Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0845	Whole bacteria Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Whole organism	Natural	It activates the p38 MAPK and JNK as well as recruitment of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Primary human small airway epithelial cells (SAEC)	LRR	O60603.fasta	O60603	784	hBD-2 elicits an antimicrobial effect on L. pneumophila.	ELISA	20154223	2010	Pubchem Assay
PRRID_0845	Whole bacteria Click for more detail	Legionella pneumophila (Bacteria)	NA	NA	Whole organism	Natural	It activates the p38 MAPK and JNK as well as recruitment of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Primary human small airway epithelial cells (SAEC)	LRR	O60603.fasta	O60603	784	hBD-2 elicits an antimicrobial effect on L. pneumophila.	ELISA	20154223	2010	Pubchem Assay
PRRID_0847	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It coauses the inflammation	NA	20740341	2010	NA
PRRID_0847	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It coauses the inflammation	NA	20740341	2010	NA
PRRID_0848	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	20713100	2010	Pubchem Assay
PRRID_0848	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	20713100	2010	Pubchem Assay
PRRID_0850	Zymosan Click for more detail	gram-positive bacteria and yeast	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	Their bindng leads to the secretion of the proinflammatory cytokines through NF-KB pathways	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	cerebral endothelial cell line hCMEC/D3	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It's activation causes tight junction disruption in CECs	NA	20637248	2010	NA
PRRID_0850	Zymosan Click for more detail	gram-positive bacteria and yeast	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	Their bindng leads to the secretion of the proinflammatory cytokines through NF-KB pathways	Toll-like receptor 2/6 (TLR2/6)	Toll-like receptor (TLR)	Human	cerebral endothelial cell line hCMEC/D3	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It's activation causes tight junction disruption in CECs	NA	20637248	2010	NA
PRRID_0851	Zymosan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	Pubchem Assay
PRRID_0851	Zymosan Click for more detail	S. cerevisiae (Bacteria)	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Cell surface	Leucine-rich Repeat (LRR) Domain	Q9NR96.fasta	Q9NR96	1032	It leadsto the secretion of the proinfalmmatory cytokines	NA	20620129	2010	Pubchem Assay
PRRID_0865	Œ≤-gal dsRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Induce type 1 IFN production	Toll-like receptor 3 (TLR3)/Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	PBMCs	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Immunostimulation	NA	20692289	2010	NA
PRRID_0865	Œ≤-gal dsRNA Click for more detail	NA	NA	NA	Nucleic Acid	Synthetic	Induce type 1 IFN production	Toll-like receptor 3 (TLR3)/Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	PBMCs	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Immunostimulation	NA	20692289	2010	NA
PRRID_0866	Œ≤2-Glycoprotein I (Œ≤2-gpI) Click for more detail	Human (others)	NA	NA	Glycoprotein	Natural	It triggers the downstream phosphorylation of kinases and activation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Endothelial cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It recruits the MyD88 adapter protein and lead to the production of proinflammatory cytokines	Reporter gene assay	20601596	2010	Pubchem Assay
PRRID_0866	Œ≤2-Glycoprotein I (Œ≤2-gpI) Click for more detail	Human (others)	NA	NA	Glycoprotein	Natural	It triggers the downstream phosphorylation of kinases and activation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Endothelial cells	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It recruits the MyD88 adapter protein and lead to the production of proinflammatory cytokines	Reporter gene assay	20601596	2010	Pubchem Assay
PRRID_0868	alum (aluminium adjuvants ) Click for more detail	NA	O.O.O.O.O.O.O.O.O.O.O.O.[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[Al+3].[K+]	NA	NA	Synthetic	NA	Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing3 (Nalp3)	NOD-like receptor (NLR)	Human	Eosinophils	NA	Q96P20.fasta	Q96P20	1036	NLRP3 responds to microbial products and host-derived danger signals and activates the caspase-1- dependent inflammasome	real-time reverse transcription-PCR, FACS, ELISA	21978001	2011	Pubchem Assay
PRRID_0868	alum (aluminium adjuvants ) Click for more detail	NA	O.O.O.O.O.O.O.O.O.O.O.O.[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[Al+3].[K+]	NA	NA	Synthetic	NA	Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing3 (Nalp3)	NOD-like receptor (NLR)	Human	Eosinophils	NA	Q96P20.fasta	Q96P20	1036	NLRP3 responds to microbial products and host-derived danger signals and activates the caspase-1- dependent inflammasome	real-time reverse transcription-PCR, FACS, ELISA	21978001	2011	Pubchem Assay
PRRID_0871	beta-defensin Click for more detail	Endogenous (others)	MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS	69	Peptide	Natural	Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0871	beta-defensin Click for more detail	Endogenous (others)	MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS	69	Peptide	Natural	Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0872	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	21982558	2011	Pubchem Assay
PRRID_0872	Bropirimine Click for more detail	NA	C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	experimental drug with¬†anti-cancer¬†and¬†antiviral¬†properties	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	21982558	2011	Pubchem Assay
PRRID_0874	Chromatin-IgG complexes Click for more detail	Endogenous (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Epithelial and B cells, dendritic cells, microglia, astrocyte, neuron	NA	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	21982558	2011	Pubchem Assay
PRRID_0874	Chromatin-IgG complexes Click for more detail	Endogenous (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	Epithelial and B cells, dendritic cells, microglia, astrocyte, neuron	NA	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	NA	21982558	2011	Pubchem Assay
PRRID_0876	Diacylated Lipopeptide Click for more detail	Mycoplasma, Gram-positive bacteria	NA	NA	Lipid	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0876	Diacylated Lipopeptide Click for more detail	Mycoplasma, Gram-positive bacteria	NA	NA	Lipid	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0878	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Epithelial cells, dendritic cells, microglia, astrocytes,oligodendrocytes, neurons	NA	O15455.fasta	O15455	904	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21982558	2011	Pubchem Assay
PRRID_0878	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Epithelial cells, dendritic cells, microglia, astrocytes,oligodendrocytes, neurons	NA	O15455.fasta	O15455	904	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21982558	2011	Pubchem Assay
PRRID_0883	Fibrinogen Click for more detail	Endogenous (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	initiates an inflammatory response by activating innate immune cells	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0883	Fibrinogen Click for more detail	Endogenous (others)	MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG	211	Damage-associated molecular patterns (DAMPs)	Natural	initiates an inflammatory response by activating innate immune cells	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0887	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Myeloid cells, epithelial cells, microglia, astrocytes	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21982558	2011	Pubchem Assay
PRRID_0887	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	triggers immune responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Myeloid cells, epithelial cells, microglia, astrocytes	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21982558	2011	Pubchem Assay
PRRID_0890	Flagellin Click for more detail	S. typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	elicits innate responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Human colon adenocarcinoma intestinal epithelial cells	amino (N) and carboxyl (C) domains (D) of the flagellin protein (ND1/2ECHCD2/1)	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21949773	2011	Pubchem Assay
PRRID_0890	Flagellin Click for more detail	S. typhimurium (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	elicits innate responses	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Human colon adenocarcinoma intestinal epithelial cells	amino (N) and carboxyl (C) domains (D) of the flagellin protein (ND1/2ECHCD2/1)	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	21949773	2011	Pubchem Assay
PRRID_0892	Glycoinositol phospholipids Click for more detail	eukaryotic cell membranes (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0892	Glycoinositol phospholipids Click for more detail	eukaryotic cell membranes (others)	C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O	NA	Lipid	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0894	Glycolipids Click for more detail	eukaryotic cell membranes (others)	NA	NA	Lipid	Natural	Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0894	Glycolipids Click for more detail	eukaryotic cell membranes (others)	NA	NA	Lipid	Natural	Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0896	Gp96 (HSP90B1) Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0896	Gp96 (HSP90B1) Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0897	Gp96 (HSP90B1) Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0897	Gp96 (HSP90B1) Click for more detail	Endogenous (others)	MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL	803	Damage-associated molecular patterns (DAMPs)	Natural	It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0898	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0898	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0899	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0899	Heat-shock protein 70 Click for more detail	Endogenous (others)	MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD	641	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0902	Heat-shock proteins 60 Click for more detail	Endogenous (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0902	Heat-shock proteins 60 Click for more detail	Endogenous (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0903	Heat-shock proteins 60 Click for more detail	Endogenous (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0903	Heat-shock proteins 60 Click for more detail	Endogenous (others)	MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF	573	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0905	Heparan sulfate Click for more detail	Endogenous (others)	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	released in responses to local stresses (hypoxia or inflammation)	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0905	Heparan sulfate Click for more detail	Endogenous (others)	COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	released in responses to local stresses (hypoxia or inflammation)	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0908	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 plays a pivotal role in ischemic brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0908	HMGB1 Click for more detail	Endogenous (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	HMGB1 plays a pivotal role in ischemic brain injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0911	iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail	Bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	peptidoglycan substructures	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Eosinophils	NA	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	real-time reverse transcription-PCR, FACS, ELISA	21978001	2011	Pubchem Assay
PRRID_0911	iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail	Bacteria	N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O	NA	Pattern-associated molecular patterns (PAMPs)	Natural	peptidoglycan substructures	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	Human	Eosinophils	NA	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of¬†innate immune response. NLRs can cooperate with¬†Toll-like receptors¬†and regulate inflammatory and apoptotic response.	real-time reverse transcription-PCR, FACS, ELISA	21978001	2011	Pubchem Assay
PRRID_0912	Imidazoquinoline Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	NA	21982558	2011	Pubchem Assay
PRRID_0912	Imidazoquinoline Click for more detail	A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring	CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-12	NA	21982558	2011	Pubchem Assay
PRRID_0916	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.¬†	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0916	lipo-arabinomannan Click for more detail	Mycobacteria (Bacteria)	CCC(CO)NCCNC(CC)CO	NA	Glycolipid	Natural	serve as a modulin with immunoregulatory and anti-inflammatory effects.¬†	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0918	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS was also shown to play a role in alloimmune lung injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0918	Lipopolysaccharide (LPS) Click for more detail	Gram-negative bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS was also shown to play a role in alloimmune lung injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0919	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Intracellular TIR domains	O15455.fasta	O15455	904	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21959264	2011	Pubchem Assay
PRRID_0919	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	NA	Intracellular TIR domains	O15455.fasta	O15455	904	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21959264	2011	Pubchem Assay
PRRID_0926	Lipoproteins/lipopeptides Click for more detail	Bacteria	NA	NA	Lipid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0926	Lipoproteins/lipopeptides Click for more detail	Bacteria	NA	NA	Lipid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0928	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0928	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0929	Lipoteichoic Acid (LTA) Click for more detail	Gram-positive bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0929	Lipoteichoic Acid (LTA) Click for more detail	Gram-positive bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0932	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	up-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-13	NA	21982558	2011	Pubchem Assay
PRRID_0932	Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail	Guanosine (others)	C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O	NA	Nucleic Acid	Synthetic	up-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-Œ±, IFN-Œ≤, TNF-Œ±, and IL-13	NA	21982558	2011	Pubchem Assay
PRRID_0934	LyoVec Click for more detail	mimic of viral RNA (virus)	NA	NA	Nucleic Acid	Synthetic	elicit innate immune response	RIG-1	Rig-like receptor (RLR)	Human	Eosinophils	NA	O95786.fasta	O95786	925	NA	real-time reverse transcription-PCR, FACS, ELISA	21978001	2011	Pubchem Assay
PRRID_0934	LyoVec Click for more detail	mimic of viral RNA (virus)	NA	NA	Nucleic Acid	Synthetic	elicit innate immune response	RIG-1	Rig-like receptor (RLR)	Human	Eosinophils	NA	O95786.fasta	O95786	925	NA	real-time reverse transcription-PCR, FACS, ELISA	21978001	2011	Pubchem Assay
PRRID_0935	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	leads to cytokine activation, especially¬†IL-1Œ±¬†and¬†IL-1Œ≤.	Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing3 (Nalp3)	NOD-like receptor (NLR)	Human	Eosinophils	NA	Q96P20.fasta	Q96P20	1036	recognizes fragments of the bacterial cell wall	real-time reverse transcription-PCR, FACS, ELISA	21978001	2011	Pubchem Assay
PRRID_0935	MDP (muramyldipeptide) Click for more detail	Gram-negative and Gram-positive bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	leads to cytokine activation, especially¬†IL-1Œ±¬†and¬†IL-1Œ≤.	Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing3 (Nalp3)	NOD-like receptor (NLR)	Human	Eosinophils	NA	Q96P20.fasta	Q96P20	1036	recognizes fragments of the bacterial cell wall	real-time reverse transcription-PCR, FACS, ELISA	21978001	2011	Pubchem Assay
PRRID_0937	mRNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	Q9NYK1.fasta	Q9NYK1	1049	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21982558	2011	Pubchem Assay
PRRID_0937	mRNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	Q9NYK1.fasta	Q9NYK1	1049	TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands	NA	21982558	2011	Pubchem Assay
PRRID_0938	Oligosaccharides of hyaluronic acid (HA) Click for more detail	Endogenous (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	MDA5	Rig-like receptor (RLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	Q53TB6.fasta	Q53TB6	435	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0938	Oligosaccharides of hyaluronic acid (HA) Click for more detail	Endogenous (others)	CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O	NA	Damage-associated molecular patterns (DAMPs)	Natural	the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction	MDA5	Rig-like receptor (RLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	Q53TB6.fasta	Q53TB6	435	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0939	Paclitaxel Click for more detail	Pacific yew (plant)	C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	used to treat a number of types of¬†cancer	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	Q9HC29.fasta	Q9HC29	1040	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0939	Paclitaxel Click for more detail	Pacific yew (plant)	C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	used to treat a number of types of¬†cancer	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	Q9HC29.fasta	Q9HC29	1040	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21982558	2011	Pubchem Assay
PRRID_0940	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS was also shown to play a role in alloimmune lung injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	Intracellular TIR domains	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21959264	2011	Pubchem Assay
PRRID_0940	Lipopolysaccharide (LPS) Click for more detail	Gram negative Bacteria (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS was also shown to play a role in alloimmune lung injury	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	NA	Intracellular TIR domains	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway¬†NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	NA	21959264	2011	Pubchem Assay
PRRID_0943	Pam2CSK4 Click for more detail	NA	CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	diacylated lipopeptide	Synthetic	Bacterial lipoproteins are strong immune modulators that activate early innate host responses after infection	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Intracellular TIR domains	O60603.fasta	O60603	784	fundamental role in pathogen recognition and activation of innate immunity	NA	21959264	2011	Pubchem Assay
PRRID_0943	Pam2CSK4 Click for more detail	NA	CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	diacylated lipopeptide	Synthetic	Bacterial lipoproteins are strong immune modulators that activate early innate host responses after infection	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Intracellular TIR domains	O60603.fasta	O60603	784	fundamental role in pathogen recognition and activation of innate immunity	NA	21959264	2011	Pubchem Assay
PRRID_0946	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0946	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0948	phenol-soluble modulin Click for more detail	S. aureus (Bacteria)	MEFVAKLFKFFKDLLGKFLGNN	22	Protein	Natural	triggers immune responses	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0948	phenol-soluble modulin Click for more detail	S. aureus (Bacteria)	MEFVAKLFKFFKDLLGKFLGNN	22	Protein	Natural	triggers immune responses	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	Myeloid cells, dendritic cells, microglia, astrocytes	NA	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0950	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	elicit innate immune response	RIG-1	Rig-like receptor (RLR)	Human	Eosinophils	NA	O95786.fasta	O95786	925	mediate the efficient induction of the type I IFN response	real-time reverse transcription-PCR, FACS, ELISA	21978001	2011	Pubchem Assay
PRRID_0950	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	elicit innate immune response	RIG-1	Rig-like receptor (RLR)	Human	Eosinophils	NA	O95786.fasta	O95786	925	mediate the efficient induction of the type I IFN response	real-time reverse transcription-PCR, FACS, ELISA	21978001	2011	Pubchem Assay
PRRID_0953	Porins Click for more detail	outer membrane of bacterial cell wall (others)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	act as a pore, through which molecules can diffuse	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0953	Porins Click for more detail	outer membrane of bacterial cell wall (others)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	act as a pore, through which molecules can diffuse	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	NA	21982558	2011	Pubchem Assay
PRRID_0955	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	induction of immune response against T. gondii	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	Myeloid cells, uroepithelial cells	NA	NA	NA	NA	induces the release of interleukin 12 against T. gondii infected mice	NA	21982558	2011	NA
PRRID_0955	profilin-like protein Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	induction of immune response against T. gondii	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Human	Myeloid cells, uroepithelial cells	NA	NA	NA	NA	induces the release of interleukin 12 against T. gondii infected mice	NA	21982558	2011	NA
PRRID_0958	Saturated fatty acids Click for more detail	Endogenous (others)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0958	Saturated fatty acids Click for more detail	Endogenous (others)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons	NA	O60603.fasta	O60603	784	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	21982558	2011	Pubchem Assay
PRRID_0959	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	21982558	2011	Pubchem Assay
PRRID_0959	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	B cells, dendritic cells, microglia, astrocytes	NA	Q9NYK1.fasta	Q9NYK1	1049	important role in the immune response to viral infection	NA	21982558	2011	Pubchem Assay
PRRID_0960	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	21982558	2011	Pubchem Assay
PRRID_0960	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	Myeloid cells, microglia, astrocytes, neurons	NA	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	21982558	2011	Pubchem Assay

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