Detailed description page of PRRDB2.0

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PRRID_1480 details
Primary information
PRRIDPRRID_1480
Ligand NameMaltose-binding protein (MBP)
SourceE. coli(Bacteria)
Sequence of ligandMKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK
Length396
TypePattern-associated molecular patterns (PAMPs)
OccurenceNatural
Role of Ligandinduce dendritic cell activation and the production of pro-inflammatory cytokines
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationperitoneal macrophages
Domaintransmembrane
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionTLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system
Assay usedELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR
PMID24825603
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1480
Ligand NameMaltose-binding protein (MBP)
SourceE. coli(Bacteria)
Sequence of ligandMKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK
Length396
TypePattern-associated molecular patterns (PAMPs)
OccurenceNatural
Role of Ligandinduce dendritic cell activation and the production of pro-inflammatory cytokines
Name of receptorToll-like receptor 4 (TLR4)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationperitoneal macrophages
Domaintransmembrane
Sequence of ReceptorQ9QUK6.fasta
Swiss prot IDQ9QUK6
Length Of Receptor835
FunctionTLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system
Assay usedELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR
PMID24825603
Year of Publication2014
Pubchem assayPubchem_assay