| Primary information |
|---|
| ID | antitb_1137 |
| Peptide Name | NK-2 |
| Sequence | KILRGVCKKIMRTFLRRISKDILTGKK |
| N-terminal Modification | Free |
| C-terminal Modification | Amidation |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Length | 27 |
| Chirality | L |
| Nature | Cationic |
| Source | Protein Derived |
| Origin | Core region of the lymphocytic effector protein NK-lysin, found in NK cells and cytotoxic T cells |
| Species | Mycobacterium smegmatis |
| Strain | Mycobacterium smegmatis mc2155 (ATCC 700084) |
| Inhibition Concentartion | 7 μg of NK- 2/ml combined with 0.5 ppm of NP-1 kills 90% of M. smegmatis |
| In vitro/In vivo | In vitro |
| Cell Line | RAW264.7 |
| Inhibition Concentartion | Combination of NP-1 and NK-2 showed 35% reduction in intracellular survival of M. smegmatis |
| Cytotoxicity | No significant reduction in cell viability either treating alone or combination |
| In vivo Model | None |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | Permeabilization of the bacterial cell membrane |
| Target | Cell envelope |
| Combination Therapy | AgNPs synthesiszed only in the presence of a plant Alstonia macrophylla (NP-1). |
| Other Activities | Antibacterial, Antiprotozoan (Trypanosoma cruzi and Plasmodium falciparum) and antifungal (Candida albicans) |
| Pubmed ID | 23689720 |
| Year of Publication | 2013 |
| 3-D Structure | NA |