Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_0845 | Whole bacteria Click for more detail | Legionella pneumophila (Bacteria) | NA | NA | Whole organism | Natural | It activates the p38 MAPK and JNK as well as recruitment of NF- | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Primary human small airway epithelial cells (SAEC) | LRR | O60603.fasta | O60603 | 784 | hBD-2 elicits an antimicrobial effect on L. pneumophila. | ELISA | 20154223 | 2010 | Pubchem Assay |
| PRRID_0845 | Whole bacteria Click for more detail | Legionella pneumophila (Bacteria) | NA | NA | Whole organism | Natural | It activates the p38 MAPK and JNK as well as recruitment of NF- | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Primary human small airway epithelial cells (SAEC) | LRR | O60603.fasta | O60603 | 784 | hBD-2 elicits an antimicrobial effect on L. pneumophila. | ELISA | 20154223 | 2010 | Pubchem Assay |
| PRRID_0847 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It coauses the inflammation | NA | 20740341 | 2010 | NA |
| PRRID_0847 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins | Toll-like receptor 2 (TLR2)-Toll-like receptor 6 (TLR6) dimer | Toll-like receptor (TLR) | Human | NA | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It coauses the inflammation | NA | 20740341 | 2010 | NA |
| PRRID_0848 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0848 | Zymosan Click for more detail | Fungi | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | NA | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | dendritic cells, macrophages and lymphocytes | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | NA | NA | 20713100 | 2010 | Pubchem Assay |
| PRRID_0850 | Zymosan Click for more detail | gram-positive bacteria and yeast | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Their bindng leads to the secretion of the proinflammatory cytokines through NF-KB pathways | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | cerebral endothelial cell line hCMEC/D3 | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It's activation causes tight junction disruption in CECs | NA | 20637248 | 2010 | NA |
| PRRID_0850 | Zymosan Click for more detail | gram-positive bacteria and yeast | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Their bindng leads to the secretion of the proinflammatory cytokines through NF-KB pathways | Toll-like receptor 2/6 (TLR2/6) | Toll-like receptor (TLR) | Human | cerebral endothelial cell line hCMEC/D3 | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | It's activation causes tight junction disruption in CECs | NA | 20637248 | 2010 | NA |
| PRRID_0851 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0851 | Zymosan Click for more detail | S. cerevisiae (Bacteria) | C(C1C(C(C(C(O1)O)O)O)O)O | NA | Glucan | Natural | Upon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effector | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Cell surface | Leucine-rich Repeat (LRR) Domain | Q9NR96.fasta | Q9NR96 | 1032 | It leadsto the secretion of the proinfalmmatory cytokines | NA | 20620129 | 2010 | Pubchem Assay |
| PRRID_0865 | β-gal dsRNA Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | Induce type 1 IFN production | Toll-like receptor 3 (TLR3)/Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | PBMCs | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Immunostimulation | NA | 20692289 | 2010 | NA |
| PRRID_0865 | β-gal dsRNA Click for more detail | NA | NA | NA | Nucleic Acid | Synthetic | Induce type 1 IFN production | Toll-like receptor 3 (TLR3)/Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | PBMCs | Leucine-rich Repeat (LRR) Domain | NA | NA | NA | Immunostimulation | NA | 20692289 | 2010 | NA |
| PRRID_0866 | β2-Glycoprotein I (β2-gpI) Click for more detail | Human (others) | NA | NA | Glycoprotein | Natural | It triggers the downstream phosphorylation of kinases and activation of NF- | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Endothelial cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It recruits the MyD88 adapter protein and lead to the production of proinflammatory cytokines | Reporter gene assay | 20601596 | 2010 | Pubchem Assay |
| PRRID_0866 | β2-Glycoprotein I (β2-gpI) Click for more detail | Human (others) | NA | NA | Glycoprotein | Natural | It triggers the downstream phosphorylation of kinases and activation of NF- | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Endothelial cells | Leucine-rich Repeat (LRR) Domain | O60603.fasta | O60603 | 784 | It recruits the MyD88 adapter protein and lead to the production of proinflammatory cytokines | Reporter gene assay | 20601596 | 2010 | Pubchem Assay |
| PRRID_0868 | alum (aluminium adjuvants ) Click for more detail | NA | O.O.O.O.O.O.O.O.O.O.O.O.[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[Al+3].[K+] | NA | NA | Synthetic | NA | Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing3 (Nalp3) | NOD-like receptor (NLR) | Human | Eosinophils | NA | Q96P20.fasta | Q96P20 | 1036 | NLRP3 responds to microbial products and host-derived danger signals and activates the caspase-1- dependent inflammasome | real-time reverse transcription-PCR, FACS, ELISA | 21978001 | 2011 | Pubchem Assay |
| PRRID_0868 | alum (aluminium adjuvants ) Click for more detail | NA | O.O.O.O.O.O.O.O.O.O.O.O.[O-]S(=O)(=O)[O-].[O-]S(=O)(=O)[O-].[Al+3].[K+] | NA | NA | Synthetic | NA | Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing3 (Nalp3) | NOD-like receptor (NLR) | Human | Eosinophils | NA | Q96P20.fasta | Q96P20 | 1036 | NLRP3 responds to microbial products and host-derived danger signals and activates the caspase-1- dependent inflammasome | real-time reverse transcription-PCR, FACS, ELISA | 21978001 | 2011 | Pubchem Assay |
| PRRID_0871 | beta-defensin Click for more detail | Endogenous (others) | MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS | 69 | Peptide | Natural | Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0871 | beta-defensin Click for more detail | Endogenous (others) | MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS | 69 | Peptide | Natural | Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0872 | Bropirimine Click for more detail | NA | C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | experimental drug with anti-cancer and antiviral properties | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells, dendritic cells, microglia, astrocytes | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0872 | Bropirimine Click for more detail | NA | C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | experimental drug with anti-cancer and antiviral properties | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells, dendritic cells, microglia, astrocytes | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0874 | Chromatin-IgG complexes Click for more detail | Endogenous (others) | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Epithelial and B cells, dendritic cells, microglia, astrocyte, neuron | NA | Q9NR96.fasta | Q9NR96 | 1032 | TLR9 plays a crucial role in breaking tolerance and developing autoimmunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0874 | Chromatin-IgG complexes Click for more detail | Endogenous (others) | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Human | Epithelial and B cells, dendritic cells, microglia, astrocyte, neuron | NA | Q9NR96.fasta | Q9NR96 | 1032 | TLR9 plays a crucial role in breaking tolerance and developing autoimmunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0876 | Diacylated Lipopeptide Click for more detail | Mycoplasma, Gram-positive bacteria | NA | NA | Lipid | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Myeloid cells, dendritic cells, microglia, astrocytes | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0876 | Diacylated Lipopeptide Click for more detail | Mycoplasma, Gram-positive bacteria | NA | NA | Lipid | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Myeloid cells, dendritic cells, microglia, astrocytes | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0878 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Epithelial cells, dendritic cells, microglia, astrocytes,oligodendrocytes, neurons | NA | O15455.fasta | O15455 | 904 | TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0878 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | Epithelial cells, dendritic cells, microglia, astrocytes,oligodendrocytes, neurons | NA | O15455.fasta | O15455 | 904 | TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0883 | Fibrinogen Click for more detail | Endogenous (others) | MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG | 211 | Damage-associated molecular patterns (DAMPs) | Natural | initiates an inflammatory response by activating innate immune cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0883 | Fibrinogen Click for more detail | Endogenous (others) | MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG | 211 | Damage-associated molecular patterns (DAMPs) | Natural | initiates an inflammatory response by activating innate immune cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0887 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Myeloid cells, epithelial cells, microglia, astrocytes | NA | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0887 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Myeloid cells, epithelial cells, microglia, astrocytes | NA | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0890 | Flagellin Click for more detail | S. typhimurium (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | elicits innate responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Human colon adenocarcinoma intestinal epithelial cells | amino (N) and carboxyl (C) domains (D) of the flagellin protein (ND1/2ECHCD2/1) | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 21949773 | 2011 | Pubchem Assay |
| PRRID_0890 | Flagellin Click for more detail | S. typhimurium (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | elicits innate responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Human | Human colon adenocarcinoma intestinal epithelial cells | amino (N) and carboxyl (C) domains (D) of the flagellin protein (ND1/2ECHCD2/1) | O60602.fasta | O60602 | 858 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 21949773 | 2011 | Pubchem Assay |
| PRRID_0892 | Glycoinositol phospholipids Click for more detail | eukaryotic cell membranes (others) | C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O | NA | Lipid | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0892 | Glycoinositol phospholipids Click for more detail | eukaryotic cell membranes (others) | C(C(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)OC=O)OC=O | NA | Lipid | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0894 | Glycolipids Click for more detail | eukaryotic cell membranes (others) | NA | NA | Lipid | Natural | Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0894 | Glycolipids Click for more detail | eukaryotic cell membranes (others) | NA | NA | Lipid | Natural | Their role is to maintain the stability of the cell membrane and to facilitate cellular recognition, which is crucial to the immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0896 | Gp96 (HSP90B1) Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Damage-associated molecular patterns (DAMPs) | Natural | It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0896 | Gp96 (HSP90B1) Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Damage-associated molecular patterns (DAMPs) | Natural | It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0897 | Gp96 (HSP90B1) Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Damage-associated molecular patterns (DAMPs) | Natural | It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0897 | Gp96 (HSP90B1) Click for more detail | Endogenous (others) | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL | 803 | Damage-associated molecular patterns (DAMPs) | Natural | It plays critical roles in folding proteins in the secretory pathway such as Toll-like receptors and integrins | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0898 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0898 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0899 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0899 | Heat-shock protein 70 Click for more detail | Endogenous (others) | MAKAAAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDPVVQSDMKHWPFQVINDGDKPKVQVSYKGETKAFYPEEISSMVLTKMKEIAEAYLGYPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVNHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEGIDFYTSITRARFEELCSDLFRSTLEPVEKALRDAKLDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTALIKRNSTIPTKQTQIFTTYSDNQPGVLIQVYEGERAMTKDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAEKYKAEDEVQRERVSAKNALESYAFNMKSAVEDEGLKGKISEADKKKVLDKCQEVISWLDANTLAEKDEFEHKRKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0902 | Heat-shock proteins 60 Click for more detail | Endogenous (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0902 | Heat-shock proteins 60 Click for more detail | Endogenous (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0903 | Heat-shock proteins 60 Click for more detail | Endogenous (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0903 | Heat-shock proteins 60 Click for more detail | Endogenous (others) | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0905 | Heparan sulfate Click for more detail | Endogenous (others) | COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | released in responses to local stresses (hypoxia or inflammation) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0905 | Heparan sulfate Click for more detail | Endogenous (others) | COC1C(C(C(OC1C(=O)[O-])OC2C(OC(C(C2[O-])NOS(=O)(=O)O)OC)COS(=O)(=O)O)OS(=O)(=O)O)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | released in responses to local stresses (hypoxia or inflammation) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0908 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | HMGB1 plays a pivotal role in ischemic brain injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0908 | HMGB1 Click for more detail | Endogenous (others) | MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE | 215 | Protein | Natural | HMGB1 plays a pivotal role in ischemic brain injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0911 | iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail | Bacteria | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | peptidoglycan substructures | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Eosinophils | NA | Q9Y239.fasta | Q9Y239 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | real-time reverse transcription-PCR, FACS, ELISA | 21978001 | 2011 | Pubchem Assay |
| PRRID_0911 | iE-DAP (gamma-D-glutamyl-meso diaminopimelic acid) Click for more detail | Bacteria | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Pattern-associated molecular patterns (PAMPs) | Natural | peptidoglycan substructures | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | Eosinophils | NA | Q9Y239.fasta | Q9Y239 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | real-time reverse transcription-PCR, FACS, ELISA | 21978001 | 2011 | Pubchem Assay |
| PRRID_0912 | Imidazoquinoline Click for more detail | A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring | CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells, dendritic cells, microglia, astrocytes | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-12 | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0912 | Imidazoquinoline Click for more detail | A tricyclic aromatic heterocycle formed by fusion of an imidazole ring with the pyridine ring | CC1=C(NC(=C(C1=C2C=CC(=C(C2=O)OC)OC)N)C3=NC4=C(C=C3)C(=O)C(=C5C4=NC(N5)(C)C)OC)C(=O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | Imidazoquinolines are being actively being pursued for therapeutic use anti-viral and anti- allergic | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells, dendritic cells, microglia, astrocytes | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-12 | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0916 | lipo-arabinomannan Click for more detail | Mycobacteria (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | serve as a modulin with immunoregulatory and anti-inflammatory effects.  | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0916 | lipo-arabinomannan Click for more detail | Mycobacteria (Bacteria) | CCC(CO)NCCNC(CC)CO | NA | Glycolipid | Natural | serve as a modulin with immunoregulatory and anti-inflammatory effects.  | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0918 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0918 | Lipopolysaccharide (LPS) Click for more detail | Gram-negative bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0919 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | NA | Intracellular TIR domains | O15455.fasta | O15455 | 904 | TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands | NA | 21959264 | 2011 | Pubchem Assay |
| PRRID_0919 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Human | NA | Intracellular TIR domains | O15455.fasta | O15455 | 904 | TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands | NA | 21959264 | 2011 | Pubchem Assay |
| PRRID_0926 | Lipoproteins/lipopeptides Click for more detail | Bacteria | NA | NA | Lipid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0926 | Lipoproteins/lipopeptides Click for more detail | Bacteria | NA | NA | Lipid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0928 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0928 | Lipoteichoic Acid (LTA) Click for more detail | Bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0929 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Myeloid cells, dendritic cells, microglia, astrocytes | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0929 | Lipoteichoic Acid (LTA) Click for more detail | Gram-positive bacteria | C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O | NA | Amphiphile | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Myeloid cells, dendritic cells, microglia, astrocytes | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0932 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | up-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells, dendritic cells, microglia, astrocytes | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13 | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0932 | Loxoribine (7-allyl-7,8-dihydro-8-oxo-guanosine) Click for more detail | Guanosine (others) | C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O | NA | Nucleic Acid | Synthetic | up-regulate B-cells lymphoma-2 (Bcl-2) and promote the survival of lung cancer cells | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells, dendritic cells, microglia, astrocytes | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | TLR7-mediated activation of these cells resulted in the induction of the pro-inflammatory cytokines IFN-α, IFN-β, TNF-α, and IL-13 | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0934 | LyoVec Click for more detail | mimic of viral RNA (virus) | NA | NA | Nucleic Acid | Synthetic | elicit innate immune response | RIG-1 | Rig-like receptor (RLR) | Human | Eosinophils | NA | O95786.fasta | O95786 | 925 | NA | real-time reverse transcription-PCR, FACS, ELISA | 21978001 | 2011 | Pubchem Assay |
| PRRID_0934 | LyoVec Click for more detail | mimic of viral RNA (virus) | NA | NA | Nucleic Acid | Synthetic | elicit innate immune response | RIG-1 | Rig-like receptor (RLR) | Human | Eosinophils | NA | O95786.fasta | O95786 | 925 | NA | real-time reverse transcription-PCR, FACS, ELISA | 21978001 | 2011 | Pubchem Assay |
| PRRID_0935 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | leads to cytokine activation, especially IL-1α and IL-1β. | Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing3 (Nalp3) | NOD-like receptor (NLR) | Human | Eosinophils | NA | Q96P20.fasta | Q96P20 | 1036 | recognizes fragments of the bacterial cell wall | real-time reverse transcription-PCR, FACS, ELISA | 21978001 | 2011 | Pubchem Assay |
| PRRID_0935 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | leads to cytokine activation, especially IL-1α and IL-1β. | Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing3 (Nalp3) | NOD-like receptor (NLR) | Human | Eosinophils | NA | Q96P20.fasta | Q96P20 | 1036 | recognizes fragments of the bacterial cell wall | real-time reverse transcription-PCR, FACS, ELISA | 21978001 | 2011 | Pubchem Assay |
| PRRID_0937 | mRNA Click for more detail | Endogenous (others) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0937 | mRNA Click for more detail | Endogenous (others) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | TLR3 ligands induced the release of both proinflammatory cytokines [interleukin (IL)-6 and IL-8] and type I interferon by nmMSCs compared with other TLR ligands | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0938 | Oligosaccharides of hyaluronic acid (HA) Click for more detail | Endogenous (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction | MDA5 | Rig-like receptor (RLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | Q53TB6.fasta | Q53TB6 | 435 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0938 | Oligosaccharides of hyaluronic acid (HA) Click for more detail | Endogenous (others) | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | the activation of TLR4 by hyaluronic acid leads to a different pattern of gene induction | MDA5 | Rig-like receptor (RLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | Q53TB6.fasta | Q53TB6 | 435 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0939 | Paclitaxel Click for more detail | Pacific yew (plant) | C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | used to treat a number of types of cancer | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | Q9HC29.fasta | Q9HC29 | 1040 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0939 | Paclitaxel Click for more detail | Pacific yew (plant) | C1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | used to treat a number of types of cancer | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | Q9HC29.fasta | Q9HC29 | 1040 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0940 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Intracellular TIR domains | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21959264 | 2011 | Pubchem Assay |
| PRRID_0940 | Lipopolysaccharide (LPS) Click for more detail | Gram negative Bacteria (Bacteria) | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | LPS was also shown to play a role in alloimmune lung injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Human | NA | Intracellular TIR domains | O00206.fasta | O00206 | 839 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 21959264 | 2011 | Pubchem Assay |
| PRRID_0943 | Pam2CSK4 Click for more detail | NA | CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | diacylated lipopeptide | Synthetic | Bacterial lipoproteins are strong immune modulators that activate early innate host responses after infection | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Intracellular TIR domains | O60603.fasta | O60603 | 784 | fundamental role in pathogen recognition and activation of innate immunity | NA | 21959264 | 2011 | Pubchem Assay |
| PRRID_0943 | Pam2CSK4 Click for more detail | NA | CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC | NA | diacylated lipopeptide | Synthetic | Bacterial lipoproteins are strong immune modulators that activate early innate host responses after infection | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | NA | Intracellular TIR domains | O60603.fasta | O60603 | 784 | fundamental role in pathogen recognition and activation of innate immunity | NA | 21959264 | 2011 | Pubchem Assay |
| PRRID_0946 | Peptidoglycan (PGN) Click for more detail | Bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0946 | Peptidoglycan (PGN) Click for more detail | Bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0948 | phenol-soluble modulin Click for more detail | S. aureus (Bacteria) | MEFVAKLFKFFKDLLGKFLGNN | 22 | Protein | Natural | triggers immune responses | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Myeloid cells, dendritic cells, microglia, astrocytes | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0948 | phenol-soluble modulin Click for more detail | S. aureus (Bacteria) | MEFVAKLFKFFKDLLGKFLGNN | 22 | Protein | Natural | triggers immune responses | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Human | Myeloid cells, dendritic cells, microglia, astrocytes | NA | Q9Y2C9.fasta | Q9Y2C9 | 796 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0950 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | elicit innate immune response | RIG-1 | Rig-like receptor (RLR) | Human | Eosinophils | NA | O95786.fasta | O95786 | 925 | mediate the efficient induction of the type I IFN response | real-time reverse transcription-PCR, FACS, ELISA | 21978001 | 2011 | Pubchem Assay |
| PRRID_0950 | polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail | NA | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O | NA | Nucleic Acid | Synthetic | elicit innate immune response | RIG-1 | Rig-like receptor (RLR) | Human | Eosinophils | NA | O95786.fasta | O95786 | 925 | mediate the efficient induction of the type I IFN response | real-time reverse transcription-PCR, FACS, ELISA | 21978001 | 2011 | Pubchem Assay |
| PRRID_0953 | Porins Click for more detail | outer membrane of bacterial cell wall (others) | MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF | 396 | Protein | Natural | act as a pore, through which molecules can diffuse | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0953 | Porins Click for more detail | outer membrane of bacterial cell wall (others) | MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF | 396 | Protein | Natural | act as a pore, through which molecules can diffuse | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | significant role in the pathogenesis of severe inflammatory responses | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0955 | profilin-like protein Click for more detail | T. gondii (others) | MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY | 165 | Protein | Natural | induction of immune response against T. gondii | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | Myeloid cells, uroepithelial cells | NA | NA | NA | NA | induces the release of interleukin 12 against T. gondii infected mice | NA | 21982558 | 2011 | NA |
| PRRID_0955 | profilin-like protein Click for more detail | T. gondii (others) | MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY | 165 | Protein | Natural | induction of immune response against T. gondii | Toll-like receptor 10 (TLR10) | Toll-like receptor (TLR) | Human | Myeloid cells, uroepithelial cells | NA | NA | NA | NA | induces the release of interleukin 12 against T. gondii infected mice | NA | 21982558 | 2011 | NA |
| PRRID_0958 | Saturated fatty acids Click for more detail | Endogenous (others) | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0958 | Saturated fatty acids Click for more detail | Endogenous (others) | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Human | Myeloid cells, T cells, microglia, astrocytes, oligodendrocytes, neurons | NA | O60603.fasta | O60603 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0959 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells, dendritic cells, microglia, astrocytes | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0959 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Human | B cells, dendritic cells, microglia, astrocytes | NA | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0960 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | Q9NR97.fasta | Q9NR97 | 1041 | important role in the immune response to viral infection | NA | 21982558 | 2011 | Pubchem Assay |
| PRRID_0960 | single-stranded RNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Human | Myeloid cells, microglia, astrocytes, neurons | NA | Q9NR97.fasta | Q9NR97 | 1041 | important role in the immune response to viral infection | NA | 21982558 | 2011 | Pubchem Assay |