Browse result page of AntiTbPdb
The total number entries retrieved from this search are 771
ID | Name | Sequence | N-Terminal Modification | C-Terminal Modification | Chemical Modification | Linear/Cyclic | Length | Chirality | Nature | Source | Origin | Species | Strain | Inhibition Concentration | In vitro/ In vivo | Cell Line | Intracellular Inhibition | Cytotoxicity | Animal Model | Effective Dose in model organism | Immune Responce | Mechanism of Action | Target | Combination Therapy | Other Activities | Year of Publication | Pubmed ID/ Patent No. |
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antitb_1797 | Peptide-41 | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-Orn-Orn-Orn-Orn | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = Ornithine | Linear | 19 | L | Amphipathic, Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae (ATCC 110) | MIC = 10 µM or 24 µg/mL | Both | NA | NA | Not tested | NA | NA | Stimulate innate immune system | NA | NA | NA | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) | 2007 | 17547385 |
antitb_1798 | Peptide-42 | G-Fpa-Tic-Oic-GK-Tic-Oic-G-Fpa-Tic-Oic-GK-Tic-KKKK | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Fpa = 4-fluorophenylalanine | Linear | 19 | L | Amphipathic, Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae (ATCC 110) | MIC = 3 µM or 7.5 µg/mL | Both | NA | NA | Not tested | NA | NA | Stimulate innate immune system | NA | NA | NA | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) | 2007 | 17547385 |
antitb_1799 | Peptide-43 | GF-Tic-Oic-G-Orn-Tic-Oic-GF-Tic-Oic-G-Orn-Tic-Orn-Orn-Orn-Orn | Acetylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = Ornithine | Linear | 19 | L | Amphipathic, Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae (ATCC 110) | MIC = 10 µM or 24 µg/mL | Both | NA | NA | Not tested | NA | NA | Stimulate innate immune system | NA | NA | NA | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) | 2007 | 17547385 |
antitb_1800 | Peptide-44 | GF-Tic-Oic-GK-Tic-Oic-GF-Tic-Oic-GK-Tic-KKKK | Biotinylation | Amidation | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Amphipathic, Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae (ATCC 110) | MIC = 10 µM or 26 µg/mL | Both | NA | NA | Not tested | NA | NA | Stimulate innate immune system | NA | NA | NA | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) | 2007 | 17547385 |
antitb_1801 | Peptide-45 | GF-Tic-Oic-G-Dpr-Tic-Oic-GF-Tic-Oic-G-Dpr-Tic-Dpr-Dpr-Dpr-Dpr | Acetylation | Amidation | Dpr = diaminopropionic acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Amphipathic, Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae (ATCC 110) | MIC = 100 µM or 220 µg/mL | Both | NA | NA | Not tested | NA | NA | Stimulate innate immune system | NA | NA | NA | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) | 2007 | 17547385 |
antitb_1802 | Peptide-46 | βAla-Fpa-Tic-Oic-βAla-Dpr-Tic-Oic-βAla-Fpa-Tic-Oic-βAla-Dpr-Tic-Dpr-Dpr-Dpr-Dpr | Acetylation | Amidation | βAla = beta-alanine, Fpa, 4-fluorophenylalanine, Dpr = diaminopropionic acid, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Amphipathic, Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae (ATCC 110) | MIC = 100 µM or 228 µg/mL | Both | NA | NA | Not tested | NA | NA | Stimulate innate immune system | NA | NA | NA | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) | 2007 | 17547385 |
antitb_1805 | Peptide-49 | G-Nph-Tic-Oic-GK-Tic-Oic-G-Nph-Tic-Oic-GK-Tic-KKKK | Acetylation | Amidation | Nph = 4-nitrophenylalanine, Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid | Linear | 19 | L | Amphipathic, Hydrophobic | Synthetic | NA | Mycobacterium ranae | Mycobacterium ranae (ATCC 110) | MIC = 10 µM or 25 µg/mL | Both | NA | NA | Not tested | NA | NA | Stimulate innate immune system | NA | NA | NA | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) | 2007 | 17547385 |
antitb_1806 | NK-2 | KILRGVCKKIMRTFLRRISKDILTGKK | Free | Amidation | None | Linear | 27 | L | Cationic | Protein Derived | Core region of the lymphocytic effector protein NK-lysin | Mycobacterium smegmatis | Mycobacterium smegmatis mc2155 | After 24 h more than 70% killing of M. smegmatis was found at 30 μM | In vitro | mouse macrophage RAW 264.7 | 10 μM NK-2 diminished the intracellular bacterial loadwhen compared to the untreated macrophages | Non-toxic | NA | NA | NA | NA | NA | NA | NA | 2011 | 21396418 |
antitb_1807 | NK-3 | KILRGVCKKIMRTFLRRISKDILTGKK | Free | Amidation | None | Linear | 27 | L | Cationic | Protein Derived | Core region of the lymphocytic effector protein NK-lysin | Mycobacterium bovis | Mycobacterium bovis BCG Pasteur (ATCC35734) | After 24 h, more than 78% killing was observed at 30 μM | In vitro | mouse macrophage RAW 264.8 | 11 μM NK-2 diminished the intracellular bacterial loadwhen compared to the untreated macrophages | Non-toxic | NA | NA | NA | NA | NA | NA | NA | 2011 | 21396418 |
antitb_1808 | Ci-MAM-A24 | WRSLGRTLLRLSHALKPLARRSGW | Free | Amidation | None | Linear | 24 | L | Cationic | Protein Derived | Derived from immune cells of Ciona intestinalis, | Mycobacterium smegmatis | Mycobacterium smegmatis mc2155 | 45% bacterial population was killed at 10 μM peptide incubated for 1 hr | In vitro | mouse macrophage RAW 264.9 | NA | Slight toxic (two-fold decrease in cell viability was observed at 50 μM | NA | NA | NA | NA | NA | NA | NA | 2011 | 21396418 |
antitb_1809 | Ci-MAM-A25 | WRSLGRTLLRLSHALKPLARRSGW | Free | Amidation | None | Linear | 24 | L | Cationic | Protein Derived | Derived from immune cells of Ciona intestinalis, | Mycobacterium bovis | Mycobacterium bovis BCG Pasteur (ATCC35734) | After 24 h, more than 78% killing was observed at 30 μM | In vitro | mouse macrophage RAW 264.10 | NA | Slight toxic (two-fold decrease in cell viability was observed at 50 μM | NA | NA | NA | NA | NA | NA | NA | 2011 | 21396418 |
antitb_1810 | Mcdef | GFGCPNDYSCSNHCRDSIGCRGGYCKYQLICTCYGCKKRRSIQE | Free | Free | 4 disulfide linkages between 4-25, 10-31, 14-33, 20-36 | Cyclic | 44 | L | Cationic | Protein Derived | detected in hemocytes of Manila clams (Ruditapes philippinarum). | Mycobacterium fortuitum | Mycobacterium fortuitum | MIC >20 μM | In vitro | NA | NA | NA | NA | NA | NA | NA | NA | NA | Antibacterial (Staphylococcus aureus KCTC 1916, Streptococcus iniae KCTC 3651, orynebacterium diphtheriae, Bacillus subtilis, ibrio logei KCCM 12281, Vibrio salmonicida KCCM 41663) | 2011 | 21945146 |
antitb_1811 | LL- 37 | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES | Free | Free | None | Linear | 37 | L | Cationic | Natural | Human cells | Mycobacterium tuberculosis | Mycobacterium tuberculosis strain H37Rv | MIC = 5 μM | Both | NA | NA | NA | Male BALB/c mice | a significant reduction in bacilli loads | NA | Disruption of cell wall and membrane | cell wall and membrane | NA | Antibacterial (P.aeruginosa) | 2012 | 23141114 |
antitb_1812 | mouse CRAMP | GLLRKGGEKIGEKLKKIGQKIKNFFQKLVPQPEQ | Free | Free | None | Linear | 34 | L | Cationic | Natural | Mouse cells | Mycobacterium tuberculosis | Mycobacterium tuberculosis strain H37Rv | MIC = 4 μM | Both | NA | NA | NA | Male BALB/c mice | a significant reduction in bacilli loads | NA | Disruption of cell wall and membrane | cell wall and membrane | NA | Antibacterial (P.aeruginosa) | 2012 | 23141114 |
antitb_1813 | E2 (also known as Bac8c) | RIWVIWRR | Free | Amidation | None | Linear | 8 | L | Cationic | Synthetic | NA | Mycobacterium tuberculosis | Mycobacterium tuberculosis strain H37Rv | MIC = 2.6 ± 0.34 g/mL | Both | NA | NA | NA | Male BALB/c mice | a significant reduction in bacilli loads | NA | Disruption of cell wall and membrane | cell wall and membrane | NA | Antibacterial (P.aeruginosa) | 2012 | 23141114 |
antitb_1814 | E6 (also called Sub3) | RRWRIVVIRVRR | Free | Amidation | None | Linear | 12 | L | Cationic | Synthetic | NA | Mycobacterium tuberculosis | Mycobacterium tuberculosis strain H37Rv | MIC = 3.2 ± 0.10 g/mL | Both | NA | NA | NA | Male BALB/c mice | a significant reduction in bacilli loads | NA | Disruption of cell wall and membrane | cell wall and membrane | NA | Antibacterial (P.aeruginosa) | 2012 | 23141114 |
antitb_1815 | CP26 | KWKSFIKKLTSAAKKVVTTAKPLISS | Free | Free | None | Linear | 26 | L | Cationic | Protein Derived | derived from a hybrid peptide comprising the amphipathic α -helical Nterminal region of cecropin A and the hydrophobic N-terminal α-helix of the bee venom peptide melittin | Mycobacterium tuberculosis | Mycobacterium tuberculosis strain H37Rv | MIC = 2.1 ± 0.33 g/mL | Both | NA | NA | NA | Male BALB/c mice | a significant reduction in bacilli loads | NA | Disruption of cell wall and membrane | cell wall and membrane | NA | Antibacterial (P.aeruginosa) | 2012 | 23141114 |
antitb_1816 | ubiquitin-derived peptide Ub2 | STLHLVLRLRGG | Free | Free | None | Linear | 12 | L | Cationic | Protein Derived | Ubiquitin derived | Mycobacterium smegmatis | Mycobacterium smegmatis mc2155 | MIC = 50 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1817 | Ub2scr | RLGRLVSLHTLG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub2 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2156 | MIC > 400 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1818 | Ub2S1A | ATLHLVLRLRGG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub3 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2157 | MIC = 25 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1819 | Ub2T2A | SALHLVLRLRGG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub4 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2158 | MIC = 50 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1820 | Ub2L3A | STAHLVLRLRGG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub5 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2159 | MIC = 100 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1821 | Ub2H4A | STLALVLRLRGG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub6 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2160 | MIC > 400 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1822 | Ub2L5A | STLHAVLRLRGG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub7 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2161 | MIC = 50 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1823 | Ub2V6A | STLHLALRLRGG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub8 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2162 | MIC = 25 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1824 | Ub2L7A | STLHLVARLRGG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub9 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2163 | MIC = 100 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1825 | Ub2R8A | STLHLVLALRGG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub10 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2164 | MIC > 400 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1826 | Ub2L9A | STLHLVLRARGG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub11 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2165 | MIC = 50 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1827 | Ub2R10A | STLHLVLRLAGG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub12 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2166 | MIC > 400μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1828 | Ub2G11A | STLHLVLRLRAG | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub13 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2167 | MIC > 400 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1829 | Ub2G12A | STLHLVLRLRGA | Free | Free | None | Linear | 12 | L | Cationic | Synthetic | Analogue of Ub14 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2168 | MIC > 400 μM | In vitro | None | NA | NA | NA | NA | NA | Micellar aggregate channel model | Cytoplasmic membrane | NA | NA | 2012 | 23173767 |
antitb_1830 | Peptide Ub 17.1 | KTLTGKTITLE | Free | Free | None | Linear | 11 | L | Cationic | Synthetic | Analogue of Ub15 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2169 | MIC = 50 μM | In vitro | None | NA | NA | NA | NA | NA | Targeting the membrane in a less disruptive manner | Cell Membrane | NA | NA | 2012 | 23173767 |
antitb_1831 | Peptide Ub 21 | EVEPSDTIENVKAKIQ | Free | Free | None | Linear | 16 | L | Cationic | Synthetic | Analogue of Ub16 | Mycobacterium smegmatis | Mycobacterium smegmatis mc2170 | MIC = 50 μM | In vitro | None | NA | NA | NA | NA | NA | Targeting the membrane in a less disruptive manner | Cell Membrane | NA | NA | 2012 | 23173767 |
antitb_1860 | Anoplin | GLLKRIKTLL | Free | Amidation | None | Linear | 10 | L | Cationic | Natural | Derived from the venom sac of the solitary wasp, Anoplius samariensis | Mycobacterium smegmatis | Mycobacterium smegmatis mc2 155 | MIC = 200 μg/mL | In vitro | RBC | NA | Non toxic to erythrocytes | NA | NA | NA | NA | NA | NA | Antifungal (C. parapsilosis) and Antibacterial (Escherichia coli DH5a, Pseudomonas aeruginosa PAO, and Zymomonas mobilis ATCC 10988; Gram-positive bacteria: Bacillus subtilis DELTA) | 2016 | 27862650 |
antitb_1861 | Anoplin | GLLKRIKTLL | Addition of octanoic acid (C8H16O2) | Amidation | None | Linear | 10 | L | Amphipathic | Synthetic | Anlogue of Anoplin | Mycobacterium smegmatis | Mycobacterium smegmatis mc2 156 | MIC = 200 μg/mL | In vitro | RBC | NA | Non toxic to erythrocytes | NA | NA | NA | NA | NA | NA | Antifungal (C. parapsilosis) and Antibacterial (Escherichia coli DH5a, Pseudomonas aeruginosa PAO, and Zymomonas mobilis ATCC 10988; Gram-positive bacteria: Bacillus subtilis DELTA) | 2016 | 27862650 |
antitb_1862 | Anoplin | GLLKRIKTLL | Addition of decanoic acid (C10H20O2) | Amidation | None | Linear | 10 | L | Amphipathic | Synthetic | Anlogue of Anoplin | Mycobacterium smegmatis | Mycobacterium smegmatis mc2 157 | MIC = 200 μg/mL | In vitro | RBC | NA | Non toxic to erythrocytes | NA | NA | NA | NA | NA | NA | Antifungal (C. parapsilosis) and Antibacterial (Escherichia coli DH5a, Pseudomonas aeruginosa PAO, and Zymomonas mobilis ATCC 10988; Gram-positive bacteria: Bacillus subtilis DELTA) | 2016 | 27862650 |
antitb_1863 | Anoplin | GLLKFIKKLL | Free | Amidation | None | Linear | 10 | L | Amphipathic | Synthetic | Anlogue of Anoplin | Mycobacterium smegmatis | Mycobacterium smegmatis mc2 158 | MIC = 15 μg/mL | In vitro | RBC | NA | Non toxic to erythrocytes | NA | NA | NA | NA | NA | NA | Antifungal (C. parapsilosis) and Antibacterial (Escherichia coli DH5a, Pseudomonas aeruginosa PAO, and Zymomonas mobilis ATCC 10988; Gram-positive bacteria: Bacillus subtilis DELTA) | 2016 | 27862650 |
antitb_1864 | Anoplin | KLLKFIKKLL | Free | Amidation | None | Linear | 10 | L | Amphipathic | Synthetic | Anlogue of Anoplin | Mycobacterium smegmatis | Mycobacterium smegmatis mc2 159 | MIC = 15 μg/mL | In vitro | RBC | NA | Non toxic to erythrocytes | NA | NA | NA | NA | NA | NA | Antifungal (C. parapsilosis) and Antibacterial (Escherichia coli DH5a, Pseudomonas aeruginosa PAO, and Zymomonas mobilis ATCC 10988; Gram-positive bacteria: Bacillus subtilis DELTA) | 2016 | 27862650 |
antitb_1865 | Anoplin | RLLKFIKKLL | Free | Amidation | None | Linear | 10 | L | Amphipathic | Synthetic | Anlogue of Anoplin | Mycobacterium smegmatis | Mycobacterium smegmatis mc2 160 | MIC = 20 μg/mL | In vitro | RBC | NA | Non toxic to erythrocytes | NA | NA | NA | NA | NA | NA | Antifungal (C. parapsilosis) and Antibacterial (Escherichia coli DH5a, Pseudomonas aeruginosa PAO, and Zymomonas mobilis ATCC 10988; Gram-positive bacteria: Bacillus subtilis DELTA) | 2016 | 27862650 |
antitb_1866 | Anoplin | GLLKFIKKLL | Addition of octanoic acid (C8H16O2) | Amidation | None | Linear | 10 | L | Amphipathic | Synthetic | Anlogue of Anoplin | Mycobacterium smegmatis | Mycobacterium smegmatis mc2 161 | MIC = 5 μg/mL | In vitro | RBC | NA | Non toxic to erythrocytes | NA | NA | NA | NA | NA | NA | Antifungal (C. parapsilosis) and Antibacterial (Escherichia coli DH5a, Pseudomonas aeruginosa PAO, and Zymomonas mobilis ATCC 10988; Gram-positive bacteria: Bacillus subtilis DELTA) | 2016 | 27862650 |
antitb_1867 | Anoplin | GLLKFIKKLL | Addition of decanoic acid (C10H20O2) | Amidation | None | Linear | 10 | L | Amphipathic | Synthetic | Anlogue of Anoplin | Mycobacterium smegmatis | Mycobacterium smegmatis mc2 162 | MIC = 5 μg/mL | In vitro | RBC | NA | Non toxic to erythrocytes | NA | NA | NA | NA | NA | NA | Antifungal (C. parapsilosis) and Antibacterial (Escherichia coli DH5a, Pseudomonas aeruginosa PAO, and Zymomonas mobilis ATCC 10988; Gram-positive bacteria: Bacillus subtilis DELTA) | 2016 | 27862650 |
antitb_1868 | Anoplin | GLLKFIKKLL | Addition of dodecanoic acid (C12H24O2) | Amidation | None | Linear | 10 | L | Amphipathic | Synthetic | Anlogue of Anoplin | Mycobacterium smegmatis | Mycobacterium smegmatis mc2 163 | MIC = 5 μg/mL | In vitro | RBC | NA | Non toxic to erythrocytes | NA | NA | NA | NA | NA | NA | Antifungal (C. parapsilosis) and Antibacterial (Escherichia coli DH5a, Pseudomonas aeruginosa PAO, and Zymomonas mobilis ATCC 10988; Gram-positive bacteria: Bacillus subtilis DELTA) | 2016 | 27862650 |
antitb_1869 | Mastoparan Polybia-MPII | INWLKLGKMVIDAL | Free | Free | None | Linear | 14 | L | Cationic | Natural | Isolated from venom of the social wasp Pseudopolybia vespiceps testacea | Mycobacterium abscessus | Mycobacterium abscessus subsp. massiliense GO06 | 80% inhibition at 12.5 μM | In vitro | murine macrophages, human and mouse erythrocytes | 80% inhibition at 12.5 μM | 50% hemolysis at 24.18 μM and 48.47 μM against mouse and human erythrocytes respectively | NA | NA | NA | membrane pore formation | cell membrane | NA | Antifungal (Candida albicans and Cryptococcus neoformans) and Antibacterial (Staphylococcus aureus) | 2017 | 28108242 |
antitb_1870 | Tat(47–57) | YGRKKRRQRRR | Free | Free | None | Linear | 11 | L | Cationic | Protein Derived | HIV transactivator protein | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (ATCC 27294) | MIC >300 μM | In vitro | RBC | NA | 50% hemolysis at >300 μM | NA | NA | NA | NA | NA | NA | Antibacterial (Streptococcus pneumoniae) | 2017 | 28314993 |
antitb_1871 | Penetratin | RQIKIWFQNRRMKWKK | Free | Free | None | Linear | 16 | L | Cationic | Protein Derived | Drosophila Antennapedia protein | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (ATCC 27294) | MIC >300 μM | In vitro | RBC | NA | 50% hemolysis at >300 μM | NA | NA | NA | NA | NA | NA | Antibacterial (Streptococcus pneumoniae) | 2017 | 28314993 |
antitb_1872 | Transportan | AGYLLGKINLKALAALAKKIL | Free | Free | None | Linear | 21 | L | Cationic | Synthetic | Constructed from Galanin and Mastoparan proteins | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (ATCC 27294) | MIC = 80 μM | In vitro | RBC | NA | 50% hemolysis at 38.0 ± 3.79 μM | NA | NA | NA | NA | NA | NA | Antibacterial (Streptococcus pneumoniae) | 2017 | 28314993 |
antitb_1873 | Magainin | GIGKFLHSAKKFGKAFVGEIMNS | Free | Free | None | Linear | 23 | L | Cationic | Natural | Peptide from Xenopus laevis skin | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (ATCC 27294) | MIC >300 μM | In vitro | RBC | NA | 50% hemolysis at >300 μM | NA | NA | NA | NA | NA | NA | Antibacterial (Streptococcus pneumoniae) | 2017 | 28314993 |
antitb_1874 | Buforin II (5–21) | RAGLQFPVGRVHRLLRK | Free | Free | None | Linear | 17 | L | Cationic | Natural | Peptide from the stomach tissue of Bufo bufo garagrizans | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (ATCC 27294) | MIC >300 μM | In vitro | RBC | NA | 50% hemolysis at >300 μM | NA | NA | NA | NA | NA | NA | Antibacterial (Streptococcus pneumoniae) | 2017 | 28314993 |
antitb_1875 | GranF2 | VCRTGRSRWRDVCRNFMRRYQSR | Free | Free | None | Linear | 23 | L | Cationic | Protein Derived | Peptide derived from Granulysin protein | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (ATCC 27294) | MIC >300 μM | In vitro | RBC | NA | 50% hemolysis at >300 μM | NA | NA | NA | NA | NA | NA | Antibacterial (Streptococcus pneumoniae) | 2017 | 28314993 |
antitb_1876 | Dhvar4 | KRLFKKLLFSLRKY | Free | Free | None | Linear | 14 | L | Cationic | Protein Derived | Human salivary Histatin derivative | Mycobacterium tuberculosis | Mycobacterium tuberculosis H37Rv (ATCC 27294) | MIC >300 μM | In vitro | RBC | NA | 50% hemolysis at >300 μM | NA | NA | NA | NA | NA | NA | Antibacterial (Streptococcus pneumoniae) | 2017 | 28314993 |