| Primary information |
|---|
| ID | antitb_1869 |
| Peptide Name | Mastoparan Polybia-MPII |
| Sequence | INWLKLGKMVIDAL |
| N-terminal Modification | Free |
| C-terminal Modification | Free |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Length | 14 |
| Chirality | L |
| Nature | Cationic |
| Source | Natural |
| Origin | Isolated from venom of the social wasp Pseudopolybia vespiceps testacea |
| Species | Mycobacterium abscessus |
| Strain | Mycobacterium abscessus subsp. massiliense GO06 |
| Inhibition Concentartion | 80% inhibition at 12.5 μM |
| In vitro/In vivo | In vitro |
| Cell Line | murine macrophages, human and mouse erythrocytes |
| Inhibition Concentartion | 80% inhibition at 12.5 μM |
| Cytotoxicity | 50% hemolysis at 24.18 μM and 48.47 μM against mouse and human erythrocytes respectively |
| In vivo Model | NA |
| Lethal Dose | NA |
| Immune Response | NA |
| Mechanism of Action | membrane pore formation |
| Target | cell membrane |
| Combination Therapy | NA |
| Other Activities | Antifungal (Candida albicans and Cryptococcus neoformans) and Antibacterial (Staphylococcus aureus) |
| Pubmed ID | 28108242 |
| Year of Publication | 2017 |
| 3-D Structure | NA |