for more detail | Hepatitis C Virus (virus) | MAGSWLRDVWDWICTVLSDFKTWLQSKLLPRLPGVPFLSCQRGYRGVWRGDGIMHTTCPCGAEITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNIKCPCQVPAPEFFTELDGVRLHRYAPACKPLLRDEVTFLVGLHQYPVGSQLPCEPEPNVTVLTSMLTDPSHITAETAKRRLARGSPPSMASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRKFPQAMPIWARPDYNPPLLESWKNPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSESSAVDSGTATAPPDQPSDDGGSGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSH | 452 | Protein | Natural | Inhibit NF-κB activation (Bind to MyD88) and Inhibit JNK activation (Bind to TRAF2) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress cytokine production and Suppress TNF pathway activation | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0716 | NS5A Click for more detail | Hepatitis C Virus (virus) | MAGSWLRDVWDWICTVLSDFKTWLQSKLLPRLPGVPFLSCQRGYRGVWRGDGIMHTTCPCGAEITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNIKCPCQVPAPEFFTELDGVRLHRYAPACKPLLRDEVTFLVGLHQYPVGSQLPCEPEPNVTVLTSMLTDPSHITAETAKRRLARGSPPSMASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRKFPQAMPIWARPDYNPPLLESWKNPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSESSAVDSGTATAPPDQPSDDGGSGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSH | 452 | Protein | Natural | Inhibit NF-κB activation (Bind to MyD88) and Inhibit JNK activation (Bind to TRAF2) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress cytokine production and Suppress TNF pathway activation | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0719 | p30 Click for more detail | Human T-lymphotropic leukemia virus 1 (virus) | MALCCFAFSAPCLHLRSRRSCSSCFLLATSAAFFSARLLRRAFSSSFLFKYSAICFSSSFSRSFFRFLFSSARRCRSRCVSPRGGAFSPGGPRRSRPRLSSSKDSKPSSTASSSSLSFNSSSKDNSPSTNSSTSRSSGHDTGKHRNSPADTKLTMLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL | 241 | Protein | Natural | Suppress TLR4 expression and Inhibit GSK3-β | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress cytokine production ad enhance IL-10 prduction | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0719 | p30 Click for more detail | Human T-lymphotropic leukemia virus 1 (virus) | MALCCFAFSAPCLHLRSRRSCSSCFLLATSAAFFSARLLRRAFSSSFLFKYSAICFSSSFSRSFFRFLFSSARRCRSRCVSPRGGAFSPGGPRRSRPRLSSSKDSKPSSTASSSSLSFNSSSKDNSPSTNSSTSRSSGHDTGKHRNSPADTKLTMLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL | 241 | Protein | Natural | Suppress TLR4 expression and Inhibit GSK3-β | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Suppress cytokine production ad enhance IL-10 prduction | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0720 | Paclitaxel Click for more detail | NA | C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C | NA | Drug | Synthetic | It hasthe role in the activation of the adapter protein MyD88 was linked to reduction of apoptosis in cancer cells. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human(Ovarian Cancer Patient) | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NA | NA | 20728343 | 2010 | Pubchem Assay |
| PRRID_0720 | Paclitaxel Click for more detail | NA | C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C | NA | Drug | Synthetic | It hasthe role in the activation of the adapter protein MyD88 was linked to reduction of apoptosis in cancer cells. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human(Ovarian Cancer Patient) | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NA | NA | 20728343 | 2010 | Pubchem Assay |
| PRRID_0721 | Diacylated Lipopeptide Click for more detail | Bacteria | NA | NA | Lipopeptides | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0721 | Diacylated Lipopeptide Click for more detail | Bacteria | NA | NA | Lipopeptides | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0722 | Pam2Cys Click for more detail | B. burgdorferi(Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Peptidoglycan | Synthetic | Induction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0722 | Pam2Cys Click for more detail | B. burgdorferi(Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | Peptidoglycan | Synthetic | Induction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0725 | Pam3Cys Click for more detail | Plasmodium falciparum circumsporozoite protein (others) | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Peptidoglycan | Synthetic | Vaccine targeting malaria | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0725 | Pam3Cys Click for more detail | Plasmodium falciparum circumsporozoite protein (others) | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Peptidoglycan | Synthetic | Vaccine targeting malaria | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0729 | Peptidoglycan (PGN) Click for more detail | Escherichia coli, Chlamydia pneumoniae, Campylobacter jejuni, Salmonella typhimurium, Pseudomonas ae | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Activates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1β, which results into pathogen clearance and sepsis resistance | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | NA | NA | Q9Y239.fasta | Q9Y239 | 953 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0729 | Peptidoglycan (PGN) Click for more detail | Escherichia coli, Chlamydia pneumoniae, Campylobacter jejuni, Salmonella typhimurium, Pseudomonas ae | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Activates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1β, which results into pathogen clearance and sepsis resistance | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | NA | NA | Q9Y239.fasta | Q9Y239 | 953 | It results into pathogen clearance and sepsis resistance | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0731 | Peptidoglycan (PGN) Click for more detail | S. aureus (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0731 | Peptidoglycan (PGN) Click for more detail | S. aureus (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0735 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0735 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0736 | Peptidoglycan (PGN) Click for more detail | streptomyces species (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP1 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0736 | Peptidoglycan (PGN) Click for more detail | streptomyces species (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP1 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0739 | Peptidoglycan (PGN) Click for more detail | Borrelia burgdorferi(Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | PBMCs | NA | Q9HC29.fasta | Q9HC29 | 1040 | It aids in the induction of inflammtory reaction against Borrelia burgdorferi | ELISA | 20441518 | 2010 | Pubchem Assay |
| PRRID_0739 | Peptidoglycan (PGN) Click for more detail | Borrelia burgdorferi(Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | PBMCs | NA | Q9HC29.fasta | Q9HC29 | 1040 | It aids in the induction of inflammtory reaction against Borrelia burgdorferi | ELISA | 20441518 | 2010 | Pubchem Assay |
| PRRID_0742 | Pam3Cys Click for more detail | B. burgdorferi(Bacteria) | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Peptidoglycan | Synthetic | Induction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0742 | Pam3Cys Click for more detail | B. burgdorferi(Bacteria) | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Peptidoglycan | Synthetic | Induction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0749 | Phospholipomannan Click for more detail | Candida albicans(fungi) | NA | NA | Carbohydrate | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0749 | Phospholipomannan Click for more detail | Candida albicans(fungi) | NA | NA | Carbohydrate | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |