| Primary information |
|---|
| ID | antitb_1137, |
| Name | 23689720 |
| N-Terminal modification | NK-2 |
| C-Terminal Modification | KILRGVCKKIMRTFLRRISKDILTGKK |
| Chemical Modification | Free |
| Linear/Cyclic | Amidation |
| Length | None |
| Chirality | Linear |
| Nature | 27 |
| Source | L |
| Origin | Cationic |
| Species | Protein Derived |
| Strain | Core region of the lymphocytic effector protein NK-lysin, found in NK cells and cytotoxic T cells |
| Inhibition Concentration | Mycobacterium smegmatis |
| In Vitro/ In vivo | Mycobacterium smegmatis mc2155 (ATCC 700084) |
| Cell Line | 7 μg of NK- 2/ml combined with 0.5 ppm of NP-1 kills 90% of M. smegmatis |
| Inhibition Concentration | In vitro |
| Sequence | 2013 |
| Cytotoxicity | RAW264.7 |
| In vivo Model | Combination of NP-1 and NK-2 showed 35% reduction in intracellular survival of M. smegmatis |
| Lethal Dose | No significant reduction in cell viability either treating alone or combination |
| Immune Responce | None |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | Permeabilization of the bacterial cell membrane |
| Other activities | Cell envelope |
| PMID | AgNPs synthesiszed only in the presence of a plant Alstonia macrophylla (NP-1). |
| Year of Publication | Antibacterial, Antiprotozoan (Trypanosoma cruzi and Plasmodium falciparum) and antifungal (Candida albicans) |
Tertiary Structure
(Technique) | Not Predicted), |
| Primary information |
|---|
| ID | antitb_1138, |
| Name | 23689720 |
| N-Terminal modification | NK-2 |
| C-Terminal Modification | KILRGVCKKIMRTFLRRISKDILTGKK |
| Chemical Modification | Free |
| Linear/Cyclic | Amidation |
| Length | None |
| Chirality | Linear |
| Nature | 27 |
| Source | L |
| Origin | Cationic |
| Species | Protein Derived |
| Strain | Core region of the lymphocytic effector protein NK-lysin, found in NK cells and cytotoxic T cells |
| Inhibition Concentration | Mycobacterium smegmatis |
| In Vitro/ In vivo | Mycobacterium smegmatis mc2155 (ATCC 700084) |
| Cell Line | 7 μg of NK- 2/ml combined with 0.5 ppm of NP-2 kills 90% of M. smegmatis |
| Inhibition Concentration | In vitro |
| Sequence | 2013 |
| Cytotoxicity | RAW264.7 |
| In vivo Model | NP-2 in combination with NK-2 killed >52% intra- cellular M. smegmatis. |
| Lethal Dose | No significant reduction in cell viability either treating alone or combination |
| Immune Responce | None |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | Permeabilization of the bacterial cell membrane |
| Other activities | Cell envelope |
| PMID | AgNPs synthesiszed only in the presence of a fungal Trichoderma sp. (NP-2). |
| Year of Publication | Antibacterial, Antiprotozoan (Trypanosoma cruzi and Plasmodium falciparum) and antifungal (Candida albicans) |
Tertiary Structure
(Technique) | Not Predicted), |
| Primary information |
|---|
| ID | antitb_1139, |
| Name | 23689720 |
| N-Terminal modification | NK-2 |
| C-Terminal Modification | KILRGVCKKIMRTFLRRISKDILTGKK |
| Chemical Modification | Free |
| Linear/Cyclic | Amidation |
| Length | None |
| Chirality | Linear |
| Nature | 27 |
| Source | L |
| Origin | Cationic |
| Species | Protein Derived |
| Strain | Core region of the lymphocytic effector protein NK-lysin, found in NK cells and cytotoxic T cells |
| Inhibition Concentration | Mycobacterium marinum |
| In Vitro/ In vivo | Mycobacterium marinum (ATCC 927) |
| Cell Line | IC90 = 3.5 μg/ml |
| Inhibition Concentration | In vitro |
| Sequence | 2013 |
| Cytotoxicity | RAW264.7 |
| In vivo Model | Moderate killing was observed |
| Lethal Dose | No significant reduction in cell viability either treating alone or combination |
| Immune Responce | None |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | Permeabilization of the bacterial cell membrane |
| Other activities | Cell envelope |
| PMID | None |
| Year of Publication | Antibacterial, Antiprotozoan (Trypanosoma cruzi and Plasmodium falciparum) and antifungal (Candida albicans) |
Tertiary Structure
(Technique) | Not Predicted), |
| Primary information |
|---|
| ID | antitb_1806, |
| Name | 21396418 |
| N-Terminal modification | NK-2 |
| C-Terminal Modification | KILRGVCKKIMRTFLRRISKDILTGKK |
| Chemical Modification | Free |
| Linear/Cyclic | Amidation |
| Length | None |
| Chirality | Linear |
| Nature | 27 |
| Source | L |
| Origin | Cationic |
| Species | Protein Derived |
| Strain | Core region of the lymphocytic effector protein NK-lysin |
| Inhibition Concentration | Mycobacterium smegmatis |
| In Vitro/ In vivo | Mycobacterium smegmatis mc2155 |
| Cell Line | After 24 h more than 70% killing of M. smegmatis was found at 30 μM |
| Inhibition Concentration | In vitro |
| Sequence | 2011 |
| Cytotoxicity | mouse macrophage RAW 264.7 |
| In vivo Model | 10 μM NK-2 diminished the intracellular bacterial loadwhen compared to the untreated macrophages |
| Lethal Dose | Non-toxic |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | NA |
Tertiary Structure
(Technique) | Not Predicted), |
| Primary information |
|---|
| ID | antitb_1807, |
| Name | 21396418 |
| N-Terminal modification | NK-3 |
| C-Terminal Modification | KILRGVCKKIMRTFLRRISKDILTGKK |
| Chemical Modification | Free |
| Linear/Cyclic | Amidation |
| Length | None |
| Chirality | Linear |
| Nature | 27 |
| Source | L |
| Origin | Cationic |
| Species | Protein Derived |
| Strain | Core region of the lymphocytic effector protein NK-lysin |
| Inhibition Concentration | Mycobacterium bovis |
| In Vitro/ In vivo | Mycobacterium bovis BCG Pasteur (ATCC35734) |
| Cell Line | After 24 h, more than 78% killing was observed at 30 μM |
| Inhibition Concentration | In vitro |
| Sequence | 2011 |
| Cytotoxicity | mouse macrophage RAW 264.8 |
| In vivo Model | 11 μM NK-2 diminished the intracellular bacterial loadwhen compared to the untreated macrophages |
| Lethal Dose | Non-toxic |
| Immune Responce | NA |
| Mechanism of Action | NA |
| Target | NA |
| Combination Therapy | NA |
| Other activities | NA |
| PMID | NA |
| Year of Publication | NA |
Tertiary Structure
(Technique) | Not Predicted), |