Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0378	Pseudomonas aeruginosa Click for more detail	Pseudomonas aeruginosa (Bacteria)	NA	NA	Whole organism	Natural	P. aeruginosa activates NF-kappaB and MAPK, leads to the producion of proinflammatory cytokines.	Mannose receptor	Mannose receptor (MR)	Human	Monocytes	NA	P22897.fasta	P22897	1456	It has the role in the inflammation.	ELISA	19197942	2009	Pubchem Assay
PRRID_0378	Pseudomonas aeruginosa Click for more detail	Pseudomonas aeruginosa (Bacteria)	NA	NA	Whole organism	Natural	P. aeruginosa activates NF-kappaB and MAPK, leads to the producion of proinflammatory cytokines.	Mannose receptor	Mannose receptor (MR)	Human	Monocytes	NA	P22897.fasta	P22897	1456	It has the role in the inflammation.	ELISA	19197942	2009	Pubchem Assay
PRRID_0379	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0379	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0380	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0380	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0381	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0381	SIMRA Compound 1 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0382	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0382	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0383	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0383	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0384	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0384	SIMRA Compound 2 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0385	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0385	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0386	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NYK1.fasta	Q9NYK1	1049	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0386	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NYK1.fasta	Q9NYK1	1049	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0387	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	PBMCs	NA	NA	NA	NA	This induces the inflammatory response.	PBMC assay	19269175	2009	NA
PRRID_0387	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	PBMCs	NA	NA	NA	NA	This induces the inflammatory response.	PBMC assay	19269175	2009	NA
PRRID_0388	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	pDCs	NA	NA	NA	NA	This induces the inflammatory response.	NA	19269175	2009	NA
PRRID_0388	SIMRA Compound 3 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	pDCs	NA	NA	NA	NA	This induces the inflammatory response.	NA	19269175	2009	NA
PRRID_0390	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0390	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0391	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0391	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0392	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0392	SIMRA Compound 4 Click for more detail	NA	5'-UGCUGCUUGUG-X-GUGUUCGUCGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0393	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0393	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0394	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0394	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0395	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0395	SIMRA Compound 5 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0396	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0396	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	Stminulation leads to the activation of NF-kappaB, leads to the release of proinflammatory cytokines	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	HEK293XL cells	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0397	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0397	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1Œ≤, IL-2R, IL-8, IL-10, IL-12, IFN-Œ±, IFN-Œ≥, MCP-1, RANTES, MIP-1Œ±, MIP-1Œ≤, TNF-Œ±.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	PBMCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	PBMC assay	19269175	2009	Pubchem Assay
PRRID_0398	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0398	SIMRA Compound 6 Click for more detail	NA	5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5'	23	Nucleic Acid	Synthetic	SIMRA compounds containing arabinonucleotides induces the cytokines production in human pDCs cultures such as IFN-Œ≥, IFN-Œ±, IL-12, TNF-Œ±, MIP-1Œ±, MIP-1Œ≤.	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	pDCs	NA	Q9NR97.fasta	Q9NR97	1041	This induces the inflammatory response.	NA	19269175	2009	Pubchem Assay
PRRID_0400	Viral Genome Click for more detail	Rabies virus (virus)	NA	NA	Nucleic Acid	Natural	Rabies genome is a potent activator of TLR3	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Neuronal cells	NA	O15455.fasta	O15455	904	TLR3 is involved in the spatial arrangement of rabies virus‚Äìinduced NBs and viral replication.	NA	19247444	2009	Pubchem Assay
PRRID_0400	Viral Genome Click for more detail	Rabies virus (virus)	NA	NA	Nucleic Acid	Natural	Rabies genome is a potent activator of TLR3	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Neuronal cells	NA	O15455.fasta	O15455	904	TLR3 is involved in the spatial arrangement of rabies virus‚Äìinduced NBs and viral replication.	NA	19247444	2009	Pubchem Assay
PRRID_0402	3pRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of IFN-	RIG-1	Rig-like receptor (RLR)	Human	NK cells	NA	O95786.fasta	O95786	925	It resulted in direct activation NK cells leading to high IFN-Œ≥ production in synergy with mDC-released soluble mediators induced by dsRNA	NA	20639488	2010	Pubchem Assay
PRRID_0402	3pRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of IFN-	RIG-1	Rig-like receptor (RLR)	Human	NK cells	NA	O95786.fasta	O95786	925	It resulted in direct activation NK cells leading to high IFN-Œ≥ production in synergy with mDC-released soluble mediators induced by dsRNA	NA	20639488	2010	Pubchem Assay
PRRID_0404	A46R Click for more detail	Vaccinia(virus)	MAFDISVNASKTINALVYFSTQQNKLVIRNEVNDTHYTVEFDRDKVVDTFISYNRHNDTIEIRGVLPEETNIGCAVNTPVSMTYLYNKYSFKLILAEYIRHRNTISGNIYSALMTLDDLAIKQYGDIDLLFNEKLKVDSDSGLFDFVNFVKDMICCDSRIVVALSSLVSKHWELTNKKYRCMALANIYLIVFQYLSYLDYDTIYVSIYAGTLRA	214	Protein	Natural	Suppress NF-Œ∫B activation (Bind to MyD88, TRAM, and TRIF)	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Suppress cytokine production	NA	20672047	2010	NA
PRRID_0404	A46R Click for more detail	Vaccinia(virus)	MAFDISVNASKTINALVYFSTQQNKLVIRNEVNDTHYTVEFDRDKVVDTFISYNRHNDTIEIRGVLPEETNIGCAVNTPVSMTYLYNKYSFKLILAEYIRHRNTISGNIYSALMTLDDLAIKQYGDIDLLFNEKLKVDSDSGLFDFVNFVKDMICCDSRIVVALSSLVSKHWELTNKKYRCMALANIYLIVFQYLSYLDYDTIYVSIYAGTLRA	214	Protein	Natural	Suppress NF-Œ∫B activation (Bind to MyD88, TRAM, and TRIF)	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Suppress cytokine production	NA	20672047	2010	NA
PRRID_0405	A52R Click for more detail	Vaccinia(virus)	MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS	190	Protein	Natural	Suppress NF-Œ∫B activation (Bind to IRAK2) and	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Suppress cytokine production	NA	20672047	2010	NA
PRRID_0405	A52R Click for more detail	Vaccinia(virus)	MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS	190	Protein	Natural	Suppress NF-Œ∫B activation (Bind to IRAK2) and	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Suppress cytokine production	NA	20672047	2010	NA
PRRID_0406	A52R Click for more detail	Vaccinia(virus)	MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS	190	Protein	Natural	Activate p38 MAPK and JNK (Bind to TRAF6)	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Induce IL-10 production	NA	20672047	2010	NA
PRRID_0406	A52R Click for more detail	Vaccinia(virus)	MDIKIDISISGDKFTVTTRRENEERKKYLPLQKEKTTDVIKPDYLEYDDLLDRDEMSTILEEYFMYRGLLGLRIKYGRLFNEIKKFDNDAEEQFGTIEELKQKLRLNSEEGADNFIDYIKVQKQDIVKLTVYDCISMIGLCACVVDVWRNEKLFSRWKYCLRAIKLFINDHMLDKIKSILQNRLVYVEMS	190	Protein	Natural	Activate p38 MAPK and JNK (Bind to TRAF6)	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Induce IL-10 production	NA	20672047	2010	NA
PRRID_0407	acylated LprA Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Induced IL-8 secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0407	acylated LprA Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Induced IL-8 secretion	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0408	acylated LprG Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Delivery of glycolipds to TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0408	acylated LprG Click for more detail	M. tuberculosis (Bacteria)	NA	NA	Lipoprotein	Natural	Delivery of glycolipds to TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Phagocytosis	ELISA	20694006	2010	Pubchem Assay
PRRID_0426	Bacterial DNA Click for more detail	Porphyromonas gingivalis and Tannerella forsythia (Bacteria)	NA	NA	Nucleic Acid	Natural	It induces the release of IL-8 , IL-1beta, IL-6 TNF-alpha, and NF-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Monocytic cells (THP-1 cells)	LRR	Q9NR96.fasta	Q9NR96	1032	Immune responses triggered by periodontal bacterial nucleic acids mediated by inducing proinflammatory cytokine production through the TLR9 signaling pathway.	ELISA	20331800	2010	Pubchem Assay
PRRID_0426	Bacterial DNA Click for more detail	Porphyromonas gingivalis and Tannerella forsythia (Bacteria)	NA	NA	Nucleic Acid	Natural	It induces the release of IL-8 , IL-1beta, IL-6 TNF-alpha, and NF-	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Monocytic cells (THP-1 cells)	LRR	Q9NR96.fasta	Q9NR96	1032	Immune responses triggered by periodontal bacterial nucleic acids mediated by inducing proinflammatory cytokine production through the TLR9 signaling pathway.	ELISA	20331800	2010	Pubchem Assay
PRRID_0435	CL097 Click for more detail	derivative of the imidazoquinoline compound R848(others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	The binding induces the production of IL-6, IL-10, TNF-‚ç∫ and IL-23	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	Lamina propria DCs obtained from the human GI tract	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It induces intestinal inflammation and potentially alter the homeostatic response to commensal flora	NA	20483758	2010	NA
PRRID_0435	CL097 Click for more detail	derivative of the imidazoquinoline compound R848(others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	The binding induces the production of IL-6, IL-10, TNF-‚ç∫ and IL-23	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	Lamina propria DCs obtained from the human GI tract	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It induces intestinal inflammation and potentially alter the homeostatic response to commensal flora	NA	20483758	2010	NA
PRRID_0436	Compound A Click for more detail	NA	NA	NA	Chemical Compunds	Synthetic	it induces IL-6 production in murine macrophage	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0436	Compound A Click for more detail	NA	NA	NA	Chemical Compunds	Synthetic	it induces IL-6 production in murine macrophage	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0437	Compound B Click for more detail	3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It casues inflammation in the respective cells	ELISA	20504771	2010	Pubchem Assay
PRRID_0437	Compound B Click for more detail	3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It casues inflammation in the respective cells	ELISA	20504771	2010	Pubchem Assay
PRRID_0438	Compound C Click for more detail	3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It casues inflammation in the respective cells	ELISA	20504771	2010	Pubchem Assay
PRRID_0438	Compound C Click for more detail	3-carboxylbenzothiophene linked via a carbonothioylamino bridge to an anilino group (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It casues inflammation in the respective cells	ELISA	20504771	2010	Pubchem Assay
PRRID_0439	Compound E Click for more detail	N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0439	Compound E Click for more detail	N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0440	Compound F Click for more detail	N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0440	Compound F Click for more detail	N1-(benzyl)-N2-(phenyl)-N2-(sulfonyl)glycinamide (others)	NA	NA	Chemical Compunds	Synthetic	it induces TNF-‚ç∫ production from human monocytes	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Peripheral blood monocytes and macrophages	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It casues inflammation in the respective cells	ELISA	20504771	2010	NA
PRRID_0441	core protein Click for more detail	Hepatitis C Virus (virus)	MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA	319	Protein	Natural	Induce cytokines responses through nuclear translocation of nuclear factor-kB (NF-kB) subunits	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Antigen presenting cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It reduces the IL-6 production in these cells	NA	20677943	2010	Pubchem Assay
PRRID_0441	core protein Click for more detail	Hepatitis C Virus (virus)	MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA	319	Protein	Natural	Induce cytokines responses through nuclear translocation of nuclear factor-kB (NF-kB) subunits	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Antigen presenting cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It reduces the IL-6 production in these cells	NA	20677943	2010	Pubchem Assay
PRRID_0442	core protein Click for more detail	Hepatitis C Virus (virus)	MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA	319	Protein	Natural	Activate MAP kinase pathway, NF-Œ∫B, and AP-1	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocytes and Kupffer cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Dysfunction of pDCs by enhanced production of IL-10 and TNF- Œ±	NA	20672047	2010	Pubchem Assay
PRRID_0442	core protein Click for more detail	Hepatitis C Virus (virus)	MSTNPKPQRKTKRNTNRRPMDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKARRTEGRSWAQPGYPWPLYGNEGCGWAGWLLSPRGSRXSWGPNDPRXRSRNLGKVIDTLTCGFADLMGYIPLVGAPVGGVARALAHGVRAVEDGINYATGNLPGCSFSIFLLALLSCLTVPTSAVNYRNASGIYHITNDCPNASIVYETENHILHLPGCVPCVRTGNQSRCWVALTPTVASPYAGAPLEPLRRHVDLMVGAATMCSALYIGDLCGGLFLVGQMFTFQPRRHWTTQDCNCSIYTGHITGHRMA	319	Protein	Natural	Activate MAP kinase pathway, NF-Œ∫B, and AP-1	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocytes and Kupffer cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	Dysfunction of pDCs by enhanced production of IL-10 and TNF- Œ±	NA	20672047	2010	Pubchem Assay
PRRID_0443	CpG DNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0443	CpG DNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0445	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0445	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0446	CpG motif Click for more detail	HSV-1 (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It recognize and raise the inflammatory response	NA	20713890	2010	Pubchem Assay
PRRID_0446	CpG motif Click for more detail	HSV-1 (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It recognize and raise the inflammatory response	NA	20713890	2010	Pubchem Assay
PRRID_0447	CpG motif Click for more detail	HSV-2 (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	Q9BXR5.fasta	Q9BXR5	811	It recognize and raise the inflammatory response	NA	20713890	2010	Pubchem Assay
PRRID_0447	CpG motif Click for more detail	HSV-2 (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	Q9BXR5.fasta	Q9BXR5	811	It recognize and raise the inflammatory response	NA	20713890	2010	Pubchem Assay
PRRID_0448	CpG motif Click for more detail	murine CMV (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It recognize and raise the inflammatory response	NA	20713890	2010	NA
PRRID_0448	CpG motif Click for more detail	murine CMV (virus)	NA	NA	Nucleic Acid	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	DCs	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It recognize and raise the inflammatory response	NA	20713890	2010	NA
PRRID_0452	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD92	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Endosomes	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫	NA	20620129	2010	Pubchem Assay
PRRID_0452	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD92	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Endosomes	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leadsto the secretion of the proinfalmmatory and IFN-‚ç∫	NA	20620129	2010	Pubchem Assay
PRRID_0457	Curli (amyloid fibrils) Click for more detail	E. coli strain MC4100(Bacteria)	MNTLLLLAALSSQITFNTTQQGDVYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISPDDRVKIVVTVSDGQSLHLSQQWPPSSEKS	110	Protein	Natural	The binding of curli mediates the immune respionse cooperatively	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	Human	cervical cancer	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It elicits the immune response via NF-	ELISA	20497180	2010	NA
PRRID_0457	Curli (amyloid fibrils) Click for more detail	E. coli strain MC4100(Bacteria)	MNTLLLLAALSSQITFNTTQQGDVYTIIPEVTLTQSCLCRVQILSLREGSSGQSQTKQEKTLSLPANQPIALTKLSLNISPDDRVKIVVTVSDGQSLHLSQQWPPSSEKS	110	Protein	Natural	The binding of curli mediates the immune respionse cooperatively	Toll-like receptor 2/1 (TLR2/1)	Toll-like receptor (TLR)	Human	cervical cancer	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It elicits the immune response via NF-	ELISA	20497180	2010	NA
PRRID_0463	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	NA
PRRID_0463	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Lipopeptides	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	NA
PRRID_0465	DNA Click for more detail	EBV(virus)	NA	NA	Nucleic Acid	Natural	It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Monocytes	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It provides antiviral immunity	NA	20713890	2010	Pubchem Assay
PRRID_0465	DNA Click for more detail	EBV(virus)	NA	NA	Nucleic Acid	Natural	It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Monocytes	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It provides antiviral immunity	NA	20713890	2010	Pubchem Assay
PRRID_0466	DNA Click for more detail	murine CMV (virus)	GTAATCTAACCACTTGTGTGTGTGTGTGTGTGTGTCGAGTCGTGTCGTCTGTACATTTGAGTCGTGCTGTCCGCACATTTTATTTATCTTTGTTCAGTGTGTTAGATTTCCCGAGGCATGGCTTTCCAAGGTACCAGTAGGACTTTAACTCAACAGTCCTCAGCGGCTACGTCTGACGATCTTCAAAAGATATTATTTAGCCCTGAAGCCATTAAGAAAATGGCTACTGAGTGTGACCTAGGCCGGCATCACTGGATGCGCGCTGATAATGCTATTTCAGTCCGGCCCCTCGTTCCCGAAGTAACCCACGGTCGTATTGCTTCTTTCTTTAAGTCTGGATATGATGTTGGTGAATTATGCTCAAAAGGATATATGAGCGTCCCTCAAGTGTTATGTGCTGTTACTCGAACAGTTTCCACTGATGCTGAAGGGTCCCTGAGAATTTACTTAGCTGATCTAGGCGACAAGGAGTTATCTCCTATAGACGGGCAGTGCGTTTCGTTACATAACCATGATCTTCCCGCTTTGGTGTCTTTCCAACCGACGTATGATTGTCCTATGGAAACAGTTGGGAATCGTAAGCGGTGTTTTGCTGTTGTTATCGAAAGACATGGTTACATTGGGTATACCGGTACCACAGCTAGCGTGTGTAGTAATTGGCAAGCAAGGTTTTCTTCTAAGAATAACAACTACACTCATATCGCAGCTGGGAAGACTCTAGTACTACCTTTCAACAGATTAGCCGAGCAAACAAAACCGTCAGCTGTCGCTCGCCTGTTGAAATCGCAATTGAACAACATTGAATCTTCGCAATATCTGTTAACGAACGCGAAGATTAATCAAAATGCGCGTAGTGAGTCCGAGGAATTAAATGTTGAGAGCCCTCCCGCCGCAATCGGGAGTTCTTCCGCGTCCCGCTCCGAAGCCTTCAGACCGCAGGTGGTTAACGGTCTTTAGCACTTTGGTGCGTATTAGTATATAAGTATTTGTGAGTCTGTAC	2213	Nucleic Acid	Natural	It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	PDCs	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	It provides antiviral immunity	NA	20713890	2010	Pubchem Assay
PRRID_0466	DNA Click for more detail	murine CMV (virus)	GTAATCTAACCACTTGTGTGTGTGTGTGTGTGTGTCGAGTCGTGTCGTCTGTACATTTGAGTCGTGCTGTCCGCACATTTTATTTATCTTTGTTCAGTGTGTTAGATTTCCCGAGGCATGGCTTTCCAAGGTACCAGTAGGACTTTAACTCAACAGTCCTCAGCGGCTACGTCTGACGATCTTCAAAAGATATTATTTAGCCCTGAAGCCATTAAGAAAATGGCTACTGAGTGTGACCTAGGCCGGCATCACTGGATGCGCGCTGATAATGCTATTTCAGTCCGGCCCCTCGTTCCCGAAGTAACCCACGGTCGTATTGCTTCTTTCTTTAAGTCTGGATATGATGTTGGTGAATTATGCTCAAAAGGATATATGAGCGTCCCTCAAGTGTTATGTGCTGTTACTCGAACAGTTTCCACTGATGCTGAAGGGTCCCTGAGAATTTACTTAGCTGATCTAGGCGACAAGGAGTTATCTCCTATAGACGGGCAGTGCGTTTCGTTACATAACCATGATCTTCCCGCTTTGGTGTCTTTCCAACCGACGTATGATTGTCCTATGGAAACAGTTGGGAATCGTAAGCGGTGTTTTGCTGTTGTTATCGAAAGACATGGTTACATTGGGTATACCGGTACCACAGCTAGCGTGTGTAGTAATTGGCAAGCAAGGTTTTCTTCTAAGAATAACAACTACACTCATATCGCAGCTGGGAAGACTCTAGTACTACCTTTCAACAGATTAGCCGAGCAAACAAAACCGTCAGCTGTCGCTCGCCTGTTGAAATCGCAATTGAACAACATTGAATCTTCGCAATATCTGTTAACGAACGCGAAGATTAATCAAAATGCGCGTAGTGAGTCCGAGGAATTAAATGTTGAGAGCCCTCCCGCCGCAATCGGGAGTTCTTCCGCGTCCCGCTCCGAAGCCTTCAGACCGCAGGTGGTTAACGGTCTTTAGCACTTTGGTGCGTATTAGTATATAAGTATTTGTGAGTCTGTAC	2213	Nucleic Acid	Natural	It leads to the release of monocyte chemoattractant protein-1 (MCP-1) and to an increase of several cytokine mRNA levels	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	PDCs	Leucine-rich Repeat (LRR) Domain	Q9NYK1.fasta	Q9NYK1	1049	It provides antiviral immunity	NA	20713890	2010	Pubchem Assay
PRRID_0469	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Activates caspase-1 which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0469	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	Activates caspase-1 which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0474	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	The activation of NF-kB, MAP kinases and IRF3 and culminates in the production of inflammatory cytokines and type I IFNs	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It has the role in the inflammation.	NA	20713100	2010	Pubchem Assay
PRRID_0474	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	The activation of NF-kB, MAP kinases and IRF3 and culminates in the production of inflammatory cytokines and type I IFNs	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It has the role in the inflammation.	NA	20713100	2010	Pubchem Assay
PRRID_0482	dsDNA Click for more detail	Rabies virus (virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	neurons	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	20706642	2010	Pubchem Assay
PRRID_0482	dsDNA Click for more detail	Rabies virus (virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	neurons	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	20706642	2010	Pubchem Assay
PRRID_0483	dsDNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	neurons	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	20706642	2010	Pubchem Assay
PRRID_0483	dsDNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	NA	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	neurons	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	NA	NA	20706642	2010	Pubchem Assay

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