Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0963Soluble factors

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Neisseria meningitidis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NANANANANANANANA219554432011NA
PRRID_0963Soluble factors

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Neisseria meningitidis (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NANANANANANANANA219554432011NA
PRRID_0966Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanMyeloid cells, T, B and NK cells, microglia, astrocytesNAQ15399.fastaQ15399786NANA219825582011Pubchem Assay
PRRID_0966Triacylated lipopeptides

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BacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanMyeloid cells, T, B and NK cells, microglia, astrocytesNAQ15399.fastaQ15399786NANA219825582011Pubchem Assay
PRRID_0967Triacylated lipopeptides

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Bacteria and mycobacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NANANANANANANANA219554432011NA
PRRID_0967Triacylated lipopeptides

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Bacteria and mycobacteriaNANALipopeptidesNaturalelicit innate immune responseToll-like receptor 1 (TLR1)Toll-like receptor (TLR)NANANANANANANANA219554432011NA
PRRID_0969Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEpithelial and B cells, dendritic cells, microglia, astrocyte, neuronNAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA219825582011Pubchem Assay
PRRID_0969Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)HumanEpithelial and B cells, dendritic cells, microglia, astrocyte, neuronNAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA219825582011Pubchem Assay
PRRID_0970Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANANANANANATLR9 plays a crucial role in breaking tolerance and developing autoimmunity NA219554432011NA
PRRID_0970Unmethylated CpG DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)NANANANANANATLR9 plays a crucial role in breaking tolerance and developing autoimmunity NA219554432011NA
PRRID_0971Uropathogenic E. coli

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BacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanMyeloid cells, uroepithelial cellsNANANANATLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.NA219825582011NA
PRRID_0971Uropathogenic E. coli

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BacteriaNANAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 10 (TLR10)Toll-like receptor (TLR)HumanMyeloid cells, uroepithelial cellsNANANANATLR11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha,the Interleukin 12 (IL-12) response and Interferon-gamma (IFN-gamma) secretion.NA219825582011NA
PRRID_0973Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMyeloid cells, dendritic cells, microglia, astrocytesNAQ9Y2C9.fastaQ9Y2C9796significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0973Zymosan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAGlucanNaturalinduction of proinflammatory cytokinesToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanMyeloid cells, dendritic cells, microglia, astrocytesNAQ9Y2C9.fastaQ9Y2C9796significant role in the pathogenesis of severe inflammatory responses NA219825582011Pubchem Assay
PRRID_0983CBLB613

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Mycoplasma (Bacteria)NANALipopeptidesNaturalreduced radiation-induced cytopenia and increased bone marrow cellularity in irradiated miceToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)CD2F1 MiceNALeucine-rich Repeat (LRR) DomainNANANANANA221753002012NA
PRRID_0983CBLB613

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Mycoplasma (Bacteria)NANALipopeptidesNaturalreduced radiation-induced cytopenia and increased bone marrow cellularity in irradiated miceToll-like receptor 2/6 (TLR2/6)Toll-like receptor (TLR)CD2F1 MiceNALeucine-rich Repeat (LRR) DomainNANANANANA221753002012NA
PRRID_1002Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanPBMCsNAO60603.fastaO60603784induction of IL-6 and IL-8ELISA229989422012Pubchem Assay
PRRID_1002Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanPBMCsNAO60603.fastaO60603784induction of IL-6 and IL-8ELISA229989422012Pubchem Assay
PRRID_1007NA

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 B. fragilis(Bacteria)NANANANAImmunostimulantToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanPBMCsNAQ15399.fastaQ15399786induction of IL-6 and IL-8ELISA229989422012Pubchem Assay
PRRID_1007NA

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 B. fragilis(Bacteria)NANANANAImmunostimulantToll-like receptor 1 (TLR1)Toll-like receptor (TLR)HumanPBMCsNAQ15399.fastaQ15399786induction of IL-6 and IL-8ELISA229989422012Pubchem Assay
PRRID_1017V. vulnificus

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BacteriaNANANANaturalNALmGNBP3Gram-negative Bacteria-binding Protein (GNBPs)Locusta migRatoriaNAb-1,3-glu- canase-like domainNANANANA16S rRNA gene analysis220622472012NA
PRRID_1017V. vulnificus

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BacteriaNANANANaturalNALmGNBP3Gram-negative Bacteria-binding Protein (GNBPs)Locusta migRatoriaNAb-1,3-glu- canase-like domainNANANANA16S rRNA gene analysis220622472012NA
PRRID_10201,3 beta glucan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784triggers the MyD88-dependent signaling pathway, leading to NF-kB activationNF-240985082013Pubchem Assay
PRRID_10201,3 beta glucan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784triggers the MyD88-dependent signaling pathway, leading to NF-kB activationNF-240985082013Pubchem Assay
PRRID_1023b-1,3-glucans.

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Bacteria and fungiC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNAPibGRPGastrin-releasing peptide receptor (GRP)Plodia interpunctellahemolymphNANANANAactivation of the proPO pathwayCurdlan Pull-down Assay232374932013NA
PRRID_1023b-1,3-glucans.

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Bacteria and fungiC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNAPibGRPGastrin-releasing peptide receptor (GRP)Plodia interpunctellahemolymphNANANANAactivation of the proPO pathwayCurdlan Pull-down Assay232374932013NA
PRRID_1024b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNASebGRPGastrin-releasing peptide receptor (GRP)Spodoptera exiguaAll tissueβ-1,3-glucanase-like domainNANANAinduce the activity of a serine protease, thereby triggering a phenoloxidase enzyme cascade and the Toll pathway.NA239561462013NA
PRRID_1024b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNASebGRPGastrin-releasing peptide receptor (GRP)Spodoptera exiguaAll tissueβ-1,3-glucanase-like domainNANANAinduce the activity of a serine protease, thereby triggering a phenoloxidase enzyme cascade and the Toll pathway.NA239561462013NA
PRRID_1025Bacterial RNA

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BacteriaNANANucleic AcidNaturalelicit innate immune responseToll-like receptor 13 (TLR13)Toll-like receptor (TLR)MiceNANAQ6R5N8.fastaQ6R5N8991NANA239853022013Pubchem Assay
PRRID_1025Bacterial RNA

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BacteriaNANANucleic AcidNaturalelicit innate immune responseToll-like receptor 13 (TLR13)Toll-like receptor (TLR)MiceNANAQ6R5N8.fastaQ6R5N8991NANA239853022013Pubchem Assay
PRRID_1027cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs)

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BacteriaNANANucleic AcidSyntheticmimic bacterial and viral DNA and was also shown to be involved in GVHDToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Micegraft-versus-host disease (GVHD)NAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA239853022013Pubchem Assay
PRRID_1027cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs)

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BacteriaNANANucleic AcidSyntheticmimic bacterial and viral DNA and was also shown to be involved in GVHDToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Micegraft-versus-host disease (GVHD)NAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA239853022013Pubchem Assay
PRRID_1037EfLTA

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Enterococcus faecalis (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalLTA contributes to the inflammatory responses and to the production of chemokines through TLR2 signaling Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57BL/6 miceMacrophagesNAQ9QUN7.fastaQ9QUN7784triggers the MyD88-dependent signaling pathway, leading to NF-kB activationELISA, RT-PCR, Flow cytometric analysis239641172013Pubchem_assay
PRRID_1037EfLTA

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Enterococcus faecalis (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalLTA contributes to the inflammatory responses and to the production of chemokines through TLR2 signaling Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)C57BL/6 miceMacrophagesNAQ9QUN7.fastaQ9QUN7784triggers the MyD88-dependent signaling pathway, leading to NF-kB activationELISA, RT-PCR, Flow cytometric analysis239641172013Pubchem_assay
PRRID_1042Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)TRIF mutant (C57BL/6J-Ticam1Lps2) micebone marrow-derived macrophage (BMDM) culture Toll/IL-1R (TIR) domainQ9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations240195322013Pubchem_assay
PRRID_1042Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)TRIF mutant (C57BL/6J-Ticam1Lps2) micebone marrow-derived macrophage (BMDM) culture Toll/IL-1R (TIR) domainQ9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations240195322013Pubchem_assay
PRRID_1043Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.RT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1043Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.RT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1045Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs extracellular domains of leucine-rich repeat motifs Q9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA239853022013Pubchem_assay
PRRID_1045Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs extracellular domains of leucine-rich repeat motifs Q9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA239853022013Pubchem_assay
PRRID_1046cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs)

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BacteriaNANANucleic AcidSyntheticmimic bacterial and viral DNA and was also shown to be involved in GVHDToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA239853022013Pubchem_assay
PRRID_1046cytosine-phosphorothioate-guanine oligodeoxynucleotides (CpG ODNs)

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BacteriaNANANucleic AcidSyntheticmimic bacterial and viral DNA and was also shown to be involved in GVHDToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humangraft-versus-host disease (GVHD)NAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseNA239853022013Pubchem_assay
PRRID_1047Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalregulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicityToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micegraft-versus-host disease (GVHD)NAQ9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA239853022013Pubchem_assay
PRRID_1047Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturalregulates CD4 T-cell response by increasing the generation of regulatory T-cells (Tregs) [16] and protects epithelial cells from radiation- induced toxicityToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Micegraft-versus-host disease (GVHD)NAQ9JLF7.fastaQ9JLF7859It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA239853022013Pubchem_assay
PRRID_1048Flagellin

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S. typhimurium (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanHEK293 cellsNAO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NF-240985082013Pubchem_assay
PRRID_1048Flagellin

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S. typhimurium (Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)HumanHEK293 cellsNAO60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NF-240985082013Pubchem_assay
PRRID_1049Flagellin

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Pseudomonas aeruginosa (Bacteria)MALTVNTNIASLNTQRNLNASSNDLNTSLQRLTTGYRINSAKDDAAGLQISNRLSNQISGLNVATRNANDGISLAQTAEGALQQSTNILQRIRDLALQSANGSNSDADRAALQKEVAAQQAELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTIVTGYVQLNSPTAYSVSGTGTQASQVFGNASAAQKSSVASVDISTADGAQNAIAVVDNALAAIDAQRADLGAVQNRFKNTIDNLTNISENATNARSRIKDTDFAAETAALSKNQVLQQAGTAILAQANQLPQAVLSLLR488ProteinNaturalinvolved in the upregulation of airway serous secretionToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Swinetracheal submucosal acinar glandsNANANANATLR5 is also involved in the airway mucosal defense systems as a unique endogenous potentiator of elec- trolyte-water secretion from submucosal gland acinar cells and that NO/cGMP/cGK signaling is involved in this rapid TLR5 signaling pathwayRT-PCR, Intracellular calcium assays240975632013NA
PRRID_1049Flagellin

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Pseudomonas aeruginosa (Bacteria)MALTVNTNIASLNTQRNLNASSNDLNTSLQRLTTGYRINSAKDDAAGLQISNRLSNQISGLNVATRNANDGISLAQTAEGALQQSTNILQRIRDLALQSANGSNSDADRAALQKEVAAQQAELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTIVTGYVQLNSPTAYSVSGTGTQASQVFGNASAAQKSSVASVDISTADGAQNAIAVVDNALAAIDAQRADLGAVQNRFKNTIDNLTNISENATNARSRIKDTDFAAETAALSKNQVLQQAGTAILAQANQLPQAVLSLLR488ProteinNaturalinvolved in the upregulation of airway serous secretionToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Swinetracheal submucosal acinar glandsNANANANATLR5 is also involved in the airway mucosal defense systems as a unique endogenous potentiator of elec- trolyte-water secretion from submucosal gland acinar cells and that NO/cGMP/cGK signaling is involved in this rapid TLR5 signaling pathwayRT-PCR, Intracellular calcium assays240975632013NA
PRRID_1051Glucan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalelicit innate immune responseCgToll-like receptor 3 (TLR3)Toll-like receptor (TLR)C. gigasHEK293 cellsNANANANANANF-240985082013NA
PRRID_1051Glucan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalelicit innate immune responseCgToll-like receptor 3 (TLR3)Toll-like receptor (TLR)C. gigasHEK293 cellsNANANANANANF-240985082013NA
PRRID_1054H protein

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fimbriae of Escherichia coli (Bacteria)MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLAAVKSGTKAKRAQRPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEQGKSLDDFLIKQ137ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman peripheral blood mononuclear cells (hPBMCs)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA240168502013Pubchem_assay
PRRID_1054H protein

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fimbriae of Escherichia coli (Bacteria)MSEALKILNNIRTLRAQARECTLETLEEMLEKLEVVVNERREEESAAAAEVEERTRKLQQYREMLIADGIDPNELLNSLAAVKSGTKAKRAQRPAKYSYVDENGETKTWTGQGRTPAVIKKAMDEQGKSLDDFLIKQ137ProteinNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman peripheral blood mononuclear cells (hPBMCs)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA240168502013Pubchem_assay
PRRID_1058Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs extracellular domains of leucine-rich repeat motifs O60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA239853022013Pubchem_assay
PRRID_1058Flagellin

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BacteriaMAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs extracellular domains of leucine-rich repeat motifs O60602.fastaO60602858It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88.NA239853022013Pubchem_assay
PRRID_1065HKLM

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heat-killed Listeria monocytogenes (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NF-240985082013Pubchem_assay
PRRID_1065HKLM

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heat-killed Listeria monocytogenes (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NF-240985082013Pubchem_assay
PRRID_1066HKVP

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heat-killed Vibrio Parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784NANF-240985082013Pubchem_assay
PRRID_1066HKVP

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heat-killed Vibrio Parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturaltriggers immune responsesToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784NANF-240985082013Pubchem_assay
PRRID_1067HMGB1

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Neisseria meningitidis (Bacteria)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs O60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1067HMGB1

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Neisseria meningitidis (Bacteria)MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE215ProteinNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs O60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NA239853022013Pubchem_assay
PRRID_1088Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)TRIF mutant (C57BL/6J-Ticam1Lps2) micebone marrow-derived macrophage (BMDM) culture Toll/IL-1R (TIR) domainQ9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemQuantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations240195322013Pubchem_assay
PRRID_1088Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)TRIF mutant (C57BL/6J-Ticam1Lps2) micebone marrow-derived macrophage (BMDM) culture Toll/IL-1R (TIR) domainQ9QUK6.fastaQ9QUK6835TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemQuantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations240195322013Pubchem_assay
PRRID_1090Lipopolysaccharide (LPS)

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outer membrane of Gram- negative bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANATLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA240053212013NA
PRRID_1090Lipopolysaccharide (LPS)

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outer membrane of Gram- negative bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANATLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemNA240053212013NA
PRRID_1092Lipopolysaccharide (LPS)

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E. coli Serotype 055:B5(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responsePcLec5C type Lectin (CTL/CLR)red swamp crayfish (Procambarus clarkii)hepatopancreas, gills and intestinecarbohydrate recognition domain (CRD)NANANAplay important roles in the innate immune system of crustaceansELISA239890402013NA
PRRID_1092Lipopolysaccharide (LPS)

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E. coli Serotype 055:B5(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responsePcLec5C type Lectin (CTL/CLR)red swamp crayfish (Procambarus clarkii)hepatopancreas, gills and intestinecarbohydrate recognition domain (CRD)NANANAplay important roles in the innate immune system of crustaceansELISA239890402013NA
PRRID_1096Lipopolysaccharide (LPS)

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E. coli K12(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHEK293 cellsNAO00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNF-240985082013Pubchem_assay
PRRID_1096Lipopolysaccharide (LPS)

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E. coli K12(Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanHEK293 cellsNAO00206.fastaO00206839plays a fundamental role in pathogen recognition and activation of innate immunityNF-240985082013Pubchem_assay
PRRID_1097Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseCgToll-like receptor 2 (TLR2)Toll-like receptor (TLR)C. gigasHEK293 cellsNANANANANANF-240985082013NA
PRRID_1097Lipopolysaccharide (LPS)

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Gram negative Bacteria (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseCgToll-like receptor 2 (TLR2)Toll-like receptor (TLR)C. gigasHEK293 cellsNANANANANANF-240985082013NA
PRRID_1098Lipopolysaccharide (LPS)

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Pseudomonas aeruginosa (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalunique, endogenous potentiator of serous secretion from tracheal gland acinar cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Swinetracheal submucosal acinar glandsNANANANAplays a fundamental role in pathogen recognition and activation of innate immunityRT-PCR, Intracellular calcium assays240975632013NA
PRRID_1098Lipopolysaccharide (LPS)

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Pseudomonas aeruginosa (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalunique, endogenous potentiator of serous secretion from tracheal gland acinar cellsToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Swinetracheal submucosal acinar glandsNANANANAplays a fundamental role in pathogen recognition and activation of innate immunityRT-PCR, Intracellular calcium assays240975632013NA
PRRID_1102Lipoteichoic Acid (LTA)

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Staphylococcus staphylolyticus (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responsePcLec5C type Lectin (CTL/CLR)red swamp crayfish (Procambarus clarkii)hepatopancreas, gills and intestinecarbohydrate recognition domain (CRD)NANANAplay important roles in the innate immune system of crustaceansELISA239890402013NA
PRRID_1102Lipoteichoic Acid (LTA)

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Staphylococcus staphylolyticus (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responsePcLec5C type Lectin (CTL/CLR)red swamp crayfish (Procambarus clarkii)hepatopancreas, gills and intestinecarbohydrate recognition domain (CRD)NANANAplay important roles in the innate immune system of crustaceansELISA239890402013NA
PRRID_1103Lipoteichoic Acid (LTA)

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Streptococcus pyogenes (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalPPL is a glycoprotein with a lipoteichoic acid binding specificity and elicits the downstream cascade.Philyra pisum lectin (PPL)Mannose receptor (MR)Philyra pisumNANANANANAIt has antiproliferative effects on human cancer cellsHemagglutination inhibition assay243815052013NA
PRRID_1103Lipoteichoic Acid (LTA)

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Streptococcus pyogenes (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalPPL is a glycoprotein with a lipoteichoic acid binding specificity and elicits the downstream cascade.Philyra pisum lectin (PPL)Mannose receptor (MR)Philyra pisumNANANANANAIt has antiproliferative effects on human cancer cellsHemagglutination inhibition assay243815052013NA
PRRID_1105Macrophage activating lipoprotein-2 (MALP-2)

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Mycoplasma fermentans (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt primes macrophages for cytokines secretion Toll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1105Macrophage activating lipoprotein-2 (MALP-2)

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Mycoplasma fermentans (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt primes macrophages for cytokines secretion Toll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1106Mannan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)O)CO)CO)CO)O)O)O)ONAPolysaccharidesNaturalPPL is a glycoprotein with a mannan-binding specificity and elicits the downstream cascade.Philyra pisum lectin (PPL)Mannose receptor (MR)Philyra pisumNANANANANAIt has antiproliferative effects on human cancer cellsHemagglutination inhibition assay243815052013NA
PRRID_1106Mannan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)O)CO)CO)CO)O)O)O)ONAPolysaccharidesNaturalPPL is a glycoprotein with a mannan-binding specificity and elicits the downstream cascade.Philyra pisum lectin (PPL)Mannose receptor (MR)Philyra pisumNANANANANAIt has antiproliferative effects on human cancer cellsHemagglutination inhibition assay243815052013NA
PRRID_1107Macrophage activating lipoprotein-2 (MALP-2)

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Mycoplasma fermentans (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt primes macrophages for cytokines secretion Toll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1107Macrophage activating lipoprotein-2 (MALP-2)

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Mycoplasma fermentans (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalIt primes macrophages for cytokines secretion Toll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)NANANAfundamental role in pathogen recognition and activation of innate immunity.NA239853022013NA
PRRID_1111nonmethylated CpG-containing DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseRT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1111nonmethylated CpG-containing DNA

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BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Humantestis, epididymis, vasa deferens, prostate and prepuceNAQ9NR96.fastaQ9NR961032induces pro-inflammatory cytokine responseRT-PCR, Quantitative real-time PCR239982722013Pubchem_assay
PRRID_1114Pam3CysK

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)ONALipoproteinSynthetictriacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB. Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)TRIF mutant (C57BL/6J-Ticam1Lps2) micebone marrow-derived macrophage (BMDM) culture Toll/IL-1R (TIR) domainQ9QUN7.fastaQ9QUN7784TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations240195322013Pubchem_assay
PRRID_1114Pam3CysK

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)ONALipoproteinSynthetictriacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB. Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)TRIF mutant (C57BL/6J-Ticam1Lps2) micebone marrow-derived macrophage (BMDM) culture Toll/IL-1R (TIR) domainQ9QUN7.fastaQ9QUN7784TLR2 is involved in the specific recognition of a wide range of ligands, either as a homodimer or as a heterodimer with TLR1 or TLR6.Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations240195322013Pubchem_assay
PRRID_1115Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)TRIF mutant (C57BL/6J-Ticam1Lps2) micebone marrow-derived macrophage (BMDM) culture Toll/IL-1R (TIR) domainQ9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responses Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations240195322013Pubchem_assay
PRRID_1115Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)TRIF mutant (C57BL/6J-Ticam1Lps2) micebone marrow-derived macrophage (BMDM) culture Toll/IL-1R (TIR) domainQ9QUN7.fastaQ9QUN7784significant role in the pathogenesis of severe inflammatory responses Quantitative Real Time PCR, Cell Viability Assays, Immunoblot and Immunoprecipitations240195322013Pubchem_assay
PRRID_1117Peptidoglycan (PGN)

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Staphylococcus staphylolyticus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responsePcLec5C type Lectin (CTL/CLR)red swamp crayfish (Procambarus clarkii)hepatopancreas, gills and intestinecarbohydrate recognition domain (CRD)NANANAplay important roles in the innate immune system of crustaceansELISA239890402013NA
PRRID_1117Peptidoglycan (PGN)

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Staphylococcus staphylolyticus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responsePcLec5C type Lectin (CTL/CLR)red swamp crayfish (Procambarus clarkii)hepatopancreas, gills and intestinecarbohydrate recognition domain (CRD)NANANAplay important roles in the innate immune system of crustaceansELISA239890402013NA
PRRID_1120Peptidoglycan (PGN)

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Bacillus subtilis(Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NF-240985082013Pubchem_assay
PRRID_1120Peptidoglycan (PGN)

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Bacillus subtilis(Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanHEK293 cellsNAO60603.fastaO60603784significant role in the pathogenesis of severe inflammatory responses NF-240985082013Pubchem_assay
PRRID_1121Poly-g-glutamic acid (g-PGA)

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Bacillus subtilis(Bacteria)C(CC(C(=O)O)NC(=O)CCC(C(=O)O)NC(=O)CCC(C(=O)O)NC(=O)CCC(C(=O)O)N)C=ONAanionic polypeptideNaturalactivate immune cells through interactions with toll-like receptor 4 (TLR4). It is able to activate the subsequent signals through TLR4/MD2 to result in dimerization of IRF-3Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman peripheral blood mononuclear cells (hPBMCs)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA240168502013Pubchem_assay
PRRID_1121Poly-g-glutamic acid (g-PGA)

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Bacillus subtilis(Bacteria)C(CC(C(=O)O)NC(=O)CCC(C(=O)O)NC(=O)CCC(C(=O)O)NC(=O)CCC(C(=O)O)N)C=ONAanionic polypeptideNaturalactivate immune cells through interactions with toll-like receptor 4 (TLR4). It is able to activate the subsequent signals through TLR4/MD2 to result in dimerization of IRF-3Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)Humanhuman peripheral blood mononuclear cells (hPBMCs)NAO00206.fastaO00206839TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune systemELISA240168502013Pubchem_assay
PRRID_1126Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1126Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 6 /2 (TLR6/2)Toll-like receptor (TLR)Micemonocyte/macrophages, DCs, B-lymphocytesextracellular domains of leucine-rich repeat motifs NANANAsignificant role in the pathogenesis of severe inflammatory responses NA239853022013NA
PRRID_1128Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)Q9QUN7.fastaQ9QUN7784fundamental role in pathogen recognition and activation of innate immunity.NA239853022013Pubchem_assay
PRRID_1128Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Micemonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)Q9QUN7.fastaQ9QUN7784fundamental role in pathogen recognition and activation of innate immunity.NA239853022013Pubchem_assay
PRRID_1132Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)O60603.fastaO60603784fundamental role in pathogen recognition and activation of innate immunity.NA239853022013Pubchem_assay
PRRID_1132Porins

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Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396Pattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Humanmonocyte/macrophages, Myeloid DCs, neutrophils, Mast cellsCell Surface (Exogenous)O60603.fastaO60603784fundamental role in pathogen recognition and activation of innate immunity.NA239853022013Pubchem_assay