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Details of TopicalPdb ID 1129

PRIMARY INFORMATION
ID1129
PMID18601987
Year2009
SequenceGIGKFLHSAKKFGKA
FVGEIMNS
NameMagainin
Length23
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicLinear
ChiralityL
Chemical ModificationNone
Origin of PeptideSkin of African clawed frogs
Nature of Peptide/CargoAntimicrobial
MechanismNot mentioned
Cargo Sequence/StructureNot mentioned
Name of cargo
Fluorescein
AssayMulti-photon excitation microscopy
EnhancerPBS (pH from 7.4 to 11) or 1 wt% granisetron hydrochloride solution in PBS (pH from 5 to 10)
Properties of enhancerChanging pH can alter the structure and properties of antimicrobial peptide
Concentration1 mM
Incubation time12 hours
Tissue permeability (value with units)The increase in permeation of fluorescein Faciliated by magnine can be seen the the microscopic images
Tissue SampleHuman cadaver skin
Ex vivo/In vivo/In vitroin vitro
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESNCC(=O)N[C@@H]([C@@H](C)CC)C(=O)
NCC(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H]
(Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1nc[nH]c1)
C(=O)N[C@@H](CO)C(=O)N[C@H](O)N[C@@H](CCCC[NH3])
C(=O)N[C@@H](CCCC[NH3])C(=O)N[C@@H]
(Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCC[NH3])
C(=O)N[C@@H](C)C(=O)N[C@@H](CC)C(=O)N[C@@H](C(C)C)C
(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H]([C@@H]
(C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]
(CC(=O)N)C(=O)N[C@@H](CO)C=O.CC.C.C.C.C.C