| Primary information |
|---|
| OV_ID | OV_4076 |
| Virus Name | Newcastle disease virus |
| Strain | NDVwild 770 |
| Virus type | RNA |
| Virus family | Paramyxoviridae |
| Modification in virus genome | None |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | Research institute of fundamental and clinical immunology, Russia |
| Origin of cell line | Human non-small lung carcinoma cell line |
| Cell line | A549 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | SCID mice xenograft for A459 cell (3.5 × 10â¶) |
| In-vivo virus concentration | 16 HAU |
| In-vivo toxicity | NA |
| In-vivo result | 4.2 fold decrease in tumor size compared to control after 15th day |
| Mode of delivery | NA |
| Pathway induction | Virus induces apoptosis, necrosis and autophagy in cancer cells |
| Immunogenic effect | Induction of MARK signalling pathway |
| Clinical trial | NA |
| PMID | 29621357 |