| Role of Ligand | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. |
| Primary information |
|---|
| PRRID | PRRID_0394 |
| Ligand Name | SIMRA Compound 5 |
| Source | NA |
| Sequence of ligand | 5'-UGUUGUGUGAC-X-CAGUGUGUUGU-5' |
| Length | 23 |
| Type | Nucleic Acid |
| Occurence | Synthetic |
| Role of Ligand | SIMRA compounds containing arabinonucleotides induced Th1-type cytokine/chemokine profiles in human PBMC cultures such as IL-1β, IL-2R, IL-8, IL-10, IL-12, IFN-α, IFN-γ, MCP-1, RANTES, MIP-1α, MIP-1β, TNF-α. |
| Name of receptor | Toll-like receptor 8 (TLR8) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | PBMCs |
| Domain | NA |
| Sequence of Receptor | Q9NR97.fasta |
| Swiss prot ID | Q9NR97 |
| Length Of Receptor | 1041 |
| Function | This induces the inflammatory response. |
| Assay used | PBMC assay |
| PMID | 19269175 |
| Year of Publication | 2009 |
| Pubchem assay | Pubchem Assay |