Detailed description page of Selected OV_ID


OV_4076 details
Primary information
OV_IDOV_4076
Virus Name Newcastle disease virus
StrainNDVwild 770
Virus typeRNA
Virus familyParamyxoviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineResearch institute of fundamental and clinical immunology, Russia
Origin of cell lineHuman non-small lung carcinoma cell line
Cell lineA549
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismSCID mice xenograft for A459 cell (3.5 × 10⁶)
In-vivo virus concentration16 HAU
In-vivo toxicityNA
In-vivo result4.2 fold decrease in tumor size compared to control after 15th day
Mode of deliveryNA
Pathway inductionVirus induces apoptosis, necrosis and autophagy in cancer cells
Immunogenic effectInduction of MARK signalling pathway
Clinical trialNA
PMID29621357