| Primary information |
|---|
| OV_ID | OV_354 |
| Virus Name | Adenovirus |
| Strain | Adhz60 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | E1b-deleted mutant |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus in combination with temozolomide (TMZ) and 3-MA at -0.75 mM and 10 mM concentration, respectively |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Human lung cancer cell line |
| Cell line | A549 |
| Concentration of cell line | 3 |
| In-vitro toxicity | NA |
| Assay | MTT assay |
| In-vitro virus concentration | 10 MOI |
| In-vitro result | 44% cancer cell viability |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | JNK activation induces autophagy (Autophagy effect slightly inhibited by 3-MA) |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 26561948 |