Welcome to Entry Card of Peptide


Details of TopicalPdb ID 1137

PRIMARY INFORMATION
ID1137
PMID18426410
Year2008
SequenceSLIGR
NameSLIGR
Length5
N-Terminal ModificationFree
C-Terminal ModificationAmidation
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptidePeptide of the mouse PAR-2-cleaved sequence
Nature of Peptide/CargoActivation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivo
MechanismSLIGR sequence mimic the tethered ligand Sequence of PAR-2 receptor
Cargo Sequence/StructureNot mentioned
Name of cargo
Not applicable
AssayFontana-Mason (F&M) stain
EnhancerNone
Properties of enhancerNot applicable
Concentration250 µM
Incubation timeTwice daily, 5 days ⁄ week, for 8 weeks
Tissue permeability (value with units)The increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of swine skin sections
Tissue SampleDorsum skin of pigmented yucatan microswine
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN[C@@H](CO)C(=O)N[C@@H](CC(C)C)C
(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)
N[C@@H](CCCNC(=[NH2])N)C(=O)N