| Primary information |
|---|
| PRRID | PRRID_1533 |
| Ligand Name | Pam3CSK4 + Ara-C |
| Source | NA |
| Sequence of ligand | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O |
| Length | NA |
| Type | Pattern-associated molecular patterns (PAMPs) |
| Occurence | Synthetic |
| Role of Ligand | enhanced the expressions of several immunomodulatory molecules and increased their sensitivity to effector cells of the immune system leading to decreased tumorigenicity of B-cell lymphoma cells. |
| Name of receptor | Toll-like receptor 1/2 (TLR1/2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas) |
| Localization | B-cell lymphoma cell lines |
| Domain | cell surface |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | Cotreatment of cells with Pam3CSK4 and Ara-C induced the expression of a number of several immunomodulatory molecules including cell surface proteins, cytokines, and chemokines. |
| Assay used | ELISA |
| PMID | 24799523 |
| Year of Publication | 2014 |
| Pubchem assay | NA |
| Primary information |
|---|
| PRRID | PRRID_1533 |
| Ligand Name | Pam3CSK4 + Ara-C |
| Source | NA |
| Sequence of ligand | CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O |
| Length | NA |
| Type | Pattern-associated molecular patterns (PAMPs) |
| Occurence | Synthetic |
| Role of Ligand | enhanced the expressions of several immunomodulatory molecules and increased their sensitivity to effector cells of the immune system leading to decreased tumorigenicity of B-cell lymphoma cells. |
| Name of receptor | Toll-like receptor 1/2 (TLR1/2) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Em-Myc Mice (a Mouse model for Human Burkitt lymphoma and non-Hodgkin lymphomas) |
| Localization | B-cell lymphoma cell lines |
| Domain | cell surface |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | Cotreatment of cells with Pam3CSK4 and Ara-C induced the expression of a number of several immunomodulatory molecules including cell surface proteins, cytokines, and chemokines. |
| Assay used | ELISA |
| PMID | 24799523 |
| Year of Publication | 2014 |
| Pubchem assay | NA |