| Primary information |
|---|
| PRRID | PRRID_1526 |
| Ligand Name | Pam3CSK4 |
| Source | Bacteria |
| Sequence of ligand | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O |
| Length | NA |
| Type | Lipoprotein |
| Occurence | Synthetic |
| Role of Ligand | increases the immunogenicity of B- cell lymphoma cells and alters their trafficking pattern when combined with the genotoxic anticancer drug 1-b-D-arabinofuranosylcytosine. |
| Name of receptor | Toll-like receptor 1/2 (TLR1/2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas) |
| Localization | B-cell lymphoma cell lines |
| Domain | cell surface |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | TLR2 forms a heterodimer with TLR1 in response to Pam3CSK4 leading to the recruitment of the adaptor proteins MAL and MYD88 and the activation of IL1 receptor-associated kinase 4 (IRAK4), IRAK1, and TNF receptor-associated factor 6 |
| Assay used | ELISA |
| PMID | 24799523 |
| Year of Publication | 2014 |
| Pubchem assay | NA |
| Primary information |
|---|
| PRRID | PRRID_1526 |
| Ligand Name | Pam3CSK4 |
| Source | Bacteria |
| Sequence of ligand | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O |
| Length | NA |
| Type | Lipoprotein |
| Occurence | Synthetic |
| Role of Ligand | increases the immunogenicity of B- cell lymphoma cells and alters their trafficking pattern when combined with the genotoxic anticancer drug 1-b-D-arabinofuranosylcytosine. |
| Name of receptor | Toll-like receptor 1/2 (TLR1/2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas) |
| Localization | B-cell lymphoma cell lines |
| Domain | cell surface |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | TLR2 forms a heterodimer with TLR1 in response to Pam3CSK4 leading to the recruitment of the adaptor proteins MAL and MYD88 and the activation of IL1 receptor-associated kinase 4 (IRAK4), IRAK1, and TNF receptor-associated factor 6 |
| Assay used | ELISA |
| PMID | 24799523 |
| Year of Publication | 2014 |
| Pubchem assay | NA |