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GF-Tic-Oic-G-Orn-Tic-Oic-GF-Tic-Oic-G-Orn-Tic-Orn-Orn-Orn-Orn details |
| Primary information | |
|---|---|
| ID | antitb_1758, |
| Name | US 2012/0197004 |
| N-Terminal modification | FKAB-1Gp |
| C-Terminal Modification | GF-Tic-Oic-G-Orn-Tic-Oic-GF-Tic-Oic-G-Orn-Tic-Orn-Orn-Orn-Orn |
| Chemical Modification | Acetylation |
| Linear/Cyclic | Amidation |
| Length | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = Ornithine |
| Chirality | Linear |
| Nature | 19 |
| Source | L |
| Origin | Hydrophobic |
| Species | Synthetic |
| Inhibition Concentration | Mycobacterium ranae |
| In Vitro/ In vivo | Mycobacterium ranae |
| Cell Line | MIC = 10 μM |
| Inhibition Concentration | Both |
| Sequence | 2012 |
| Cytotoxicity | None |
| In vivo Model | NA |
| Lethal Dose | not tested |
| Immune Responce | Mice |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | None |
| Year of Publication | Anti-bacterial (Salmonella typhimurium, Staphylococcus aureus, Bacillus subtillis) |
| Tertiary Structure (Technique) | Not Predicted), |
| Primary information | |
|---|---|
| ID | antitb_1799, |
| Name | 17547385 |
| N-Terminal modification | Peptide-43 |
| C-Terminal Modification | GF-Tic-Oic-G-Orn-Tic-Oic-GF-Tic-Oic-G-Orn-Tic-Orn-Orn-Orn-Orn |
| Chemical Modification | Acetylation |
| Linear/Cyclic | Amidation |
| Length | Tic = tetrahydroisoquinolinecarboxylic acid, Oic = Octahydroindolecarboxylic acid, Orn = Ornithine |
| Chirality | Linear |
| Nature | 19 |
| Source | L |
| Origin | Amphipathic, Hydrophobic |
| Species | Synthetic |
| Inhibition Concentration | Mycobacterium ranae |
| In Vitro/ In vivo | Mycobacterium ranae (ATCC 110) |
| Cell Line | MIC = 10 µM or 24 µg/mL |
| Inhibition Concentration | Both |
| Sequence | 2007 |
| Cytotoxicity | NA |
| In vivo Model | NA |
| Lethal Dose | Not tested |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | Stimulate innate immune system |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | Antibacterial (Salmonella typhimurium (ATCC 13311), Staphylococcus aureus methicillin/gentamicin/tetrac+AB20ycline resistant (ATCC 33592), Bacillus subtillis (ATCC 43223)) |
| Tertiary Structure (Technique) | Not Predicted), |