Primary information |
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ID | antitb_1806 |
Peptide Name | NK-2 |
Sequence | KILRGVCKKIMRTFLRRISKDILTGKK |
N-terminal Modification | Free |
C-terminal Modification | Amidation |
Chemical Modification | None |
Linear/ Cyclic | Linear |
Length | 27 |
Chirality | L |
Nature | Cationic |
Source | Protein Derived |
Origin | Core region of the lymphocytic effector protein NK-lysin |
Species | Mycobacterium smegmatis |
Strain | Mycobacterium smegmatis mc2155 |
Inhibition Concentartion | After 24 h more than 70% killing of M. smegmatis was found at 30 μM |
In vitro/In vivo | In vitro |
Cell Line | mouse macrophage RAW 264.7 |
Inhibition Concentartion | 10 μM NK-2 diminished the intracellular bacterial loadwhen compared to the untreated macrophages |
Cytotoxicity | Non-toxic |
In vivo Model | NA |
Lethal Dose | NA |
Immune Response | NA |
Mechanism of Action | NA |
Target | NA |
Combination Therapy | NA |
Other Activities | NA |
Pubmed ID | 21396418 |
Year of Publication | 2011 |
3-D Structure | NA |