Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1153	SNApin A Click for more detail	Endogenous (others)	MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK	136	Peptide	Natural	Play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1153	SNApin A Click for more detail	Endogenous (others)	MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK	136	Peptide	Natural	Play an important role in infectious inflammatory responses.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1155	single-stranded RNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1155	single-stranded RNA Click for more detail	Endogenous (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	23985302	2013	Pubchem_assay
PRRID_1157	Soluble tuberculosis factor Click for more detail	Endogenous (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	23985302	2013	NA
PRRID_1157	Soluble tuberculosis factor Click for more detail	Endogenous (others)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	elicit innate immune response	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	23985302	2013	NA
PRRID_1159	surfactant protein-A Click for more detail	Endogenous (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1159	surfactant protein-A Click for more detail	Endogenous (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1161	Tenascin C Click for more detail	Endogenous (others)	MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDS	2110 and 2201	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1161	Tenascin C Click for more detail	Endogenous (others)	MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDS	2110 and 2201	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in¬†pathogen¬†recognition and activation of¬†innate immunity	NA	23985302	2013	Pubchem_assay
PRRID_1164	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1164	Triacylated lipopeptides Click for more detail	Bacteria and mycobacteria	NA	NA	Lipopeptides	Natural	elicit innate immune response	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, B-lymphocytes	extracellular domains of leucine-rich repeat motifs	NA	NA	NA	significant role in the pathogenesis of severe inflammatory responses	NA	23985302	2013	NA
PRRID_1166	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	induction of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1166	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	induction of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	testis, epididymis, vasa deferens, prostate and prepuce	NA	O60603.fasta	O60603	784	significant role in the pathogenesis of severe inflammatory responses	RT-PCR, Quantitative real-time PCR	23998272	2013	Pubchem_assay
PRRID_1169	Unmethylated CpG DNA Click for more detail	Host/microbial (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1169	Unmethylated CpG DNA Click for more detail	Host/microbial (others)	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	NA	23985302	2013	Pubchem_assay
PRRID_1171	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	elicit innate immune response	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	23985302	2013	NA
PRRID_1171	Zymosan Click for more detail	Fungi	C(C1C(C(C(C(O1)O)O)O)O)O	NA	Glucan	Natural	elicit innate immune response	Toll-like receptor 6 /2 (TLR6/2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	23985302	2013	NA
PRRID_1172	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR97.fasta	Q9NR97	1041	induces anti-viral response	NA	23985302	2013	Pubchem_assay
PRRID_1172	single-stranded RNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	Q9NR97.fasta	Q9NR97	1041	induces anti-viral response	NA	23985302	2013	Pubchem_assay
PRRID_1173	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1173	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	regulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicity	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	graft-versus-host disease (GVHD)	NA	O60602.fasta	O60602	858	It stimulates the production of proinflammatory cytokines, such as TNF-Œ±, through signaling via the adaptor protein MyD88.	NA	23985302	2013	Pubchem_assay
PRRID_1175	1-b-D-arabinofuranosylcytosine (Ara-C) Click for more detail	Lipid (PAMPS) (others)	C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O	NA	Fatty acid	Synthetic	genotoxic anticancer agent	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas)	B-cell lymphoma cell lines	cell surface	NA	NA	NA	an alkylating chemotherapeutic agent that induces immunogenic cell death and is commonly used to treat B-cell NHL	ELISA	24799523	2014	NA
PRRID_1175	1-b-D-arabinofuranosylcytosine (Ara-C) Click for more detail	Lipid (PAMPS) (others)	C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O	NA	Fatty acid	Synthetic	genotoxic anticancer agent	Toll-like receptor 1/2 (TLR1/2)	Toll-like receptor (TLR)	Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas)	B-cell lymphoma cell lines	cell surface	NA	NA	NA	an alkylating chemotherapeutic agent that induces immunogenic cell death and is commonly used to treat B-cell NHL	ELISA	24799523	2014	NA
PRRID_1176	5‚Ä- triphosphate ssRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	RIG-1	Rig-like receptor (RLR)	Human	most adult tissues	helicase domain	O95786.fasta	O95786	925	mediate the efficient induction of the type I IFN response.	NA	24762827	2014	Pubchem_assay
PRRID_1176	5‚Ä- triphosphate ssRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	RIG-1	Rig-like receptor (RLR)	Human	most adult tissues	helicase domain	O95786.fasta	O95786	925	mediate the efficient induction of the type I IFN response.	NA	24762827	2014	Pubchem_assay
PRRID_1179	Albeit lipoproteins Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	O60603.fasta	O60603	784	promote pro-inflammatory cytokine responses and prime Th1 and Th17 responses.	ELISA	24810614	2014	Pubchem_assay
PRRID_1179	Albeit lipoproteins Click for more detail	cell wall of Gram-positive bacteria(Bacteria)	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	O60603.fasta	O60603	784	promote pro-inflammatory cytokine responses and prime Th1 and Th17 responses.	ELISA	24810614	2014	Pubchem_assay
PRRID_1181	amidation of the mesoDAP Click for more detail	PGN of Gram-positive bacteria	C(CC(C(=O)O)N)CC(C(=O)O)N	NA	Protein	Natural	activates NOD2 but not recognised by NOD2	CAD	NOD-like receptor (NLR)	Human	most adult tissues	intracellular receptors	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24779390	2014	Pubchem_assay
PRRID_1181	amidation of the mesoDAP Click for more detail	PGN of Gram-positive bacteria	C(CC(C(=O)O)N)CC(C(=O)O)N	NA	Protein	Natural	activates NOD2 but not recognised by NOD2	CAD	NOD-like receptor (NLR)	Human	most adult tissues	intracellular receptors	Q9Y239.fasta	Q9Y239	953	play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response.	NA	24779390	2014	Pubchem_assay
PRRID_1182	anti-citrullinated protein antibody-positive (ACPA+) RA. Click for more detail	Present in the majority of patients with Rheumatoid arthritis (others)	NA	NA	NA	Natural	NA	Caspase-1	NOD-like receptor (NLR)	Human	mast cells	NA	B4DVD8.fasta	B4DVD8	301	contribute to the protective functions of the immune cells	Flow cytometry	24818634	2014	Pubchem_assay
PRRID_1182	anti-citrullinated protein antibody-positive (ACPA+) RA. Click for more detail	Present in the majority of patients with Rheumatoid arthritis (others)	NA	NA	NA	Natural	NA	Caspase-1	NOD-like receptor (NLR)	Human	mast cells	NA	B4DVD8.fasta	B4DVD8	301	contribute to the protective functions of the immune cells	Flow cytometry	24818634	2014	Pubchem_assay
PRRID_1183	bacterial and viral nucleic acids containing CpG motifs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	HSP90	Pattern recognition receptor (PRR)	Human	induces pro-inflammatory cytokine response	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1183	bacterial and viral nucleic acids containing CpG motifs Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	HSP90	Pattern recognition receptor (PRR)	Human	induces pro-inflammatory cytokine response	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1184	bacterial RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1184	bacterial RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1185	Viral RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1185	Viral RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NYK1.fasta	Q9NYK1	1049	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1186	bacterialRNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor protein 12(NLRP12)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1186	bacterialRNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	Nod-like receptor protein 12(NLRP12)	NOD-like receptor (NLR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1188	Bacterial lipoprotein Click for more detail	Francisella novicida (Bacteria)	MKYGNLMMTKKKLLIGMVTISGIVILGSCGKTETVNELLIVDQCNDVRDLCRLELANAQVSRYTNFLGKTIKRLQSQTPLRDIQGTVTWNASAGTSLADNSDVQSELGLSCQDDNCTANSNSTAYTLPVGSNTISVSGTVTVDGKTIDLATDVPALVINTSAAGSSVHVFPTELEGNLTLQDLVDSLNQGRHYAHATFSADGSNLKIQCDPGYVWLDDINPEYGGQSSAASARSVAMVSWVEELEEFRVDEFRFLHFDMSSLTLNGVRLGNHVFWEMGCWPT	282	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24772391	2014	Pubchem_assay
PRRID_1188	Bacterial lipoprotein Click for more detail	Francisella novicida (Bacteria)	MKYGNLMMTKKKLLIGMVTISGIVILGSCGKTETVNELLIVDQCNDVRDLCRLELANAQVSRYTNFLGKTIKRLQSQTPLRDIQGTVTWNASAGTSLADNSDVQSELGLSCQDDNCTANSNSTAYTLPVGSNTISVSGTVTVDGKTIDLATDVPALVINTSAAGSSVHVFPTELEGNLTLQDLVDSLNQGRHYAHATFSADGSNLKIQCDPGYVWLDDINPEYGGQSSAASARSVAMVSWVEELEEFRVDEFRFLHFDMSSLTLNGVRLGNHVFWEMGCWPT	282	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	cell surface	O60603.fasta	O60603	784	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24772391	2014	Pubchem_assay
PRRID_1200	Viral RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	JNKBP1	Pattern recognition receptor (PRR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1200	Viral RNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	elicit innate immune response	JNKBP1	Pattern recognition receptor (PRR)	Human	plasmacytoid and myeloid DCs	extracellular domain (ECD)	Q9NR97.fasta	Q9NR97	1041	controlling antiviral host defense or autoimmune diseases and TLR8 and respond to its activation with TNF production and/or degranulation	Microarray analysis, Quantitative PCR, Phosphoproteomic screen, Confocal cell imaging,RNA40 pull-down assay and Immunoblot	24813206	2014	Pubchem_assay
PRRID_1205	CL075 Click for more detail	Thiazoloquinoline compound (others)	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-Œ∫B and triggers preferentially the production of TNF-Œ± and IL-12	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	lung cancer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	binding of TLR8 to its ligand stimulated cell proliferation	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1205	CL075 Click for more detail	Thiazoloquinoline compound (others)	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-Œ∫B and triggers preferentially the production of TNF-Œ± and IL-12	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	lung cancer cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	binding of TLR8 to its ligand stimulated cell proliferation	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1207	CL075 Click for more detail	Thiazoloquinoline compound (others)	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-Œ∫B and triggers preferentially the production of TNF-Œ± and IL-12	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1207	CL075 Click for more detail	Thiazoloquinoline compound (others)	CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-Œ∫B and triggers preferentially the production of TNF-Œ± and IL-12	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1209	CL097 Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces the activation of NF-Œ∫B	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1209	CL097 Click for more detail	imidazoquinoline (others)	CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N	NA	Nucleic Acid	Synthetic	It induces the activation of NF-Œ∫B	Toll-like receptor 7/8 (TLR7/8)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	cell compartment	NA	NA	NA	important role in the immune response to viral infection	ELISA	24771328	2014	NA
PRRID_1212	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1212	CpG DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	T cell differentiation assay	24760154	2014	Pubchem_assay
PRRID_1213	CpG motif Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1213	CpG motif Click for more detail	Bacteria	NA	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	Real-time PCR	24818634	2014	Pubchem_assay
PRRID_1215	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1215	CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	cell compartment	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1221	CpG-A (ODN2216) Click for more detail	Bacteria	5‚Äô-ggGGGACGA:TCGTCgggggg-3‚Äô	20	Nucleic Acid	Synthetic	A-class CpG ODNs activate Toll-like receptor 9 (TLR9), leading to strong immunostimulatory effects.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1221	CpG-A (ODN2216) Click for more detail	Bacteria	5‚Äô-ggGGGACGA:TCGTCgggggg-3‚Äô	20	Nucleic Acid	Synthetic	A-class CpG ODNs activate Toll-like receptor 9 (TLR9), leading to strong immunostimulatory effects.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1222	CpG-B (ODN2006) Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	B-class strongly activate B cells but weakly stimulate IFN-Œ± secretion in pDCs.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	pDCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1222	CpG-B (ODN2006) Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	B-class strongly activate B cells but weakly stimulate IFN-Œ± secretion in pDCs.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	pDCs, mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1223	CpG-C (ODN M362) Click for more detail	Bacteria	5‚Äô-tcgtcgtcgttc:gaacgacgttgat-3‚Äô	25	Nucleic Acid	Synthetic	C-class act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1223	CpG-C (ODN M362) Click for more detail	Bacteria	5‚Äô-tcgtcgtcgttc:gaacgacgttgat-3‚Äô	25	Nucleic Acid	Synthetic	C-class act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	mast cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	TLR9 plays a crucial role in breaking tolerance and developing autoimmunity	ELISA	24771328	2014	Pubchem_assay
PRRID_1225	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	caused an increase in the mean tumor weight and the size of tumor mass in nude mice, and the proliferation and migration of H460 human lung cancer cells.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	H460 human lung cancer cell line	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays significant role in cancer and promoted the growth and migration of lung cancer and miR-26a is involved in the TLR9-mediated growth and migration of lung cancer through the PI3K-Akt signaling pathway.	Cell proliferation assay, BrdUrd ELISA colorimetric assay, Cell migration assay	24788552	2014	Pubchem_assay
PRRID_1225	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	caused an increase in the mean tumor weight and the size of tumor mass in nude mice, and the proliferation and migration of H460 human lung cancer cells.	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	H460 human lung cancer cell line	intracellular receptors	Q9NR96.fasta	Q9NR96	1032	TLR9 plays significant role in cancer and promoted the growth and migration of lung cancer and miR-26a is involved in the TLR9-mediated growth and migration of lung cancer through the PI3K-Akt signaling pathway.	Cell proliferation assay, BrdUrd ELISA colorimetric assay, Cell migration assay	24788552	2014	Pubchem_assay
PRRID_1228	cytosine-phosphate-guanine (CpG) oligonucleotides (pG-ODN2006 Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	endosomal receptor	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISA and Immunofluoroscence assay	24830384	2014	Pubchem_assay
PRRID_1228	cytosine-phosphate-guanine (CpG) oligonucleotides (pG-ODN2006 Click for more detail	Bacteria	5‚Äô-tcgtcgttttgtcgttttgtcgtt-3‚Äô	24	Nucleic Acid	Synthetic	act as immuno stimulants	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	endosomal receptor	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	ELISA and Immunofluoroscence assay	24830384	2014	Pubchem_assay
PRRID_1230	Defensins Click for more detail	Host (Endogenous) (others)	MRTSYLLLFTLCLLLSEMASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK	68	Peptide	Natural	Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell surface	O00206.fasta	O00206	839	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1230	Defensins Click for more detail	Host (Endogenous) (others)	MRTSYLLLFTLCLLLSEMASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK	68	Peptide	Natural	Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell surface	O00206.fasta	O00206	839	play a role in UVB induced immune suppression	NA	24786223	2014	Pubchem_assay
PRRID_1234	Diacylated Lipopeptide Click for more detail	Mycoplasma, Gram-positive bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	24830024	2014	NA
PRRID_1234	Diacylated Lipopeptide Click for more detail	Mycoplasma, Gram-positive bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells	Cell Surface (Exogenous)	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	NA	24830024	2014	NA
PRRID_1237	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, mast cells and B-lymphocytes	cell surface	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	24807166	2014	Pubchem_assay
PRRID_1237	Diacylated Lipopeptide Click for more detail	Mycoplasma (Bacteria)	NA	NA	Pattern-associated molecular patterns (PAMPs)	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, mast cells and B-lymphocytes	cell surface	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	24807166	2014	Pubchem_assay
PRRID_1239	Diacylated lipoprotein Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, mast cells and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1239	Diacylated lipoprotein Click for more detail	Bacteria	NA	NA	Fatty acid	Natural	elicit innate immune response	Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	monocyte/macrophages, mast cells and B-lymphocytes	extracellular domains of leucine-rich repeat motifs	Q9Y2C9.fasta	Q9Y2C9	796	significant role in the pathogenesis of severe inflammatory responses	NA	24754320	2014	Pubchem_assay
PRRID_1240	diacylated macrophage-activating lipopeptide 2 (MALP-2) Click for more detail	Mycoplasma fermentans (Bacteria)	NA	NA	Microbe associated molecular patterns (MAMP)	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA and Immunofluoroscence assay	24830384	2014	NA
PRRID_1240	diacylated macrophage-activating lipopeptide 2 (MALP-2) Click for more detail	Mycoplasma fermentans (Bacteria)	NA	NA	Microbe associated molecular patterns (MAMP)	Natural	It primes macrophages for cytokines secretion	Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6)	Toll-like receptor (TLR)	Human	nasal mucosa Mesenchymal stromal cells (nmMSCs) inferior nasal concha of healthy individuals	cell surface	NA	NA	NA	fundamental role in pathogen recognition and activation of innate immunity.	ELISA and Immunofluoroscence assay	24830384	2014	NA
PRRID_1242	DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1242	DNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages, natural killer cells	Cell Compartment/Intracellular (Endosome)	Q9NR96.fasta	Q9NR96	1032	induces pro-inflammatory cytokine response	MTT assay, Cell Proliferation Assay	24782650	2014	Pubchem_assay
PRRID_1245	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	Toll-like receptor 3 (TLR3) is a viral sensor that induces apoptosis in response to double-stranded RNA (dsRNA), which is presumably formed during viral infection that is produced by most viruses at some point during their replication	NA	24819172	2014	Pubchem_assay
PRRID_1245	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	Toll-like receptor 3 (TLR3) is a viral sensor that induces apoptosis in response to double-stranded RNA (dsRNA), which is presumably formed during viral infection that is produced by most viruses at some point during their replication	NA	24819172	2014	Pubchem_assay
PRRID_1247	dsRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	cell compartment	O15455.fasta	O15455	904	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1247	dsRNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	cell compartment	O15455.fasta	O15455	904	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1251	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell compartment	O15455.fasta	O15455	904	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1251	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Keratinocytes and mouse skin	cell compartment	O15455.fasta	O15455	904	important for inflammation in the skin following injury	NA	24786223	2014	Pubchem_assay
PRRID_1253	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1253	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	Cell Compartment/Intracellular (Endosome)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	whole blood assay (WBA), ELISA	24766820	2014	Pubchem_assay
PRRID_1255	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	endosomes	LRR- and pyrin domain-containing 3 (NLRP3)	O15455.fasta	O15455	904	production of pro-inflammatory cytokines	NA	24762827	2014	Pubchem_assay
PRRID_1255	dsRNA Click for more detail	Virus	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	endosomes	LRR- and pyrin domain-containing 3 (NLRP3)	O15455.fasta	O15455	904	production of pro-inflammatory cytokines	NA	24762827	2014	Pubchem_assay
PRRID_1257	dsRNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1257	dsRNA Click for more detail	herpes simplex virus (virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	Dendritic Cell, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O15455.fasta	O15455	904	induce type I interferons (IFN) and other cytokines production.	NA	24754320	2014	Pubchem_assay
PRRID_1260	Endogenous DNA Click for more detail	DNA Virus(virus)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NR96.fasta	Q9NR96	1032	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1260	Endogenous DNA Click for more detail	DNA Virus(virus)	NA	NA	Damage-associated molecular patterns (DAMPs)	Natural	triggers immune responses	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NR96.fasta	Q9NR96	1032	Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia	NA	24807166	2014	Pubchem_assay
PRRID_1263	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1263	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Human	monocyte/macrophages, plasmacytoid DCs and B-lymphocytes	cell compartment	Q9NYK1.fasta	Q9NYK1	1049	Possible effect in case of stroke i.e it is Involved in preconditioning	NA	24807166	2014	Pubchem_assay
PRRID_1265	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1265	Endogenous RNA Click for more detail	RNA virus (Virus)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 8 (TLR8)	Toll-like receptor (TLR)	Human	monocyte/macrophages, DCs, mast cells	cell compartment	Q9NR97.fasta	Q9NR97	1041	important role in the immune response to viral infection	NA	24807166	2014	Pubchem_assay
PRRID_1267	eosinophil-derived neurotoxin (EDN) Click for more detail	NA	MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII	161	Damage-associated molecular patterns (DAMPs)	Natural	breakdown prod- ucts of extracellular matrix	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1267	eosinophil-derived neurotoxin (EDN) Click for more detail	NA	MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII	161	Damage-associated molecular patterns (DAMPs)	Natural	breakdown prod- ucts of extracellular matrix	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1268	fetuin A (Fet-A) Click for more detail	Fetal bovine serum (others)	MKSFVLLFCLAQLWGCHSIPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPLANCSVRQQTQHAVEGDCDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVSVSVEFAVAATDCIAKEVVDPTKCNLLAEKQYGFCKGSVIQKALGGEDVRVTCTLFQTQPVIPQPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI	359	Pattern-associated molecular patterns (PAMPs)	Natural	associated with atherosclerosis.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24823872	2014	Pubchem_assay
PRRID_1268	fetuin A (Fet-A) Click for more detail	Fetal bovine serum (others)	MKSFVLLFCLAQLWGCHSIPLDPVAGYKEPACDDPDTEQAALAAVDYINKHLPRGYKHTLNQIDSVKVWPRRPTGEVYDIEIDTLETTCHVLDPTPLANCSVRQQTQHAVEGDCDIHVLKQDGQFSVLFTKCDSSPDSAEDVRKLCPDCPLLAPLNDSRVVHAVEVALATFNAESNGSYLQLVEISRAQFVPLPVSVSVEFAVAATDCIAKEVVDPTKCNLLAEKQYGFCKGSVIQKALGGEDVRVTCTLFQTQPVIPQPQPDGAEAEAPSAVPDAAGPTPSAAGPPVASVVVGPSVVAVPLPLHRAHYDLRHTFSGVASVESSSGEAFHVGKTPIVGQPSIPGGPVRLCPGRIRYFKI	359	Pattern-associated molecular patterns (PAMPs)	Natural	associated with atherosclerosis.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	cell surface	O00206.fasta	O00206	839	TLR 4 leads to an intracellular signaling pathway NF-Œ∫B and inflammatory cytokine production which is responsible for activating the innate immune system	ELISA	24823872	2014	Pubchem_assay

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