Role of Ligand | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. |
Primary information |
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PRRID | PRRID_0387 |
Ligand Name | SIMRA Compound 3 |
Source | NA |
Sequence of ligand | 5'-UGC*UGC*UUGUG-X-GUGUUC*GUC*GU-5' |
Length | 23 |
Type | Nucleic Acid |
Occurence | Synthetic |
Role of Ligand | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. |
Name of receptor | Toll-like receptor 7/8 (TLR7/8) |
Type of receptor | Toll-like receptor (TLR) |
Source | Human |
Localization | PBMCs |
Domain | NA |
Sequence of Receptor | NA |
Swiss prot ID | NA |
Length Of Receptor | NA |
Function | This induces the inflammatory response. |
Assay used | PBMC assay |
PMID | 19269175 |
Year of Publication | 2009 |
Pubchem assay | NA |