| Primary information |
|---|
| PRRID | PRRID_1225 |
| Ligand Name | CpG-ODN |
| Source | Bacteria |
| Sequence of ligand | NA |
| Length | NA |
| Type | Nucleic Acid |
| Occurence | Synthetic |
| Role of Ligand | caused an increase in the mean tumor weight and the size of tumor mass in nude mice, and the proliferation and migration of H460 human lung cancer cells. |
| Name of receptor | Toll-like receptor 9 (TLR9) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | H460 human lung cancer cell line |
| Domain | intracellular receptors |
| Sequence of Receptor | Q9NR96.fasta |
| Swiss prot ID | Q9NR96 |
| Length Of Receptor | 1032 |
| Function | TLR9 plays significant role in cancer and promoted the growth and migration of lung cancer and miR-26a is involved in the TLR9-mediated growth and migration of lung cancer through the PI3K-Akt signaling pathway. |
| Assay used | Cell proliferation assay, BrdUrd ELISA colorimetric assay, Cell migration assay |
| PMID | 24788552 |
| Year of Publication | 2014 |
| Pubchem assay | Pubchem_assay |
| Primary information |
|---|
| PRRID | PRRID_1225 |
| Ligand Name | CpG-ODN |
| Source | Bacteria |
| Sequence of ligand | NA |
| Length | NA |
| Type | Nucleic Acid |
| Occurence | Synthetic |
| Role of Ligand | caused an increase in the mean tumor weight and the size of tumor mass in nude mice, and the proliferation and migration of H460 human lung cancer cells. |
| Name of receptor | Toll-like receptor 9 (TLR9) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | H460 human lung cancer cell line |
| Domain | intracellular receptors |
| Sequence of Receptor | Q9NR96.fasta |
| Swiss prot ID | Q9NR96 |
| Length Of Receptor | 1032 |
| Function | TLR9 plays significant role in cancer and promoted the growth and migration of lung cancer and miR-26a is involved in the TLR9-mediated growth and migration of lung cancer through the PI3K-Akt signaling pathway. |
| Assay used | Cell proliferation assay, BrdUrd ELISA colorimetric assay, Cell migration assay |
| PMID | 24788552 |
| Year of Publication | 2014 |
| Pubchem assay | Pubchem_assay |