| Primary information |
|---|
| OV_ID | OV_4476 |
| Virus Name | Adenovirus |
| Strain | oAD/DCN-shMet/PPE |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Adenovirus conjugated with DCN, shMet and Erbitux-conjugated PEGylated at PAMAM |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | ATCC |
| Origin of cell line | Human lung carcinoma cell line |
| Cell line | A549 |
| Concentration of cell line | 70 |
| In-vitro toxicity | NA |
| Assay | MTT assay |
| In-vitro virus concentration | 1 MOI |
| In-vitro result | 18% cancer cell survivalability after 48 hours |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | NA |
| Immunogenic effect | Increased in IL-6 level to 40pg/ml compared to control 20 pg/ml |
| Clinical trial | NA |
| PMID | 26951927 |