Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 266. Click on ID to see further detail.
IDOV_19Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_20Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result58% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_21Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result38% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_22Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_23Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result95% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_24Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result94% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_25Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result77% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_26Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result72% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_27Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result58% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_40Virus nameAdenovirusVirus strainAdCMV/GFPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationMutant with E1 deletion carrying a green fluorescent protein (GFP)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineDesnity of 1000000 in 60mm dishIn-vitro toxicityHighly toxic to NIH/3T3 as measured by crystal violet staining at 10 MOIAssayMTT assayIn-vitro virus concentration3.5 MOIIn-vitro result13% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26475304
IDOV_41Virus nameAdenovirusVirus strainAd dl1520Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b mutant with 827-bp deletion and a point mutation with premature stop codon in the E1B55K coding regionVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineDesnity of 1000000 in 60mm dishIn-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOIAssayMTT assayIn-vitro virus concentration3.5 MOIIn-vitro result54% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26475304
IDOV_42Virus nameAdenovirusVirus strainAd-cycEVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutant with a human cyclin E promoter driving an intact E1A expression cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineDesnity of 1000000 in 60mm dishIn-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOIAssayMTT assayIn-vitro virus concentration3.5 MOIIn-vitro result18% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivates CDK2 and targets the transcriptional repressor pRbClinical trialNAPMID26475304
IDOV_47Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result57% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_48Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with etoposide (0.5 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.67 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result24% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_49Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with epirubicin (0.5 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.46 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result16% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_50Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with doxorubicin (0.1 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.88 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result26% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_51Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with vincristine (0.1 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.79 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result25% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_52Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with colchcine (0.02 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.81 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result28% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_53Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result18% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_54Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with etoposide (0.5 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.27 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result4% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_55Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with epirubicin (0.5 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.31 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result4% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_56Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with doxorubicin (0.1 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.33 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result6% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_57Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with vincristine (0.1 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.89 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result12% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_58Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with colchcine (0.02 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.78 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result10% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_314Virus nameAdenovirusVirus strainAd.sp-E1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationViral E1A promoter was replaced by human survivin promoter (hsurP)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.5 MOIIn-vitro result28% cancer cell viability at 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26554307
IDOV_315Virus nameAdenovirusVirus strainAd.4N1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationViral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.5 MOIIn-vitro result78% cancer cell viability at 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduces apoptosis by upregulating Bax and activated caspase 3 levelsImmunogenic effectInduces expression of IL-24Clinical trialNAPMID26554307
IDOV_316Virus nameAdenovirusVirus strainAd.4N1-IL24Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationViral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettesVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.5 MOIIn-vitro result24% cancer cell viability at 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduces apoptosis by upregulating Bax and activated caspase 3 levelsImmunogenic effectInduces expression of IL-24Clinical trialNAPMID26554307
IDOV_317Virus nameAdenovirusVirus strainAd.sp-E1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationViral E1A promoter was replaced by human survivin promoter (hsurP)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result24% cancer cell viability at 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26554307
IDOV_318Virus nameAdenovirusVirus strainAd.4N1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationViral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result57% cancer cell viability at 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduces apoptosis by upregulating Bax and activated caspase 3 levelsImmunogenic effectInduces expression of IL-24Clinical trialNAPMID26554307
IDOV_319Virus nameAdenovirusVirus strainAd.4N1-IL24Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationViral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettesVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result18% cancer cell viability at 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduces apoptosis by upregulating Bax and activated caspase 3 levelsImmunogenic effectInduces expression of IL-24Clinical trialNAPMID26554307
IDOV_320Virus nameAdenovirusVirus strainAd.sp-E1AVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationViral E1A promoter was replaced by human survivin promoter (hsurP)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result22% cancer cell viability at 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26554307
IDOV_321Virus nameAdenovirusVirus strainAd.4N1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationViral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result45% cancer cell viability at 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduces apoptosis by upregulating Bax and activated caspase 3 levelsImmunogenic effectInduces expression of IL-24Clinical trialNAPMID26554307
IDOV_322Virus nameAdenovirusVirus strainAd.4N1-IL24Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationViral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettesVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result11% cancer cell viability at 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduces apoptosis by upregulating Bax and activated caspase 3 levelsImmunogenic effectInduces expression of IL-24Clinical trialNAPMID26554307
IDOV_326Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro result1% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_330Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration2.5 MOIIn-vitro result10% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_334Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration5 MOIIn-vitro result92% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_338Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result92% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_342Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration20 MOIIn-vitro result100% cancer cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_345Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result58% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_348Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneNoVirus in combination with drug/radiationVirus in combination with temozolomide (TMZ) - 0.6 mMImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2.5 MOIIn-vitro result18% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedJNK activation induces autophagyImmunogenic effectNAClinical trialNAPMID26561948
IDOV_351Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result49% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_352Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result26% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26561948
IDOV_353Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneNoVirus in combination with drug/radiationVirus in combination with temozolomide (TMZ) and 3-MA at -0.75 mM and 10 mM concentration, respectivelyImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result62% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedJNK activation induces autophagy (Autophagy effect slightly inhibited by 3-MA)Immunogenic effectNAClinical trialNAPMID26561948
IDOV_354Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneNoVirus in combination with drug/radiationVirus in combination with temozolomide (TMZ) and 3-MA at -0.75 mM and 10 mM concentration, respectivelyImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result44% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedJNK activation induces autophagy (Autophagy effect slightly inhibited by 3-MA)Immunogenic effectNAClinical trialNAPMID26561948
IDOV_355Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneNoVirus in combination with drug/radiationVirus in combination with temozolomide (TMZ) and BAF-A1 at -0.75 mM and 10 nM concentration, respectivelyImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result65% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedJNK activation induces autophagy (Autophagy effect slightly inhibited by Baf-A1)Immunogenic effectNAClinical trialNAPMID26561948
IDOV_356Virus nameAdenovirusVirus strainAdhz60Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutantVirus aloneNoVirus in combination with drug/radiationVirus in combination with temozolomide (TMZ) and BAF-A1 at -0.75 mM and 10 nM concentration, respectivelyImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line2.5E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result47% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedJNK activation induces autophagy (Autophagy effect slightly inhibited by Baf-A1)Immunogenic effectNAClinical trialNAPMID26561948
IDOV_1444Virus nameReovirusVirus strainReoT3DVirus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNCIOrigin of cell lineHuman NSCLC cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayXTT assayIn-vitro virus concentrationLog10 pfu/cellIn-vitro resultLess than 10% cell survived 48 hours after post infectionModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis, activation of caspase 3Immunogenic effectNAClinical trialNAPMID19594950
IDOV_2077Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of shMPP1 expressing cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineNAOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro resultSome cell death observedModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of senescenceImmunogenic effectNAClinical trialNAPMID21794078
IDOV_2078Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of shMPP1 expressing cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineNAOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro resultAll cells was deadModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of senescenceImmunogenic effectNAClinical trialNAPMID21794078
IDOV_2079Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of shMPP1 expressing cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineNAOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro resultAll cells was deadModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of senescenceImmunogenic effectNAClinical trialNAPMID21794078
IDOV_2080Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of shMPP1 expressing cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineNAOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration100 MOIIn-vitro resultAll cells was deadModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID21794078
IDOV_2106Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of AFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineATCCOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro resultSome cell death observedModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID21979578
IDOV_2107Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of AFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineATCCOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro resultSome cell death observedModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID21979578
IDOV_2108Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of AFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineATCCOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro resultSome cell death observedModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID21979578
IDOV_2109Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of AFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineATCCOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration100 MOIIn-vitro resultMost of the cells are diedModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID21979578
IDOV_2126Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of TRAIL geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineATCCOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro resultSome cell death observedModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID21979578
IDOV_2127Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of TRAIL geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineATCCOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro resultSome cell death observedModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID21979578
IDOV_2128Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of TRAIL geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineATCCOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro resultSome cell death observedModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID21979578
IDOV_2129Virus nameAdenovirusVirus strainMutantVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of E1BK55KD gene and addition of TRAIL geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing TRAIL geneSource of cell lineATCCOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration100 MOIIn-vitro resultSome cell death observedModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID21979578
IDOV_2211Virus nameNewcastle disease virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatinImmune gene insertion in viral genomeNoSource of cell lineChinese academy of scieceOrigin of cell lineHuman small cell lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/c nude mice xenograft for A549 cell lineIn-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume decreased to 500mm after 57 daysMode of deliveryIntratumoralPathway inducedInduction of caspase and apoptotic pathway as detected by Hoechst staining and TUNEL assayImmunogenic effectNAClinical trialNAPMID22095029
IDOV_2780Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro resultNo cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2781Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.5 MOIIn-vitro resultNo cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2782Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro resultNo cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2783Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration5 MOIIn-vitro resultModerate cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2784Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro resultAll cell was deadModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2795Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.5 MOIIn-vitro result90% cells are viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2796Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result90% cells are viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2797Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 MOIIn-vitro result80% cells are viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2798Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result70% cells are viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2799Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result50% cells are viableModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2805Virus nameAdenovirusVirus strainAd.sp-E1A-TSLC1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationDeletion of 24bp with in E1A gene and insertion of TSLC1 geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/c nude mice xenograft for A549In-vivo virus concentration5.0E+8 pfuIn-vivo toxicityNA In-vivo resultSignificant reduction in tumor volume and increased in survival rate fro 15% to 87% at day 60Mode of deliveryIntratumoralPathway inducedInduction of apotosis by virus in cancer cell line as measured by TUNEL assayImmunogenic effectNAClinical trialNAPMID23503473
IDOV_2844Virus nameMeasles virusVirus strainAttenuated strainVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1 million cells per wellIn-vitro toxicityNAAssayCell death detection kitIn-vitro virus concentration1 MOIIn-vitro result28% cells survivedModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedActivation of caspase-3Immunogenic effectNAClinical trialNAPMID23586034
IDOV_2852Virus nameMeasles virusVirus strainAttenuated strainVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineLaboratory grown own cultureOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismRJ:NMRI nude mice xenograft for A549 cell line (1.5E+7) In-vivo virus concentration1.0E+6 pfuIn-vivo toxicityNA In-vivo resultSignificant reduction in tumor volume after 42 daysMode of deliveryIntratumoralPathway inducedActivation of caspase-3Immunogenic effectNAClinical trialNAPMID23586034
IDOV_2934Virus nameNewcastle disease virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationExpressing rl geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell linePeking university chinaOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/c nude mice xenograft for A549 cell line (6.3E+8)In-vivo virus concentration6.3E+8 pfuIn-vivo toxicityNA In-vivo resultTumor volume regressed to 274 +/- 114.20 compared to control 271.78 +/- 110.79 after day 1Mode of deliveryIntratumoralPathway inducedInduction of apoptosis by virusImmunogenic effectNAClinical trialNAPMID25364430
IDOV_2935Virus nameNewcastle disease virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationExpressing rl geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell linePeking university chinaOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/c nude mice xenograft for A549 cell line (6.3E+8)In-vivo virus concentration6.3E+8 pfuIn-vivo toxicityNA In-vivo resultTumor volume regressed to 444.18 +/- 111.22 compared to control 591.45 +/- 244.50 after day 7Mode of deliveryIntratumoralPathway inducedInduction of apoptosis by virusImmunogenic effectNAClinical trialNAPMID25364430
IDOV_2936Virus nameNewcastle disease virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationExpressing rl geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell linePeking university chinaOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/c nude mice xenograft for A549 cell line (6.3E+8)In-vivo virus concentration6.3E+8 pfuIn-vivo toxicityNA In-vivo resultTumor volume regressed to 657.56 +/- 176.74 compared to control 1483.21 +/- 446.75 after 14 dayMode of deliveryIntratumoralPathway inducedInduction of apoptosis by virusImmunogenic effectNAClinical trialNAPMID25364430
IDOV_2937Virus nameNewcastle disease virusVirus strainwild typeVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationExpressing rl geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell linePeking university chinaOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/c nude mice xenograft for A549 cell line (6.3E+8)In-vivo virus concentration6.3E+8 pfuIn-vivo toxicityNA In-vivo resultTumor volume regressed to 804.96 +/- 176.74 compared to control 1127.88 +/- 274.09 after 21 daysMode of deliveryIntratumoralPathway inducedInduction of apoptosis by virusImmunogenic effectNAClinical trialNAPMID25364430
IDOV_3051Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result18% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3052Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3053Virus nameVaccinia virusVirus strainDeltaJ2R/FCU1 VACVVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result1% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3081Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻⁴ MOIIn-vitro result30% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3082Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻³ MOIIn-vitro result15% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3083Virus nameVaccinia virusVirus strainDeltaJ2R-I4L/FCU1 VACV (TG6002)Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of J2R and I4L gene and insertion of gene FCU1Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line3.0E+5 cells per wellIn-vitro toxicityNAAssayTrypan blue assayIn-vitro virus concentration10⁻² MOIIn-vitro result5% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID31011628
IDOV_3464Virus nameAdenovirusVirus strainAdenovirus CRAdsVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell collection centre chinaOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration100 MOIIn-vitro result22% inhibition in tumor inhibitionModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28638457
IDOV_3465Virus nameAdenovirusVirus strainAdenovirus CRAdsVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell collection centre chinaOrigin of cell lineHuman lung cancer cell lineCell lineA549-DDPR cisplatin resistantConcentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration100 MOIIn-vitro result55% inhibition in tumor inhibitionModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28638457
IDOV_3498Virus nameAdenovirusVirus strainAdenovirus CRAdsVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell collection centre chinaOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBalb/c nude mice xenograft for SW-620 cell line (1.0E+6)In-vivo virus concentration8.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor size regressed to 700mm compared to control 900mm after 65 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID28638457
IDOV_3499Virus nameAdenovirusVirus strainAdenovirus CRAdsVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatinImmune gene insertion in viral genomeNoSource of cell lineCell collection centre chinaOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBalb/c nude mice xenograft for SW-620 cell line (1.0E+6)In-vivo virus concentration8.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor size regressed to 100mm compared to control 900mm after 65 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID28638457
IDOV_3500Virus nameAdenovirusVirus strainAdenovirus CRAdsVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell collection centre chinaOrigin of cell lineHuman lung cancer cell lineCell lineA549-DDPR cisplatin resistantConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBalb/c nude mice xenograft for SW-620 cell line (1.0E+6)In-vivo virus concentration8.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor size regressed to 800mm compared to control 900mm after 65 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID28638457
IDOV_3501Virus nameAdenovirusVirus strainAdenovirus CRAdsVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with cisplatinImmune gene insertion in viral genomeNoSource of cell lineCell collection centre chinaOrigin of cell lineHuman lung cancer cell lineCell lineA549-DDPR cisplatin resistantConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBalb/c nude mice xenograft for SW-620 cell line (1.0E+6)In-vivo virus concentration8.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor size regressed to 300mm compared to control 900mm after 65 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID28638457
IDOV_3711Virus nameEnterovirusVirus strainECHO-7 virus stain RigvirVirus genome typeRNAVirus familyPicornaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell linePublic health englandOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayLive cell imaging systemIn-vitro virus concentration1% virus concentrationIn-vitro result92% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID29581783
IDOV_3718Virus nameEnterovirusVirus strainECHO-7 virus stain RigvirVirus genome typeRNAVirus familyPicornaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell linePublic health englandOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayLive cell imaging systemIn-vitro virus concentration10% virus concentrationIn-vitro result91% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID29581783
IDOV_3831Virus nameNewcastle disease virusVirus strainNDVstrain 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result23% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3832Virus nameNewcastle disease virusVirus strainNDVstrain 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result34% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3833Virus nameNewcastle disease virusVirus strainNDVstrain 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result35% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3834Virus nameNewcastle disease virusVirus strainNDVstrain 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result38% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3835Virus nameNewcastle disease virusVirus strainNDVstrain 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result39% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3836Virus nameNewcastle disease virusVirus strainNDVstrain 14Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result40% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3837Virus nameNewcastle disease virusVirus strainNDVstrain 860Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result40% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3838Virus nameNewcastle disease virusVirus strainNDVstrain 753Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result40% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3839Virus nameNewcastle disease virusVirus strainNDVstrain ADVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result42% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3840Virus nameNewcastle disease virusVirus strainNDVstrain 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result42% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3841Virus nameNewcastle disease virusVirus strainNDVstrain 718Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result50% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3842Virus nameNewcastle disease virusVirus strainNDVstrain 922Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result50% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3843Virus nameNewcastle disease virusVirus strainNDVstrain 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result58% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3844Virus nameNewcastle disease virusVirus strainNDVstrain 53Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result60% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3845Virus nameNewcastle disease virusVirus strainNDVstrain 777Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result60% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3846Virus nameNewcastle disease virusVirus strainNDVstrain 27Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result61% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3847Virus nameNewcastle disease virusVirus strainNDVstrain 769Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result61% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3848Virus nameNewcastle disease virusVirus strainNDVstrain 12Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result70% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3849Virus nameNewcastle disease virusVirus strainNDVstrain 945Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result78% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3850Virus nameNewcastle disease virusVirus strainNDVstrain 49Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result80% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3851Virus nameNewcastle disease virusVirus strainNDVstrain 52Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result81% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3852Virus nameNewcastle disease virusVirus strainNDVstrain 746Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result90% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3853Virus nameNewcastle disease virusVirus strainNDVstrain 465Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result90% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3854Virus nameNewcastle disease virusVirus strainNDVstrain 429Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result90% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3855Virus nameNewcastle disease virusVirus strainNDVstrain 329Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result97% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3856Virus nameNewcastle disease virusVirus strainNDVstrain 339Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result98% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3857Virus nameNewcastle disease virusVirus strainNDVstrain 389Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result98% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3858Virus nameNewcastle disease virusVirus strainNDVstrain 48Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result100% cell viability after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3941Virus nameNewcastle disease virusVirus strainNDVstrain 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result49% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3942Virus nameNewcastle disease virusVirus strainNDVstrain 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result36% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3943Virus nameNewcastle disease virusVirus strainNDVstrain 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result34% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3944Virus nameNewcastle disease virusVirus strainNDVstrain 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result30% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3945Virus nameNewcastle disease virusVirus strainNDVstrain 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result33% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3946Virus nameNewcastle disease virusVirus strainNDVstrain 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result34% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3947Virus nameNewcastle disease virusVirus strainNDVstrain 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result51% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3948Virus nameNewcastle disease virusVirus strainNDVstrain 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result47% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3949Virus nameNewcastle disease virusVirus strainNDVstrain 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result46% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3950Virus nameNewcastle disease virusVirus strainNDVstrain 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result58% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3951Virus nameNewcastle disease virusVirus strainNDVstrain 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result59% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3952Virus nameNewcastle disease virusVirus strainNDVstrain 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result57% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3953Virus nameNewcastle disease virusVirus strainNDVstrain 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result34% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3954Virus nameNewcastle disease virusVirus strainNDVstrain 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result45% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3955Virus nameNewcastle disease virusVirus strainNDVstrain 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result40% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3956Virus nameNewcastle disease virusVirus strainNDVstrain 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result44% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3957Virus nameNewcastle disease virusVirus strainNDVstrain 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result22% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3958Virus nameNewcastle disease virusVirus strainNDVstrain 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result22% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3959Virus nameNewcastle disease virusVirus strainNDVstrain 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result40% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3960Virus nameNewcastle disease virusVirus strainNDVstrain 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result38% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3961Virus nameNewcastle disease virusVirus strainNDVstrain 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result38% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3962Virus nameNewcastle disease virusVirus strainNDVstrain 769Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result53% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3963Virus nameNewcastle disease virusVirus strainNDVstrain 769Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result60% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3964Virus nameNewcastle disease virusVirus strainNDVstrain 769Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result62% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3965Virus nameNewcastle disease virusVirus strainNDVstrain 860Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result59% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3966Virus nameNewcastle disease virusVirus strainNDVstrain 860Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result49% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3967Virus nameNewcastle disease virusVirus strainNDVstrain 860Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result40% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3968Virus nameNewcastle disease virusVirus strainNDVstrain 777Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result72 cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3969Virus nameNewcastle disease virusVirus strainNDVstrain 777Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result70% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3970Virus nameNewcastle disease virusVirus strainNDVstrain 777Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result60% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3971Virus nameNewcastle disease virusVirus strainNDVstrain 14Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result44% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3972Virus nameNewcastle disease virusVirus strainNDVstrain 14Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result39% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3973Virus nameNewcastle disease virusVirus strainNDVstrain 14Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result39% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3974Virus nameNewcastle disease virusVirus strainNDVstrain 718Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result59% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3975Virus nameNewcastle disease virusVirus strainNDVstrain 718Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result55% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3976Virus nameNewcastle disease virusVirus strainNDVstrain 718Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result49% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3977Virus nameNewcastle disease virusVirus strainNDVstrain 465Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result69% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3978Virus nameNewcastle disease virusVirus strainNDVstrain 465Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result61% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3979Virus nameNewcastle disease virusVirus strainNDVstrain 465Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result59% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3980Virus nameNewcastle disease virusVirus strainNDVstrain 922Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result79% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3981Virus nameNewcastle disease virusVirus strainNDVstrain 922Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result65% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3982Virus nameNewcastle disease virusVirus strainNDVstrain 922Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result52% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3983Virus nameNewcastle disease virusVirus strainNDVstrain 27Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result75% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3984Virus nameNewcastle disease virusVirus strainNDVstrain 27Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result65% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3985Virus nameNewcastle disease virusVirus strainNDVstrain 27Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result61% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3986Virus nameNewcastle disease virusVirus strainNDVstrain ADVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result63% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3987Virus nameNewcastle disease virusVirus strainNDVstrain ADVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result49% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3988Virus nameNewcastle disease virusVirus strainNDVstrain ADVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result46% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3989Virus nameNewcastle disease virusVirus strainNDVstrain 753Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result50% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3990Virus nameNewcastle disease virusVirus strainNDVstrain 753Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result50% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3991Virus nameNewcastle disease virusVirus strainNDVstrain 753Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result45% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3998Virus nameNewcastle disease virusVirus strainNDVwild 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result50% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_3999Virus nameNewcastle disease virusVirus strainNDVwild 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result45% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4000Virus nameNewcastle disease virusVirus strainNDVwild 264Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result45% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4010Virus nameNewcastle disease virusVirus strainNDVwild 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result35% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4011Virus nameNewcastle disease virusVirus strainNDVwild 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result37% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4012Virus nameNewcastle disease virusVirus strainNDVwild 320Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result38% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4022Virus nameNewcastle disease virusVirus strainNDVwild 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result50% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4023Virus nameNewcastle disease virusVirus strainNDVwild 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result45% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4024Virus nameNewcastle disease virusVirus strainNDVwild 321Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result44% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4034Virus nameNewcastle disease virusVirus strainNDVwild 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result59% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4035Virus nameNewcastle disease virusVirus strainNDVwild 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result59% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4036Virus nameNewcastle disease virusVirus strainNDVwild 373Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result59% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4046Virus nameNewcastle disease virusVirus strainNDVwild 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result30% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4047Virus nameNewcastle disease virusVirus strainNDVwild 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result42% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4048Virus nameNewcastle disease virusVirus strainNDVwild 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result39% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4058Virus nameNewcastle disease virusVirus strainNDVwild 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result45% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4059Virus nameNewcastle disease virusVirus strainNDVwild 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result20% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4060Virus nameNewcastle disease virusVirus strainNDVwild 852Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result20% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4070Virus nameNewcastle disease virusVirus strainNDVwild 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration2 HAUIn-vitro result40% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4071Virus nameNewcastle disease virusVirus strainNDVwild 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration8 HAUIn-vitro result38% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4072Virus nameNewcastle disease virusVirus strainNDVwild 776Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell line10000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration16 HAUIn-vitro result38% cell survival after 4th dayModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4076Virus nameNewcastle disease virusVirus strainNDVwild 770Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineResearch institute of fundamental and clinical immunology, RussiaOrigin of cell lineHuman non-small lung carcinoma cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismSCID mice xenograft for A459 cell (3.5E+6)In-vivo virus concentration16 HAUIn-vivo toxicityNA In-vivo result4.2 fold decrease in tumor size compared to control after 15th dayMode of deliveryNAPathway inducedVirus induces apoptosis, necrosis and autophagy in cancer cellsImmunogenic effectInduction of MARK signalling pathwayClinical trialNAPMID29621357
IDOV_4111Virus nameAdenovirusVirus strainAd-CCL20-CD40LVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAddition of CCL20 and CD40L gene near by TERT promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomevirus expressing CCL20 chemokine geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+5 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result90% cell survival after 7 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26208317
IDOV_4194Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell bank of chinese academy of scienceOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayCCK-8 assayIn-vitro virus concentration100 MOIIn-vitro result100% cell viability after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26280082
IDOV_4195Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell bank of chinese academy of scienceOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayCCK-8 assayIn-vitro virus concentration100 MOIIn-vitro result100% cell viability after day 2Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26280082
IDOV_4196Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell bank of chinese academy of scienceOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayCCK-8 assayIn-vitro virus concentration100 MOIIn-vitro result100% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26280082
IDOV_4197Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell bank of chinese academy of scienceOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayCCK-8 assayIn-vitro virus concentration100 MOIIn-vitro result100% cell viability after day 4Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26280082
IDOV_4198Virus nameAdenovirusVirus strainwild typeVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell bank of chinese academy of scienceOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayCCK-8 assayIn-vitro virus concentration100 MOIIn-vitro result100% cell viability after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26280082
IDOV_4199Virus nameAdenovirusVirus strainAd-CXCR4-DAL1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus expressing DAL-1 gene under promoter CXXR4Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell bank of chinese academy of scienceOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayCCK-8 assayIn-vitro virus concentration100 MOIIn-vitro result100% cell viability after day 1Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26280082
IDOV_4200Virus nameAdenovirusVirus strainAd-CXCR4-DAL1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus expressing DAL-1 gene under promoter CXXR4Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell bank of chinese academy of scienceOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayCCK-8 assayIn-vitro virus concentration100 MOIIn-vitro result100% cell viability after day 2Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26280082
IDOV_4201Virus nameAdenovirusVirus strainAd-CXCR4-DAL1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus expressing DAL-1 gene under promoter CXXR4Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell bank of chinese academy of scienceOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayCCK-8 assayIn-vitro virus concentration100 MOIIn-vitro result100% cell viability after day 3Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26280082
IDOV_4202Virus nameAdenovirusVirus strainAd-CXCR4-DAL1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus expressing DAL-1 gene under promoter CXXR4Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell bank of chinese academy of scienceOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayCCK-8 assayIn-vitro virus concentration100 MOIIn-vitro result100% cell viability after day 4Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26280082
IDOV_4203Virus nameAdenovirusVirus strainAd-CXCR4-DAL1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus expressing DAL-1 gene under promoter CXXR4Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineCell bank of chinese academy of scienceOrigin of cell lineHuman lung adenocarcinoma cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayCCK-8 assayIn-vitro virus concentration100 MOIIn-vitro result10% cell viability after day 5Model organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosis process leads to cancer cell deathImmunogenic effectNAClinical trialNAPMID26280082
IDOV_4305Virus nameAlphavirusVirus strainM1Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung carcinomaCell lineA549Concentration of cell line4000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 pfuIn-vitro result68.2 % cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosisImmunogenic effectNAClinical trialNAPMID26373347
IDOV_4422Virus nameVesicular stomatitis virusVirus strainRdBVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationVirus expressing VSVG epitope, with no dletion in HI-loop, no addition of linkerVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.2E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration21:1 particle to pfuIn-vitro result48% cell survival after 4 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26430798
IDOV_4430Virus nameVesicular stomatitis virusVirus strainRdB-1L-VSVGVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationVirus expressing VSVG epitope, with no dletion in HI-loop, addition of single linkerVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.2E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration24:1 particle to pfuIn-vitro result20% cell survival after 4 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26430798
IDOV_4474Virus nameAdenovirusVirus strainoAD/DCN-shMetVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAdenovirus conjugated with DCN and shMetVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line70% confluence in 24 well plateIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result65% cancer cell survivalability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectIncreased in IL-6 level to 140pg/ml compared to control 20 pg/mlClinical trialNAPMID26951927
IDOV_4475Virus nameAdenovirusVirus strainoAD/DCN-shMet/PPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAdenovirus conjugated with DCN, shMet and PEGylated at PAMAMVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line70% confluence in 24 well plateIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result58% cancer cell survivalability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectIncreased in IL-6 level to 40pg/ml compared to control 20 pg/mlClinical trialNAPMID26951927
IDOV_4476Virus nameAdenovirusVirus strainoAD/DCN-shMet/PPEVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationAdenovirus conjugated with DCN, shMet and Erbitux-conjugated PEGylated at PAMAMVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line70% confluence in 24 well plateIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result18% cancer cell survivalability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectIncreased in IL-6 level to 40pg/ml compared to control 20 pg/mlClinical trialNAPMID26951927
IDOV_4539Virus nameAdenovirusVirus strainCD55-TRAIL+ CD55-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing TRAIl and MnSOD geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result100% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4540Virus nameAdenovirusVirus strainCD55-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing MnSOD geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result97% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4541Virus nameAdenovirusVirus strainCD55-TRAILVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing TRAIL geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result97% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4542Virus nameAdenovirusVirus strainCD55-TRAIL-IETD-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus having TRAIL, MnSOD gene linked via IETD caspase 8 cleavage siteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result90% cell survival after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4543Virus nameAdenovirusVirus strainCD55-TRAIL+ CD55-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing TRAIl and MnSOD geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result90% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4544Virus nameAdenovirusVirus strainCD55-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing MnSOD geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result82% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4545Virus nameAdenovirusVirus strainCD55-TRAILVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing TRAIL geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result82% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4546Virus nameAdenovirusVirus strainCD55-TRAIL-IETD-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus having TRAIL, MnSOD gene linked via IETD caspase 8 cleavage siteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result72% cell survival after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4547Virus nameAdenovirusVirus strainCD55-TRAIL+ CD55-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing TRAIl and MnSOD geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result72% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4548Virus nameAdenovirusVirus strainCD55-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing MnSOD geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result60% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4549Virus nameAdenovirusVirus strainCD55-TRAILVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing TRAIL geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result60% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4550Virus nameAdenovirusVirus strainCD55-TRAIL-IETD-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus having TRAIL, MnSOD gene linked via IETD caspase 8 cleavage siteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result50% cell survival after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4551Virus nameAdenovirusVirus strainCD55-TRAIL+ CD55-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing TRAIl and MnSOD geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result40% cell survival after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4552Virus nameAdenovirusVirus strainCD55-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing MnSOD geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result42% cell survival after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4553Virus nameAdenovirusVirus strainCD55-TRAILVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationvirus containing TRAIL geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result42% cell survival after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4554Virus nameAdenovirusVirus strainCD55-TRAIL-IETD-MnSODVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus having TRAIL, MnSOD gene linked via IETD caspase 8 cleavage siteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result35% cell survival after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induced apoptosisImmunogenic effectNAClinical trialNAPMID27080225
IDOV_4951Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4952Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result25% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4953Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result40% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4954Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result60% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4955Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result40% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4956Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result60% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4957Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result70% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4958Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result80% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4959Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result70% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4960Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result80% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4961Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result90% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4962Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result90% cell viability after 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4963Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result20% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4964Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result50% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4965Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result60% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4966Virus nameVaccinia virusVirus strainvv-IL-24Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of IL-24 gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing IL-24 geneSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result80% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4967Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result60% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4968Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4969Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_4970Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineShanghai cell collectionOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.01 MOIIn-vitro result100% cell viability after 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMID27208781
IDOV_5016Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result55% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5017Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result42% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5018Virus nameVaccinia virusVirus strainVG9Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result30% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5019Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result58% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5020Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result44% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5021Virus nameVaccinia virusVirus strainVG9-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result40% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5022Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result58% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5023Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result46% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5024Virus nameVaccinia virusVirus strainWR-EGFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationAddition of EGFP gene in tk locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result40% cell viability after 3 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28465492
IDOV_5070Virus nameAvian orthoreovirusVirus strainARV-PB1Virus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line1.0E+3 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result80% cell viability after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28441762
IDOV_5108Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.001 MOIIn-vitro result100% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5109Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.01 MOIIn-vitro result80% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5110Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result50% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5111Virus nameVaccinia virusVirus strainvvdd-tdTomato-hDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of human DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing human DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5112Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.001 MOIIn-vitro result100% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5113Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.01 MOIIn-vitro result100% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5114Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration0.1 MOIIn-vitro result60% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5115Virus nameVaccinia virusVirus strainvvdd-tdTomato-mDAIVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion of tk gene and vaccinia growth gene and addition of murine DAIVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeVirus expressing murine DAI geneSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+4 cells per wellIn-vitro toxicityNAAssayMTS assayIn-vitro virus concentration1 MOIIn-vitro result10% cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduction of Immunogenic gene such as T cell activationClinical trialNAPMID27626058
IDOV_5339Virus nameNewcastle disease virusVirus strainLaSotaVirus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman nonsmall cell lung carcinomaCell lineA549Concentration of cell line5.0E+4 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.001 MOIIn-vitro result16% cells remain viable after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedVirus induce apoptosisImmunogenic effectInduced production of IFN-alpha, IFN-beta, IL-6and IFN-gammaClinical trialNAPMID28293547
IDOV_5598Virus nameNewcastle disease virusVirus strainNDV-MK107Virus genome typeRNAVirus familyParamyxoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung carcinoma cell lineCell lineA549Concentration of cell line80% confluencyIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration13 pfuIn-vitro result50% of cancer cell death occursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis by virus infectionImmunogenic effectInduction of IFN-Gamma productionClinical trialNAPMIDUS7470426
IDOV_5891Virus nameAdenovirusVirus strainCGTG-602Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationVirus E1A promoter is replaced by human E2F1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineNAIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 ×10⁴ pfuIn-vitro result80% of cancer cell death occurs after 100 daysModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMIDUS9410129