Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0004Thrombospondin (TSP)

Click for more detail

NAMGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGY1170GlycoproteinNaturalelicit innate immune responsecluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanTumor cell linesNAP16671.fastaP16671472 cellular TSP receptor.NA24357571987Pubchem Assay
PRRID_0004Thrombospondin (TSP)

Click for more detail

NAMGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGY1170GlycoproteinNaturalelicit innate immune responsecluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanTumor cell linesNAP16671.fastaP16671472 cellular TSP receptor.NA24357571987Pubchem Assay
PRRID_0008Candida albicans

Click for more detail

Candida albicans(fungi)NANAWhole cellNaturalCandida albicans binds with human macrophage mannose receptor via carbohydrate recognition-like domains.Mannose receptorMannose receptor (MR)HumanMacrophagesCRDsP22897.fastaP228971456It leads to the receptor-mediated endorytosis of mannose-rich glycoconjugate as well as phagocytosis as well as pinocytisisof yeasts.Phagocytosis assay22587071990Pubchem Assay
PRRID_0008Candida albicans

Click for more detail

Candida albicans(fungi)NANAWhole cellNaturalCandida albicans binds with human macrophage mannose receptor via carbohydrate recognition-like domains.Mannose receptorMannose receptor (MR)HumanMacrophagesCRDsP22897.fastaP228971456It leads to the receptor-mediated endorytosis of mannose-rich glycoconjugate as well as phagocytosis as well as pinocytisisof yeasts.Phagocytosis assay22587071990Pubchem Assay
PRRID_0011D-mannose

Click for more detail

BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0011D-mannose

Click for more detail

BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0013L-fucose

Click for more detail

BacteriaCC(C(C(C(C=O)O)O)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0013L-fucose

Click for more detail

BacteriaCC(C(C(C(C=O)O)O)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0014N-acetylmannosamine

Click for more detail

BacteriaCC(=O)NC1C(C(C(OC1O)CO)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0014N-acetylmannosamine

Click for more detail

BacteriaCC(=O)NC1C(C(C(OC1O)CO)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0017TPA (tissue plasminogen activator)

Click for more detail

Endogenous (others)PERLQRVVTPVLARTDSEPSGLRGTHKPHRWGCRCGAHRAGARLVGTGMGPGESALGWAARMPPALFPPSHPFHFQRPRDIFKGKGKDREKCQAGLGSGPVGSSGRRGGLYHDGLELGLEVSLPGCWESPGGQEGCSRLREGQVQSPEWGRRWAAVWVVQPDWTEC166ProteinNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0017TPA (tissue plasminogen activator)

Click for more detail

Endogenous (others)PERLQRVVTPVLARTDSEPSGLRGTHKPHRWGCRCGAHRAGARLVGTGMGPGESALGWAARMPPALFPPSHPFHFQRPRDIFKGKGKDREKCQAGLGSGPVGSSGRRGGLYHDGLELGLEVSLPGCWESPGGQEGCSRLREGQVQSPEWGRRWAAVWVVQPDWTEC166ProteinNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0018Advanced Glycation End Products (AGE)

Click for more detail

Endogenous (others)NANAOthersNaturalelicit innate immune responseReceptor for Advanced Glycation End-productsReceptor for advanced glycation endproducts (RAGE)HumanNANANANANAinduces pro-inflammatory cytokine responseNA13788431992NA
PRRID_0018Advanced Glycation End Products (AGE)

Click for more detail

Endogenous (others)NANAOthersNaturalelicit innate immune responseReceptor for Advanced Glycation End-productsReceptor for advanced glycation endproducts (RAGE)HumanNANANANANAinduces pro-inflammatory cytokine responseNA13788431992NA
PRRID_0023Fatty acid

Click for more detail

Endogenous (others)NANAOthersNaturalImmunostimulantcluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanHeart, intestine, fat, muscle, and testis. NAP16671.fastaP16671472increase in oleate transportNA76887291993Pubchem Assay
PRRID_0023Fatty acid

Click for more detail

Endogenous (others)NANAOthersNaturalImmunostimulantcluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanHeart, intestine, fat, muscle, and testis. NAP16671.fastaP16671472increase in oleate transportNA76887291993Pubchem Assay
PRRID_0029Thrombospondin (TSP)

Click for more detail

Thrombin-induced platelet (others)MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGY1170GlycoproteinNaturalCD36 sequence 139-155 binds TSP and induces a second CD36-binding site, which binds CD36 sequence 93-110 with high affinity.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanPlatelet MembraneNAP16671.fastaP16671472It participates in the adhesive cell interactions.NA76883641993Pubchem Assay
PRRID_0029Thrombospondin (TSP)

Click for more detail

Thrombin-induced platelet (others)MGLAWGLGVLFLMHVCGTNRIPESGGDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPDDKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLALERKDHSGQVFSVVSNGKAGTLDLSLTVQGKQHVVSVEEALLATGQWKSITLFVQEDRAQLYIDCEKMENAELDVPIQSVFTRDLASIARLRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGCSSSTSVLLTLDNNVVNGSSPAIRTNYIGHKTKDLQAICGISCDELSSMVLELRGLRTIVTTLQDSIRKVTEENKELANELRRPPLCYHNGVQYRNNEEWTVDSCTECHCQNSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDGCLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNGIQCTDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFTGSQPFGQGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNENLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQRDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHDKDGKGDACDHDDDNDGIPDDKDNCRLVPNPDQKDSDGDGRGDACKDDFDHDSVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGY1170GlycoproteinNaturalCD36 sequence 139-155 binds TSP and induces a second CD36-binding site, which binds CD36 sequence 93-110 with high affinity.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanPlatelet MembraneNAP16671.fastaP16671472It participates in the adhesive cell interactions.NA76883641993Pubchem Assay
PRRID_0034Acetylated LDL

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalAcetylated-LDL is a potent activator of MSR.Macrophage Scavenger Receptor (MSR)Scavenger receptor (SR)HumanMacrophagesNAP21757.fastaP21757451The MSR mediates the endocytic uptake and degradation of LDL.NA76072091995Pubchem Assay
PRRID_0034Acetylated LDL

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalAcetylated-LDL is a potent activator of MSR.Macrophage Scavenger Receptor (MSR)Scavenger receptor (SR)HumanMacrophagesNAP21757.fastaP21757451The MSR mediates the endocytic uptake and degradation of LDL.NA76072091995Pubchem Assay
PRRID_0036Advanced Glycation End Products (AGE)

Click for more detail

Host (Endogenous) (others)NANAProteinNaturalAGE is a potent activator of MSR.Macrophage Scavenger Receptor (MSR)Scavenger receptor (SR)HumanMacrophagesNAP21757.fastaP21757451The MSR mediates the endocytic uptake and degradation of AGE proteins.NA76072091995Pubchem Assay
PRRID_0036Advanced Glycation End Products (AGE)

Click for more detail

Host (Endogenous) (others)NANAProteinNaturalAGE is a potent activator of MSR.Macrophage Scavenger Receptor (MSR)Scavenger receptor (SR)HumanMacrophagesNAP21757.fastaP21757451The MSR mediates the endocytic uptake and degradation of AGE proteins.NA76072091995Pubchem Assay
PRRID_0044surfactant protein-A

Click for more detail

Host (Endogenous) (others)MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF248ProteinNaturalCarbohydrate moieties of SP-A enhanced adherence of Mycobacterium tuberculosis.Mannose receptorMannose receptor (MR)HumanMonocytes-derived macrophagesNAP22897.fastaP228971456Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis.NA75945491995Pubchem Assay
PRRID_0044surfactant protein-A

Click for more detail

Host (Endogenous) (others)MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF248ProteinNaturalCarbohydrate moieties of SP-A enhanced adherence of Mycobacterium tuberculosis.Mannose receptorMannose receptor (MR)HumanMonocytes-derived macrophagesNAP22897.fastaP228971456Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis.NA75945491995Pubchem Assay
PRRID_0045surfactant protein-A

Click for more detail

Host (Endogenous) (others)MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF248ProteinNaturalCarbohydrate moieties of SP-A enhanced adherence of Mycobacterium tuberculosis.Mannose receptorMannose receptor (MR)HumanAlveolar macrophagesNAP22897.fastaP228971456Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis.NA75945491995Pubchem Assay
PRRID_0045surfactant protein-A

Click for more detail

Host (Endogenous) (others)MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF248ProteinNaturalCarbohydrate moieties of SP-A enhanced adherence of Mycobacterium tuberculosis.Mannose receptorMannose receptor (MR)HumanAlveolar macrophagesNAP22897.fastaP228971456Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis.NA75945491995Pubchem Assay
PRRID_0050lipo-arabinomannan

Click for more detail

mycobacteria (Mycobacterium tuberculosis; Erdman strain) (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalImmunostimulantMannose receptorMannose receptor (MR)HumanMacrophagesNAP22897.fastaP228971456NAChromatographic analyses 89068351996Pubchem Assay
PRRID_0050lipo-arabinomannan

Click for more detail

mycobacteria (Mycobacterium tuberculosis; Erdman strain) (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalImmunostimulantMannose receptorMannose receptor (MR)HumanMacrophagesNAP22897.fastaP228971456NAChromatographic analyses 89068351996Pubchem Assay
PRRID_0060Advanced Glycation End-products (AGE)-BSA

Click for more detail

Human (others)NANAProteinNaturalAGE-modified proteins binds to scavenger receptor with high affinity.Scavenger receptor class AScavenger receptor (SR)Humanhepatic sinusoidal Kupffer and endothelial cellsNANANANAAGE-proteins are eliminated very efficiently from the circulation by scavenger-receptor-mediated endocytosis in both LECs and KCs.NA90657781997NA
PRRID_0060Advanced Glycation End-products (AGE)-BSA

Click for more detail

Human (others)NANAProteinNaturalAGE-modified proteins binds to scavenger receptor with high affinity.Scavenger receptor class AScavenger receptor (SR)Humanhepatic sinusoidal Kupffer and endothelial cellsNANANANAAGE-proteins are eliminated very efficiently from the circulation by scavenger-receptor-mediated endocytosis in both LECs and KCs.NA90657781997NA
PRRID_0061Advanced Glycation End-products (AGE)-Hb

Click for more detail

Human (others)NANAProteinNaturalAGE-modified proteins binds to scavenger receptor with high affinity.Scavenger receptor class AScavenger receptor (SR)Humanhepatic sinusoidal Kupffer and endothelial cellsNANANANAAGE-proteins are eliminated very efficiently from the circulation by scavenger-receptor-mediated endocytosis in both LECs and KCs.NA90657781997NA
PRRID_0061Advanced Glycation End-products (AGE)-Hb

Click for more detail

Human (others)NANAProteinNaturalAGE-modified proteins binds to scavenger receptor with high affinity.Scavenger receptor class AScavenger receptor (SR)Humanhepatic sinusoidal Kupffer and endothelial cellsNANANANAAGE-proteins are eliminated very efficiently from the circulation by scavenger-receptor-mediated endocytosis in both LECs and KCs.NA90657781997NA
PRRID_0066Apoptotic cells

Click for more detail

Host (Endogenous) (others)NANAWhole cellNaturalNAcluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanImmature dendritic cellsNAP16671.fastaP16671472It leads to the phagocytosis of the apoptotic cells as well as Cross-present Antigens to Cytotoxic T Lymphocytes.NA97636151998Pubchem Assay
PRRID_0066Apoptotic cells

Click for more detail

Host (Endogenous) (others)NANAWhole cellNaturalNAcluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanImmature dendritic cellsNAP16671.fastaP16671472It leads to the phagocytosis of the apoptotic cells as well as Cross-present Antigens to Cytotoxic T Lymphocytes.NA97636151998Pubchem Assay
PRRID_0067Gram-negative

Click for more detail

Gram-positive and negative bacteriaNANANANaturalNAMacrophage receptor with collagenous structure (MARCO)Scavenger receptor (SR)HumanMacrophagescysteine-rich motif (SRCR)Q9UEW3.fastaQ9UEW3520MARCO is likely to play a role in host defense.NA94685081998Pubchem Assay
PRRID_0067Gram-negative

Click for more detail

Gram-positive and negative bacteriaNANANANaturalNAMacrophage receptor with collagenous structure (MARCO)Scavenger receptor (SR)HumanMacrophagescysteine-rich motif (SRCR)Q9UEW3.fastaQ9UEW3520MARCO is likely to play a role in host defense.NA94685081998Pubchem Assay
PRRID_0068High Density Lipoprotein (HDL)

Click for more detail

Host (Endogenous) (others)CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)CNALipoproteinNaturalCD36 is a high affinity receptor for the native lipoproteins LDL.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanMonocytes/MacrophagesNAP16671.fastaP16671472Lipoprotein binding assayNA95559431998Pubchem Assay
PRRID_0068High Density Lipoprotein (HDL)

Click for more detail

Host (Endogenous) (others)CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)CNALipoproteinNaturalCD36 is a high affinity receptor for the native lipoproteins LDL.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanMonocytes/MacrophagesNAP16671.fastaP16671472Lipoprotein binding assayNA95559431998Pubchem Assay
PRRID_0069Low Density Lipoprotein (LDL)

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalCD36 is a high affinity receptor for the native lipoproteins HDL.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanMonocytes/MacrophagesNAP16671.fastaP16671472Lipoprotein binding assayNA95559431998Pubchem Assay
PRRID_0069Low Density Lipoprotein (LDL)

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalCD36 is a high affinity receptor for the native lipoproteins HDL.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanMonocytes/MacrophagesNAP16671.fastaP16671472Lipoprotein binding assayNA95559431998Pubchem Assay
PRRID_0072Very Low Density Lipoprotein (VLDL)

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalCD36 is a high affinity receptor for the native lipoproteins VLDL.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanMonocytes/MacrophagesNAP16671.fastaP16671472Lipoprotein binding assayNA95559431998Pubchem Assay
PRRID_0072Very Low Density Lipoprotein (VLDL)

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalCD36 is a high affinity receptor for the native lipoproteins VLDL.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanMonocytes/MacrophagesNAP16671.fastaP16671472Lipoprotein binding assayNA95559431998Pubchem Assay
PRRID_0073Gram-positive bacteria

Click for more detail

Gram-positive and negative bacteriaNANANANaturalNAMacrophage receptor with collagenous structure (MARCO)Scavenger receptor (SR)HumanMacrophagescysteine-rich motif (SRCR)Q9UEW3.fastaQ9UEW3520MARCO is likely to play a role in host defense.NA94685081998Pubchem Assay
PRRID_0073Gram-positive bacteria

Click for more detail

Gram-positive and negative bacteriaNANANANaturalNAMacrophage receptor with collagenous structure (MARCO)Scavenger receptor (SR)HumanMacrophagescysteine-rich motif (SRCR)Q9UEW3.fastaQ9UEW3520MARCO is likely to play a role in host defense.NA94685081998Pubchem Assay
PRRID_0074Peptidoglycan (PGN)

Click for more detail

S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPeptidoglycan recognition by TLR 2 leads to the activation of NF-KB, which leads to the secretion of proinflammatory cytokines.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanFibroblastsLRRO60603.fastaO60603784TLR2 is responsible for recognzing the cell wall components of the gram-positive bacteria and induces the respective immune response.EMSA103840901999Pubchem Assay
PRRID_0074Peptidoglycan (PGN)

Click for more detail

S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalPeptidoglycan recognition by TLR 2 leads to the activation of NF-KB, which leads to the secretion of proinflammatory cytokines.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanFibroblastsLRRO60603.fastaO60603784TLR2 is responsible for recognzing the cell wall components of the gram-positive bacteria and induces the respective immune response.EMSA103840901999Pubchem Assay
PRRID_0075pneumolysin

Click for more detail

S. pneumoniae (Bacteria)MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND471NANaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNANAO00206.fastaO00206839ytokine induction is mediated through NF-kappaB activationNA104112781999Pubchem Assay
PRRID_0075pneumolysin

Click for more detail

S. pneumoniae (Bacteria)MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND471NANaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNANAO00206.fastaO00206839ytokine induction is mediated through NF-kappaB activationNA104112781999Pubchem Assay
PRRID_0076Acetylated LDL

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalIt binds to the CD36 with high affinitycluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanCHO cellsNAP16671.fastaP16671472CD36 mediates the endocytic uptake and subsequent intracellular degradation.Cellular assay110350132000Pubchem Assay
PRRID_0076Acetylated LDL

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalIt binds to the CD36 with high affinitycluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanCHO cellsNAP16671.fastaP16671472CD36 mediates the endocytic uptake and subsequent intracellular degradation.Cellular assay110350132000Pubchem Assay
PRRID_0078Advanced Glycation End Products (AGE)

Click for more detail

Host (Endogenous) (others)NANAProteinNaturalIt binds to the CD36 with high affinitycluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanCHO cellsNAP16671.fastaP16671472CD36 mediates the endocytic uptake and subsequent intracellular degradation.Cellular assay110350132000Pubchem Assay
PRRID_0078Advanced Glycation End Products (AGE)

Click for more detail

Host (Endogenous) (others)NANAProteinNaturalIt binds to the CD36 with high affinitycluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanCHO cellsNAP16671.fastaP16671472CD36 mediates the endocytic uptake and subsequent intracellular degradation.Cellular assay110350132000Pubchem Assay
PRRID_0079Chondroitin Sulfates A

Click for more detail

Host (Endogenous) (others)CC(=O)NC1C(C(C(OC1O)CO)OS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)O)O)ONACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0079Chondroitin Sulfates A

Click for more detail

Host (Endogenous) (others)CC(=O)NC1C(C(C(OC1O)CO)OS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)O)O)ONACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0080Chondroitin Sulfates B

Click for more detail

Host (Endogenous) (others)NANACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0080Chondroitin Sulfates B

Click for more detail

Host (Endogenous) (others)NANACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0083ER-112022

Click for more detail

lipid A derivative (others)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipidSyntheticIt activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanU373 human astrocytoma cellsLRRO00206.fastaO00206839It has the role in immuno inflammation.ELISA110328432000Pubchem Assay
PRRID_0083ER-112022

Click for more detail

lipid A derivative (others)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipidSyntheticIt activated the NF-KB pathway and resulted into the secretion of TNF-alpha and IL-6.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanU373 human astrocytoma cellsLRRO00206.fastaO00206839It has the role in immuno inflammation.ELISA110328432000Pubchem Assay
PRRID_0084Heat-shock proteins 60

Click for more detail

Endogenous (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573ProteinNaturalimmunostimulanttToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNANAO00206.fastaO00206839 induction of TNF-alpha and NO formation NA106237942000Pubchem Assay
PRRID_0084Heat-shock proteins 60

Click for more detail

Endogenous (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573ProteinNaturalimmunostimulanttToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanNANAO00206.fastaO00206839 induction of TNF-alpha and NO formation NA106237942000Pubchem Assay
PRRID_0085High Density Lipoprotein (HDL)

Click for more detail

Host (Endogenous) (others)CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)CNALipoproteinNaturalIt binds to the CD36 with high affinitycluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanCHO cellsNAP16671.fastaP16671472CD36 mediates the endocytic uptake and subsequent intracellular degradation.Cellular assay110350132000Pubchem Assay
PRRID_0085High Density Lipoprotein (HDL)

Click for more detail

Host (Endogenous) (others)CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)CNALipoproteinNaturalIt binds to the CD36 with high affinitycluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanCHO cellsNAP16671.fastaP16671472CD36 mediates the endocytic uptake and subsequent intracellular degradation.Cellular assay110350132000Pubchem Assay
PRRID_0087Lipoteichoic Acid (LTA)

Click for more detail

Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMacrophagesNAQ9Y2C9.fastaQ9Y2C9796production of pro-inflammatory cytokines ELISA110957402000Pubchem Assay
PRRID_0087Lipoteichoic Acid (LTA)

Click for more detail

Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMacrophagesNAQ9Y2C9.fastaQ9Y2C9796production of pro-inflammatory cytokines ELISA110957402000Pubchem Assay
PRRID_0088Lipoteichoic Acid (LTA)

Click for more detail

Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMacrophagesNAO60603.fastaO60603784production of pro-inflammatory cytokines ELISA110957402000Pubchem Assay
PRRID_0088Lipoteichoic Acid (LTA)

Click for more detail

Gram-positive bacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanMacrophagesNAO60603.fastaO60603784production of pro-inflammatory cytokines ELISA110957402000Pubchem Assay
PRRID_0089Murabutide

Click for more detail

MDP (others)CCCCOC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptidoglycanSyntheticStimulation with murabutide leads to the significant release of TNF-a, IL-6, MIP-1a, MIP-1b, RANTES and high levels of beta-chemokines.NANAHumanMonocytes-derived macrophages and dendritic cellsNANANANAMurabutide has the capacity to enhance nonspecific resistance against viral infections and to target cells of the reticuloendothelial system.ELISA109336862000NA
PRRID_0089Murabutide

Click for more detail

MDP (others)CCCCOC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)CNAPeptidoglycanSyntheticStimulation with murabutide leads to the significant release of TNF-a, IL-6, MIP-1a, MIP-1b, RANTES and high levels of beta-chemokines.NANAHumanMonocytes-derived macrophages and dendritic cellsNANANANAMurabutide has the capacity to enhance nonspecific resistance against viral infections and to target cells of the reticuloendothelial system.ELISA109336862000NA
PRRID_0092oxidized LDL (OxLDL)

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalOx-LDL binds with SR-PSOX with high affinity.Scavenger receptor PSOX (SR-PSOX)Scavenger receptor (SR)HumanMacrophagesNAQ9H2A7.fastaQ9H2A7254SR-PSOX specifically binds with high affinity, internalize and degrade OxLDL, hence play important roles in pathophysiology including atherogenesis.ELISA110602822000Pubchem Assay
PRRID_0092oxidized LDL (OxLDL)

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalOx-LDL binds with SR-PSOX with high affinity.Scavenger receptor PSOX (SR-PSOX)Scavenger receptor (SR)HumanMacrophagesNAQ9H2A7.fastaQ9H2A7254SR-PSOX specifically binds with high affinity, internalize and degrade OxLDL, hence play important roles in pathophysiology including atherogenesis.ELISA110602822000Pubchem Assay
PRRID_0093oxidized LDL (OxLDL)

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalIt binds to the CD36 with high affinitycluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanCHO cellsNAP16671.fastaP16671472CD36 mediates the endocytic uptake and subsequent intracellular degradation.Cellular assay110350132000Pubchem Assay
PRRID_0093oxidized LDL (OxLDL)

Click for more detail

Host (Endogenous) (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalIt binds to the CD36 with high affinitycluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanCHO cellsNAP16671.fastaP16671472CD36 mediates the endocytic uptake and subsequent intracellular degradation.Cellular assay110350132000Pubchem Assay
PRRID_0095Sulfated blood group chains

Click for more detail

Host (Endogenous) (others)NANACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0095Sulfated blood group chains

Click for more detail

Host (Endogenous) (others)NANACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0099dsRNA

Click for more detail

Type I Lang mammalian reovirus (virus)NANANucleic AcidNaturalIt induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Human(HEK293 t cells)NAO15455.fastaO15455904IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.EMSA116070322001Pubchem Assay
PRRID_0099dsRNA

Click for more detail

Type I Lang mammalian reovirus (virus)NANANucleic AcidNaturalIt induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Human(HEK293 t cells)NAO15455.fastaO15455904IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.EMSA116070322001Pubchem Assay
PRRID_0101Heat-shock proteins 60

Click for more detail

Human (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573ProteinNaturalHSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK).Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanFibroblastsLRRO60603.fastaO60603784It has the role in immuno inflammation.Luciferase reporter assay114020402001Pubchem Assay
PRRID_0101Heat-shock proteins 60

Click for more detail

Human (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573ProteinNaturalHSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK).Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanFibroblastsLRRO60603.fastaO60603784It has the role in immuno inflammation.Luciferase reporter assay114020402001Pubchem Assay
PRRID_0102Heat-shock proteins 60

Click for more detail

Human (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573ProteinNaturalHSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK).Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanFibroblastsLRRO00206.fastaO00206839It has the role in immuno inflammation.Luciferase reporter assay114020402001Pubchem Assay
PRRID_0102Heat-shock proteins 60

Click for more detail

Human (others)MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKEIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKGKGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIAKNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF573ProteinNaturalHSP60 activate the stress activated protein kinases p38 and JNK1/2, the mitogen activated protein kinases ERK1/2, and the I-kB kinase (IKK).Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanFibroblastsLRRO00206.fastaO00206839It has the role in immuno inflammation.Luciferase reporter assay114020402001Pubchem Assay
PRRID_0108Others

Click for more detail

Gram-positive and negative bacteriaNANANANaturalImmunostimulantLOX1LectinsHumanNANAP78380.fastaP78380273NAELISA112907922001Pubchem Assay
PRRID_0108Others

Click for more detail

Gram-positive and negative bacteriaNANANANaturalImmunostimulantLOX1LectinsHumanNANAP78380.fastaP78380273NAELISA112907922001Pubchem Assay
PRRID_0109oxidized LDL (OxLDL)

Click for more detail

Endogenous (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticOx-LDL binds with SR-PSOX with high affinity. Scavenger Receptor for PhosphatidylSerine and Oxidized lipoprotein (SR-PSOX)Scavenger receptor (SR)HumanMacrophagesNAQ9H2A7.fastaQ9H2A7254SR-PSOX is involved in Ox-LDL uptake and subsequent foam cell transformation in macrophages in vivo and thus may play important roles in human atherosclerotic lesion formation.ELISA117014682001Pubchem Assay
PRRID_0109oxidized LDL (OxLDL)

Click for more detail

Endogenous (others)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinSyntheticOx-LDL binds with SR-PSOX with high affinity. Scavenger Receptor for PhosphatidylSerine and Oxidized lipoprotein (SR-PSOX)Scavenger receptor (SR)HumanMacrophagesNAQ9H2A7.fastaQ9H2A7254SR-PSOX is involved in Ox-LDL uptake and subsequent foam cell transformation in macrophages in vivo and thus may play important roles in human atherosclerotic lesion formation.ELISA117014682001Pubchem Assay
PRRID_0110plasmodium-infected erythrocytes

Click for more detail

OthersNANAOthersNaturalimmunostimulantcluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanthrombospondinNAP16671.fastaP16671472nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha productionNA113236732001Pubchem Assay
PRRID_0110plasmodium-infected erythrocytes

Click for more detail

OthersNANAOthersNaturalimmunostimulantcluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)HumanthrombospondinNAP16671.fastaP16671472nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha productionNA113236732001Pubchem Assay
PRRID_0111polyinosinic-polycytidylic acid [poly(I:C)]

Click for more detail

NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticIt induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Human(HEK293 t cells)NAO15455.fastaO15455904IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.EMSA116070322001Pubchem Assay
PRRID_0111polyinosinic-polycytidylic acid [poly(I:C)]

Click for more detail

NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticIt induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12.Toll-like receptor 3 (TLR3)Toll-like receptor (TLR)Human(HEK293 t cells)NAO15455.fastaO15455904IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens.EMSA116070322001Pubchem Assay
PRRID_0112Advanced Glycation End Products (AGE)

Click for more detail

Host (Endogenous) (others)NANAProteinNaturalAGE behaves as al ligand for BLOX-1.Lectin-like oxidized LDLreceptor 1C type Lectin (CTL/CLR)HumanEndothelial cellsNAP78380.fastaP78380273Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products.Endocytic degradation assays118210702002Pubchem Assay
PRRID_0112Advanced Glycation End Products (AGE)

Click for more detail

Host (Endogenous) (others)NANAProteinNaturalAGE behaves as al ligand for BLOX-1.Lectin-like oxidized LDLreceptor 1C type Lectin (CTL/CLR)HumanEndothelial cellsNAP78380.fastaP78380273Lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) serves as an endothelial receptor for advanced glycation end products.Endocytic degradation assays118210702002Pubchem Assay
PRRID_0114alpha-methylmannoside

Click for more detail

BacteriaCOC1C(C(C(C(O1)CO)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0114alpha-methylmannoside

Click for more detail

BacteriaCOC1C(C(C(C(O1)CO)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0117Fucose

Click for more detail

BacteriaCC(C(C(C(C=O)O)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0117Fucose

Click for more detail

BacteriaCC(C(C(C(C=O)O)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0118glucose

Click for more detail

BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0118glucose

Click for more detail

BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0119GP96

Click for more detail

Human (others)MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL803ProteinNaturalIt results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces IToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanEmbryonic Kidney Fibroblasts— 293TLRRO60603.fastaO60603784Gp96 has the ability to induce specific immune responses against tumors and pathogensLuciferase reporter assay119122012002Pubchem Assay
PRRID_0119GP96

Click for more detail

Human (others)MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL803ProteinNaturalIt results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces IToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanEmbryonic Kidney Fibroblasts— 293TLRRO60603.fastaO60603784Gp96 has the ability to induce specific immune responses against tumors and pathogensLuciferase reporter assay119122012002Pubchem Assay
PRRID_0120GP96

Click for more detail

Human (others)MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL803ProteinNaturalIt results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces IToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanEmbryonic Kidney Fibroblasts— 293TLRRO00206.fastaO00206839Gp96 has the ability to induce specific immune responses against tumors and pathogensLuciferase reporter assay119122012002Pubchem Assay
PRRID_0120GP96

Click for more detail

Human (others)MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEEMDVGTDEEEETAKESTAEKDEL803ProteinNaturalIt results in activation of nuclear factor kappaB-driven reporter genes, and mitogen- and stress-activated protein kinases and induces IToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanEmbryonic Kidney Fibroblasts— 293TLRRO00206.fastaO00206839Gp96 has the ability to induce specific immune responses against tumors and pathogensLuciferase reporter assay119122012002Pubchem Assay