Primary information |
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ID | antitb_1137 |
Peptide Name | NK-2 |
Sequence | KILRGVCKKIMRTFLRRISKDILTGKK |
N-terminal Modification | Free |
C-terminal Modification | Amidation |
Chemical Modification | None |
Linear/ Cyclic | Linear |
Length | 27 |
Chirality | L |
Nature | Cationic |
Source | Protein Derived |
Origin | Core region of the lymphocytic effector protein NK-lysin, found in NK cells and cytotoxic T cells |
Species | Mycobacterium smegmatis |
Strain | Mycobacterium smegmatis mc2155 (ATCC 700084) |
Inhibition Concentartion | 7 μg of NK- 2/ml combined with 0.5 ppm of NP-1 kills 90% of M. smegmatis |
In vitro/In vivo | In vitro |
Cell Line | RAW264.7 |
Inhibition Concentartion | Combination of NP-1 and NK-2 showed 35% reduction in intracellular survival of M. smegmatis |
Cytotoxicity | No significant reduction in cell viability either treating alone or combination |
In vivo Model | None |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | Permeabilization of the bacterial cell membrane |
Target | Cell envelope |
Combination Therapy | AgNPs synthesiszed only in the presence of a plant Alstonia macrophylla (NP-1). |
Other Activities | Antibacterial, Antiprotozoan (Trypanosoma cruzi and Plasmodium falciparum) and antifungal (Candida albicans) |
Pubmed ID | 23689720 |
Year of Publication | 2013 |
3-D Structure | NA |