Detailed description page of Selected OV_ID


OV_42 details
Primary information
OV_IDOV_42
Virus Name Adenovirus
StrainAd-cycE
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeE1b-deleted mutant with a human cyclin E promoter driving an intact E1A expression cassette
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman lung cancer cell line
Cell lineA549
Concentration of cell line0
In-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOI
AssayMTT assay
In-vitro virus concentration3.5 MOI
In-vitro result18% cancer cell viability
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionNA
Immunogenic effectActivates CDK2 and targets the transcriptional repressor pRb
Clinical trialNA
PMID26475304