Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_0658	Lipoteichoic Acid (LTA) Click for more detail	Micrococcus luteus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	NA	GmCP9	Pattern recognition receptor (PRR)	Galleria mellonella	hemolymph	NA	NA	NA	NA	It has opsonin activity for the phagocytosis of the microorganisms by hemocytes.	NA	20519517	2010	NA
PRRID_0658	Lipoteichoic Acid (LTA) Click for more detail	Micrococcus luteus (Bacteria)	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	NA	GmCP9	Pattern recognition receptor (PRR)	Galleria mellonella	hemolymph	NA	NA	NA	NA	It has opsonin activity for the phagocytosis of the microorganisms by hemocytes.	NA	20519517	2010	NA
PRRID_0659	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It is the responsive PAMP for the FcLec5	FcLec5	C type Lectin (CTL/CLR)	Fenneropenaeus chinensis	hepatopancreas	CRD	NA	NA	NA	It elicit the immune response, which leads to the clearance of bacteria	ELISA	20349323	2010	NA
PRRID_0659	Lipoteichoic Acid (LTA) Click for more detail	Bacteria	C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)O	NA	Amphiphile	Natural	It is the responsive PAMP for the FcLec5	FcLec5	C type Lectin (CTL/CLR)	Fenneropenaeus chinensis	hepatopancreas	CRD	NA	NA	NA	It elicit the immune response, which leads to the clearance of bacteria	ELISA	20349323	2010	NA
PRRID_0664	LpqH Click for more detail	Mtb H37Ra (Bacteria)	MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS	159	Lipoprotein	Natural	It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Primary Monocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It leads to the clearance of the pathogen via autophagy	NA	20560977	2010	Pubchem Assay
PRRID_0664	LpqH Click for more detail	Mtb H37Ra (Bacteria)	MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS	159	Lipoprotein	Natural	It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Primary Monocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It leads to the clearance of the pathogen via autophagy	NA	20560977	2010	Pubchem Assay
PRRID_0665	LpqH Click for more detail	Mtb H37Ra (Bacteria)	MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS	159	Lipoprotein	Natural	It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Primary Monocytes	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	It leads to the clearance of the pathogen via autophagy	NA	20560977	2010	Pubchem Assay
PRRID_0665	LpqH Click for more detail	Mtb H37Ra (Bacteria)	MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS	159	Lipoprotein	Natural	It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Human	Primary Monocytes	Leucine-rich Repeat (LRR) Domain	Q15399.fasta	Q15399	786	It leads to the clearance of the pathogen via autophagy	NA	20560977	2010	Pubchem Assay
PRRID_0666	LpqH Click for more detail	Mtb H37Ra (Bacteria)	MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS	159	Lipoprotein	Natural	It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.	cluster of differentiation 14 (CD14)	Pattern recognition receptor (PRR)	Human	Primary Monocytes	Leucine-rich Repeat (LRR) Domain	P08571.fasta	P08571	375	It leads to the clearance of the pathogen via autophagy	NA	20560977	2010	Pubchem Assay
PRRID_0666	LpqH Click for more detail	Mtb H37Ra (Bacteria)	MKRGLTVAVAGAAILVAGLSGCSSNKSTTGSGETTTAAGTTASPGAASGPKVVIDGKDQNVTGSVVCTTAAGNVNIAIGGAATGIAAVLTDGNPPEVKSVGLGNVNGVTLGYTSGTGQGNASATKDGSHYKITGTATGVDMANPMSPVNKSFEIEVTCS	159	Lipoprotein	Natural	It activate antibacterial autophagy through vitamin D receptor signalling activation and cathelicidin induction.	cluster of differentiation 14 (CD14)	Pattern recognition receptor (PRR)	Human	Primary Monocytes	Leucine-rich Repeat (LRR) Domain	P08571.fasta	P08571	375	It leads to the clearance of the pathogen via autophagy	NA	20560977	2010	Pubchem Assay
PRRID_0667	LprG (Rv1411c) Click for more detail	Mtb H37Rv (Bacteria)	MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLVEEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADFVVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQNTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLSKWGEKVQVTKPPVS	236	Lipoprotein	Natural	Delivery of glycolipds to TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6 Mouse pulmonary aerosol Infection models	NA	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	Reduces virulence of Mtb	ELISA	20694006	2010	Pubchem Assay
PRRID_0667	LprG (Rv1411c) Click for more detail	Mtb H37Rv (Bacteria)	MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLVEEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADFVVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQNTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLSKWGEKVQVTKPPVS	236	Lipoprotein	Natural	Delivery of glycolipds to TLR2	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	C57BL/6 Mouse pulmonary aerosol Infection models	NA	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	Reduces virulence of Mtb	ELISA	20694006	2010	Pubchem Assay
PRRID_0668	Lipopolysaccharide (LPS) Click for more detail	Bacteria and fungi	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS and Œ≤-glucan binds to the LGBP and induce innate immunity	Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP)	Pattern recognition receptor (PRR)	Drosophila melanogaster	NA	NA	NA	NA	NA	It helps in pathogen recognition, activation of proPO system, induction of antimicrobial peptide	NA	20659562	2010	NA
PRRID_0668	Lipopolysaccharide (LPS) Click for more detail	Bacteria and fungi	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	LPS and Œ≤-glucan binds to the LGBP and induce innate immunity	Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP)	Pattern recognition receptor (PRR)	Drosophila melanogaster	NA	NA	NA	NA	NA	It helps in pathogen recognition, activation of proPO system, induction of antimicrobial peptide	NA	20659562	2010	NA
PRRID_0670	macrophage-activating lipopeptide Click for more detail	Mycoplasma fermentans (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	20713100	2010	Pubchem Assay
PRRID_0670	macrophage-activating lipopeptide Click for more detail	Mycoplasma fermentans (Bacteria)	C1=CC=C2C(=C1)C(=CN2)CC(C(=O)O)NC(=O)CCC(C(=O)O)N	NA	Lipopeptides	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	20713100	2010	Pubchem Assay
PRRID_0673	Mannan Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	It is the responsive PAMP for the FcLec5	FcLec5	C type Lectin (CTL/CLR)	Fenneropenaeus chinensis	hepatopancreas	CRD	NA	NA	NA	It elicit the immune response, which leads to the clearance of bacteria	ELISA	20349323	2010	NA
PRRID_0673	Mannan Click for more detail	Bacteria	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Polysaccharides	Natural	It is the responsive PAMP for the FcLec5	FcLec5	C type Lectin (CTL/CLR)	Fenneropenaeus chinensis	hepatopancreas	CRD	NA	NA	NA	It elicit the immune response, which leads to the clearance of bacteria	ELISA	20349323	2010	NA
PRRID_0679	mesodiaminopimelic acid Click for more detail	Bacteria	C(CC(C(=O)O)N)CC(C(=O)O)N	NA	Peptide	Natural	upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation	NA	20303873	2010	NA
PRRID_0679	mesodiaminopimelic acid Click for more detail	Bacteria	C(CC(C(=O)O)N)CC(C(=O)O)N	NA	Peptide	Natural	upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions	Nucleotide Binding Oligomerization Domain Containing 1 (Nod1)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation	NA	20303873	2010	NA
PRRID_0684	MOMP Click for more detail	Shigella flexneri (Bacteria)	NA	NA	Protein	Natural	It stimulates macrophages, up regulates the surface expression of MHC-II and B7-1 and enhances the production of different cytokines (such as ILp70, TNF-‚ç∫, Il-6) and chemokines (like MIP-1‚ç∫, MIP-1Œ≤ and RANTES)	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macropahes	LRR	Q9QUN7.fasta	Q9QUN7	784	It initiates event in the antibacterial host response.	ELISA	20347487	2010	Pubchem Assay
PRRID_0684	MOMP Click for more detail	Shigella flexneri (Bacteria)	NA	NA	Protein	Natural	It stimulates macrophages, up regulates the surface expression of MHC-II and B7-1 and enhances the production of different cytokines (such as ILp70, TNF-‚ç∫, Il-6) and chemokines (like MIP-1‚ç∫, MIP-1Œ≤ and RANTES)	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Macropahes	LRR	Q9QUN7.fasta	Q9QUN7	784	It initiates event in the antibacterial host response.	ELISA	20347487	2010	Pubchem Assay
PRRID_0685	MPLA Click for more detail	Salmonella minnesota R595 (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Rabbit	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	G1SH24.fasta	G1SH24	839	1,000-fold less toxic than LPS and can be used as vaccines	NA	20713100	2010	Pubchem Assay
PRRID_0685	MPLA Click for more detail	Salmonella minnesota R595 (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Rabbit	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	G1SH24.fasta	G1SH24	839	1,000-fold less toxic than LPS and can be used as vaccines	NA	20713100	2010	Pubchem Assay
PRRID_0686	MPLA Click for more detail	Salmonella minnesota R595 (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Guinea Pig	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	H0VSQ0.fasta	H0VSQ0	837	1,000-fold less toxic than LPS and can be used as vaccines	NA	20713100	2010	Pubchem Assay
PRRID_0686	MPLA Click for more detail	Salmonella minnesota R595 (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Guinea Pig	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	H0VSQ0.fasta	H0VSQ0	837	1,000-fold less toxic than LPS and can be used as vaccines	NA	20713100	2010	Pubchem Assay
PRRID_0687	MPLA Click for more detail	Salmonella minnesota R595 (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Dogs	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	F1PDB9.fasta	F1PDB9	833	1,000-fold less toxic than LPS and can be used as vaccines	NA	20713100	2010	Pubchem Assay
PRRID_0687	MPLA Click for more detail	Salmonella minnesota R595 (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Dogs	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	F1PDB9.fasta	F1PDB9	833	1,000-fold less toxic than LPS and can be used as vaccines	NA	20713100	2010	Pubchem Assay
PRRID_0688	MPLA Click for more detail	Salmonella minnesota R595 (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Horse	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	F6RL35.fasta	F6RL35	843	1,000-fold less toxic than LPS and can be used as vaccines	NA	20713100	2010	Pubchem Assay
PRRID_0688	MPLA Click for more detail	Salmonella minnesota R595 (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)NC1C(C(C(OC1O)COC2C(C(C(C(O2)CO)OP(=O)(O)O)OC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O)O	NA	Pattern-associated molecular patterns (PAMPs)	Synthetic	NA	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Horse	dendritic cells and macrophages	Leucine-rich Repeat (LRR) Domain	F6RL35.fasta	F6RL35	843	1,000-fold less toxic than LPS and can be used as vaccines	NA	20713100	2010	Pubchem Assay
PRRID_0691	MsST Click for more detail	Streptococcus thermophilus lacZ (Bacteria)	MNMTEKIQTYLNDPKIVSVNTVDAHSDHKYFESLEEFSEGEMKLRQSLNGKWKIHYAQNTNQVLKDFYKTEFDETDLNFINVPGHLELQGFGSPQYVNTQYPWDGKEFLRPPQVPQESNAVASYVKHFTLNDALKDKKVFISFQGVATSIFVWVNGNFVGYSEDSFTPSEFEISDYLVEGDNKLAVAVYRYSTASWLEDQDFWRLYGIFRDVYLYAIPKVHVQDLFVKGDYDYQTKAGQLDIDLKTVGDYEDKKIKYVLSDYEGIVTEGDASVNGDGELSVSLENLKIKPWSAESPKLYDLILHVLDDDQVVEVVPVKVGFRRFEIKDKLMLLNGKRIVFKGVNRHEFNARTGRCITEEDMLWDIKVMKQHNINAVRTSHYPNQTRWYELCDEYGLYVIDEANLETHGTWQKLGLCEPSWNIPASEPEWLPACLDRANNMFQRDKNHASVIIWSCGNESYAGKDIADMADYFRSVDNTRPVHYEGVAWCREFDYITDIESRMYAKPADIEEYLTTGKLVDLSSVSDKHFASGNLTNKPQKPYISCEYMHTMGNSGGGLQLYTDLEKYPEYQGGFIWDFIDQAIYKTLPNGSEFLSYGGDWHDRPSDYEFCGNGIVFADRTLTPKLQTVKHLYSNIKIAVDEKSVTIKNDNLFEDLSAYTFLARVYEDGRKVSESEYHFDVKPGEEATFPVNFVVEASNSEQIYEVACVLREATEWAPKGHEIVRGQYVVEKISTETPVKAPLNVVEGDFNIGIQGQNFSILLSRAQNTLVSAKYNGVEFIEKGPKLSFTRAYTDNDRGAGYPFEMAGWKVAGNYSKVTDTQIQIEDDSVKVTYVHELPGLSDVEVKVTYQVDYKGRIFVTANYDGKAGLPNFPEFGLEFAIGSQFTNLSYYGYGAEESYRDKLPGAYLGRYETSVEKTFAPYLMPQESGNHYGTREFTVSDDNHNGLKFTALNKAFEFSALRNSTEQIENARHQYELQESDATWIKVLAAQMGVGGDDTW	1026	Nucleic Acid	Natural	It increases the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells and also induces the production of IL-6.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	Q99MB1.fasta	Q99MB1	905	It is a potent stimulators of innate immunity.	ELISA	20163626	2010	Pubchem Assay
PRRID_0691	MsST Click for more detail	Streptococcus thermophilus lacZ (Bacteria)	MNMTEKIQTYLNDPKIVSVNTVDAHSDHKYFESLEEFSEGEMKLRQSLNGKWKIHYAQNTNQVLKDFYKTEFDETDLNFINVPGHLELQGFGSPQYVNTQYPWDGKEFLRPPQVPQESNAVASYVKHFTLNDALKDKKVFISFQGVATSIFVWVNGNFVGYSEDSFTPSEFEISDYLVEGDNKLAVAVYRYSTASWLEDQDFWRLYGIFRDVYLYAIPKVHVQDLFVKGDYDYQTKAGQLDIDLKTVGDYEDKKIKYVLSDYEGIVTEGDASVNGDGELSVSLENLKIKPWSAESPKLYDLILHVLDDDQVVEVVPVKVGFRRFEIKDKLMLLNGKRIVFKGVNRHEFNARTGRCITEEDMLWDIKVMKQHNINAVRTSHYPNQTRWYELCDEYGLYVIDEANLETHGTWQKLGLCEPSWNIPASEPEWLPACLDRANNMFQRDKNHASVIIWSCGNESYAGKDIADMADYFRSVDNTRPVHYEGVAWCREFDYITDIESRMYAKPADIEEYLTTGKLVDLSSVSDKHFASGNLTNKPQKPYISCEYMHTMGNSGGGLQLYTDLEKYPEYQGGFIWDFIDQAIYKTLPNGSEFLSYGGDWHDRPSDYEFCGNGIVFADRTLTPKLQTVKHLYSNIKIAVDEKSVTIKNDNLFEDLSAYTFLARVYEDGRKVSESEYHFDVKPGEEATFPVNFVVEASNSEQIYEVACVLREATEWAPKGHEIVRGQYVVEKISTETPVKAPLNVVEGDFNIGIQGQNFSILLSRAQNTLVSAKYNGVEFIEKGPKLSFTRAYTDNDRGAGYPFEMAGWKVAGNYSKVTDTQIQIEDDSVKVTYVHELPGLSDVEVKVTYQVDYKGRIFVTANYDGKAGLPNFPEFGLEFAIGSQFTNLSYYGYGAEESYRDKLPGAYLGRYETSVEKTFAPYLMPQESGNHYGTREFTVSDDNHNGLKFTALNKAFEFSALRNSTEQIENARHQYELQESDATWIKVLAAQMGVGGDDTW	1026	Nucleic Acid	Natural	It increases the number of CD80+CD11c+and CD86+CD11c+ dendritic cells and CD4+CD25+ regulatory T cells and also induces the production of IL-6.	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Mice	Spleenocytes	LRR	Q99MB1.fasta	Q99MB1	905	It is a potent stimulators of innate immunity.	ELISA	20163626	2010	Pubchem Assay
PRRID_0692	muramyl dipeptide (MDP) Click for more detail	Streptococcus pneumoniae, Mycobacterium tuberculosis, and Listeria monocytogenes (Bacteria)	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	Activates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤, which results into pathogen clearance and sepsis resistance	cluster of differentiation 14 (CD14)	Pattern recognition receptor (PRR)	Human	NA	NA	Q9HC29.fasta	Q9HC29	1040	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0692	muramyl dipeptide (MDP) Click for more detail	Streptococcus pneumoniae, Mycobacterium tuberculosis, and Listeria monocytogenes (Bacteria)	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	Activates NF-KB which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤, which results into pathogen clearance and sepsis resistance	cluster of differentiation 14 (CD14)	Pattern recognition receptor (PRR)	Human	NA	NA	Q9HC29.fasta	Q9HC29	1040	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0693	muramyl dipeptide (MDP) Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation	NA	20303873	2010	NA
PRRID_0693	muramyl dipeptide (MDP) Click for more detail	Bacteria	CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C	NA	Peptide	Natural	upon ligand sensing, oligomerize and recruit RIP2 via CARD-CARD interactions	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	It culminates in the activation of the NF-kB transcription factor, which drives proinflammatory gene regulation	NA	20303873	2010	NA
PRRID_0694	muramyl dipeptide (MDP) + LPS + Poly(I:C) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Peptide	Natural	It help in NF	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	C57BL/6 Mice	liver and Hepatocytes	NA	Q3UP24.fasta	Q3UP24	1024	It plays an important regulatory role in many inflammatory processes involving the liver.	Immunoblotting and EMSA	20615568	2010	Pubchem Assay
PRRID_0694	muramyl dipeptide (MDP) + LPS + Poly(I:C) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Peptide	Natural	It help in NF	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	C57BL/6 Mice	liver and Hepatocytes	NA	Q3UP24.fasta	Q3UP24	1024	It plays an important regulatory role in many inflammatory processes involving the liver.	Immunoblotting and EMSA	20615568	2010	Pubchem Assay
PRRID_0697	MxiI Click for more detail	Shigella flexneri (Bacteria)	MNYIYPVNQVDIIKASDFQSQEISSLEDVVSAKYSDIKMDTDIQVSQIMEMVSNPESLNPESLAKLQTTLSNYSIGVSLAGTLARKTVSAVETLLKS	97	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0697	MxiI Click for more detail	Shigella flexneri (Bacteria)	MNYIYPVNQVDIIKASDFQSQEISSLEDVVSAKYSDIKMDTDIQVSQIMEMVSNPESLNPESLAKLQTTLSNYSIGVSLAGTLARKTVSAVETLLKS	97	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0700	NA Click for more detail	Edwardsiella tarda(Bacteria)	NA	NA	NA	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Paralichthys olivaceus	Head Kidney	Leucine-rich Repeat (LRR) Domain	E9RGG6.fasta	E9RGG6	868	It provides immune response against the E.tarda	NA	20728538	2010	Pubchem Assay
PRRID_0700	NA Click for more detail	Edwardsiella tarda(Bacteria)	NA	NA	NA	Natural	It's binding leads to the release of the arra of cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Paralichthys olivaceus	Head Kidney	Leucine-rich Repeat (LRR) Domain	E9RGG6.fasta	E9RGG6	868	It provides immune response against the E.tarda	NA	20728538	2010	Pubchem Assay
PRRID_0706	naked dsRNS (poly(I:C)) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	induced a reduction in maximal mitochondrial respiration	Toll-like receptor 3,7,9 (TLR3/7/9)	Toll-like receptor (TLR)	Human	Human hepatocytes (HepG2 cells)	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	This resultsinto mitochondrial dysfunction which is accompanied by caspase-8	NA	20691286	2010	NA
PRRID_0706	naked dsRNS (poly(I:C)) Click for more detail	Bacteria	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	induced a reduction in maximal mitochondrial respiration	Toll-like receptor 3,7,9 (TLR3/7/9)	Toll-like receptor (TLR)	Human	Human hepatocytes (HepG2 cells)	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	This resultsinto mitochondrial dysfunction which is accompanied by caspase-8	NA	20691286	2010	NA
PRRID_0717	ODN with CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	ODN and CpG motifs activates the TLR9, which results in the activation of the downstream signalling cascade.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Raw 264.7 macrophage cell line	Cells of the immune system and initially localized at ER	Leucine-rich Repeat (LRR) Domain	Q9EQU3.fasta	Q9EQU3	1032	Pleiotropic immune responses and regulates apoptosis	NA	20739833	2010	Pubchem Assay
PRRID_0717	ODN with CpG motif Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	ODN and CpG motifs activates the TLR9, which results in the activation of the downstream signalling cascade.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Raw 264.7 macrophage cell line	Cells of the immune system and initially localized at ER	Leucine-rich Repeat (LRR) Domain	Q9EQU3.fasta	Q9EQU3	1032	Pleiotropic immune responses and regulates apoptosis	NA	20739833	2010	Pubchem Assay
PRRID_0718	OM-174 Click for more detail	E. coli(Bacteria)	CCCCCCCCCCC[C@@H](O)CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]2NC(=O)C[C@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O[C@@H]1OP(O)(O)=O	NA	Lipid	Natural	it induce the expression of iNOS, tumour suppressive proteins and cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Rat	Liver	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It results into inhibition of invasion and metastasis of HCC	NA	20675699	2010	NA
PRRID_0718	OM-174 Click for more detail	E. coli(Bacteria)	CCCCCCCCCCC[C@@H](O)CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H](O)[C@H]2NC(=O)C[C@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCC)O[C@@H]1OP(O)(O)=O	NA	Lipid	Natural	it induce the expression of iNOS, tumour suppressive proteins and cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Rat	Liver	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It results into inhibition of invasion and metastasis of HCC	NA	20675699	2010	NA
PRRID_0721	Diacylated Lipopeptide Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0721	Diacylated Lipopeptide Click for more detail	Bacteria	NA	NA	Lipopeptides	Natural	Activates NF-KB and MAPK which lead to the production of cytokines as TNF and other proinflammatory proteins	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It coauses the inflammation	NA	20740341	2010	Pubchem Assay
PRRID_0722	Pam2Cys Click for more detail	B. burgdorferi(Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Peptidoglycan	Synthetic	Induction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It has the role in the inflammation.	NA	20713100	2010	Pubchem Assay
PRRID_0722	Pam2Cys Click for more detail	B. burgdorferi(Bacteria)	CCCCCCCCCCCCCCCC(=O)OCC(CSCC(C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC	NA	Peptidoglycan	Synthetic	Induction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It has the role in the inflammation.	NA	20713100	2010	Pubchem Assay
PRRID_0723	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-Œ∫B which results in secretion of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	embryonic mouse telencephalon and NPC	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	its activation inhibits NPC proliferation and decreases cell proliferation.	NA	20456021	2010	Pubchem Assay
PRRID_0723	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	Binding of the ligand leads to Akt phosphorylation and activation of the transcription factor NF-Œ∫B which results in secretion of proinflammatory cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	embryonic mouse telencephalon and NPC	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	its activation inhibits NPC proliferation and decreases cell proliferation.	NA	20456021	2010	Pubchem Assay
PRRID_0724	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	It mediates the effect through a TLR2/PI3K/Aktdependent mechanism.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Heart	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It induces induce cardioprotection against ischaemia/reperfusion injury	EMSA	20421349	2010	Pubchem Assay
PRRID_0724	Pam3CSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Lipopeptides	Synthetic	It mediates the effect through a TLR2/PI3K/Aktdependent mechanism.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Heart	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It induces induce cardioprotection against ischaemia/reperfusion injury	EMSA	20421349	2010	Pubchem Assay
PRRID_0726	Pam3CysSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Peptidoglycan	Synthetic	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	CNS	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It causes neurodegeneration	NA	20706642	2010	NA
PRRID_0726	Pam3CysSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Peptidoglycan	Synthetic	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	CNS	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	It causes neurodegeneration	NA	20706642	2010	NA
PRRID_0727	Pam3CysSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Peptidoglycan	Synthetic	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Macropahges	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	Helps in IgM production and clear pathogen from blood	NA	20696824	2010	Pubchem Assay
PRRID_0727	Pam3CysSK4 Click for more detail	Bacteria	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Peptidoglycan	Synthetic	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Macropahges	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	Helps in IgM production and clear pathogen from blood	NA	20696824	2010	Pubchem Assay
PRRID_0728	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	On binding to the receptor it leads to the release of an array of cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	P815 cells	NA	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	Immunostimulation and inflammation	NA	20798518	2010	Pubchem Assay
PRRID_0728	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	On binding to the receptor it leads to the release of an array of cytokines	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	P815 cells	NA	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	Immunostimulation and inflammation	NA	20798518	2010	Pubchem Assay
PRRID_0731	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	20713100	2010	Pubchem Assay
PRRID_0731	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	NA	NA	20713100	2010	Pubchem Assay
PRRID_0733	Peptidoglycan (PGN) Click for more detail	E. coli K12(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Macropahges	NA	Q8K3Z0.fasta	Q8K3Z0	1020	NA	NA	20696824	2010	Pubchem Assay
PRRID_0733	Peptidoglycan (PGN) Click for more detail	E. coli K12(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	Macropahges	NA	Q8K3Z0.fasta	Q8K3Z0	1020	NA	NA	20696824	2010	Pubchem Assay
PRRID_0734	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN binds to the LGBP and induce innate immunity	Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP)	Pattern recognition receptor (PRR)	Chlamys farreri	Hemocytes, gills and mantle	NA	NA	NA	NA	It is involved in pathogens recognition and bacterial agglutination.	NA	20659562	2010	NA
PRRID_0734	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN binds to the LGBP and induce innate immunity	Lipopolysaccharide and b-1, 3-glucan binding protein (LGBP)	Pattern recognition receptor (PRR)	Chlamys farreri	Hemocytes, gills and mantle	NA	NA	NA	NA	It is involved in pathogens recognition and bacterial agglutination.	NA	20659562	2010	NA
PRRID_0736	Peptidoglycan (PGN) Click for more detail	streptomyces species (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It's binding induces the production of IL6, IL8, MMP3 and MMP1	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Fibroblast Like Synoviocytes (FLS)	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction	ELISA	20571165	2010	Pubchem Assay
PRRID_0736	Peptidoglycan (PGN) Click for more detail	streptomyces species (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It's binding induces the production of IL6, IL8, MMP3 and MMP1	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	Fibroblast Like Synoviocytes (FLS)	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It has a role in the pathogenesis of juvenile idiopathic arthritis and cartilage destruction	ELISA	20571165	2010	Pubchem Assay
PRRID_0737	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN induced iNOS, COX-2 and proinflammatory cytokine expression was mediated through the TLR2/MyD88/PI3-kinase/AKT pathway, which in turn initiates IKKŒ±/Œ≤ and NF-Œ∫B.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Microglial cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It enhances proinflammatory cytokine expression	Transfection and reporter gene assay	20451669	2010	Pubchem Assay
PRRID_0737	Peptidoglycan (PGN) Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	PGN induced iNOS, COX-2 and proinflammatory cytokine expression was mediated through the TLR2/MyD88/PI3-kinase/AKT pathway, which in turn initiates IKKŒ±/Œ≤ and NF-Œ∫B.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice (Murine)	Microglial cells	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It enhances proinflammatory cytokine expression	Transfection and reporter gene assay	20451669	2010	Pubchem Assay
PRRID_0738	Peptidoglycan (PGN) Click for more detail	Borrelia burgdorferi(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	PBMCs	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It aids in the induction of inflammtory reaction against Borrelia burgdorferi	ELISA	20441518	2010	Pubchem Assay
PRRID_0738	Peptidoglycan (PGN) Click for more detail	Borrelia burgdorferi(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice	PBMCs	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It aids in the induction of inflammtory reaction against Borrelia burgdorferi	ELISA	20441518	2010	Pubchem Assay
PRRID_0739	Peptidoglycan (PGN) Click for more detail	Borrelia burgdorferi(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	PBMCs	NA	Q9HC29.fasta	Q9HC29	1040	It aids in the induction of inflammtory reaction against Borrelia burgdorferi	ELISA	20441518	2010	Pubchem Assay
PRRID_0739	Peptidoglycan (PGN) Click for more detail	Borrelia burgdorferi(Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	Peptidoglycans are recognized by active NOD2 molecules and the adaptor molecule RICK is recruited, which ultimately leads to activation of NF-kB and transcription of cytokines	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Human	PBMCs	NA	Q9HC29.fasta	Q9HC29	1040	It aids in the induction of inflammtory reaction against Borrelia burgdorferi	ELISA	20441518	2010	Pubchem Assay
PRRID_0741	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It is the responsive PAMP for the FcLec5	FcLec5	C type Lectin (CTL/CLR)	Fenneropenaeus chinensis	hepatopancreas	CRD	NA	NA	NA	It elicit the immune response, which leads to the clearance of bacteria	ELISA	20349323	2010	NA
PRRID_0741	Peptidoglycan (PGN) Click for more detail	Bacteria	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It is the responsive PAMP for the FcLec5	FcLec5	C type Lectin (CTL/CLR)	Fenneropenaeus chinensis	hepatopancreas	CRD	NA	NA	NA	It elicit the immune response, which leads to the clearance of bacteria	ELISA	20349323	2010	NA
PRRID_0742	Pam3Cys Click for more detail	B. burgdorferi(Bacteria)	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Peptidoglycan	Synthetic	Induction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It has the role in the inflammation.	NA	20713100	2010	Pubchem Assay
PRRID_0742	Pam3Cys Click for more detail	B. burgdorferi(Bacteria)	CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O	NA	Peptidoglycan	Synthetic	Induction of protective immunity correlated with the development of Abs against an epitope on the C-terminus of OspA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Human	dendritic cells, macrophages and lymphocytes	Leucine-rich Repeat (LRR) Domain	O60603.fasta	O60603	784	It has the role in the inflammation.	NA	20713100	2010	Pubchem Assay
PRRID_0743	Peptidoglycan (PGN) Click for more detail	Vibrio anguillarum and Micrococcus lysodeikticus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	PGRP-S1	Peptidoglycan Recognition Receptor (PGRPs)	Chlamys farreri	mantle, gill, kidney and gonad	NA	Q9VYX7.fasta	Q9VYX7	203	It leads to the degradation of PGN, induction of phagocytosis and activation of prophenoloxidase (proPO) system	ELISA	20713100	2010	Pubchem Assay
PRRID_0743	Peptidoglycan (PGN) Click for more detail	Vibrio anguillarum and Micrococcus lysodeikticus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	NA	PGRP-S1	Peptidoglycan Recognition Receptor (PGRPs)	Chlamys farreri	mantle, gill, kidney and gonad	NA	Q9VYX7.fasta	Q9VYX7	203	It leads to the degradation of PGN, induction of phagocytosis and activation of prophenoloxidase (proPO) system	ELISA	20713100	2010	Pubchem Assay
PRRID_0744	Lipopolysaccharide (LPS) Click for more detail	Vibrio anguillarum and Micrococcus lysodeikticus (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	NA	PGRP-S1	Peptidoglycan Recognition Receptor (PGRPs)	Chlamys farreri	mantle, gill, kidney and gonad	NA	Q9VYX7.fasta	Q9VYX7	203	It leads to the degradation of PGN, induction of phagocytosis and activation of prophenoloxidase (proPO) system	ELISA	20713100	2010	Pubchem Assay
PRRID_0744	Lipopolysaccharide (LPS) Click for more detail	Vibrio anguillarum and Micrococcus lysodeikticus (Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Lipopolysaccharide (LPS)	Natural	NA	PGRP-S1	Peptidoglycan Recognition Receptor (PGRPs)	Chlamys farreri	mantle, gill, kidney and gonad	NA	Q9VYX7.fasta	Q9VYX7	203	It leads to the degradation of PGN, induction of phagocytosis and activation of prophenoloxidase (proPO) system	ELISA	20713100	2010	Pubchem Assay
PRRID_0746	PGNmonomer Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It initiates the activation of NF-	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	NA	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It act as potent costimulator of the innate immune system in the presence of TLR signals	Luciferase assay	20522786	2010	Pubchem Assay
PRRID_0746	PGNmonomer Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It initiates the activation of NF-	Nucleotide Binding Oligomerization Domain Containing 2 (Nod2)	NOD-like receptor (NLR)	Mice (Murine)	NA	NA	Q8K3Z0.fasta	Q8K3Z0	1020	It act as potent costimulator of the innate immune system in the presence of TLR signals	Luciferase assay	20522786	2010	Pubchem Assay
PRRID_0747	PGNpolymer Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It initiates the activation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	HEK293	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It induced murine dendritic cell (DC) maturation and cytokine production.	Luciferase assay	20522786	2010	Pubchem Assay
PRRID_0747	PGNpolymer Click for more detail	S. aureus (Bacteria)	CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N	NA	Peptidoglycan	Natural	It initiates the activation of NF-	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	HEK293	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It induced murine dendritic cell (DC) maturation and cytokine production.	Luciferase assay	20522786	2010	Pubchem Assay
PRRID_0748	phenol-soluble modulin Click for more detail	Staphylococcus epidermis (Bacteria)	MSKLAEAIANTVKAAQDQDWTKLGTSIVDIVESGVSVLGKIFGF	44	Protein	Natural	Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-Œ± and induces augment PMN migration.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung's endothelial cell	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20706658	2010	Pubchem Assay
PRRID_0748	phenol-soluble modulin Click for more detail	Staphylococcus epidermis (Bacteria)	MSKLAEAIANTVKAAQDQDWTKLGTSIVDIVESGVSVLGKIFGF	44	Protein	Natural	Increases expression of macrophage inflammatory protein-2 , cytokine migration inhibitory factor (MIF), and TNF-Œ± and induces augment PMN migration.	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	Mice	Lung's endothelial cell	Leucine-rich Repeat (LRR) Domain	Q9QUN7.fasta	Q9QUN7	784	It has the role in the inflammation.	NA	20706658	2010	Pubchem Assay
PRRID_0752	poly-UG dsRNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	production of IFN-‚ç∫, IL-6 and IL-1Œ≤	Toll-like receptor 3 (TLR3)/Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Chicken	Spleenocytes	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Immunostimulation and inflammation	NA	20692289	2010	NA
PRRID_0752	poly-UG dsRNA Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	production of IFN-‚ç∫, IL-6 and IL-1Œ≤	Toll-like receptor 3 (TLR3)/Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Chicken	Spleenocytes	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	Immunostimulation and inflammation	NA	20692289	2010	NA
PRRID_0753	polyadenylic-polyuridylic acid Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of IFN-	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	mDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It resulted in direct activation NK cells leading to high IFN-Œ≥ production.	NA	20639488	2010	Pubchem Assay
PRRID_0753	polyadenylic-polyuridylic acid Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	Their binding leads to the enhanced production of IFN-	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Human	mDCs	Leucine-rich Repeat (LRR) Domain	O15455.fasta	O15455	904	It resulted in direct activation NK cells leading to high IFN-Œ≥ production.	NA	20639488	2010	Pubchem Assay
PRRID_0775	Pore-forming toxins Click for more detail	Listeria monocytogenes, Staphylococcus aureus, Aeromonas hydrophila, microbial toxins (Bacteria)	NA	NA	Protein	Natural	Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤ and IL-18, leads to pathogen clearance and sepsis resistance.	Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containin (NALP)	NOD-like receptor (NLR)		NA	NA	Q9C000.fasta	Q9C000	1473	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0775	Pore-forming toxins Click for more detail	Listeria monocytogenes, Staphylococcus aureus, Aeromonas hydrophila, microbial toxins (Bacteria)	NA	NA	Protein	Natural	Activates Caspase-1, which results in the processing and release of the proinfl ammatory cytokines IL-1Œ≤ and IL-18, leads to pathogen clearance and sepsis resistance.	Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containin (NALP)	NOD-like receptor (NLR)		NA	NA	Q9C000.fasta	Q9C000	1473	It results into pathogen clearance and sepsis resistance	NA	20740341	2010	Pubchem Assay
PRRID_0776	Porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	20679445	2010	NA
PRRID_0776	Porins Click for more detail	Neisseria meningitidis (Bacteria)	MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF	396	Protein	Natural	NA	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	20679445	2010	NA
PRRID_0777	PrgJ Click for more detail	S. typhimurium (Bacteria)	MSIATIVPENAVIGQAVNIRSMETDIVSLDDRLLQAFSGSAIATAVDKQTITNRIEDPNLVTDPKELAISQEMISDYNLYVSMVSTLTRKGVGAVETLLRS	101	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay
PRRID_0777	PrgJ Click for more detail	S. typhimurium (Bacteria)	MSIATIVPENAVIGQAVNIRSMETDIVSLDDRLLQAFSGSAIATAVDKQTITNRIEDPNLVTDPKELAISQEMISDYNLYVSMVSTLTRKGVGAVETLLRS	101	Protein	Natural	It activates caspase-1 through NLRC4 and secrete IL-1Œ≤	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	Mice	Bone marrow‚Äìderived macrophages	NA	Q3UP24.fasta	Q3UP24	1024	It leads to the clearance of the pathogen from the system	ELISA	20133635	2010	Pubchem Assay

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