Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0589 | IMO-3 Click for more detail | NA | 5'-TCAGToCG2TTAC-Z-CATTG2CoTGACT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-3 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0589 | IMO-3 Click for more detail | NA | 5'-TCAGToCG2TTAC-Z-CATTG2CoTGACT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-3 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0590 | IMO-4 Click for more detail | NA | 5'-TCTGoToCG2TTAG-M-GATTG2CoToGTCT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-4 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0590 | IMO-4 Click for more detail | NA | 5'-TCTGoToCG2TTAG-M-GATTG2CoToGTCT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-4 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0591 | IMO-5 Click for more detail | NA | 5'-CAGTCoG2TTCAG-Z-GACTTG2oCTGAC-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-5 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0591 | IMO-5 Click for more detail | NA | 5'-CAGTCoG2TTCAG-Z-GACTTG2oCTGAC-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-5 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0592 | IMO-6 Click for more detail | NA | 5'-TCG1TCG1TTTY-M-YTTTG1CTG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-6 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0592 | IMO-6 Click for more detail | NA | 5'-TCG1TCG1TTTY-M-YTTTG1CTG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-6 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0593 | IMO-7 Click for more detail | NA | 5'-TCG1TCG1TTTY-X-YTTTG1CTG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-7 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0593 | IMO-7 Click for more detail | NA | 5'-TCG1TCG1TTTY-X-YTTTG1CTG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-7 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0594 | IMO-8 Click for more detail | NA | 5'-TCG1TCG1TTTUU-X-UUTTTG1CTG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-8 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0594 | IMO-8 Click for more detail | NA | 5'-TCG1TCG1TTTUU-X-UUTTTG1CTG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-8 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0595 | IMO-9 Click for more detail | NA | 5'-TCG1TCG1TTdUY-Z-YdUTTG1CTG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-9 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0595 | IMO-9 Click for more detail | NA | 5'-TCG1TCG1TTdUY-Z-YdUTTG1CTG1CT-5' | NA | Nucleic Acid | Synthetic | Binding leads to the secretion of cytokines and chemokines such as IL-6, IP-10, IL-12 and MCP-9 | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | HEK293 cells, Bcells, PDCs, mDCs, PBMC | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | This has immunostimulatory effect | Cytokines assay | 20381019 | 2010 | Pubchem Assay |
| PRRID_0596 | intranigral Lipopolysaccharide (LPS) injection Click for more detail | exogenous (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | PD animal model | microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It upregulates proinflammatory cytokines and free radical production, leads to dopaminergic cell death. | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0596 | intranigral Lipopolysaccharide (LPS) injection Click for more detail | exogenous (others) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | PD animal model | microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It upregulates proinflammatory cytokines and free radical production, leads to dopaminergic cell death. | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0599 | Korean mistletoe lectin (KML-C) Click for more detail | Korean mistletoe (Viscum album coloratum) (plant) | NA | NA | Lectin | Natural | Binding leads to the upregulation of interleukin-1 receptor-associated kinase-1 (IRAK1), resulting in macrophage activation and TNF-a production. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | KML-C has strong immunomodulatory effects, such as immune cell activation and cytokine induction, which results in antitumor activities or protection from microbial infections. | ELISA | 20450885 | 2010 | Pubchem Assay |
| PRRID_0599 | Korean mistletoe lectin (KML-C) Click for more detail | Korean mistletoe (Viscum album coloratum) (plant) | NA | NA | Lectin | Natural | Binding leads to the upregulation of interleukin-1 receptor-associated kinase-1 (IRAK1), resulting in macrophage activation and TNF-a production. | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | KML-C has strong immunomodulatory effects, such as immune cell activation and cytokine induction, which results in antitumor activities or protection from microbial infections. | ELISA | 20450885 | 2010 | Pubchem Assay |
| PRRID_0600 | Lactoferrin Click for more detail | Human (others) | MKLVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQRNMRRVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRNAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAEDAGDVAFVKGVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK | 711 | Glycoprotein | Natural | It activates the NF- | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human monocytic leukemia cell line, THP-1 | LRR | O00206.fasta | O00206 | 839 | It has a immunostimulatory role | EMSA | 20345905 | 2010 | Pubchem Assay |
| PRRID_0600 | Lactoferrin Click for more detail | Human (others) | MKLVFLVLLFLGALGLCLAGRRRRSVQWCAVSQPEATKCFQWQRNMRRVRGPPVSCIKRDSPIQCIQAIAENRADAVTLDGGFIYEAGLAPYKLRPVAAEVYGTERQPRTHYYAVAVVKKGGSFQLNELQGLKSCHTGLRRNAGWNVPIGTLRPFLNWTGPPEPIEAAVARFFSASCVPGADKGQFPNLCRLCAGTGENKCAFSSQEPYFSYSGAFKCLRDGAGDVAFIRESTVFEDLSDEAERDEYELLCPDNTRKPVDKFKDCHLARVPSHAVVARSVNGKEDAIWNLLRQAQEKFGKDKSPKFQLFGSPSGQKDLLFKDSAIGFSRVPPRIDSGLYLGSGYFTAIQNLRKSEEEVAARRARVVWCAVGEQELRKCNQWSGLSEGSVTCSSASTTEDCIALVLKGEADAMSLDGGYVYTAGKCGLVPVLAENYKSQQSSDPDPNCVDRPVEGYLAVAVVRRSDTSLTWNSVKGKKSCHTAVDRTAGWNIPMGLLFNQTGSCKFDEYFSQSCAPGSDPRSNLCALCIGDEQGENKCVPNSNERYYGYTGAFRCLAEDAGDVAFVKGVTVLQNTDGNNNEAWAKDLKLADFALLCLDGKRKPVTEARSCHLAMAPNHAVVSRMDKVERLKQVLLHQQAKFGRNGSDCPDKFCLFQSETKNLLFNDNTECLARLHGKTTYEKYLGPQYVAGITNLKKCSTSPLLEACEFLRK | 711 | Glycoprotein | Natural | It activates the NF- | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | human monocytic leukemia cell line, THP-1 | LRR | O00206.fasta | O00206 | 839 | It has a immunostimulatory role | EMSA | 20345905 | 2010 | Pubchem Assay |
| PRRID_0601 | LAM Click for more detail | Mycobacteria (Bacteria) | OC[C@H]1O[C@@H](S[C@H]2[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@H](O)[C@@H](CO)O[C@H](Oc4ccc(cc4)[N+]([O-])=O)[C@@H]3O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0601 | LAM Click for more detail | Mycobacteria (Bacteria) | OC[C@H]1O[C@@H](S[C@H]2[C@H](O)[C@@H](CO)O[C@@H](O[C@@H]3[C@H](O)[C@@H](CO)O[C@H](Oc4ccc(cc4)[N+]([O-])=O)[C@@H]3O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-α and induces augment PMN migration. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | Lung's endothelial cell | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | It has the role in the inflammation. | NA | 20706658 | 2010 | Pubchem Assay |
| PRRID_0602 | lentinan Click for more detail | Lentinus edodes (fungi) | C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)OC5C(C(C(C(O5)COC6C(C(C(C(O6)CO)O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)O)O)O)O)O)O)O)O | NA | Biological response modifiers (BRMs) | Natural | Medicinal properties | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | used clinically for cancer therapy | NA | 20699131 | 2010 | Pubchem Assay |
| PRRID_0602 | lentinan Click for more detail | Lentinus edodes (fungi) | C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)OC5C(C(C(C(O5)COC6C(C(C(C(O6)CO)O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)O)O)O)O)O)O)O)O | NA | Biological response modifiers (BRMs) | Natural | Medicinal properties | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | used clinically for cancer therapy | NA | 20699131 | 2010 | Pubchem Assay |
| PRRID_0604 | lipo-arabinomannan Click for more detail | Mycobacteria (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0604 | lipo-arabinomannan Click for more detail | Mycobacteria (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0605 | lipo-arabinomannan Click for more detail | Mycobacteria (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0605 | lipo-arabinomannan Click for more detail | Mycobacteria (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0607 | lipomannas Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Glycolipid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0607 | lipomannas Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Glycolipid | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0608 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | K63-linked ubiquitination of Beclin1 using TRAF6 and A20 and triggered autophagy | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Plasma Membrane | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to autophagy and hence clearance of the pathogen | NA | 20798608 | 2010 | Pubchem Assay |
| PRRID_0608 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | K63-linked ubiquitination of Beclin1 using TRAF6 and A20 and triggered autophagy | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Plasma Membrane | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to autophagy and hence clearance of the pathogen | NA | 20798608 | 2010 | Pubchem Assay |
| PRRID_0609 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | On binding to the receptor it leads to the release of an array of cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | P815 cells | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Immunostimulation and inflammation | NA | 20798518 | 2010 | Pubchem Assay |
| PRRID_0609 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | On binding to the receptor it leads to the release of an array of cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | P815 cells | NA | Leucine-rich Repeat (LRR) Domain | Q9QUN7.fasta | Q9QUN7 | 784 | Immunostimulation and inflammation | NA | 20798518 | 2010 | Pubchem Assay |
| PRRID_0610 | Lipopolysaccharide (LPS) Click for more detail | M. tuberculosis (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS is a potent activator of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | DNA samples from peripheral blood of TB patients | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Immunostimulation and inflammation | NA | 20797905 | 2010 | Pubchem Assay |
| PRRID_0610 | Lipopolysaccharide (LPS) Click for more detail | M. tuberculosis (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS is a potent activator of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | DNA samples from peripheral blood of TB patients | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Immunostimulation and inflammation | NA | 20797905 | 2010 | Pubchem Assay |
| PRRID_0611 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0611 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It coauses the inflammation | NA | 20740341 | 2010 | Pubchem Assay |
| PRRID_0612 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Secretion of proinflammatory cytokines such as TFG-β and IL-6 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | DF-MSCs & DP-MSCs | Tooth | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20731536 | 2010 | Pubchem Assay |
| PRRID_0612 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Secretion of proinflammatory cytokines such as TFG-β and IL-6 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | DF-MSCs & DP-MSCs | Tooth | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20731536 | 2010 | Pubchem Assay |
| PRRID_0613 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lipopolysaccharides are the potent activators of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | stage 3-4 CKD and HD patients | CD14+ Monocytes | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Immunostimulation and inflammation | NA | 20729266 | 2010 | Pubchem Assay |
| PRRID_0613 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lipopolysaccharides are the potent activators of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | stage 3-4 CKD and HD patients | CD14+ Monocytes | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | Immunostimulation and inflammation | NA | 20729266 | 2010 | Pubchem Assay |
| PRRID_0614 | Lipopolysaccharide (LPS) Click for more detail | S. aureus (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lipopolysaccharides are the potent activators of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | C57BL/6 Mice | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implants | NA | 20729214 | 2010 | Pubchem Assay |
| PRRID_0614 | Lipopolysaccharide (LPS) Click for more detail | S. aureus (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lipopolysaccharides are the potent activators of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | C57BL/6 Mice | Macropahges | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | Contributes to inflammatory responses induced by orthopaedic wear particles in cell culture and murine models of aseptic loosening of orthopaedic implants | NA | 20729214 | 2010 | Pubchem Assay |
| PRRID_0615 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lps is a potent activator of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Keratinocytes | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20728939 | 2010 | Pubchem Assay |
| PRRID_0615 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Lps is a potent activator of TLR4 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Keratinocytes | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20728939 | 2010 | Pubchem Assay |
| PRRID_0616 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli O111: B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | BCAP-L is a negative regulator of TLR signaling-induced production of IL-6 and IL10 but not TNF-a in macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in the inflammation. | NA | 20728433 | 2010 | Pubchem Assay |
| PRRID_0616 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli O111: B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | BCAP-L is a negative regulator of TLR signaling-induced production of IL-6 and IL10 but not TNF-a in macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in the inflammation. | NA | 20728433 | 2010 | Pubchem Assay |
| PRRID_0617 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Reduced HIV-1 expression and cell toxicity in macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the clearance of the pathogen from the system | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0617 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Reduced HIV-1 expression and cell toxicity in macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macrophages | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the clearance of the pathogen from the system | NA | 20719993 | 2010 | Pubchem Assay |
| PRRID_0618 | Lipopolysaccharide (LPS) Click for more detail | Salmonella minnesota (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 Asp299Gly (TLR-4 Asp299Gly) | Toll-like receptor (TLR) | FMF patients | monocytes and granulocytes | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Downregulate inflammation in FMF patients | NA | 20714796 | 2010 | NA |
| PRRID_0618 | Lipopolysaccharide (LPS) Click for more detail | Salmonella minnesota (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 Asp299Gly (TLR-4 Asp299Gly) | Toll-like receptor (TLR) | FMF patients | monocytes and granulocytes | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Downregulate inflammation in FMF patients | NA | 20714796 | 2010 | NA |
| PRRID_0619 | Lipopolysaccharide (LPS) Click for more detail | Salmonella minnesota (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR-4 Thre399Ile) | Toll-like receptor (TLR) | FMF patients | monocytes and granulocytes | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Downregulate inflammation in FMF patients | NA | 20714796 | 2010 | NA |
| PRRID_0619 | Lipopolysaccharide (LPS) Click for more detail | Salmonella minnesota (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR-4 Thre399Ile) | Toll-like receptor (TLR) | FMF patients | monocytes and granulocytes | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Downregulate inflammation in FMF patients | NA | 20714796 | 2010 | NA |
| PRRID_0620 | Lipopolysaccharide (LPS) Click for more detail | Bacterial strains | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0620 | Lipopolysaccharide (LPS) Click for more detail | Bacterial strains | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0621 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a signaling cascade that utilizes both the MyD88- and TRIF-dependent pathways, leading to NF-kB and IRF3/7 activation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0621 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induces a signaling cascade that utilizes both the MyD88- and TRIF-dependent pathways, leading to NF-kB and IRF3/7 activation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | dendritic cells and macrophages | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | It has the role in the inflammation. | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0622 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | New Zealand White rabbits | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Involvement of exogenous TLR ligands during arteriogenesis | NA | 20708624 | 2010 | NA |
| PRRID_0622 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | New Zealand White rabbits | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Involvement of exogenous TLR ligands during arteriogenesis | NA | 20708624 | 2010 | NA |
| PRRID_0623 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver disease | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macropahges | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the inflammation of the cells | NA | 20706677 | 2010 | Pubchem Assay |
| PRRID_0623 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It produces various inflammatory cytokines including TNF-α, IL-1β, IL-6, IL-12, IL-18, and chemokines in granulomatous liver disease, ischemia/reperfusion liver injury, nonalcoholic steatohepatitis, and alcoholic liver disease | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Macropahges | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leads to the inflammation of the cells | NA | 20706677 | 2010 | Pubchem Assay |
| PRRID_0624 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It produces a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | produce a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injury | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0624 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It produces a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | produce a large amount of glutamate, an important neurotransmitter but also a potent neurotoxin and is linked to oligodendrocyte injury | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0625 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces the expression of nociceptin, an opioid-related neuropeptide | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0625 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | neurons | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces the expression of nociceptin, an opioid-related neuropeptide | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0626 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Microglia | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injury | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0626 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Microglia | Leucine-rich Repeat (LRR) Domain | O60602.fasta | O60602 | 858 | It causes profound microglial activation associated with oligodendrocyte death, demyelination, and increased vulnerability of neurons to injury | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0627 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | CNS | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It cause severe loss of dopamine neurons in the substantia nigra and neurons in the hippocampus | NA | 20706642 | 2010 | NA |
| PRRID_0627 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | CNS | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It cause severe loss of dopamine neurons in the substantia nigra and neurons in the hippocampus | NA | 20706642 | 2010 | NA |
| PRRID_0628 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | AD Mice's hippocampus | microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | Involved in the clearance of Aβ deposits in the brain | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0628 | Lipopolysaccharide (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | AD Mice's hippocampus | microglia | Leucine-rich Repeat (LRR) Domain | Q9QUK6.fasta | Q9QUK6 | 835 | Involved in the clearance of Aβ deposits in the brain | NA | 20706642 | 2010 | Pubchem Assay |
| PRRID_0629 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induced the secretion of IL-6 and IL-9 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | peripheral mononuclear cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20703156 | 2010 | Pubchem Assay |
| PRRID_0629 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | induced the secretion of IL-6 and IL-9 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | peripheral mononuclear cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has the role in the inflammation. | NA | 20703156 | 2010 | Pubchem Assay |
| PRRID_0632 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Rat | myocardium | Leucine-rich Repeat (LRR) Domain | Q9QX05.fasta | Q9QX05 | 835 | NA | NA | 20697548 | 2010 | Pubchem Assay |
| PRRID_0632 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Rat | myocardium | Leucine-rich Repeat (LRR) Domain | Q9QX05.fasta | Q9QX05 | 835 | NA | NA | 20697548 | 2010 | Pubchem Assay |
| PRRID_0636 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | The binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cord blood cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NA | NA | 20636030 | 2010 | Pubchem Assay |
| PRRID_0636 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | The binding results into secretion of low amounts of IL-12(p70) and high levels of IL-10 ompared with adult cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cord blood cells | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | NA | NA | 20636030 | 2010 | Pubchem Assay |
| PRRID_0637 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contraction | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Intestinal Fibroblasts | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury. | Luciferase assay | 20632282 | 2010 | Pubchem Assay |
| PRRID_0637 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS treatment of fibroblasts induced IκBα degradation, enhanced NFκB promoter activity and increased collagen contraction | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Intestinal Fibroblasts | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It induces collagen contraction and reduces the expression of the TGF-β1 inhibitor, smad-7 which results in intestinal injury following injury. | Luciferase assay | 20632282 | 2010 | Pubchem Assay |
| PRRID_0638 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0638 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIF | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It leadsto the secretion of the proinfalmmatory cytokines and IFN-β | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0640 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli serotype 0127:B9 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Binding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytes | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Wistar Rat | Pineal gland (pinealocytes) | Leucine-rich Repeat (LRR) Domain | Q9QX05.fasta | Q9QX05 | 835 | The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory response | EMSA | 20586888 | 2010 | Pubchem Assay |
| PRRID_0640 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli serotype 0127:B9 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | Binding of LPS trigger the NFKB pathway and inducing a local synthesis of the cytokine TNF, and the TNF receptor 1 (TNFR1) up-regulation in pinealocytes | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Wistar Rat | Pineal gland (pinealocytes) | Leucine-rich Repeat (LRR) Domain | Q9QX05.fasta | Q9QX05 | 835 | The pineal gland transduces Gram-negative endotoxin stimulation by producing TNF by inhibiting the NE-induced melatonin biosynthetic pathway and mount the inflammatory response | EMSA | 20586888 | 2010 | Pubchem Assay |
| PRRID_0641 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP2 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0641 | Lipopolysaccharide (LPS) Click for more detail | E. coli(Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It's binding induces the production of IL6, IL8, MMP3 and MMP2 | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Fibroblast Like Synoviocytes (FLS) | Leucine-rich Repeat (LRR) Domain | O00206.fasta | O00206 | 839 | It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction | ELISA | 20571165 | 2010 | Pubchem Assay |
| PRRID_0644 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli strain 0111:B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It induces the release of microparticles by the macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Macropahes | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to the release of MPs which act as the novel signals for innate immunity | Griess assay | 20335312 | 2010 | Pubchem Assay |
| PRRID_0644 | Lipopolysaccharide (LPS) Click for more detail | Escherichia coli strain 0111:B4 (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It induces the release of microparticles by the macrophages | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice (Murine) | Macropahes | LRR | Q9QUK6.fasta | Q9QUK6 | 835 | It leads to the release of MPs which act as the novel signals for innate immunity | Griess assay | 20335312 | 2010 | Pubchem Assay |
| PRRID_0645 | Lipopolysaccharide (LPS) Click for more detail | Aspergillus fumigatus(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4). | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Telomerase-Immortalized Human Stroma Fibroblasts (THSFs) | NA | O00206.fasta | O00206 | 839 | It has the immunostimulatory role. | ELISA | 20305039 | 2010 | Pubchem Assay |
| PRRID_0645 | Lipopolysaccharide (LPS) Click for more detail | Aspergillus fumigatus(fungi) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | It induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4). | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Telomerase-Immortalized Human Stroma Fibroblasts (THSFs) | NA | O00206.fasta | O00206 | 839 | It has the immunostimulatory role. | ELISA | 20305039 | 2010 | Pubchem Assay |
| PRRID_0646 | Lipoprotein Click for more detail | Staphylococcus epidermis & aureus (Bacteria) | NA | NA | Lipoprotein | Natural | TLR-2 mediated by the NF-kB pathway in septic arthritic chondrocytes and cytokine production | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Septic Chondrocytes from homo sapiens | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Immunostimulation and inflammation | NA | 20740673 | 2010 | Pubchem Assay |
| PRRID_0646 | Lipoprotein Click for more detail | Staphylococcus epidermis & aureus (Bacteria) | NA | NA | Lipoprotein | Natural | TLR-2 mediated by the NF-kB pathway in septic arthritic chondrocytes and cytokine production | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Septic Chondrocytes from homo sapiens | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Immunostimulation and inflammation | NA | 20740673 | 2010 | Pubchem Assay |
| PRRID_0647 | Lipoprotein Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | Lipoprotein binds to the TLR2 and activates the downstream cascades | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20729207 | 2010 | Pubchem Assay |
| PRRID_0647 | Lipoprotein Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | Lipoprotein binds to the TLR2 and activates the downstream cascades | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It has the role in the inflammation. | NA | 20729207 | 2010 | Pubchem Assay |
| PRRID_0648 | NS3 Click for more detail | Hepatitis C Virus (virus) | APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT | 631 | Protein | Natural | Activate MAP kinase pathway, NF-κB, and AP-1 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocytes and Kupffer cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Dysfunction of pDCs by enhanced production of IL-10 and TNF- α | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0648 | NS3 Click for more detail | Hepatitis C Virus (virus) | APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT | 631 | Protein | Natural | Activate MAP kinase pathway, NF-κB, and AP-1 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | monocytes and Kupffer cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Dysfunction of pDCs by enhanced production of IL-10 and TNF- α | NA | 20672047 | 2010 | Pubchem Assay |
| PRRID_0649 | Lipoprotein Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | lipoprotein and lipoarabinomannan are the poteny activators of the TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | DNA samples from peripheral blood of TB patients | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Immunostimulation and inflammation | NA | 20797905 | 2010 | Pubchem Assay |
| PRRID_0649 | Lipoprotein Click for more detail | M. tuberculosis (Bacteria) | NA | NA | Lipoprotein | Natural | lipoprotein and lipoarabinomannan are the poteny activators of the TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | DNA samples from peripheral blood of TB patients | NA | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | Immunostimulation and inflammation | NA | 20797905 | 2010 | Pubchem Assay |
| PRRID_0650 | Peptidoglycan (PGN) Click for more detail | S. aureus (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Their binding to the TLR2 leads to the activation of the downstream signalling | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | C57/BL Mice cell line | NA | Leucine-rich Repeat (LRR) Domain | O53505.fasta | O53505 | 227 | maturation of the Dendritic cells | NA | 20795386 | 2010 | Pubchem Assay |
| PRRID_0650 | Peptidoglycan (PGN) Click for more detail | S. aureus (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Their binding to the TLR2 leads to the activation of the downstream signalling | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | C57/BL Mice cell line | NA | Leucine-rich Repeat (LRR) Domain | O53505.fasta | O53505 | 227 | maturation of the Dendritic cells | NA | 20795386 | 2010 | Pubchem Assay |