Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_1425 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1425 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1427 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | T cell differentiation assay | 24760154 | 2014 | Pubchem_assay |
| PRRID_1427 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | T cell differentiation assay | 24760154 | 2014 | Pubchem_assay |
| PRRID_1429 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1429 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1435 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Soluble CD14 (sCD14) | Pattern recognition receptor (PRR) | Mice | in bodily fluids such as tears (0.5 | TIRAP-MyD88 dependent pathway and the TRAM-TRIF dependent pathway | NA | NA | NA | signal an immune response through Toll- like receptor 4 (TLR4) | NA | 24703105 | 2014 | NA |
| PRRID_1435 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | triggers immune responses | Soluble CD14 (sCD14) | Pattern recognition receptor (PRR) | Mice | in bodily fluids such as tears (0.5 | TIRAP-MyD88 dependent pathway and the TRAM-TRIF dependent pathway | NA | NA | NA | signal an immune response through Toll- like receptor 4 (TLR4) | NA | 24703105 | 2014 | NA |
| PRRID_1436 | Lipoprotein Click for more detail | Gram-positive bacteria | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1436 | Lipoprotein Click for more detail | Gram-positive bacteria | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1439 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 24830024 | 2014 | NA |
| PRRID_1439 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | significant role in the pathogenesis of severe inflammatory responses | NA | 24830024 | 2014 | NA |
| PRRID_1440 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1440 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1441 | Lipoteichoic Acid (LTA) Click for more detail | cell wall of Gram-positive bacteria(Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | Histological analyses, Real-time PCR analysis, Western blotting | 24815695 | 2014 | Pubchem_assay |
| PRRID_1441 | Lipoteichoic Acid (LTA) Click for more detail | cell wall of Gram-positive bacteria(Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | Histological analyses, Real-time PCR analysis, Western blotting | 24815695 | 2014 | Pubchem_assay |
| PRRID_1442 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1442 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1444 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, mast cells and B-lymphocytes | cell surface | Q9EPW9.fasta | Q9EPW9 | 795 | significant role in the pathogenesis of severe inflammatory responses | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1444 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, mast cells and B-lymphocytes | cell surface | Q9EPW9.fasta | Q9EPW9 | 795 | significant role in the pathogenesis of severe inflammatory responses | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1447 | Lipoteichoic Acid (LTA) Click for more detail | Staphylococcus epidermidis (Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | keratinocytes and mouse skin | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | important for inflammation in the skin following injury | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1447 | Lipoteichoic Acid (LTA) Click for more detail | Staphylococcus epidermidis (Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | keratinocytes and mouse skin | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | important for inflammation in the skin following injury | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1449 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | ischemic brain tissue | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | important for inflammation in the skin following injury | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1449 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | ischemic brain tissue | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | important for inflammation in the skin following injury | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1451 | Lipoteichoic Acid (LTA) Click for more detail | cell wall of Gram-positive bacteria(Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1451 | Lipoteichoic Acid (LTA) Click for more detail | cell wall of Gram-positive bacteria(Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1453 | Lipoteichoic Acid (LTA) Click for more detail | cell wall of Gram-positive bacteria(Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 24771328 | 2014 | Pubchem_assay |
| PRRID_1453 | Lipoteichoic Acid (LTA) Click for more detail | cell wall of Gram-positive bacteria(Bacteria) | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 24771328 | 2014 | Pubchem_assay |
| PRRID_1455 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1455 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1460 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | It activates the innate immune system through Toll-like receptor 7 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1460 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | It activates the innate immune system through Toll-like receptor 7 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1474 | macrophage-activating lipopeptide-2 (MALP-2) Click for more detail | Mycoplasma fementans (Bacteria) | NA | NA | Lipopeptides | Natural | It primes macrophages for cytokines secretion | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1474 | macrophage-activating lipopeptide-2 (MALP-2) Click for more detail | Mycoplasma fementans (Bacteria) | NA | NA | Lipopeptides | Natural | It primes macrophages for cytokines secretion | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1476 | MALP-2 (macrophage-activating lipopeptide 2) Click for more detail | Mycoplasma (Bacteria) | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N | NA | Lipopeptides | Natural | It primes macrophages for cytokines secretion | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | ELISA | 24771854 | 2014 | NA |
| PRRID_1476 | MALP-2 (macrophage-activating lipopeptide 2) Click for more detail | Mycoplasma (Bacteria) | C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N | NA | Lipopeptides | Natural | It primes macrophages for cytokines secretion | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | ELISA | 24771854 | 2014 | NA |
| PRRID_1479 | Maltose-binding protein (MBP) Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | purification of recombinant proteins as a protein tag | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR | 24825603 | 2014 | Pubchem_assay |
| PRRID_1479 | Maltose-binding protein (MBP) Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | purification of recombinant proteins as a protein tag | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR | 24825603 | 2014 | Pubchem_assay |
| PRRID_1480 | Maltose-binding protein (MBP) Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | induce dendritic cell activation and the production of pro-inflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | peritoneal macrophages | transmembrane | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR | 24825603 | 2014 | Pubchem_assay |
| PRRID_1480 | Maltose-binding protein (MBP) Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | induce dendritic cell activation and the production of pro-inflammatory cytokines | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | peritoneal macrophages | transmembrane | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR | 24825603 | 2014 | Pubchem_assay |
| PRRID_1481 | Maltose-binding protein (MBP) Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | responsible for the uptake and efficient catabolism of maltodextrins | Mannose Receptor (CD206) | Mannose receptor (MR) | Mice | peritoneal macrophages | cell surface | Q61830.fasta | Q61830 | 1456 | Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation | ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR | 24825603 | 2014 | Pubchem_assay |
| PRRID_1481 | Maltose-binding protein (MBP) Click for more detail | E. coli(Bacteria) | MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK | 396 | Pattern-associated molecular patterns (PAMPs) | Natural | responsible for the uptake and efficient catabolism of maltodextrins | Mannose Receptor (CD206) | Mannose receptor (MR) | Mice | peritoneal macrophages | cell surface | Q61830.fasta | Q61830 | 1456 | Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammation | ELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR | 24825603 | 2014 | Pubchem_assay |
| PRRID_1484 | meso-lanthionine tripeptide Click for more detail | PGN of the anaerobic bacterium Fusobacterium nucleatum (Bacteria) | NA | NA | Peptide | Natural | in vitro activates Nod | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | most adult tissues | intracellular receptors | Q8BHB0.fasta | Q8BHB0 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 24779390 | 2014 | Pubchem_assay |
| PRRID_1484 | meso-lanthionine tripeptide Click for more detail | PGN of the anaerobic bacterium Fusobacterium nucleatum (Bacteria) | NA | NA | Peptide | Natural | in vitro activates Nod | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | most adult tissues | intracellular receptors | Q8BHB0.fasta | Q8BHB0 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 24779390 | 2014 | Pubchem_assay |
| PRRID_1487 | monomeric flagellin Click for more detail | Bacteria | MAQVINTNSLSLITQNNINKNQSALSSSIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLTQAARNANDGISVAQTTEGALSEINNNLQRVRELTVQATTGTNSESDLSSIQDEIKSRLDEIDRVSGQTQFNGVNVLAKNGSMKIQVGANDNQTITIDLKQIDAKTLGLDGFSVKNNDTVTTSAPVTAFGATTTNNIKLTGITLSTEAATDTGGTNPASIEGVYTDNGNDYYAKITGGDNDGKYYAVTVANDGTVTMATGATANATVTDANTTKATTITSGGTPVQIDNTAGSATANLGAVSLVKLQDSKGNDTDTYALKDTNGNLYAADVNETTGAVSVKTITYTDSSGAASSPTAVKLGGDDGKTEVVDIDGKTYDSADLNGGNLQTGLTAGGEALTAVANGKTTDPLKALDDAIASVDKFRSSLGAVQNRLDSAVTNLNNTTTNLSEAQSRIQDADYATEVSNMSKAQIIQQAGNSVLAKANQVPQQVLSLLQG | 498 | Pattern-associated molecular patterns (PAMPs) | Natural | It directly interac with TLR 5 and induces immune response | PGLYRP-2 | Peptidoglycan Recognition Receptor (PGRPs) | Mice | monocyte/macrophages, DCs | Cell Surface (Exogenous) | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1487 | monomeric flagellin Click for more detail | Bacteria | MAQVINTNSLSLITQNNINKNQSALSSSIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLTQAARNANDGISVAQTTEGALSEINNNLQRVRELTVQATTGTNSESDLSSIQDEIKSRLDEIDRVSGQTQFNGVNVLAKNGSMKIQVGANDNQTITIDLKQIDAKTLGLDGFSVKNNDTVTTSAPVTAFGATTTNNIKLTGITLSTEAATDTGGTNPASIEGVYTDNGNDYYAKITGGDNDGKYYAVTVANDGTVTMATGATANATVTDANTTKATTITSGGTPVQIDNTAGSATANLGAVSLVKLQDSKGNDTDTYALKDTNGNLYAADVNETTGAVSVKTITYTDSSGAASSPTAVKLGGDDGKTEVVDIDGKTYDSADLNGGNLQTGLTAGGEALTAVANGKTTDPLKALDDAIASVDKFRSSLGAVQNRLDSAVTNLNNTTTNLSEAQSRIQDADYATEVSNMSKAQIIQQAGNSVLAKANQVPQQVLSLLQG | 498 | Pattern-associated molecular patterns (PAMPs) | Natural | It directly interac with TLR 5 and induces immune response | PGLYRP-2 | Peptidoglycan Recognition Receptor (PGRPs) | Mice | monocyte/macrophages, DCs | Cell Surface (Exogenous) | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1488 | mRNA Click for more detail | RNA virus (Virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | Cell Compartment/Intracellular (Endosome) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1488 | mRNA Click for more detail | RNA virus (Virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | Cell Compartment/Intracellular (Endosome) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1489 | mRNA Click for more detail | RNA virus (Virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | Dendritic Cell, B-lymphocyte | cell compartment | Q8K3Z0.fasta | Q8K3Z0 | 1020 | Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1489 | mRNA Click for more detail | RNA virus (Virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | Dendritic Cell, B-lymphocyte | cell compartment | Q8K3Z0.fasta | Q8K3Z0 | 1020 | Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1493 | muramyl dipeptide (MDP) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | induces interleu- kin-8 (IL-8) production, CD62 ligand shedding, and CD11b up-regulation | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | Neutrophils | serine/threonine RIP2 (RICK, CARDIAK) kinase | Q8K3Z0.fasta | Q8K3Z0 | 1020 | involved in neutrophil immune responses in response to bacterial infection. | ELISA | 24766550 | 2014 | Pubchem_assay |
| PRRID_1493 | muramyl dipeptide (MDP) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | induces interleu- kin-8 (IL-8) production, CD62 ligand shedding, and CD11b up-regulation | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | Neutrophils | serine/threonine RIP2 (RICK, CARDIAK) kinase | Q8K3Z0.fasta | Q8K3Z0 | 1020 | involved in neutrophil immune responses in response to bacterial infection. | ELISA | 24766550 | 2014 | Pubchem_assay |
| PRRID_1495 | muramyl tripeptide Click for more detail | Mycobacteria (Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC | NA | Peptide | Natural | in vitro activates Nod | PGLYRP-2 | Peptidoglycan Recognition Receptor (PGRPs) | Mice | intraepithelial T lymphocytes | intracellular receptors | Q9JLF7.fasta | Q9JLF7 | 859 | recognises peptidoglycan of bacterial cell wall | NA | 24779390 | 2014 | Pubchem_assay |
| PRRID_1495 | muramyl tripeptide Click for more detail | Mycobacteria (Bacteria) | CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCCNC(=O)C(C)NC(=O)CCC(C(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C)OC(=O)CCCCCCCCCCCCCCC | NA | Peptide | Natural | in vitro activates Nod | PGLYRP-2 | Peptidoglycan Recognition Receptor (PGRPs) | Mice | intraepithelial T lymphocytes | intracellular receptors | Q9JLF7.fasta | Q9JLF7 | 859 | recognises peptidoglycan of bacterial cell wall | NA | 24779390 | 2014 | Pubchem_assay |
| PRRID_1497 | N-glycolylated muramic acid Click for more detail | Mycobacterium smegmatis and Mycobacterium tuberculosis (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Carbohydrate | Natural | activates NOD2 | Nod-like receptor 1 (NLR1) | NOD-like receptor (NLR) | Mice | immune cells like peripheral blood monocytes, granulocytes and dendritic cells, as well as in astrocytes of the brain and in paneth cells of the gut | intracellular receptors | Q8K3Z0.fasta | Q8K3Z0 | 1020 | Nod2, are associ- ated with inflammatory bowel disease in humans | NA | 24779390 | 2014 | Pubchem_assay |
| PRRID_1497 | N-glycolylated muramic acid Click for more detail | Mycobacterium smegmatis and Mycobacterium tuberculosis (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Carbohydrate | Natural | activates NOD2 | Nod-like receptor 1 (NLR1) | NOD-like receptor (NLR) | Mice | immune cells like peripheral blood monocytes, granulocytes and dendritic cells, as well as in astrocytes of the brain and in paneth cells of the gut | intracellular receptors | Q8K3Z0.fasta | Q8K3Z0 | 1020 | Nod2, are associ- ated with inflammatory bowel disease in humans | NA | 24779390 | 2014 | Pubchem_assay |
| PRRID_1500 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | DCIR2 | C type Lectin (CTL/CLR) | Mice | CD11c+CD82- DCs | Exogenous | NA | NA | NA | DCs are good candidates to modulate the immune system’s activity in infection, cancer, and autoimmunity | ELISA | 24829411 | 2014 | NA |
| PRRID_1500 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | DCIR2 | C type Lectin (CTL/CLR) | Mice | CD11c+CD82- DCs | Exogenous | NA | NA | NA | DCs are good candidates to modulate the immune system’s activity in infection, cancer, and autoimmunity | ELISA | 24829411 | 2014 | NA |
| PRRID_1501 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | DEC205 | Lectins | Mice | CD11c+CD8+ DCs | Exogenous | NA | NA | NA | DCs are good candidates to modulate the immune system’s activity in infection, cancer, and autoimmunity | ELISA | 24829411 | 2014 | NA |
| PRRID_1501 | NA Click for more detail | NA | NA | NA | NA | Natural | NA | DEC205 | Lectins | Mice | CD11c+CD8+ DCs | Exogenous | NA | NA | NA | DCs are good candidates to modulate the immune system’s activity in infection, cancer, and autoimmunity | ELISA | 24829411 | 2014 | NA |
| PRRID_1513 | naloxone Click for more detail | synthetic alkaloids (others) | O=C1[C@@H]2OC3=C(O)C=CC4=C3[C@@]2([C@]5(CC1)O)CCN(CC=C)[C@@H]5C4 | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | It is primarily used for pain relief, cough and constipation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | spinal microglia, macrophage and astrocytes | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24824631 | 2014 | Pubchem_assay |
| PRRID_1513 | naloxone Click for more detail | synthetic alkaloids (others) | O=C1[C@@H]2OC3=C(O)C=CC4=C3[C@@]2([C@]5(CC1)O)CCN(CC=C)[C@@H]5C4 | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | It is primarily used for pain relief, cough and constipation | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | spinal microglia, macrophage and astrocytes | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24824631 | 2014 | Pubchem_assay |
| PRRID_1514 | Non-methylated CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | act as immuno stimulants | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9NR96.fasta | Q9NR96 | 1032 | TLR9 plays a crucial role in breaking tolerance and developing autoimmunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1514 | Non-methylated CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | act as immuno stimulants | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9NR96.fasta | Q9NR96 | 1032 | TLR9 plays a crucial role in breaking tolerance and developing autoimmunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1518 | oxidized lipids Click for more detail | Gram-negative bacteria | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | (DCs)Dendritic cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24825061 | 2014 | Pubchem_assay |
| PRRID_1518 | oxidized lipids Click for more detail | Gram-negative bacteria | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | elicit innate immune response | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | (DCs)Dendritic cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24825061 | 2014 | Pubchem_assay |
| PRRID_1519 | Paclitaxel Click for more detail | Pacific yew (plant) | C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | used to treat a number of types of cancer | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1519 | Paclitaxel Click for more detail | Pacific yew (plant) | C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | used to treat a number of types of cancer | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1524 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipoprotein | Synthetic | Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-κB. | Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs and B-lymphocytes | Cell Surface (Exogenous) | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | NA | 24830024 | 2014 | NA |
| PRRID_1524 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipoprotein | Synthetic | Mimics the acylated amino terminus of bacterial LPs and is a potent activator of the proinflammatory transcription factor NF-κB. | Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs and B-lymphocytes | Cell Surface (Exogenous) | NA | NA | NA | TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6. | NA | 24830024 | 2014 | NA |
| PRRID_1526 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipoprotein | Synthetic | increases the immunogenicity of B- cell lymphoma cells and alters their trafficking pattern when combined with the genotoxic anticancer drug 1-b-D-arabinofuranosylcytosine. | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas) | B-cell lymphoma cell lines | cell surface | NA | NA | NA | TLR2 forms a heterodimer with TLR1 in response to Pam3CSK4 leading to the recruitment of the adaptor proteins MAL and MYD88 and the activation of IL1 receptor-associated kinase 4 (IRAK4), IRAK1, and TNF receptor-associated factor 6 | ELISA | 24799523 | 2014 | NA |
| PRRID_1526 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipoprotein | Synthetic | increases the immunogenicity of B- cell lymphoma cells and alters their trafficking pattern when combined with the genotoxic anticancer drug 1-b-D-arabinofuranosylcytosine. | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas) | B-cell lymphoma cell lines | cell surface | NA | NA | NA | TLR2 forms a heterodimer with TLR1 in response to Pam3CSK4 leading to the recruitment of the adaptor proteins MAL and MYD88 and the activation of IL1 receptor-associated kinase 4 (IRAK4), IRAK1, and TNF receptor-associated factor 6 | ELISA | 24799523 | 2014 | NA |
| PRRID_1529 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipoprotein | Synthetic | triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1529 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipoprotein | Synthetic | triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB. | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1531 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipoprotein | Synthetic | triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB. | Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | NA | NA | NA | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 24771328 | 2014 | NA |
| PRRID_1531 | Pam3CSK4 Click for more detail | Bacteria | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Lipoprotein | Synthetic | triacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB. | Toll-like receptor (TLR1/Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages | cell surface | NA | NA | NA | plays a fundamental role in pathogen recognition and activation of innate immunity | ELISA | 24771328 | 2014 | NA |
| PRRID_1533 | Pam3CSK4 + Ara-C Click for more detail | NA | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | enhanced the expressions of several immunomodulatory molecules and increased their sensitivity to effector cells of the immune system leading to decreased tumorigenicity of B-cell lymphoma cells. | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas) | B-cell lymphoma cell lines | cell surface | NA | NA | NA | Cotreatment of cells with Pam3CSK4 and Ara-C induced the expression of a number of several immunomodulatory molecules including cell surface proteins, cytokines, and chemokines. | ELISA | 24799523 | 2014 | NA |
| PRRID_1533 | Pam3CSK4 + Ara-C Click for more detail | NA | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | enhanced the expressions of several immunomodulatory molecules and increased their sensitivity to effector cells of the immune system leading to decreased tumorigenicity of B-cell lymphoma cells. | Toll-like receptor 1/2 (TLR1/2) | Toll-like receptor (TLR) | Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas) | B-cell lymphoma cell lines | cell surface | NA | NA | NA | Cotreatment of cells with Pam3CSK4 and Ara-C induced the expression of a number of several immunomodulatory molecules including cell surface proteins, cytokines, and chemokines. | ELISA | 24799523 | 2014 | NA |
| PRRID_1536 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium | Intracellular receptors | Q8BHB0.fasta | Q8BHB0 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 24829146 | 2014 | Pubchem_assay |
| PRRID_1536 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium | Intracellular receptors | Q8BHB0.fasta | Q8BHB0 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 24829146 | 2014 | Pubchem_assay |
| PRRID_1538 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium | Intracellular receptors | Q8K3Z0.fasta | Q8K3Z0 | 1020 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 24829146 | 2014 | Pubchem_assay |
| PRRID_1538 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | lymphocytes, macrophages, dendritic cells and also in nonimmune cells, for example in epithelium | Intracellular receptors | Q8K3Z0.fasta | Q8K3Z0 | 1020 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 24829146 | 2014 | Pubchem_assay |
| PRRID_1540 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 24830024 | 2014 | NA |
| PRRID_1540 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 24830024 | 2014 | NA |
| PRRID_1542 | Peptidoglycan (PGN) Click for more detail | cell wall of Gram-positive bacteria(Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | Histological analyses, Real-time PCR analysis, Western blotting | 24815695 | 2014 | Pubchem_assay |
| PRRID_1542 | Peptidoglycan (PGN) Click for more detail | cell wall of Gram-positive bacteria(Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | Histological analyses, Real-time PCR analysis, Western blotting | 24815695 | 2014 | Pubchem_assay |
| PRRID_1543 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1543 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1545 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | TLR-deficient Mice on a C57BL/6 | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | ELISA | 24801735 | 2014 | Pubchem_assay |
| PRRID_1545 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | TLR-deficient Mice on a C57BL/6 | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | ELISA | 24801735 | 2014 | Pubchem_assay |
| PRRID_1548 | Peptidoglycan (PGN) Click for more detail | Bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | triggers immune responses | Nod-like receptor 1 (NLR1) | NOD-like receptor (NLR) | Mice | lymphocytes, macrophages, dendritic cells | intracellular receptors | NA | NA | NA | triggering of these receptors induces activation of the NF-κB pathway and consequently, an immune response | NA | 24779390 | 2014 | NA |
| PRRID_1548 | Peptidoglycan (PGN) Click for more detail | Bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | triggers immune responses | Nod-like receptor 1 (NLR1) | NOD-like receptor (NLR) | Mice | lymphocytes, macrophages, dendritic cells | intracellular receptors | NA | NA | NA | triggering of these receptors induces activation of the NF-κB pathway and consequently, an immune response | NA | 24779390 | 2014 | NA |
| PRRID_1549 | Peptidoglycan (PGN) Click for more detail | Bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | triggers immune responses | PGN-binding proteins (PGRPs) | Peptidoglycan Recognition Receptor (PGRPs) | Mice | lymphocytes, macrophages, dendritic cells | intracellular receptors | NA | NA | NA | triggering of these receptors induces activation of the NF-κB pathway and consequently, an immune response | NA | 24779390 | 2014 | NA |
| PRRID_1549 | Peptidoglycan (PGN) Click for more detail | Bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | triggers immune responses | PGN-binding proteins (PGRPs) | Peptidoglycan Recognition Receptor (PGRPs) | Mice | lymphocytes, macrophages, dendritic cells | intracellular receptors | NA | NA | NA | triggering of these receptors induces activation of the NF-κB pathway and consequently, an immune response | NA | 24779390 | 2014 | NA |
| PRRID_1552 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | ELISA | 24771328 | 2014 | NA |
| PRRID_1552 | Peptidoglycan (PGN) Click for more detail | Gram-positive bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | PGN is known to be a potent activator of NF-κB and TNF-α through TLR2 | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | ELISA | 24771328 | 2014 | NA |
| PRRID_1556 | Peptidoglycan (PGN) Click for more detail | Gram negative Bacteria (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | ELISA | 24757287 | 2014 | Pubchem_assay |
| PRRID_1556 | Peptidoglycan (PGN) Click for more detail | Gram negative Bacteria (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domain with leucine-rich repeats and a conservative intracellular Toll/IL- 1 receptor (TIR) domain | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | ELISA | 24757287 | 2014 | Pubchem_assay |
| PRRID_1558 | Peptidoglycan (PGN) Click for more detail | Gram negative Bacteria (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1558 | Peptidoglycan (PGN) Click for more detail | Gram negative Bacteria (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | extracellular domains of leucine-rich repeat motifs | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |