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The total number entries retrieved from this search are| ID | Sequence | Name | Nature of peptide or cargo | Assay | Tissue permeability | Tissue Sample | PUBMED ID |
|---|---|---|---|---|---|---|---|
| 1114 | FLGGLIKIVPAMICA VTKKC | Ranalexin | Antimicrobial | Franz diffusion cell | In combination these compounds reduced viable bacteria by 2.83 ± 0.26 log10 CFU | Abdominal skin from a 38-year-old white female donor | 19709343 |
| 1115 | FLGGLIKIVPAMICA VTKKC | Ranalexin | Antimicrobial | Franz diffusion cell | Ranalexin (100 mg l-1) reduced viable MRSA252 by 0.13 ± 0.06 log10 CFU | Abdominal skin from a 38-year-old white female donor | 19709343 |
| 1116 | AETTNTQQAHTQMSTQ SQDVSYGTYYTIDSNG DYHHTPDGNWNQAMFD NKEYSYTFVDAQGHTH YFYNCYPKNANANGSG QTYVNPATAGDNNDYT ASQSQQHINQYGYQSN VGPDASYYSHSNNNQAY NSHDGNGKVNYPNGTS NQNGGSASKATASGHA KDASWLTSRKQLQPYG QYHGGGAHYGVDYAMP ENSPVYSLTDGTVVQA GWSNYGGGNQVTIKEA NSNNYQWYMHNNRL | Lysostaphin | Endopeptidase,Antimicrobial | Franz diffusion cell | Lysostaphin (1 mg l-1) caused a 1.95 ± 0.23 log10 CFU reduction in bacteria | Abdominal skin from a 38-year-old white female donor | 19709343 |
| 1117 | pGlu-HWSYwLRPG | Triptorelin | Luteinizing hormone releasing hormone (LHRH) superagonist | Franz diffusion cell, HPLC | 64.9±8.8% degraded | Interior skin surface of dermatomed skin (DS) of porcine | 19486932 |
| 1118 | pGlu-HWSYwLRPG | Triptorelin | Luteinizing hormone releasing hormone (LHRH) superagonist | Franz diffusion cell, HPLC | 15±4.1% degraded | Interior skin surface of heat separated epidermis (HSE) of porcine | 19486932 |
| 1119 | pGlu-HWSYwLRPG | Triptorelin | Luteinizing hormone releasing hormone (LHRH) superagonist | Franz diffusion cell, HPLC | 100% degraded | Interior skin surface of full thickness skin (FTS) of porcine | 19486932 |
| 1120 | pGlu-HWSYwLRPG | Triptorelin | Luteinizing hormone releasing hormone (LHRH) superagonist | Franz diffusion cell, HPLC | 87.8±4.4% degraded | Interior skin surface of dermatomed skin (DS) of porcine | 19486932 |
| 1121 | pGlu-HWSYwLRPG | Triptorelin | Luteinizing hormone releasing hormone (LHRH) superagonist | Franz diffusion cell, HPLC | 51.3±6% degraded | Interior skin surface of heat separated epidermis (HSE) of porcine | 19486932 |
| 1122 | GIGKFLKKAKKFG KAFVKILKK | Pexiganan | Antimicrobial, Diabetic Foot Ulcers | Wound healing, infection progression, and the number of amputations required were calculated statistically | Clinical improvement rates were (85%–90%), Overall microbiological eradication rates (42%–47%) | Diabetic Foot Ulcers | 18990064 |
| 1123 | MNFVMISIELSETMAL IIVISGLLLCASSITT TSSNDFYAVLHGNLSQ SDRNELPKICGREFLT DTLQSRSAGGVLVREN EYPWVLLLTDPEWTRV CTAVLISRRHVLTAAH CVTNFPKDRKLEKDCH YTTIQSTYLYVYPRTR VNDALNIKRYTSSFSV ARVMVHPSFSCSNATG DIALLELTLNIFTEAS PICMPHFNESIPKNAA AAGFGKNPISNNTRPM QVVNLTYQGTTGDRI | Trypsin | Endogenous proteases trypsin is capable of digesting intercellular desmosomal proteins and hence used for in vitro epidermal separation and keratinocyte isolation | Franz diffusion cell | Permeability coefficient at 0.25% trypsin pretreatment is 5.29 X 107cm/s,permeation flux increased 5.2-fold.A higher concentration of trypsin shortened the lag time of insulin permeation | Epidermal skin of male wistar rat | 18670091 |
| 1124 | MNFVMISIELSETMAL IIVISGLLLCASSITT TSSNDFYAVLHGNLSQ SDRNELPKICGREFLT DTLQSRSAGGVLVREN EYPWVLLLTDPEWTRV CTAVLISRRHVLTAAH CVTNFPKDRKLEKDCH YTTIQSTYLYVYPRTR VNDALNIKRYTSSFSV ARVMVHPSFSCSNATG DIALLELTLNIFTEAS PICMPHFNESIPKNAA AAGFGKNPISNNTRPM QVVNLTYQGTTGDRI | Trypsin | Endogenous proteases trypsin is capable of digesting intercellular desmosomal proteins and hence used for in vitro epidermal separation and keratinocyte isolation | Franz diffusion cell | Permeation flux of insulin was 7.56 m g/cm2/h with 2.5% trypsin pretreatment, mean cumulative permeated amounts were 89.70 and 165.58 m g/cm2 at 12 and 24 h, respectively | Epidermal skin of male wistar rat | 18670091 |
| 1125 | MNFVMISIELSETMAL IIVISGLLLCASSITT TSSNDFYAVLHGNLSQ SDRNELPKICGREFLT DTLQSRSAGGVLVREN EYPWVLLLTDPEWTRV CTAVLISRRHVLTAAH CVTNFPKDRKLEKDCH YTTIQSTYLYVYPRTR VNDALNIKRYTSSFSV ARVMVHPSFSCSNATG DIALLELTLNIFTEAS PICMPHFNESIPKNAA AAGFGKNPISNNTRPM QVVNLTYQGTTGDRI | Trypsin | Endogenous proteases trypsin is capable of digesting intercellular desmosomal proteins and hence used for in vitro epidermal separation and keratinocyte isolation | Light microscope | Significant permeability of insulin and loosening of stratum corneum after trypsin application on the epidermal skin of rat can be seen in the microscopic images | Epidermal skin of male wistar rat | 18670091 |
| 1126 | MNFVMISIELSETMAL IIVISGLLLCASSITT TSSNDFYAVLHGNLSQ SDRNELPKICGREFLT DTLQSRSAGGVLVREN EYPWVLLLTDPEWTRV CTAVLISRRHVLTAAH CVTNFPKDRKLEKDCH YTTIQSTYLYVYPRTR VNDALNIKRYTSSFSV ARVMVHPSFSCSNATG DIALLELTLNIFTEAS PICMPHFNESIPKNAA AAGFGKNPISNNTRPM QVVNLTYQGTTGDRI | Trypsin | Endogenous proteases trypsin is capable of digesting intercellular desmosomal proteins and hence used for in vitro epidermal separation and keratinocyte isolation | Plasma glucose level (PGL) determination | Marked decrease in the PGL was observed in the group with trypsin pretreatment. The PGL was reduced to less than 60% of the initial value after 8 h in all groups with trypsin pretreatment | Blood collected from the tail vein of diabetic rat | 18670091 |
| 1127 | GIGKFLHSAKKFGKA FVGEIMNS | Magainin | Antimicrobial | Franz diffusion cell | The results suggest that positively charged magainin facilitated transdermal transport of negatively charged fluorescein due to electrostatic attraction at pH 7.4 and results in 35 fold increase in the permeation of maganine by the NLS control formulation (i.e., from an average of 0.037μg to 1.302 μg of fluorescein), but as the attraction decreased with increasing pH, the skin permeability enhancement decreased as well | Human cadaver skin | 18601987 |
| 1128 | GIGKFLHSAKKFGKA FVGEIMNS | Magainin | Antimicrobial | Franz diffusion cell | The results suggest that positively charged magainin facilitated transdermal transport of positively charged granisetron due to electrostatic attraction at pH 10 and results in 92–fold increase in the permeation of magnine (i.e., from and average of 2.23 μg to 205.55 μg of granisetron), but as the attraction decreased with decreasing pH, the skin permeability enhancement decreased as well | Human cadaver skin | 18601987 |
| 1129 | GIGKFLHSAKKFGKA FVGEIMNS | Magainin | Antimicrobial | Multi-photon excitation microscopy | The increase in permeation of fluorescein Faciliated by magnine can be seen the the microscopic images | Human cadaver skin | 18601987 |
| 1130 | GIGKFLHSAKKFGKA FVGEIMNS | Magainin | Antimicrobial | Multi-photon excitation microscopy | The increase in permeation of granisetron faciliated by magnine can be seen the the microscopic images | Human cadaver skin | 18601987 |
| 1131 | LIGR | LIGR | Activation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivo | Vybrant Phagocytosis Assay | Significant increase in the LIGR-induced keratinocyte phagocytosis observed using Vybrant Phagocytosis Assay | HaCaT keratinocytes | 18426410 |
| 1132 | LIGR | LIGR | Activation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivo | Fontana-Mason (F&M) stain | The increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of mice skin sections | Dorsum skin of SKH-1 hairless female mice | 18426410 |
| 1133 | LIGR | LIGR | Activation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivo | Fontana-Mason (F&M) stain | The increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of swine skin sections | Dorsum skin of pigmented yucatan microswine | 18426410 |
| 1134 | LIGR | LIGR | Activation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivo | Fontana-Mason (F&M) stain | The increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of Human skin section skin sections | Human skin samples grafted onto SCID mice | 18426410 |
| 1135 | SLIGR | SLIGR | Activation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivo | Vybrant Phagocytosis Assay | Significant increase in the LIGR-induced keratinocyte phagocytosis observed using Vybrant Phagocytosis Assay | HaCaT keratinocytes | 18426410 |
| 1136 | SLIGR | SLIGR | Activation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivo | Fontana-Mason (F&M) stain | The increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of mice skin sections | Dorsum skin of SKH-1 hairless female mice | 18426410 |
| 1137 | SLIGR | SLIGR | Activation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivo | Fontana-Mason (F&M) stain | The increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of swine skin sections | Dorsum skin of pigmented yucatan microswine | 18426410 |
| 1138 | SLIGR | SLIGR | Activation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivo | Fontana-Mason (F&M) stain | The increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of Human skin section skin sections | Human skin samples grafted onto SCID mice | 18426410 |
| 1139 | GIGKFLHSAKKFGKA FVGEIMNS | Magainin | Antimicrobial | Franz cell system, Multi-photon microscopy | Skin permeability 1.5x 103cm/h in presence of chemical enhancer,C o-administration of magainin and NLS-ethanol led to extensive magainin penetration throughout the stratum corneum which could be easily visualised in the microscopic images | Human cadaver skin | 17628164 |
| 1140 | TRWYSMKKTTMKIIP FNRL | Haptide | Improve the cell penetration and subsequent presentation of the antigen. | Anti-LT antibodies determination by ELISA | Significant increase in antibody titer (anti-LT) in the serum of mice on topical application with HR-gp100H | Ears of BALB/c mice | 17493711 |
| 1141 | ACSSSPSKHCG | TD-1 | TD1 enhances the transdermal delivery of macromolecules | Confocal Laser Scanning Microscopy, Blood glucose measurement | Significant permeability of insulin could be seen in the confocal images, TD-1 without insulin had no effect on either blood glucose or serum insulin level, indicating that the glucose-lowering effect observed with TD 1 and insulin coadministration was due to the delivered exogenous insulin and not a physiological response elicited by TD-1 | Abdominal skin of rat | 16565728 |
| 1142 | LNQEQVSPRKKC | Peptide | Peptide containing α 2-plasmin inhibitor fibrin-binding site to the free amines on the surface of the KGF molecule | Inverted fluorescence microscopy | The gradual healing of wound coould be easily visualised in th fluoresence microscopy images. Overlaid fluorescent and bright-field images of the wound show migrating cells as they degrade the fibrin matrix | Human skin equivalents were grafted to athymic mice | 16314471 |
| 1143 | r–nle–nle–nle–r–nle–nle–nle–g–y | RDP58 | Immunomodulator | Histological assay using bright field microscopy | It can be clearly seen from the histological images that topical application of RDP58results in significant decrease in tthe hickness of the ear skin as compared to control (TPA applied ear skin) | Ear of mice | 16117788 |
| 1144 | TSLDASIIWAMMQN | P144 | Interferes with TGF-β1 binding to its cellular receptors on Mv1Lu cells. Potent in vivo anti-fibrotic activity in the liver of rats receiving CCl4 | Sircol Collagen Assay kit, histological and immunohistochemical studies | Dermal thickness: Bleomycin treated-180%, Bleomycin plus P144 lipogel emulsion-120%, Bleomycin plus vehicle-200%. Soluble collagen: Bleomycin treated-215%, Bleomycin plus P144 lipogel emulsion-150%, Bleomycin plus vehicle-220%. Data represent mean±SD of 10 mice per group, and the values of PBS-treated mice are set to 100%. | Shaved skin area of female C3H mice | 16117784 |
| 1145 | SIINFEKL | OVA257–264 | It is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | ELISPOT assay | ~ 210 spots/1*106 total cells(4 folds more than the permeability of the peptide with vehicle alone) | Epidermal layer of naive C57BL mice | 16113599 |
| 1146 | SIINFEKL | OVA257–264 | It is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | ELISPOT assay | ~ 65 spots/1*106 total cells | Epidermal layer of naive C57BL mice | 16113599 |
| 1147 | SIINFEKL | OVA257–264 | It is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | ELISPOT assay | ~ 51 spots/1*106 total cells | Epidermal layer of naive C57BL mice | 16113599 |
| 1148 | SIINFEKL | OVA257–264 | It is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | ELISPOT assay | ~ 100 spots/1*106 total cells | Epidermal layer of naive C57BL mice | 16113599 |
| 1149 | SIINFEKL | OVA257–264 | It is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | ELISPOT assay | ~ 200 spots/1*106 total cells | Epidermal layer of naive C57BL mice | 16113599 |
| 1150 | SIINFEKL | OVA257–264 | It is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | ELISPOT assay | ~ 215 spots/1*106 total cells | Epidermal layer of naive C57BL mice | 16113599 |
| 1151 | SIINFEKL | OVA257–264 | It is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb. | ELISPOT assay | ~ 65 spots/1*106 total cells | Epidermal layer of naive C57BL mice | 16113599 |
| 1152 | YARAAARQARA | YARA | Molecular modification of TAT has led to the discovery of a new, optimized PTD, YARA which can penetrate intact strips of porcine coronary artery and human saphenous vein smooth muscle. | Fluorimetry analysis using Gemini SpectraMax plate reader | Rate of skin penetration(nmol/cm2/h)- -̴0.12 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1153 | YARAAARQARA | YARA | Molecular modification of TAT has led to the discovery of a new, optimized PTD, YARA which can penetrate intact strips of porcine coronary artery and human saphenous vein smooth muscle. | Fluorimetry analysis using Gemini SpectraMax plate reader | Transdermal delivery(nmol)- -̴0.054 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1154 | YGRKKRRQRRR | TAT | HIV transcription factor TAT which is a protein transduction domain characterized by a high content of positively charged arginine and lysine amino acid residues | Fluorimetry analysis using Gemini SpectraMax plate reader | Rate of skin penetration(nmol/cm2/h)- -̴0.02 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1155 | YGRKKRRQRRR | TAT | HIV transcription factor TAT which is a protein transduction domain | Fluorimetry analysis using Gemini SpectraMax plate reader | Transdermal delivery(nmol)- -̴0.06 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1156 | YKALRISRKLAK | YKAc | It is a nontransducing peptide | Fluorimetry analysis using Gemini SpectraMax plate reader | Transdermal delivery(nmol)- -̴0 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1157 | WLRRASAPLPGLK | P20 | Phosphopeptide analogue of the heat shock protein (HSP) 20 | Fluorimetry analysis using Gemini SpectraMax plate reader | Rate of skin penetration(nmol/cm2/h)- -̴0.1 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1158 | YARAAARQARA | YARA | Molecular modification of TAT has led to the discovery of a new, optimized PTD, YARA which can penetrate intact strips of porcine coronary artery and human saphenous vein smooth muscle. | Fluorimetry analysis using Gemini SpectraMax plate reader | Transdermal delivery(nmol)- -̴0.04 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1159 | YGRKKRRQRRR | TAT | HIV transcription factor TAT which is a protein transduction domain | Fluorimetry analysis using Gemini SpectraMax plate reader | Transdermal delivery(nmol)- -̴0.05 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1160 | YKALRISRKLAK | YKAc | It is a nontransducing peptide | Fluorimetry analysis using Gemini SpectraMax plate reader | Transdermal delivery(nmol)- -̴0 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1161 | YARAAARQARA | YARA | Molecular modification of TAT has led to the discovery of a new, optimized PTD, YARA which can penetrate intact strips of porcine coronary artery and human saphenous vein smooth muscle. | Fluorimetry analysis using Gemini SpectraMax plate reader | Transdermal delivery(nmol)- -̴0.046 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1162 | YGRKKRRQRRR | TAT | HIV transcription factor TAT which is a protein transduction domain | Fluorimetry analysis using Gemini SpectraMax plate reader | Transdermal delivery(nmol)- -̴0.055 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |
| 1163 | YKALRISRKLAK | YKAc | It is a nontransducing peptide | Fluorimetry analysis using Gemini SpectraMax plate reader | Transdermal delivery(nmol)- -̴0 | Freshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cell | 15906170 |