Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1060Heat-shock protein 70

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Endogenous (others)MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD641Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1060Heat-shock protein 70

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Endogenous (others)MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD641Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1062Heat-shock proteins 60

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Host (Endogenous) (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573ProteinNaturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman peripheral blood mononuclear cells (hPBMCs)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA240168502013Pubchem_assay
PRRID_1062Heat-shock proteins 60

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Host (Endogenous) (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573ProteinNaturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman peripheral blood mononuclear cells (hPBMCs)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA240168502013Pubchem_assay
PRRID_1064Heparan sulfate

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NACOC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)ONADamage-associated molecular patterns (DAMPs)Naturalinduce the maturation of DCs Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAO60602.fastaO60602858Serum heparan sulfate levels were associated with GVHDNA239853022013Pubchem_assay
PRRID_1064Heparan sulfate

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NACOC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)ONADamage-associated molecular patterns (DAMPs)Naturalinduce the maturation of DCs Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAO60602.fastaO60602858Serum heparan sulfate levels were associated with GVHDNA239853022013Pubchem_assay
PRRID_1065HKLM

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heat-killed Listeria monocytogenes (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NF-240985082013Pubchem_assay
PRRID_1065HKLM

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heat-killed Listeria monocytogenes (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NF-240985082013Pubchem_assay
PRRID_1066HKVP

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heat-killed Vibrio Parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784NANF-240985082013Pubchem_assay
PRRID_1066HKVP

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heat-killed Vibrio Parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784NANF-240985082013Pubchem_assay
PRRID_1067HMGB1

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Neisseria meningitidis (Bacteria)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs O60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1067HMGB1

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Neisseria meningitidis (Bacteria)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs O60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1069Heat-shock protein 70

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Endogenous (others)MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD641Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1069Heat-shock protein 70

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Endogenous (others)MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD641Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1071HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAO00206.fastaO00206839Polymorphisms of HMBG1 are associated with GVHD, TRM and OSNA239853022013Pubchem_assay
PRRID_1071HMGB1

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NAMGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAO00206.fastaO00206839Polymorphisms of HMBG1 are associated with GVHD, TRM and OSNA239853022013Pubchem_assay
PRRID_1072HMGB1

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Endogenous (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), Toll-like receptor 9 (TLR9), RAGE and CD24Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) NANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013NA
PRRID_1072HMGB1

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Endogenous (others)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalplay an important role in infectious inflammatory responses.Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), Toll-like receptor 9 (TLR9), RAGE and CD24Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) NANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013NA
PRRID_1074HSP-20

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Endogenous (others)MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPTTLAPYYLRAPSVALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK160Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1074HSP-20

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Endogenous (others)MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGLLEAELAALCPTTLAPYYLRAPSVALPVAQVPTDPGHFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEHGFVAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK160Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1076HSP-60

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Endogenous (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1076HSP-60

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Endogenous (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1078HSP-60

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Endogenous (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1078HSP-60

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Endogenous (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1080HSP-96

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Endogenous (others)MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL803Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1080HSP-96

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Endogenous (others)MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL803Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1082HSP-96

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Endogenous (others)MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL803Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1082HSP-96

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Endogenous (others)MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL803Damage-associated molecular patterns (DAMPs)Naturaltriggers immune responsesToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1084Hyaluronan

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)Naturalthe activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAO00206.fastaO00206839CD44– hyaluronan contribute to lymphocytotropism to skin GVHDNA239853022013Pubchem_assay
PRRID_1084Hyaluronan

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NACC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)Naturalthe activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAO00206.fastaO00206839CD44– hyaluronan contribute to lymphocytotropism to skin GVHDNA239853022013Pubchem_assay
PRRID_1085Imiquimod

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imidazoquinoline amine analogue to guanosine (others)CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)NaturalAmine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanHEK293 cellsNAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNF-240985082013Pubchem_assay
PRRID_1085Imiquimod

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imidazoquinoline amine analogue to guanosine (others)CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)NaturalAmine analog to guanosine, is an immune response modifier with potent indirect antiviral activity.Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)HumanHEK293 cellsNAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNF-240985082013Pubchem_assay
PRRID_1086Hyaluronan

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Endogenous (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)Naturalthe activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4) and CD44Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) NANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013NA
PRRID_1086Hyaluronan

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Endogenous (others)CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)ONADamage-associated molecular patterns (DAMPs)Naturalthe activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4) and CD44Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) NANANAplays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013NA
PRRID_1089Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Syntheticelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman peripheral blood mononuclear cells (hPBMCs)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA240168502013Pubchem_assay
PRRID_1089Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Syntheticelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman peripheral blood mononuclear cells (hPBMCs)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA240168502013Pubchem_assay
PRRID_1091Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4) in association with CD14 and MD2 Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemRT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1091Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4) in association with CD14 and MD2 Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemRT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1093Lipid A

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NACCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAFatty acid Syntheticelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1093Lipid A

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NACCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAFatty acid Syntheticelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1096Lipopolysaccharide (LPS)

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E. coli K12(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHEK293 cellsNAO00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNF-240985082013Pubchem_assay
PRRID_1096Lipopolysaccharide (LPS)

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E. coli K12(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHEK293 cellsNAO00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNF-240985082013Pubchem_assay
PRRID_1099Lipoprotein

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Gram-positive bacteriaNANAFatty acid Syntheticelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses RT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1099Lipoprotein

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Gram-positive bacteriaNANAFatty acid Syntheticelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses RT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1101Lipoprotein

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Various pathogens (others)NANAFatty acid Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs O60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1101Lipoprotein

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Various pathogens (others)NANAFatty acid Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs O60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1104Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1104Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNA239853022013Pubchem_assay
PRRID_1107Macrophage activating lipoprotein-2 (MALP-2)

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Mycoplasma fermentans (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt primes macrophages for cytokines secretion Toll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1107Macrophage activating lipoprotein-2 (MALP-2)

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Mycoplasma fermentans (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt primes macrophages for cytokines secretion Toll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1109Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS was also shown to play a role in alloimmune lung injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA239853022013Pubchem_assay
PRRID_1109Lipopolysaccharide (LPS)

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Gram-negative bacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS was also shown to play a role in alloimmune lung injuryToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA239853022013Pubchem_assay
PRRID_1111nonmethylated CpG-containing DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseRT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1111nonmethylated CpG-containing DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseRT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1112ODN2006

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oligonucleotides containing unmethylated CpG dinucleotides (others)5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)Syntheticinduce strong immunostimulatory effects trough activation of TLR9 in mammalian cells and type B CpG ODN2006 significantly induced IL-1b and IFN-a1Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanHEK293 cellsNAQ9NR96.fastaQ9NR961032TLR9 plays a crucial role in breaking tolerance and developing autoimmunity NF-240985082013Pubchem_assay
PRRID_1112ODN2006

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oligonucleotides containing unmethylated CpG dinucleotides (others)5’-tcgtcgttttgtcgttttgtcgtt-3’24Pattern-associated molecular patterns (PAMPs)Syntheticinduce strong immunostimulatory effects trough activation of TLR9 in mammalian cells and type B CpG ODN2006 significantly induced IL-1b and IFN-a1Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanHEK293 cellsNAQ9NR96.fastaQ9NR961032TLR9 plays a crucial role in breaking tolerance and developing autoimmunity NF-240985082013Pubchem_assay
PRRID_1113Pam3CSK4

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synthetic tripalmitoylated lipopeptide (others)CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONALipoproteinSynthetictriacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB. Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanHEK293 cellsNANANANAsignificant role in the pathogenesis of severe inflammatory responses NF-240985082013NA
PRRID_1113Pam3CSK4

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synthetic tripalmitoylated lipopeptide (others)CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONALipoproteinSynthetictriacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB. Toll-like receptor 1/2 (TLR1/2)Toll-like receptor (TLR)HumanHEK293 cellsNANANANAsignificant role in the pathogenesis of severe inflammatory responses NF-240985082013NA
PRRID_1116Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses RT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1116Peptidoglycan (PGN)

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Gram-positive bacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses RT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1118Peptidoglycan (PGN)

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Treponema maltophilum (others)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPlay an important role in infectious inflammatory responses.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1118Peptidoglycan (PGN)

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Treponema maltophilum (others)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPlay an important role in infectious inflammatory responses.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1120Peptidoglycan (PGN)

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Bacillus subtilis(Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NF-240985082013Pubchem_assay
PRRID_1120Peptidoglycan (PGN)

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Bacillus subtilis(Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NF-240985082013Pubchem_assay
PRRID_1121Poly-g-glutamic acid (g-PGA)

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Bacillus subtilis(Bacteria)C(CC(C(=O)O)NC(=O)CCC(C(=O)O)NC(=O)CCC(C(=O)O)NC(=O)CCC(C(=O)O)N)C=ONAanionic polypeptideNaturalactivate immune cells through interactions with toll-like receptor 4 (TLR4). It is able to activate the subsequent signals through TLR4/MD2 to result in dimerization of IRF-3Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman peripheral blood mononuclear cells (hPBMCs)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA240168502013Pubchem_assay
PRRID_1121Poly-g-glutamic acid (g-PGA)

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Bacillus subtilis(Bacteria)C(CC(C(=O)O)NC(=O)CCC(C(=O)O)NC(=O)CCC(C(=O)O)NC(=O)CCC(C(=O)O)N)C=ONAanionic polypeptideNaturalactivate immune cells through interactions with toll-like receptor 4 (TLR4). It is able to activate the subsequent signals through TLR4/MD2 to result in dimerization of IRF-3Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman peripheral blood mononuclear cells (hPBMCs)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA240168502013Pubchem_assay
PRRID_1122mRNA

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Endogenous (others)NANANucleic AcidNaturaltriggers immune responsesToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanDendritic Cell, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O15455.fastaO15455904induce type I interferons (IFN) and other cytokines production.NA239853022013Pubchem_assay
PRRID_1122mRNA

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Endogenous (others)NANANucleic AcidNaturaltriggers immune responsesToll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanDendritic Cell, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O15455.fastaO15455904induce type I interferons (IFN) and other cytokines production.NA239853022013Pubchem_assay
PRRID_1124polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticact as a TLR3 agonist and induces protective responses against rapidly growing tumor cells Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanHEK293 cellsNAO15455.fastaO15455904induce type I interferons (IFN) and other cytokines production.NF-240985082013Pubchem_assay
PRRID_1124polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticact as a TLR3 agonist and induces protective responses against rapidly growing tumor cells Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanHEK293 cellsNAO15455.fastaO15455904induce type I interferons (IFN) and other cytokines production.NF-240985082013Pubchem_assay
PRRID_1125Porins

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FungiMRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396ProteinNaturalelicit innate immune responseToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1125Porins

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FungiMRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396ProteinNaturalelicit innate immune responseToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1127polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticact as a TLR3 agonist and induces protective responses against rapidly growing tumor cells Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanDendritic Cell, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O15455.fastaO15455904induce type I interferons (IFN) and other cytokines production.NA239853022013Pubchem_assay
PRRID_1127polyinosinic-polycytidylic acid [poly(I:C)]

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NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticact as a TLR3 agonist and induces protective responses against rapidly growing tumor cells Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)HumanDendritic Cell, B-lymphocytesignaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) O15455.fastaO15455904induce type I interferons (IFN) and other cytokines production.NA239853022013Pubchem_assay
PRRID_1130muramyl dipeptide (MDP)

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Gram-positive and negative bacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturala component of bacterial peptidoglycan, and induces NF-jB activation, leading to enhanced Th1 responses Nod-like receptor protein 3 (P2X7R) (NLRP3 (P2X7R)NOD-like receptor (NLR)Humangraft-versus-host disease (GVHD)NAQ96P20.fastaQ96P201036NOD2 functions as a primary sensor of microbial products inducing inflammatory T-cell responses and also negatively regulates TLR-mediated responsesNA239853022013Pubchem_assay
PRRID_1130muramyl dipeptide (MDP)

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Gram-positive and negative bacteriaCC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptideNaturala component of bacterial peptidoglycan, and induces NF-jB activation, leading to enhanced Th1 responses Nod-like receptor protein 3 (P2X7R) (NLRP3 (P2X7R)NOD-like receptor (NLR)Humangraft-versus-host disease (GVHD)NAQ96P20.fastaQ96P201036NOD2 functions as a primary sensor of microbial products inducing inflammatory T-cell responses and also negatively regulates TLR-mediated responsesNA239853022013Pubchem_assay
PRRID_1132Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)O60603.fastaO60603784fundamental role in pathogen recognition and activation of innate immunity.NA239853022013Pubchem_assay
PRRID_1132Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)O60603.fastaO60603784fundamental role in pathogen recognition and activation of innate immunity.NA239853022013Pubchem_assay
PRRID_1134Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1134Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1136S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalNARAGEReceptor for advanced glycation endproducts (RAGE)Humangraft-versus-host disease (GVHD)NANANANAS100 proteins were significantly more detected in saliva of GVHD patientsNA239853022013NA
PRRID_1136S100 proteins

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NAMSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE92Damage-associated molecular patterns (DAMPs)NaturalNARAGEReceptor for advanced glycation endproducts (RAGE)Humangraft-versus-host disease (GVHD)NANANANAS100 proteins were significantly more detected in saliva of GVHD patientsNA239853022013NA
PRRID_1137Serum amyloid

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Gram-positive bacteriaMKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY122PeptideNaturalPlay an important role in infectious inflammatory responses.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1137Serum amyloid

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Gram-positive bacteriaMKLLTGLVFCSLVLGVSSRSFFSFLGEAFDGARDMWRAYSDMREANYIGSDKYFHARGNYDAAKRGPGGVWAAEAISDARENIQRFFGHGAEDSLADQAANEWGRSGKDPNHFRPAGLPEKY122PeptideNaturalPlay an important role in infectious inflammatory responses.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1139single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor (TLR7) and Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNANANANAimportant role in the immune response to viral infectionRT-PCR, Quantitative real-time PCR239982722013NA
PRRID_1139single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor (TLR7) and Toll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNANANANAimportant role in the immune response to viral infectionRT-PCR, Quantitative real-time PCR239982722013NA
PRRID_1140Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, mast cellsCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1140Resiquimod (R-848)

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticimmune-response modifier possessing antiviral and antitumor activityand also induces the differentiation of MDSCs into mature myeloid cells Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, mast cellsCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1142single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1142single-stranded RNA

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VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1144single-stranded RNA

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Endogenous (others)NANANucleic AcidSynthetictriggers immune responsesToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NR97.fastaQ9NR971041important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1144single-stranded RNA

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Endogenous (others)NANANucleic AcidSynthetictriggers immune responsesToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanmonocyte/macrophages, plasmacytoid DCs and B-lymphocytesCell Compartment/Intracellular (Endosome)Q9NR97.fastaQ9NR971041important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1146single-stranded RNA

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VirusNANANucleic AcidNaturalelicit innate immune responseToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, mast cellsCell Compartment/Intracellular (Endosome)Q9NR97.fastaQ9NR971041important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1146single-stranded RNA

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VirusNANANucleic AcidNaturalelicit innate immune responseToll-like receptor 8 (TLR8)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, mast cellsCell Compartment/Intracellular (Endosome)Q9NR97.fastaQ9NR971041important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1148R-848

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticsufficient to permit access of activated T-cells to peripheral tissues and induce GVHDToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1148R-848

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imidazoquinoline (others)CCOCC1=NC2=C(N1CC(C)(C)O)C3=CC=CC=C3N=C2NNAPattern-associated molecular patterns (PAMPs)Syntheticsufficient to permit access of activated T-cells to peripheral tissues and induce GVHDToll-like receptor 7 (TLR7)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAQ9NYK1.fastaQ9NYK11049important role in the immune response to viral infectionNA239853022013Pubchem_assay
PRRID_1150single-stranded RNA

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VirusNANANucleic AcidNaturalelicit innate immune responseToll-like receptor 7/8 (TLR7/8)Toll-like receptor (TLR)HumanHEK293 cellsNANANANAimportant role in the immune response to viral infectionNF-240985082013NA
PRRID_1150single-stranded RNA

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VirusNANANucleic AcidNaturalelicit innate immune responseToll-like receptor 7/8 (TLR7/8)Toll-like receptor (TLR)HumanHEK293 cellsNANANANAimportant role in the immune response to viral infectionNF-240985082013NA
PRRID_1151single-stranded RNA

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VirusNANANucleic AcidNaturalelicit innate immune responseToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanHEK293 cellsNAQ9NR97.fastaQ9NR971041important role in the immune response to viral infectionNF-240985082013Pubchem_assay
PRRID_1151single-stranded RNA

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VirusNANANucleic AcidNaturalelicit innate immune responseToll-like receptor 8 (TLR8)Toll-like receptor (TLR)HumanHEK293 cellsNAQ9NR97.fastaQ9NR971041important role in the immune response to viral infectionNF-240985082013Pubchem_assay