Detailed description page of PRRDB2.0

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PRRID_1440 details
Primary information
PRRIDPRRID_1440
Ligand NameLipoteichoic Acid (LTA)
SourceGram-positive bacteria
Sequence of ligandC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O
LengthNA
TypeAmphiphile
OccurenceNatural
Role of Ligandelicit innate immune response
Name of receptorToll-like receptor 2 (TLR2)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Domaincell surface
Sequence of ReceptorQ9QUN7.fasta
Swiss prot IDQ9QUN7
Length Of Receptor784
Functionplays a fundamental role in pathogen recognition and activation of innate immunity
Assay usedreverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis.
PMID24828022
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1440
Ligand NameLipoteichoic Acid (LTA)
SourceGram-positive bacteria
Sequence of ligandC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O
LengthNA
TypeAmphiphile
OccurenceNatural
Role of Ligandelicit innate immune response
Name of receptorToll-like receptor 2 (TLR2)
Type of receptorToll-like receptor (TLR)
Source Mice
Localizationmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cells
Domaincell surface
Sequence of ReceptorQ9QUN7.fasta
Swiss prot IDQ9QUN7
Length Of Receptor784
Functionplays a fundamental role in pathogen recognition and activation of innate immunity
Assay usedreverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis.
PMID24828022
Year of Publication2014
Pubchem assayPubchem_assay