Detailed description page of Selected OV_ID


OV_354 details
Primary information
OV_IDOV_354
Virus Name Adenovirus
StrainAdhz60
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeE1b-deleted mutant
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with temozolomide (TMZ) and 3-MA at -0.75 mM and 10 mM concentration, respectively
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman lung cancer cell line
Cell lineA549
Concentration of cell line3
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration10 MOI
In-vitro result44% cancer cell viability
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionJNK activation induces autophagy (Autophagy effect slightly inhibited by 3-MA)
Immunogenic effectNA
Clinical trialNA
PMID26561948