| Primary information |
|---|
| PRRID | PRRID_1049 |
| Ligand Name | Flagellin |
| Source | Pseudomonas aeruginosa (Bacteria) |
| Sequence of ligand | MALTVNTNIASLNTQRNLNASSNDLNTSLQRLTTGYRINSAKDDAAGLQISNRLSNQISGLNVATRNANDGISLAQTAEGALQQSTNILQRIRDLALQSANGSNSDADRAALQKEVAAQQAELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTIVTGYVQLNSPTAYSVSGTGTQASQVFGNASAAQKSSVASVDISTADGAQNAIAVVDNALAAIDAQRADLGAVQNRFKNTIDNLTNISENATNARSRIKDTDFAAETAALSKNQVLQQAGTAILAQANQLPQAVLSLLR |
| Length | 488 |
| Type | Protein |
| Occurence | Natural |
| Role of Ligand | involved in the upregulation of airway serous secretion |
| Name of receptor | Toll-like receptor 5 (TLR5) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Swine |
| Localization | tracheal submucosal acinar glands |
| Domain | NA |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | TLR5 is also involved in the airway mucosal defense systems as a unique endogenous potentiator of elec- trolyte-water secretion from submucosal gland acinar cells and that NO/cGMP/cGK signaling is involved in this rapid TLR5 signaling pathway |
| Assay used | RT-PCR, Intracellular calcium assays |
| PMID | 24097563 |
| Year of Publication | 2013 |
| Pubchem assay | NA |
| Primary information |
|---|
| PRRID | PRRID_1049 |
| Ligand Name | Flagellin |
| Source | Pseudomonas aeruginosa (Bacteria) |
| Sequence of ligand | MALTVNTNIASLNTQRNLNASSNDLNTSLQRLTTGYRINSAKDDAAGLQISNRLSNQISGLNVATRNANDGISLAQTAEGALQQSTNILQRIRDLALQSANGSNSDADRAALQKEVAAQQAELTRISDTTTFGGRKLLDGSFGTTSFQVGSNAYETIDISLQNASASAIGSYQVGSNGAGTVASVAGTATASGIASGTVNLVGGGQVKNIAIAAGDSAKAIAEKMDGAIPNLSARARTVFTADVSGVTGGSLNFDVTVGSNTVSLAGVTSTQDLADQLNSNSSKLGITASINDKGVLTITSATGENVKFGAQTGTATAGQVAVKVQGSDGKFEAAAKNVVAAGTAATTTIVTGYVQLNSPTAYSVSGTGTQASQVFGNASAAQKSSVASVDISTADGAQNAIAVVDNALAAIDAQRADLGAVQNRFKNTIDNLTNISENATNARSRIKDTDFAAETAALSKNQVLQQAGTAILAQANQLPQAVLSLLR |
| Length | 488 |
| Type | Protein |
| Occurence | Natural |
| Role of Ligand | involved in the upregulation of airway serous secretion |
| Name of receptor | Toll-like receptor 5 (TLR5) |
| Type of receptor | Toll-like receptor (TLR) |
| Source | Swine |
| Localization | tracheal submucosal acinar glands |
| Domain | NA |
| Sequence of Receptor | NA |
| Swiss prot ID | NA |
| Length Of Receptor | NA |
| Function | TLR5 is also involved in the airway mucosal defense systems as a unique endogenous potentiator of elec- trolyte-water secretion from submucosal gland acinar cells and that NO/cGMP/cGK signaling is involved in this rapid TLR5 signaling pathway |
| Assay used | RT-PCR, Intracellular calcium assays |
| PMID | 24097563 |
| Year of Publication | 2013 |
| Pubchem assay | NA |