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ID1114SequenceFLGGLIKIVPAMICA
VTKKC
NameRanalexinNature of peptide or cargoAntimicrobialAssayFranz diffusion cellTissue permeabilityIn combination these compounds reduced viable bacteria by 2.83 ± 0.26 log10 CFUTissue SampleAbdominal skin from a 38-year-old white female donorPUBMED ID19709343
ID1115SequenceFLGGLIKIVPAMICA
VTKKC
NameRanalexinNature of peptide or cargoAntimicrobialAssayFranz diffusion cellTissue permeabilityRanalexin (100 mg l-1) reduced viable MRSA252 by 0.13 ± 0.06 log10 CFUTissue SampleAbdominal skin from a 38-year-old white female donorPUBMED ID19709343
ID1116SequenceAETTNTQQAHTQMSTQ
SQDVSYGTYYTIDSNG
DYHHTPDGNWNQAMFD
NKEYSYTFVDAQGHTH
YFYNCYPKNANANGSG
QTYVNPATAGDNNDYT
ASQSQQHINQYGYQSN
VGPDASYYSHSNNNQAY
NSHDGNGKVNYPNGTS
NQNGGSASKATASGHA
KDASWLTSRKQLQPYG
QYHGGGAHYGVDYAMP
ENSPVYSLTDGTVVQA
GWSNYGGGNQVTIKEA
NSNNYQWYMHNNRL
NameLysostaphinNature of peptide or cargoEndopeptidase,AntimicrobialAssayFranz diffusion cellTissue permeabilityLysostaphin (1 mg l-1) caused a 1.95 ± 0.23 log10 CFU reduction in bacteriaTissue SampleAbdominal skin from a 38-year-old white female donorPUBMED ID19709343
ID1117SequencepGlu-HWSYwLRPGNameTriptorelinNature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonistAssayFranz diffusion cell, HPLCTissue permeability64.9±8.8% degradedTissue SampleInterior skin surface of dermatomed skin (DS) of porcinePUBMED ID19486932
ID1118SequencepGlu-HWSYwLRPGNameTriptorelinNature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonistAssayFranz diffusion cell, HPLCTissue permeability15±4.1% degradedTissue SampleInterior skin surface of heat separated epidermis (HSE) of porcinePUBMED ID19486932
ID1119SequencepGlu-HWSYwLRPGNameTriptorelinNature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonistAssayFranz diffusion cell, HPLCTissue permeability100% degradedTissue SampleInterior skin surface of full thickness skin (FTS) of porcinePUBMED ID19486932
ID1120SequencepGlu-HWSYwLRPGNameTriptorelinNature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonistAssayFranz diffusion cell, HPLCTissue permeability87.8±4.4% degradedTissue SampleInterior skin surface of dermatomed skin (DS) of porcinePUBMED ID19486932
ID1121SequencepGlu-HWSYwLRPGNameTriptorelinNature of peptide or cargoLuteinizing hormone releasing hormone (LHRH) superagonistAssayFranz diffusion cell, HPLCTissue permeability51.3±6% degradedTissue SampleInterior skin surface of heat separated epidermis (HSE) of porcinePUBMED ID19486932
ID1122SequenceGIGKFLKKAKKFG
KAFVKILKK
NamePexigananNature of peptide or cargoAntimicrobial, Diabetic Foot UlcersAssayWound healing, infection progression, and the number of amputations required were calculated statisticallyTissue permeabilityClinical improvement rates were (85%–90%), Overall microbiological eradication rates (42%–47%)Tissue SampleDiabetic Foot UlcersPUBMED ID18990064
ID1123SequenceMNFVMISIELSETMAL
IIVISGLLLCASSITT
TSSNDFYAVLHGNLSQ
SDRNELPKICGREFLT
DTLQSRSAGGVLVREN
EYPWVLLLTDPEWTRV
CTAVLISRRHVLTAAH
CVTNFPKDRKLEKDCH
YTTIQSTYLYVYPRTR
VNDALNIKRYTSSFSV
ARVMVHPSFSCSNATG
DIALLELTLNIFTEAS
PICMPHFNESIPKNAA
AAGFGKNPISNNTRPM
QVVNLTYQGTTGDRI
NameTrypsinNature of peptide or cargoEndogenous proteases trypsin is capable of digesting intercellular desmosomal proteins and hence used for in vitro epidermal separation and keratinocyte isolationAssayFranz diffusion cellTissue permeabilityPermeability coefficient at 0.25% trypsin pretreatment is 5.29 X 107cm/s,permeation flux increased 5.2-fold.A higher concentration of trypsin shortened the lag time of insulin permeationTissue SampleEpidermal skin of male wistar ratPUBMED ID18670091
ID1124SequenceMNFVMISIELSETMAL
IIVISGLLLCASSITT
TSSNDFYAVLHGNLSQ
SDRNELPKICGREFLT
DTLQSRSAGGVLVREN
EYPWVLLLTDPEWTRV
CTAVLISRRHVLTAAH
CVTNFPKDRKLEKDCH
YTTIQSTYLYVYPRTR
VNDALNIKRYTSSFSV
ARVMVHPSFSCSNATG
DIALLELTLNIFTEAS
PICMPHFNESIPKNAA
AAGFGKNPISNNTRPM
QVVNLTYQGTTGDRI
NameTrypsinNature of peptide or cargoEndogenous proteases trypsin is capable of digesting intercellular desmosomal proteins and hence used for in vitro epidermal separation and keratinocyte isolationAssayFranz diffusion cellTissue permeabilityPermeation flux of insulin was 7.56 m g/cm2/h with 2.5% trypsin pretreatment, mean cumulative permeated amounts were 89.70 and 165.58 m g/cm2 at 12 and 24 h, respectivelyTissue SampleEpidermal skin of male wistar ratPUBMED ID18670091
ID1125SequenceMNFVMISIELSETMAL
IIVISGLLLCASSITT
TSSNDFYAVLHGNLSQ
SDRNELPKICGREFLT
DTLQSRSAGGVLVREN
EYPWVLLLTDPEWTRV
CTAVLISRRHVLTAAH
CVTNFPKDRKLEKDCH
YTTIQSTYLYVYPRTR
VNDALNIKRYTSSFSV
ARVMVHPSFSCSNATG
DIALLELTLNIFTEAS
PICMPHFNESIPKNAA
AAGFGKNPISNNTRPM
QVVNLTYQGTTGDRI
NameTrypsinNature of peptide or cargoEndogenous proteases trypsin is capable of digesting intercellular desmosomal proteins and hence used for in vitro epidermal separation and keratinocyte isolationAssayLight microscopeTissue permeabilitySignificant permeability of insulin and loosening of stratum corneum after trypsin application on the epidermal skin of rat can be seen in the microscopic imagesTissue SampleEpidermal skin of male wistar ratPUBMED ID18670091
ID1126SequenceMNFVMISIELSETMAL
IIVISGLLLCASSITT
TSSNDFYAVLHGNLSQ
SDRNELPKICGREFLT
DTLQSRSAGGVLVREN
EYPWVLLLTDPEWTRV
CTAVLISRRHVLTAAH
CVTNFPKDRKLEKDCH
YTTIQSTYLYVYPRTR
VNDALNIKRYTSSFSV
ARVMVHPSFSCSNATG
DIALLELTLNIFTEAS
PICMPHFNESIPKNAA
AAGFGKNPISNNTRPM
QVVNLTYQGTTGDRI
NameTrypsinNature of peptide or cargoEndogenous proteases trypsin is capable of digesting intercellular desmosomal proteins and hence used for in vitro epidermal separation and keratinocyte isolationAssayPlasma glucose level (PGL) determinationTissue permeabilityMarked decrease in the PGL was observed in the group with trypsin pretreatment. The PGL was reduced to less than 60% of the initial value after 8 h in all groups with trypsin pretreatmentTissue SampleBlood collected from the tail vein of diabetic ratPUBMED ID18670091
ID1127SequenceGIGKFLHSAKKFGKA
FVGEIMNS
NameMagaininNature of peptide or cargoAntimicrobialAssayFranz diffusion cellTissue permeabilityThe results suggest that positively charged magainin facilitated transdermal transport of negatively charged fluorescein due to electrostatic attraction at pH 7.4 and results in 35 fold increase in the permeation of maganine by the NLS control formulation (i.e., from an average of 0.037μg to 1.302 μg of fluorescein), but as the attraction decreased with increasing pH, the skin permeability enhancement decreased as wellTissue SampleHuman cadaver skinPUBMED ID18601987
ID1128SequenceGIGKFLHSAKKFGKA
FVGEIMNS
NameMagaininNature of peptide or cargoAntimicrobialAssayFranz diffusion cellTissue permeabilityThe results suggest that positively charged magainin facilitated transdermal transport of positively charged granisetron due to electrostatic attraction at pH 10 and results in 92–fold increase in the permeation of magnine (i.e., from and average of 2.23 μg to 205.55 μg of granisetron), but as the attraction decreased with decreasing pH, the skin permeability enhancement decreased as wellTissue SampleHuman cadaver skinPUBMED ID18601987
ID1129SequenceGIGKFLHSAKKFGKA
FVGEIMNS
NameMagaininNature of peptide or cargoAntimicrobialAssayMulti-photon excitation microscopyTissue permeabilityThe increase in permeation of fluorescein Faciliated by magnine can be seen the the microscopic imagesTissue SampleHuman cadaver skinPUBMED ID18601987
ID1130SequenceGIGKFLHSAKKFGKA
FVGEIMNS
NameMagaininNature of peptide or cargoAntimicrobialAssayMulti-photon excitation microscopyTissue permeabilityThe increase in permeation of granisetron faciliated by magnine can be seen the the microscopic imagesTissue SampleHuman cadaver skinPUBMED ID18601987
ID1131SequenceLIGRNameLIGRNature of peptide or cargoActivation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivoAssayVybrant Phagocytosis AssayTissue permeabilitySignificant increase in the LIGR-induced keratinocyte phagocytosis observed using Vybrant Phagocytosis AssayTissue SampleHaCaT keratinocytesPUBMED ID18426410
ID1132SequenceLIGRNameLIGRNature of peptide or cargoActivation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivoAssayFontana-Mason (F&M) stainTissue permeabilityThe increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of mice skin sectionsTissue SampleDorsum skin of SKH-1 hairless female micePUBMED ID18426410
ID1133SequenceLIGRNameLIGRNature of peptide or cargoActivation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivoAssayFontana-Mason (F&M) stainTissue permeabilityThe increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of swine skin sectionsTissue SampleDorsum skin of pigmented yucatan microswinePUBMED ID18426410
ID1134SequenceLIGRNameLIGRNature of peptide or cargoActivation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivoAssayFontana-Mason (F&M) stainTissue permeabilityThe increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of Human skin section skin sectionsTissue SampleHuman skin samples grafted onto SCID micePUBMED ID18426410
ID1135SequenceSLIGRNameSLIGRNature of peptide or cargoActivation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivoAssayVybrant Phagocytosis AssayTissue permeabilitySignificant increase in the LIGR-induced keratinocyte phagocytosis observed using Vybrant Phagocytosis AssayTissue SampleHaCaT keratinocytesPUBMED ID18426410
ID1136SequenceSLIGRNameSLIGRNature of peptide or cargoActivation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivoAssayFontana-Mason (F&M) stainTissue permeabilityThe increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of mice skin sectionsTissue SampleDorsum skin of SKH-1 hairless female micePUBMED ID18426410
ID1137SequenceSLIGRNameSLIGRNature of peptide or cargoActivation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivoAssayFontana-Mason (F&M) stainTissue permeabilityThe increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of swine skin sectionsTissue SampleDorsum skin of pigmented yucatan microswinePUBMED ID18426410
ID1138SequenceSLIGRNameSLIGRNature of peptide or cargoActivation of the human PAR-2 receptor, increase melanin depositionin vitro and in vivoAssayFontana-Mason (F&M) stainTissue permeabilityThe increase in pigment deposition induced by peptide can be seen in the Fontana-Mason (F&M) stained microscopic images of Human skin section skin sectionsTissue SampleHuman skin samples grafted onto SCID micePUBMED ID18426410
ID1139SequenceGIGKFLHSAKKFGKA
FVGEIMNS
NameMagaininNature of peptide or cargoAntimicrobialAssayFranz cell system, Multi-photon microscopyTissue permeabilitySkin permeability 1.5x 103cm/h in presence of chemical enhancer,C o-administration of magainin and NLS-ethanol led to extensive magainin penetration throughout the stratum corneum which could be easily visualised in the microscopic imagesTissue SampleHuman cadaver skinPUBMED ID17628164
ID1140SequenceTRWYSMKKTTMKIIP
FNRL
NameHaptideNature of peptide or cargoImprove the cell penetration and subsequent presentation of the antigen.AssayAnti-LT antibodies determination by ELISATissue permeabilitySignificant increase in antibody titer (anti-LT) in the serum of mice on topical application with HR-gp100HTissue SampleEars of BALB/c micePUBMED ID17493711
ID1141SequenceACSSSPSKHCGNameTD-1Nature of peptide or cargoTD1 enhances the transdermal delivery of macromoleculesAssayConfocal Laser Scanning Microscopy, Blood glucose measurementTissue permeabilitySignificant permeability of insulin could be seen in the confocal images, TD-1 without insulin had no effect on either blood glucose or serum insulin level, indicating that the glucose-lowering effect observed with TD 1 and insulin coadministration was due to the delivered exogenous insulin and not a physiological response elicited by TD-1Tissue SampleAbdominal skin of ratPUBMED ID16565728
ID1142SequenceLNQEQVSPRKKCNamePeptideNature of peptide or cargoPeptide containing α 2-plasmin inhibitor fibrin-binding site to the free amines on the surface of the KGF moleculeAssayInverted fluorescence microscopyTissue permeabilityThe gradual healing of wound coould be easily visualised in th fluoresence microscopy images. Overlaid fluorescent and bright-field images of the wound show migrating cells as they degrade the fibrin matrixTissue SampleHuman skin equivalents were grafted to athymic micePUBMED ID16314471
ID1143Sequencer–nle–nle–nle–r–nle–nle–nle–g–yNameRDP58Nature of peptide or cargoImmunomodulatorAssayHistological assay using bright field microscopyTissue permeabilityIt can be clearly seen from the histological images that topical application of RDP58results in significant decrease in tthe hickness of the ear skin as compared to control (TPA applied ear skin)Tissue SampleEar of micePUBMED ID16117788
ID1144SequenceTSLDASIIWAMMQNNameP144Nature of peptide or cargoInterferes with TGF-β1 binding to its cellular receptors on Mv1Lu cells. Potent in vivo anti-fibrotic activity in the liver of rats receiving CCl4AssaySircol Collagen Assay kit, histological and immunohistochemical studiesTissue permeabilityDermal thickness: Bleomycin treated-180%, Bleomycin plus P144 lipogel emulsion-120%, Bleomycin plus vehicle-200%. Soluble collagen: Bleomycin treated-215%, Bleomycin plus P144 lipogel emulsion-150%, Bleomycin plus vehicle-220%. Data represent mean±SD of 10 mice per group, and the values of PBS-treated mice are set to 100%.Tissue SampleShaved skin area of female C3H micePUBMED ID16117784
ID1145SequenceSIINFEKLNameOVA257–264Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb.AssayELISPOT assayTissue permeability~ 210 spots/1*106 total cells(4 folds more than the permeability of the peptide with vehicle alone)Tissue SampleEpidermal layer of naive C57BL micePUBMED ID16113599
ID1146SequenceSIINFEKLNameOVA257–264Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb.AssayELISPOT assayTissue permeability~ 65 spots/1*106 total cellsTissue SampleEpidermal layer of naive C57BL micePUBMED ID16113599
ID1147SequenceSIINFEKLNameOVA257–264Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb.AssayELISPOT assayTissue permeability~ 51 spots/1*106 total cellsTissue SampleEpidermal layer of naive C57BL micePUBMED ID16113599
ID1148SequenceSIINFEKLNameOVA257–264Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb.AssayELISPOT assayTissue permeability~ 100 spots/1*106 total cellsTissue SampleEpidermal layer of naive C57BL micePUBMED ID16113599
ID1149SequenceSIINFEKLNameOVA257–264Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb.AssayELISPOT assayTissue permeability~ 200 spots/1*106 total cellsTissue SampleEpidermal layer of naive C57BL micePUBMED ID16113599
ID1150SequenceSIINFEKLNameOVA257–264Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb.AssayELISPOT assayTissue permeability~ 215 spots/1*106 total cellsTissue SampleEpidermal layer of naive C57BL micePUBMED ID16113599
ID1151SequenceSIINFEKLNameOVA257–264Nature of peptide or cargoIt is a class I (Kb)-restricted peptide epitope of ovalbumin (OVA), presented by the class I major histocompatibility complex (MHC) molecule, H-2Kb.AssayELISPOT assayTissue permeability~ 65 spots/1*106 total cellsTissue SampleEpidermal layer of naive C57BL micePUBMED ID16113599
ID1152SequenceYARAAARQARANameYARANature of peptide or cargoMolecular modification of TAT has led to the discovery of a new, optimized PTD, YARA which can penetrate intact strips of porcine coronary artery and human saphenous vein smooth muscle.AssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityRate of skin penetration(nmol/cm2/h)- -̴0.12Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1153SequenceYARAAARQARANameYARANature of peptide or cargoMolecular modification of TAT has led to the discovery of a new, optimized PTD, YARA which can penetrate intact strips of porcine coronary artery and human saphenous vein smooth muscle.AssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityTransdermal delivery(nmol)- -̴0.054Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1154SequenceYGRKKRRQRRRNameTATNature of peptide or cargoHIV transcription factor TAT which is a protein transduction domain characterized by a high content of positively charged arginine and lysine amino acid residuesAssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityRate of skin penetration(nmol/cm2/h)- -̴0.02Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1155SequenceYGRKKRRQRRRNameTATNature of peptide or cargoHIV transcription factor TAT which is a protein transduction domainAssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityTransdermal delivery(nmol)- -̴0.06Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1156SequenceYKALRISRKLAKNameYKAcNature of peptide or cargoIt is a nontransducing peptideAssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityTransdermal delivery(nmol)- -̴0Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1157SequenceWLRRASAPLPGLKNameP20Nature of peptide or cargoPhosphopeptide analogue of the heat shock protein (HSP) 20AssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityRate of skin penetration(nmol/cm2/h)- -̴0.1Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1158SequenceYARAAARQARANameYARANature of peptide or cargoMolecular modification of TAT has led to the discovery of a new, optimized PTD, YARA which can penetrate intact strips of porcine coronary artery and human saphenous vein smooth muscle.AssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityTransdermal delivery(nmol)- -̴0.04Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1159SequenceYGRKKRRQRRRNameTATNature of peptide or cargoHIV transcription factor TAT which is a protein transduction domainAssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityTransdermal delivery(nmol)- -̴0.05Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1160SequenceYKALRISRKLAKNameYKAcNature of peptide or cargoIt is a nontransducing peptideAssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityTransdermal delivery(nmol)- -̴0Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1161SequenceYARAAARQARANameYARANature of peptide or cargoMolecular modification of TAT has led to the discovery of a new, optimized PTD, YARA which can penetrate intact strips of porcine coronary artery and human saphenous vein smooth muscle.AssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityTransdermal delivery(nmol)- -̴0.046Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1162SequenceYGRKKRRQRRRNameTATNature of peptide or cargoHIV transcription factor TAT which is a protein transduction domainAssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityTransdermal delivery(nmol)- -̴0.055Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170
ID1163SequenceYKALRISRKLAKNameYKAcNature of peptide or cargoIt is a nontransducing peptideAssayFluorimetry analysis using Gemini SpectraMax plate readerTissue permeabilityTransdermal delivery(nmol)- -̴0Tissue SampleFreshly excised porcine ear skin's stratum corneum (facing the donor compartment) was mounted in a Franz diffusion cellPUBMED ID15906170