Primary information |
---|
PRRID | PRRID_1086 |
Ligand Name | Hyaluronan |
Source | Endogenous (others) |
Sequence of ligand | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O |
Length | NA |
Type | Damage-associated molecular patterns (DAMPs) |
Occurence | Natural |
Role of Ligand | the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction |
Name of receptor | Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4) and CD44 |
Type of receptor | Toll-like receptor (TLR) |
Source | Human |
Localization | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte |
Domain | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) |
Sequence of Receptor | NA |
Swiss prot ID | NA |
Length Of Receptor | NA |
Function | plays a fundamental role in pathogen recognition and activation of innate immunity |
Assay used | NA |
PMID | 23985302 |
Year of Publication | 2013 |
Pubchem assay | NA |
Primary information |
---|
PRRID | PRRID_1086 |
Ligand Name | Hyaluronan |
Source | Endogenous (others) |
Sequence of ligand | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O |
Length | NA |
Type | Damage-associated molecular patterns (DAMPs) |
Occurence | Natural |
Role of Ligand | the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction |
Name of receptor | Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4) and CD44 |
Type of receptor | Toll-like receptor (TLR) |
Source | Human |
Localization | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte |
Domain | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) |
Sequence of Receptor | NA |
Swiss prot ID | NA |
Length Of Receptor | NA |
Function | plays a fundamental role in pathogen recognition and activation of innate immunity |
Assay used | NA |
PMID | 23985302 |
Year of Publication | 2013 |
Pubchem assay | NA |