Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0631Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAMAILankyrin-repeatsHumancorneal and conjunctival epitheliaNANANANAsuppress the production of proinflammatory cytokinesNA207031562010NA
PRRID_0631Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAMAILankyrin-repeatsHumancorneal and conjunctival epitheliaNANANANAsuppress the production of proinflammatory cytokinesNA207031562010NA
PRRID_0636Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalThe binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCord blood cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA206360302010Pubchem Assay
PRRID_0636Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalThe binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCord blood cellsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA206360302010Pubchem Assay
PRRID_0637Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contractionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanIntestinal FibroblastsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury.Luciferase assay206322822010Pubchem Assay
PRRID_0637Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contractionToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanIntestinal FibroblastsLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury.Luciferase assay206322822010Pubchem Assay
PRRID_0638Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0638Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0641Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt's binding induces the production of IL6, IL8, MMP3 and MMP2Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanFibroblast Like Synoviocytes (FLS)Leucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destructionELISA205711652010Pubchem Assay
PRRID_0641Lipopolysaccharide (LPS)

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E. coli(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt's binding induces the production of IL6, IL8, MMP3 and MMP2Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanFibroblast Like Synoviocytes (FLS)Leucine-rich Repeat (LRR) DomainO00206.fastaO00206839It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destructionELISA205711652010Pubchem Assay
PRRID_0645Lipopolysaccharide (LPS)

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Aspergillus fumigatus(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4).Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanTelomerase-Immortalized Human Stroma Fibroblasts (THSFs)NAO00206.fastaO00206839It has the immunostimulatory role.ELISA203050392010Pubchem Assay
PRRID_0645Lipopolysaccharide (LPS)

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Aspergillus fumigatus(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4).Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanTelomerase-Immortalized Human Stroma Fibroblasts (THSFs)NAO00206.fastaO00206839It has the immunostimulatory role.ELISA203050392010Pubchem Assay
PRRID_0647Lipoprotein

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M. tuberculosis (Bacteria)NANALipoproteinNaturalLipoprotein binds to the TLR2 and activates the downstream cascadesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207292072010Pubchem Assay
PRRID_0647Lipoprotein

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M. tuberculosis (Bacteria)NANALipoproteinNaturalLipoprotein binds to the TLR2 and activates the downstream cascadesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207292072010Pubchem Assay
PRRID_0648NS3

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Hepatitis C Virus (virus)APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT631ProteinNaturalActivate MAP kinase pathway, NF-κB, and AP-1Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocytes and Kupffer cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Dysfunction of pDCs by enhanced production of IL-10 and TNF- αNA206720472010Pubchem Assay
PRRID_0648NS3

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Hepatitis C Virus (virus)APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT631ProteinNaturalActivate MAP kinase pathway, NF-κB, and AP-1Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocytes and Kupffer cellsLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784Dysfunction of pDCs by enhanced production of IL-10 and TNF- αNA206720472010Pubchem Assay
PRRID_0652Lipoteichoic Acid (LTA)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAAmphiphileNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimerToll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAIt coauses the inflammationNA207403412010NA
PRRID_0652Lipoteichoic Acid (LTA)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAAmphiphileNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimerToll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAIt coauses the inflammationNA207403412010NA
PRRID_0654Lipoteichoic Acid (LTA)

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Lactobacillus acidophilus, Prevotella melaninogenica, P. bivia and Mycobacterium smegmatis (BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalEnhanced HIV-1 expression in macrophagesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0654Lipoteichoic Acid (LTA)

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Lactobacillus acidophilus, Prevotella melaninogenica, P. bivia and Mycobacterium smegmatis (BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalEnhanced HIV-1 expression in macrophagesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leads to the clearance of the pathogen from the systemNA207199932010Pubchem Assay
PRRID_0656Lipoteichoic Acid (LTA)

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0656Lipoteichoic Acid (LTA)

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Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0657Lipoteichoic Acid (LTA)

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Streptococcus (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainNANANAIt leadsto the secretion of the proinfalmmatory cytokinesNA206201292010NA
PRRID_0657Lipoteichoic Acid (LTA)

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Streptococcus (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainNANANAIt leadsto the secretion of the proinfalmmatory cytokinesNA206201292010NA
PRRID_0661Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0661Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NYK1.fastaQ9NYK11049Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0662Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0662Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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Guanosine (others)C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt produce pro-inflammatory cytokines including IFNα, TNFα and/or IL-12Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanDCs, monocytes, macrophages, lymphocytes, Langerhans cells, and NK cellsLeucine-rich Repeat (LRR) DomainQ9NR97.fastaQ9NR971041Itresults into the inflammatory responseNA207131002010Pubchem Assay
PRRID_0663Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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NAC=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt led to the activation of NF-κB and upregulate the expression of the antiapoptotic protein Bcl-2.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanLung cancer cellsNAQ9NYK1.fastaQ9NYK11049This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy.ELISA202374132010Pubchem Assay
PRRID_0663Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine)

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NAC=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)ONANucleic AcidSyntheticIt led to the activation of NF-κB and upregulate the expression of the antiapoptotic protein Bcl-2.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanLung cancer cellsNAQ9NYK1.fastaQ9NYK11049This resulted into increased tumor cell survival and resistance to apoptosis induced by chemotherapy.ELISA202374132010Pubchem Assay
PRRID_0664LpqH

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Mtb H37Ra (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159LipoproteinNaturalIt activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanPrimary MonocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leads to the clearance of the pathogen via autophagyNA205609772010Pubchem Assay
PRRID_0664LpqH

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Mtb H37Ra (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159LipoproteinNaturalIt activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanPrimary MonocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leads to the clearance of the pathogen via autophagyNA205609772010Pubchem Assay
PRRID_0665LpqH

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Mtb H37Ra (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159LipoproteinNaturalIt activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.Toll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanPrimary MonocytesLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786It leads to the clearance of the pathogen via autophagyNA205609772010Pubchem Assay
PRRID_0665LpqH

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Mtb H37Ra (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159LipoproteinNaturalIt activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.Toll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanPrimary MonocytesLeucine-rich Repeat (LRR) DomainQ15399.fastaQ15399786It leads to the clearance of the pathogen via autophagyNA205609772010Pubchem Assay
PRRID_0666LpqH

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Mtb H37Ra (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159LipoproteinNaturalIt activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanPrimary MonocytesLeucine-rich Repeat (LRR) DomainP08571.fastaP08571375It leads to the clearance of the pathogen via autophagyNA205609772010Pubchem Assay
PRRID_0666LpqH

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Mtb H37Ra (Bacteria)MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS159LipoproteinNaturalIt activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanPrimary MonocytesLeucine-rich Repeat (LRR) DomainP08571.fastaP08571375It leads to the clearance of the pathogen via autophagyNA205609772010Pubchem Assay
PRRID_0670macrophage-activating lipopeptide

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Mycoplasma fermentans (Bacteria)C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)NNALipopeptidesNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0670macrophage-activating lipopeptide

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Mycoplasma fermentans (Bacteria)C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)NNALipopeptidesNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0672Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0672Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0680Mitochondrial DNA

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rhabdomyosarcoma cells (others)NANANucleic AcidNaturalIt activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinasesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNeutrophilsNAQ9NR96.fastaQ9NR961032It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli.Chemotaxis assay202036102010Pubchem Assay
PRRID_0680Mitochondrial DNA

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rhabdomyosarcoma cells (others)NANANucleic AcidNaturalIt activates the PMN in circukation and promote the Ca2+ flux and phosphorylation of MAP kinasesToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNeutrophilsNAQ9NR96.fastaQ9NR961032It incites non-specific organ attack and suppresses chemotactic responsess to infective stimuli.Chemotaxis assay202036102010Pubchem Assay
PRRID_0681mmLDL

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Native Human LDL (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticThe binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR4cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanMonocytes and MacrophagesNAP08571.fastaP08571375It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages.ELISA204720102010Pubchem Assay
PRRID_0681mmLDL

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Native Human LDL (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticThe binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR4cluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanMonocytes and MacrophagesNAP08571.fastaP08571375It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages.ELISA204720102010Pubchem Assay
PRRID_0682mmLDL

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Native Human LDL (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticThe binding of mmLDL, induces the production of TNF-and increasing the expression of TLR2 and TLR5Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMonocytes and MacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages.ELISA204720102010Pubchem Assay
PRRID_0682mmLDL

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Native Human LDL (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticThe binding of mmLDL, induces the production of TNF-and increasing the expression of TLR2 and TLR5Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMonocytes and MacrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages.ELISA204720102010Pubchem Assay
PRRID_0683mmLDL

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Native Human LDL (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticThe binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMonocytes and MacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages.ELISA204720102010Pubchem Assay
PRRID_0683mmLDL

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Native Human LDL (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticThe binding of mmLDL, induces the production of TNF- and increasing the expression of TLR2 and TLR6Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMonocytes and MacrophagesLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It triggering an inflammatory response characterized by induction of TNF-‚ç∫ production and upregulation of TLR2 and TLR4 expression in human monocytes and macrophages.ELISA204720102010Pubchem Assay
PRRID_0692muramyl dipeptide (MDP)

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Streptococcus pneumoniae, Mycobacterium tuberculosis, and Listeria monocytogenes (Bacteria)CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturalActivates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1β, which results into pathogen clearance and sepsis resistancecluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanNANAQ9HC29.fastaQ9HC291040It results into pathogen clearance and sepsis resistanceNA207403412010Pubchem Assay
PRRID_0692muramyl dipeptide (MDP)

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Streptococcus pneumoniae, Mycobacterium tuberculosis, and Listeria monocytogenes (Bacteria)CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturalActivates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1β, which results into pathogen clearance and sepsis resistancecluster of differentiation 14 (CD14)Pattern recognition receptor (PRR)HumanNANAQ9HC29.fastaQ9HC291040It results into pathogen clearance and sepsis resistanceNA207403412010Pubchem Assay
PRRID_0695murine cytomegalovirus

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MCMV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIFToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904it lead to the secretion of IFN-βNA206201292010Pubchem Assay
PRRID_0695murine cytomegalovirus

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MCMV (virus)NANANucleic AcidNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins TRIFToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanEndosomesLeucine-rich Repeat (LRR) DomainO15455.fastaO15455904it lead to the secretion of IFN-βNA206201292010Pubchem Assay
PRRID_0698N1L

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Vaccinia(virus)MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK117ProteinNaturalSuppress NF-κB activation (Bind to IKKγ)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANASuppress cytokine productionNA206720472010NA
PRRID_0698N1L

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Vaccinia(virus)MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK117ProteinNaturalSuppress NF-κB activation (Bind to IKKγ)Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANASuppress cytokine productionNA206720472010NA
PRRID_0699N1L

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Vaccinia(virus)MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK117ProteinNaturalSuppress IRF3 activation (Bind to TBK1)The class II transactivator (CIITA)NOD-like receptor (NLR)HumanNALeucine-rich Repeat (LRR) DomainP33076.fastaP330761130Suppress IFN productionNA206720472010Pubchem Assay
PRRID_0699N1L

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Vaccinia(virus)MRTLLIRYILWRNDNDQTYYNDDFKKLMLLDELVDDGDVCTLIKNMRMTLSDGPLLDRLNQPVNNIEDAKRMIAISAKVARDIGERSEIRWEESFTILFRMIETYFDDLMIDLYGEK117ProteinNaturalSuppress IRF3 activation (Bind to TBK1)The class II transactivator (CIITA)NOD-like receptor (NLR)HumanNALeucine-rich Repeat (LRR) DomainP33076.fastaP330761130Suppress IFN productionNA206720472010Pubchem Assay
PRRID_0703NA

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NANANANANaturalNAThe class II transactivator (CIITA)NOD-like receptor (NLR)HumanNANAP33076.fastaP330761130It is a key regulator of class II MHC genes, such as it exert transcriptional regulator activity or other nuclear functions.NA203038732010Pubchem Assay
PRRID_0703NA

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NANANANANaturalNAThe class II transactivator (CIITA)NOD-like receptor (NLR)HumanNANAP33076.fastaP330761130It is a key regulator of class II MHC genes, such as it exert transcriptional regulator activity or other nuclear functions.NA203038732010Pubchem Assay
PRRID_0706naked dsRNS (poly(I:C))

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BacteriaC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticinduced a reduction in maximal mitochondrial respirationToll-like receptor 3,7,9 (TLR3/7/9)Toll-like receptor (TLR)HumanHuman hepatocytes (HepG2 cells)Leucine-rich Repeat (LRR) DomainNANANAThis resultsinto mitochondrial dysfunction which is accompanied by caspase-8NA206912862010NA
PRRID_0706naked dsRNS (poly(I:C))

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BacteriaC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticinduced a reduction in maximal mitochondrial respirationToll-like receptor 3,7,9 (TLR3/7/9)Toll-like receptor (TLR)HumanHuman hepatocytes (HepG2 cells)Leucine-rich Repeat (LRR) DomainNANANAThis resultsinto mitochondrial dysfunction which is accompanied by caspase-8NA206912862010NA
PRRID_0707Nef

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HIV-1 (virus)MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC206ProteinNaturalInhibit ERK activation (Dephosphorylation of ERK by induced MKP-1)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress TNF-α productionNA206720472010Pubchem Assay
PRRID_0707Nef

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HIV-1 (virus)MGGKWSKSSVIGWPTVRERMRRAEPAADRVGAASRDLEKHGAITSSNTAATNAACAWLEAQEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGYFPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKIEEANKGENTSLLHPVSLHGMDDPEREVLEWRFDSRLAFHHVARELHPEYFKNC206ProteinNaturalInhibit ERK activation (Dephosphorylation of ERK by induced MKP-1)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress TNF-α productionNA206720472010Pubchem Assay
PRRID_0710NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAInhibit IFN production in pDCNA206720472010NA
PRRID_0710NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationToll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainNANANAInhibit IFN production in pDCNA206720472010NA
PRRID_0711NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of NF-κB and AP-1 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress DC and T cell activationNA206720472010Pubchem Assay
PRRID_0711NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of NF-κB and AP-1 activationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress DC and T cell activationNA206720472010Pubchem Assay
PRRID_0712NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Inhibit IFN production in mDCNA206720472010Pubchem Assay
PRRID_0712NS1

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Influenza A (virus)MDPNTVSSFQVDCFLWHVRKRVADQELGDAPFLDRLRRDQKSLRGRGSTLGLDIETATRAGKQIVERILKEESDEALKMTMASVPASRYLTDMTLEEMSRHWFMLMPKQKVAGPLCIRMDQAIMDKNIILKANFSVIFDRLETLILLRAFTEEGTIVGEISPLPSLPGHTDEDVKNAVGVLIGGLEWNNNTVRVSETLQRFAWRSSNENGRPPLTPKQKRKMAGTIRSEV206ProteinNaturalSuppress of IRF3/7 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Inhibit IFN production in mDCNA206720472010Pubchem Assay
PRRID_0713NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0713NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0714NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0714NS1, NS2

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Human respiratory syncytial virus (RSV)MGCNSLSMIKVRLQNLFDNDEVALLKITCYTDKLILLTNALAKAAIHTIKLNGIVFIHVITSSEVCPDNNIVVKSNFTTMPILQNGGYIWELIELTHCSQLNGLMDDNCEIKFSKRLSDSVMTDYMNQISDLLGLDLNS, MDTTHNDTTPQRLIITDMRPLSLETIITSLTRDIITHKFIYLINHECIVRKLDERQATFTFLVNYEMKLLHKVGSTKYKKYTEYNTKYGTFPMPIFINHDGFLECIGIKPTKHTPIIYKYDLNP139, 124ProteinNaturalSuppress IRF3 activationRIG-1Rig-like receptor (RLR)HumanNANAO95786.fastaO95786925Suppress IFN production in mDCNA206720472010Pubchem Assay
PRRID_0715NS3/4A

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Hepatitis C Virus (virus)APITAYAQQTRGLLGTIVTGLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPSGAKSLEPCACGSADLYLITRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGVDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEIPFYGKAIPIALLKGGRHLIFCHSKKKCEEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTGLTHIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDETWKCLVRLKPTLHGPTPLLYRLGPIQNETCLTHPVTKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGSVVIVGHIELGGKPALVPDREVLYQQYDEMEEC685ProteinNaturalDegrade TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress IFN-α/β production and Suppress CD4+ T cell activation by dysfunction of mDCsNA206720472010Pubchem Assay
PRRID_0715NS3/4A

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Hepatitis C Virus (virus)APITAYAQQTRGLLGTIVTGLTGRDKNVVTGEVQVLSTATQTFLGTTVGGVMWTVYHGAGSRTLAGAKHPALQMYTNVDQDLVGWPAPSGAKSLEPCACGSADLYLITRDADVIPARRRGDSTASLLSPRPLACLKGSSGGPVMCPSGHVAGIFRAAVCTRGVAKALQFIPVETLSTQARSPSFSDNSTPPAVPQSYQVGYLHAPTGSGKSTKVPAAYVAQGYNVLVLNPSVAATLGFGSFMSRAYGVDPNIRTGNRTVTTGAKLTYSTYGKFLADGGCSGGAYDVIICDECHAQDATSILGIGTVLDQAETAGVRLTVLATATPPGSITVPHSNIEEVALGSEGEIPFYGKAIPIALLKGGRHLIFCHSKKKCEEIASKLRGMGLNAVAYYRGLDVSVIPTTGDVVVCATDALMTGYTGDFDSVIDCNVAVEQYVDFSLDPTFSIETRTAPQDAVSRSQRRGRTGRGRLGTYRYVAPGERPSGMFDSVVLCECYDAGCSWYDLQPAETTVRLRAYLSTPGLPVCQDHLDFWESVFTGLTHIDAHFLSQTKQQGLNFSYLTAYQATVCARAQAPPPSWDETWKCLVRLKPTLHGPTPLLYRLGPIQNETCLTHPVTKYIMACMSADLEVTTSTWVLLGGVLAALAAYCLSVGSVVIVGHIELGGKPALVPDREVLYQQYDEMEEC685ProteinNaturalDegrade TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress IFN-α/β production and Suppress CD4+ T cell activation by dysfunction of mDCsNA206720472010Pubchem Assay
PRRID_0716NS5A

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Hepatitis C Virus (virus)MAGSWLRDVWDWICTVLSDFKTWLQSKLLPRLPGVPFLSCQRGYRGVWRGDGIMHTTCPCGAEITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNIKCPCQVPAPEFFTELDGVRLHRYAPACKPLLRDEVTFLVGLHQYPVGSQLPCEPEPNVTVLTSMLTDPSHITAETAKRRLARGSPPSMASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRKFPQAMPIWARPDYNPPLLESWKNPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSESSAVDSGTATAPPDQPSDDGGSGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSH452ProteinNaturalInhibit NF-κB activation (Bind to MyD88) and Inhibit JNK activation (Bind to TRAF2)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production and Suppress TNF pathway activationNA206720472010Pubchem Assay
PRRID_0716NS5A

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Hepatitis C Virus (virus)MAGSWLRDVWDWICTVLSDFKTWLQSKLLPRLPGVPFLSCQRGYRGVWRGDGIMHTTCPCGAEITGHVKNGSMRIVGPRTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFHYVTGMTTDNIKCPCQVPAPEFFTELDGVRLHRYAPACKPLLRDEVTFLVGLHQYPVGSQLPCEPEPNVTVLTSMLTDPSHITAETAKRRLARGSPPSMASSSASQLSAPSLKATCTTHHDSPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPLRAEEDEREVSVPAEILRKSRKFPQAMPIWARPDYNPPLLESWKNPDYVPPVVHGCPLPPAKAPPIPPPRRKRTVVLTESTVSSALAELATKTFGSSESSAVDSGTATAPPDQPSDDGGSGSDVESYSSMPPLEGEPGDPDLSDGSWSTVSEEASEDVVCCSMSH452ProteinNaturalInhibit NF-κB activation (Bind to MyD88) and Inhibit JNK activation (Bind to TRAF2)Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production and Suppress TNF pathway activationNA206720472010Pubchem Assay
PRRID_0719p30

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Human T-lymphotropic leukemia virus 1 (virus)MALCCFAFSAPCLHLRSRRSCSSCFLLATSAAFFSARLLRRAFSSSFLFKYSAICFSSSFSRSFFRFLFSSARRCRSRCVSPRGGAFSPGGPRRSRPRLSSSKDSKPSSTASSSSLSFNSSSKDNSPSTNSSTSRSSGHDTGKHRNSPADTKLTMLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL241ProteinNaturalSuppress TLR4 expression and Inhibit GSK3-βToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production ad enhance IL-10 prductionNA206720472010Pubchem Assay
PRRID_0719p30

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Human T-lymphotropic leukemia virus 1 (virus)MALCCFAFSAPCLHLRSRRSCSSCFLLATSAAFFSARLLRRAFSSSFLFKYSAICFSSSFSRSFFRFLFSSARRCRSRCVSPRGGAFSPGGPRRSRPRLSSSKDSKPSSTASSSSLSFNSSSKDNSPSTNSSTSRSSGHDTGKHRNSPADTKLTMLIISPLPRVWTESSFRIPSLRVWRLCTRRLVPHLWGTMFGPPTSSRPTGHLSRASDHLGPHRWTRYRLSSTVPYPSTPLLPHPENL241ProteinNaturalSuppress TLR4 expression and Inhibit GSK3-βToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839Suppress cytokine production ad enhance IL-10 prductionNA206720472010Pubchem Assay
PRRID_0720Paclitaxel

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NAC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNADrugSyntheticIt hasthe role in the activation of the adapter protein MyD88 was linked to reduction of apoptosis in cancer cells.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Human(Ovarian Cancer Patient)NALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA207283432010Pubchem Assay
PRRID_0720Paclitaxel

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NAC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)CNADrugSyntheticIt hasthe role in the activation of the adapter protein MyD88 was linked to reduction of apoptosis in cancer cells.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Human(Ovarian Cancer Patient)NALeucine-rich Repeat (LRR) DomainO00206.fastaO00206839NANA207283432010Pubchem Assay
PRRID_0721Diacylated Lipopeptide

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BacteriaNANALipopeptidesNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0721Diacylated Lipopeptide

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BacteriaNANALipopeptidesNaturalActivates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteinsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanNALeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It coauses the inflammationNA207403412010Pubchem Assay
PRRID_0722Pam2Cys

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B. burgdorferi(Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAPeptidoglycanSyntheticInduction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0722Pam2Cys

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B. burgdorferi(Bacteria)CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCCNAPeptidoglycanSyntheticInduction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0725Pam3Cys

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Plasmodium falciparum circumsporozoite protein (others)CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPeptidoglycanSyntheticVaccine targeting malariaToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0725Pam3Cys

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Plasmodium falciparum circumsporozoite protein (others)CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPeptidoglycanSyntheticVaccine targeting malariaToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0729Peptidoglycan (PGN)

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Escherichia coli, Chlamydia pneumoniae, Campylobacter jejuni, Salmonella typhimurium, Pseudomonas aeCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalActivates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1β, which results into pathogen clearance and sepsis resistanceNucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)HumanNANAQ9Y239.fastaQ9Y239953It results into pathogen clearance and sepsis resistanceNA207403412010Pubchem Assay
PRRID_0729Peptidoglycan (PGN)

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Escherichia coli, Chlamydia pneumoniae, Campylobacter jejuni, Salmonella typhimurium, Pseudomonas aeCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalActivates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1β, which results into pathogen clearance and sepsis resistanceNucleotide Binding Oligomerization Domain Containing 1 (Nod1)NOD-like receptor (NLR)HumanNANAQ9Y239.fastaQ9Y239953It results into pathogen clearance and sepsis resistanceNA207403412010Pubchem Assay
PRRID_0731Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0731Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalNAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NANA207131002010Pubchem Assay
PRRID_0735Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0735Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0736Peptidoglycan (PGN)

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streptomyces species (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalIt's binding induces the production of IL6, IL8, MMP3 and MMP1Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanFibroblast Like Synoviocytes (FLS)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destructionELISA205711652010Pubchem Assay
PRRID_0736Peptidoglycan (PGN)

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streptomyces species (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalIt's binding induces the production of IL6, IL8, MMP3 and MMP1Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanFibroblast Like Synoviocytes (FLS)Leucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destructionELISA205711652010Pubchem Assay
PRRID_0739Peptidoglycan (PGN)

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Borrelia burgdorferi(Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPeptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokinesNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)HumanPBMCsNAQ9HC29.fastaQ9HC291040It aids in the induction of inflammtory reaction against Borrelia burgdorferiELISA204415182010Pubchem Assay
PRRID_0739Peptidoglycan (PGN)

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Borrelia burgdorferi(Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPeptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokinesNucleotide Binding Oligomerization Domain Containing 2 (Nod2)NOD-like receptor (NLR)HumanPBMCsNAQ9HC29.fastaQ9HC291040It aids in the induction of inflammtory reaction against Borrelia burgdorferiELISA204415182010Pubchem Assay
PRRID_0742Pam3Cys

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B. burgdorferi(Bacteria)CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPeptidoglycanSyntheticInduction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0742Pam3Cys

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B. burgdorferi(Bacteria)CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPeptidoglycanSyntheticInduction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspAToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humandendritic cells, macrophages and lymphocytesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It has the role in the inflammation.NA207131002010Pubchem Assay
PRRID_0749Phospholipomannan

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Candida albicans(fungi)NANACarbohydrateNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0749Phospholipomannan

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Candida albicans(fungi)NANACarbohydrateNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay