Detailed description page of PRRDB2.0
| This page displays user query in tabular form. |
PRRID_0099 details |
| Primary information | |
|---|---|
| PRRID | PRRID_0099 |
| Ligand Name | dsRNA |
| Source | Type I Lang mammalian reovirus (virus) |
| Sequence of ligand | NA |
| Length | NA |
| Type | Nucleic Acid |
| Occurence | Natural |
| Role of Ligand | It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12. |
| Name of receptor | Toll-like receptor 3 (TLR3) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | (HEK293 t cells) |
| Domain | NA |
| Sequence of Receptor | O15455.fasta |
| Swiss prot ID | O15455 |
| Length Of Receptor | 904 |
| Function | IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens. |
| Assay used | EMSA |
| PMID | 11607032 |
| Year of Publication | 2001 |
| Pubchem assay | Pubchem Assay |
| Primary information | |
|---|---|
| PRRID | PRRID_0099 |
| Ligand Name | dsRNA |
| Source | Type I Lang mammalian reovirus (virus) |
| Sequence of ligand | NA |
| Length | NA |
| Type | Nucleic Acid |
| Occurence | Natural |
| Role of Ligand | It induces the activation of NF-kappaB and secretion of type I IFNs, IFN-alpha and IFN-beta and cytokines IL-6 and IL-12. |
| Name of receptor | Toll-like receptor 3 (TLR3) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Human |
| Localization | (HEK293 t cells) |
| Domain | NA |
| Sequence of Receptor | O15455.fasta |
| Swiss prot ID | O15455 |
| Length Of Receptor | 904 |
| Function | IFNs inhibit virus replication, IL-6 and IL-12, which are also induced by bacterial infections, elicit cytotoxic responses needed for elimination of intracellular pathogens. |
| Assay used | EMSA |
| PMID | 11607032 |
| Year of Publication | 2001 |
| Pubchem assay | Pubchem Assay |